The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter

Molecular Pharmacology

Volumn 54, Issue 4, 1998, Pages 601-609

  Jayanthi, Lankupalle D ^a   Apparsundaram, Subramaniam ^a   Malone, M Denise ^a   Ward, Eric ^a   Miller, David M ^a   Eppler, Mark ^b   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ZOETIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE DERIVATIVE; CARRIER PROTEIN; COCAINE; DOPAMINE TRANSPORTER; NEUROTRANSMITTER; NORADRENALIN; TRICYCLIC ANTIDEPRESSANT AGENT;

ARTICLE; CAENORHABDITIS ELEGANS; DOPAMINERGIC SYSTEM; DRUG TARGETING; GENE LOCUS; GENETIC ANALYSIS; HELA CELL; HUMAN; HUMAN CELL; NEUROTRANSMISSION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CARRIER PROTEINS; CATTLE; COCAINE; DNA, COMPLEMENTARY; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; EXONS; HELA CELLS; HUMANS; KINETICS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OLIGONUCLEOTIDES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0031754719     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Adkins EM, Barker EL, Gray MA, Niznik HB, and Blakely RD (1997) Antagonist and substrate recognition by the serotonin transporter probed by species-scanning mutagenesis. Soc Neurosci Abstr 23:162.
2. Apparsundaram S, Moore KR, Hartzell HC, Blakely RD, and Malone D (1997) Molecular cloning and characterization of an epinephrine transporter from sympathetic ganglia of the bullfrog, Rana catesbiana. J Neurosci 17:2691-2702.
3. Barker EL and Blakely, RD (1995) Norepinephrine and serotonin transporters: Molecular targets of antidepressant drugs, in Psychopharmacology: The Fourth Generation of Progress (Bloom FE and Kupfer DJ, eds) pp 321-333, Raven Press, New York.
4. Barker EL and Blakely RD (1997) Insights into structural determinants of neurotransmitter transport using cross-species chimeras: Studies on the serotonin transporter. Methods Enzymol, in press.
5. Barker EL, Perlman MA, Adkins EM, Houlihan WJ, Pristupa ZB, Niznik HB, and Blakely RB (1998) Antagonist binding sites on the serotonin transporter revealed by species-scanning mutagenesis. J Biol Chem 273:19459-19468.
6. Barstead RJ and Waterson RH (1989) The basal component of the nematode dense-body is vinculin. J Biol Chem 264:10177-10185.
7. Blakely RD, Clark JA, Rudnick G, and Amara SG (1991) Vaccinia-T7 RNA polymerase expression system: Evaluation for the expression cloning of plasma membrane transporters. Anal Biochem 194:302-308.
8. Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, Galli A, DeFelice LJ (1998) Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biol Psychiatry 44:169-178.
9. Blaxter M, and Liu L (1996) Nematode spiced leaders-ubiquity, evolution and utility. Int J Parasitology 26:1025-1033.
10. Brüss M, Hammermann R, Brimijoin S, and Bönisch H (1995) Antipeptide antibodies confirm the topology of the human norepinephrine transporter. J Biol Chem 270:9197-9201.
11. Corey JL, Quick MW, Davidson N, Lester HA, and Guastella J (1994) A cocaine-sensitive drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. Proc Natl Acad Sci USA 91:1188-1192.
12. Demchyshyn LL, Pristupa ZB, Sugamori KS, Barker EL, Blakely RD, Wolfgang WJ, Forte MA, and Niznik HB (1994) Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. Proc Natl Acad Sci USA 91:5158-5162.
13. Desai C, and Horvitz RC (1989) C.elegans mutants defective in the functioning of the motor neurons responsible for egg laying. Genetics 121:703-721.
14. Galli A, Petersen CI, deBlaquiere M, Blakely RD, and DeFelice LJ (1997) Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotoningated ion channel. J Neurosci 17:3401-3411.
15. Giros B, and Caron MG (1993) Molecular characterization of the dopamine transporter. Trends Pharmacol Sci 14:43-49.
16. Giros B, Jaber M, Jones SR, Wigthman RM, and Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (Lond) 379:606-612.
17. Guastella J, Nelson N, Nelson H, Czyzyk L, Keynan S, Miedel MC, Davidson N, Lester HA, and Kanner BI (1990) Cloning and expression of a rat brain GABA transporter. Science (Washington DC) 249:1303-1306.
18. Huang SP, Tattar TA, Rohde RA, and Zuckerman BM (1982) Caenorhabditis elegans: Effects of 5-hydroxytryptophan and dopamine on behavior and development. Exp Parasitology 54:72-79.
19. Hyman SE (1996) Addiction to cocaine and amphetamine. Neuron 16:901-904.
20. Kilty JE, Lorang D, and Amara SG (1991) Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science (Washington DC) 254:578-580.
21. Kisiel MJ, Deubert KH, and Zuckerman BM (1976) Biogenic amines in the free-living nematode C. briggsae. Exp Aging Res 2:37-44.
22. Kitayama S, Shimada S, Xu H, Markham L, Donovan DM, and Uhl GR (1992) Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci USA 89:7782-7785.
23. Kornfeld R, and Kornfeld S (1995) Asparagine-linked oligosaccharides. Ann Rev Biochem 54:631-664.
24. Kozak M (1986) Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44:283-292.
25. Kravitz EA (1988) Hormonal control of behavior: Amines and the biasing of behavioral output in lobsters. Science (Washington DC) 241:1775-1780.
26. Kuhar MJ, Ritz MC, and Boja JW (1991) The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci 14:299-302.
27. Melikian HE, Ramamoorthy S, Tate CG, and Blakely RD (1996) Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition. Mol Pharmacol 50:266-276.
28. Miller KG, Alfonso A, Nguyen M, Crowell JA, Johnson CD, and Rand JB (1996) A genetic selection for Caenorhabditis elegans synaptic transmission mutants. Proc Natl Acad Sci USA 93:12593-12598.
29. Mongeau R, Blier P, and de Montigny C (1997) The serotonergic and noradrenergic systems of the hippocampus: Their interactions and the effects of antidepressant treatments. Brain Res Rev 23:145-195.
30. Pacholczyk T, Blakely RD, and Amara SG (1991) Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature (Lond) 350: 350-354.
31. Pelham HRB (1997) EJCB-lecture. SNAREs and the organization of the secretory pathway. Eur J Cell Biol 74:311-314.
32. Rudnick G, and Clark J (1993) From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim Biophys Acta 1144:249-263.
33. Sambrook J, Fritsch EF, and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY.
34. Schafer WR and Kenyon CJ (1995) A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans. Nature (Lond) 375:73-78.
35. Soehnge H, Huang X, Becker M, Whitley P, Conover D, and Stern M (1996) A neurotransmitter transporter encoded by the Drosophila inebriated gene. Proc Natl Acad Sci USA 93:13262-13267.
36. Sulston J, Dew M, and Brenner S (1975) Dopaminergic neurons in the nematode caenorhabditis elegans. J Comp Neur 163:215-226.
37. Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, and Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science (Washington DC) 276:1699-1702.
38. Weinshenker D, Garriga G, and Thomas JH (1995) Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans. J Neurosci 15:6975-6985.
39. Wilson R, Ainscough R, Anderson K, Baynes C, Berks M, Bonfield J, Burton J, Connell M, Copsey T, Cooper J, Coulson A, Craxton M, Dear S, Du Z, Durbin R, Favello A, Fraser A, Fulton L, Gardner A, Green P, Hawkins T, Hillier L, Jier M, Johnston L, Jones M, Kershaw J, Kirsten J, Laisster N, Latreille P, Lightning J, Lloyd C, Mortimore B, O'Callaghan M, Parsons J, Percy C, Rifken L, Roopra A, Saunders D, Shownkeen R, Sims M, Smaldon N, Smith A, Smith M, Sonnhammer E, Staden R, Sulston J, Thierry-Mieg J, Thomas K, Vaudin M, Vaughan K, Waterston R, Watson A, Weinstock L, Wilkinson-Sproat J, and Wohldman P. (1994) 2.2 Mb of contiguous necleotide sequence from chromosome III of C. elegans. Nature (Lond) 368:32-38.
40. Zwaal RR, Broeks A, van Meurs J, Groenen JTM, and Plasterk RHA (1993) Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank. Proc Natl Acad Sci USA 90:7431-7435.