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Volumn 4, Issue MAY, 2013, Pages

Neuronal inputs and outputs of aging and longevity

Author keywords

Aging; Brain; Homeostasis; Longevity; Nervous system; Neuroendocrine system

Indexed keywords


EID: 84883523158     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2013.00071     Document Type: Article
Times cited : (31)

References (203)
  • 1
    • 77954955686 scopus 로고    scopus 로고
    • Heat shock factors: integrators of cell stress, development and lifespan
    • Åkerfelt, M., Morimoto, R. I., and Sistonen, L. (2010). Heat shock factors: integrators of cell stress, development and lifespan. Nat. Rev. Mol. Cell Biol. 11, 545-555.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 545-555
    • Åkerfelt, M.1    Morimoto, R.I.2    Sistonen, L.3
  • 4
    • 78651265049 scopus 로고    scopus 로고
    • Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
    • Alic, N., Hoddinott, M. P., Vinti, G., and Partridge, L. (2011). Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging Cell 10, 137-147.
    • (2011) Aging Cell , vol.10 , pp. 137-147
    • Alic, N.1    Hoddinott, M.P.2    Vinti, G.3    Partridge, L.4
  • 5
    • 66149172131 scopus 로고    scopus 로고
    • Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study
    • Anselmi, C. V., Malovini, A., Roncarati, R., Novelli, V., Villa, F., Condorelli, G., et al. (2009). Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuv. Res. 12, 95-104.
    • (2009) Rejuv. Res. , vol.12 , pp. 95-104
    • Anselmi, C.V.1    Malovini, A.2    Roncarati, R.3    Novelli, V.4    Villa, F.5    Condorelli, G.6
  • 6
    • 0033576579 scopus 로고    scopus 로고
    • Regulation of lifespan by sensory perception in Caenorhabditis elegans
    • Apfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-809.
    • (1999) Nature , vol.402 , pp. 804-809
    • Apfeld, J.1    Kenyon, C.2
  • 7
    • 0037127026 scopus 로고    scopus 로고
    • Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
    • Arantes-Oliveira, N., Apfeld, J., Dillin, A., and Kenyon, C. (2002). Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295, 502-505.
    • (2002) Science , vol.295 , pp. 502-505
    • Arantes-Oliveira, N.1    Apfeld, J.2    Dillin, A.3    Kenyon, C.4
  • 8
    • 73449104737 scopus 로고    scopus 로고
    • Modulation of aging profiles in isogenic populations of Caenorhabditis elegans by bacteria causing different extrinsic mortality rates
    • Baeriswyl, S., Diard, M., Mosser, T., Leroy, M., Manière, X., Taddei, F., et al. (2009). Modulation of aging profiles in isogenic populations of Caenorhabditis elegans by bacteria causing different extrinsic mortality rates. Biogerontology 11, 53-65.
    • (2009) Biogerontology , vol.11 , pp. 53-65
    • Baeriswyl, S.1    Diard, M.2    Mosser, T.3    Leroy, M.4    Manière, X.5    Taddei, F.6
  • 9
    • 34548847172 scopus 로고    scopus 로고
    • Diabetic larvae and obese flies - emerging studies of metabolism in Drosophila
    • Baker, K. D., and Thummel, C. S. (2007). Diabetic larvae and obese flies - emerging studies of metabolism in Drosophila. Cell Metab. 6, 257-266.
    • (2007) Cell Metab. , vol.6 , pp. 257-266
    • Baker, K.D.1    Thummel, C.S.2
  • 10
    • 0032509484 scopus 로고    scopus 로고
    • Neurobiology of the Caenorhabditis elegans genome
    • Bargmann, C. I. (1998). Neurobiology of the Caenorhabditis elegans genome. Science 282, 2028-2033.
    • (1998) Science , vol.282 , pp. 2028-2033
    • Bargmann, C.I.1
  • 11
    • 0026419552 scopus 로고
    • Control of larval development by chemosensory neurons in Caenorhabditis elegans
    • Bargmann, C. I., and Horvitz, H. R. (1991). Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science 251, 1243-1246.
    • (1991) Science , vol.251 , pp. 1243-1246
    • Bargmann, C.I.1    Horvitz, H.R.2
  • 12
    • 33747121607 scopus 로고    scopus 로고
    • Insulin/IGF signalling in neurogenesis
    • Bateman, J. M., and McNeill, H. (2006). Insulin/IGF signalling in neurogenesis. Cell. Mol. Life Sci. 63, 1701-1705.
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 1701-1705
    • Bateman, J.M.1    McNeill, H.2
  • 13
    • 79955945927 scopus 로고    scopus 로고
    • Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging
    • Batlevi, Y., and La Spada, A. R. (2011). Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging. Neurobiol. Dis. 43, 46-51.
    • (2011) Neurobiol. Dis. , vol.43 , pp. 46-51
    • Batlevi, Y.1    La Spada, A.R.2
  • 16
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C
    • Bishop, N. A., and Guarente, L. (2007). Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447, 545-549.
    • (2007) elegans. Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 17
    • 77950229880 scopus 로고    scopus 로고
    • Neural mechanisms of ageing and cognitive decline
    • Bishop, N. A., Lu, T., and Yankner, B. A. (2010). Neural mechanisms of ageing and cognitive decline. Nature 464, 529-535.
    • (2010) Nature , vol.464 , pp. 529-535
    • Bishop, N.A.1    Lu, T.2    Yankner, B.A.3
  • 18
    • 29344467120 scopus 로고    scopus 로고
    • A developmental timing microRNA and its target regulate life span in C
    • Boehm, M., and Slack, F. (2005). A developmental timing microRNA and its target regulate life span in C. elegans. Science 310, 1954-1957.
    • (2005) elegans. Science , vol.310 , pp. 1954-1957
    • Boehm, M.1    Slack, F.2
  • 20
    • 56649121807 scopus 로고    scopus 로고
    • Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
    • doi:10.1371/journal.pone.0003721
    • Broughton, S., Alic, N., Slack, C., Bass, T., Ikeya, T., Vinti, G., et al. (2008). Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PLoS ONE 3:e3721. doi:10.1371/journal.pone.0003721
    • (2008) PLoS ONE , vol.3
    • Broughton, S.1    Alic, N.2    Slack, C.3    Bass, T.4    Ikeya, T.5    Vinti, G.6
  • 21
    • 59849091257 scopus 로고    scopus 로고
    • Insulin/IGF-like signalling, the central nervous system and aging
    • Broughton, S., and Partridge, L. (2009). Insulin/IGF-like signalling, the central nervous system and aging. Biochem. J. 418, 1-12.
    • (2009) Biochem. J. , vol.418 , pp. 1-12
    • Broughton, S.1    Partridge, L.2
  • 22
    • 20044393471 scopus 로고    scopus 로고
    • Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    • Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobsen, J., Driege, Y., et al. (2005). Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl. Acad. Sci. U.S.A. 102, 3105-3110.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 3105-3110
    • Broughton, S.J.1    Piper, M.D.W.2    Ikeya, T.3    Bass, T.M.4    Jacobsen, J.5    Driege, Y.6
  • 23
    • 33646204592 scopus 로고    scopus 로고
    • Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila
    • Carbone, M. A., Jordan, K. W., Lyman, R. F., Harbison, S. T., Leips, J., Morgan, T. J., et al. (2006). Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila. Curr. Biol. 16, 912-919.
    • (2006) Curr. Biol. , vol.16 , pp. 912-919
    • Carbone, M.A.1    Jordan, K.W.2    Lyman, R.F.3    Harbison, S.T.4    Leips, J.5    Morgan, T.J.6
  • 24
    • 84455177137 scopus 로고    scopus 로고
    • Mitochondrial dysfunction during brain aging: role of oxidative stress and modulation by antioxidant supplementation
    • Chakrabarti, S., Munshi, S., Kalpita Banerjee, R., Ishita Guha Thakurta, I. G., Sinha, M., and Bagh, M. B. (2011). Mitochondrial dysfunction during brain aging: role of oxidative stress and modulation by antioxidant supplementation. Aging Dis. 2, 242-256.
    • (2011) Aging Dis. , vol.2 , pp. 242-256
    • Chakrabarti, S.1    Munshi, S.2    Kalpita Banerjee, R.3    Ishita Guha Thakurta, I.G.4    Sinha, M.5    Bagh, M.B.6
  • 25
    • 0037870773 scopus 로고    scopus 로고
    • Synchronization of the molecular clockwork by light- and food-related cues in mammals
    • Challet, E., Caldelas, I., Graff, C., and Pévet, P. (2003). Synchronization of the molecular clockwork by light- and food-related cues in mammals. Biol. Chem. 384, 711-719.
    • (2003) Biol. Chem. , vol.384 , pp. 711-719
    • Challet, E.1    Caldelas, I.2    Graff, C.3    Pévet, P.4
  • 26
    • 44449144621 scopus 로고    scopus 로고
    • Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans
    • Chang, A. J., and Bargmann, C. I. (2008). Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 105, 7321-7326.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 7321-7326
    • Chang, A.J.1    Bargmann, C.I.2
  • 27
    • 33748620917 scopus 로고    scopus 로고
    • A distributed chemosensory circuit for oxygen preference in C
    • doi:10.1371/journal.pbio.0040274
    • Chang, A. J., Chronis, N., Karow, D. S., Marletta, M. A., and Bargmann, C. I. (2006). A distributed chemosensory circuit for oxygen preference in C. elegans. PLoS Biol. 4:e274. doi:10.1371/journal.pbio.0040274
    • (2006) elegans. PLoS Biol. , vol.4
    • Chang, A.J.1    Chronis, N.2    Karow, D.S.3    Marletta, M.A.4    Bargmann, C.I.5
  • 28
    • 34447646492 scopus 로고    scopus 로고
    • Longevity determined by developmental arrest genes in Caenorhabditis elegans
    • Chen, D., Pan, K. Z., Palter, J. E., and Kapahi, P. (2007). Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell 6, 525-533.
    • (2007) Aging Cell , vol.6 , pp. 525-533
    • Chen, D.1    Pan, K.Z.2    Palter, J.E.3    Kapahi, P.4
  • 29
    • 67149107430 scopus 로고    scopus 로고
    • HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
    • doi:10.1371/journal.pgen.1000486
    • Chen, D., Thomas, E. L., and Kapahi, P. (2009). HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet. 5:e1000486. doi:10.1371/journal.pgen.1000486
    • (2009) PLoS Genet. , vol.5
    • Chen, D.1    Thomas, E.L.2    Kapahi, P.3
  • 30
    • 84873314682 scopus 로고    scopus 로고
    • Two insulin-like peptides antagonistically regulate aversive olfactory learning in C
    • Chen, Z., Hendricks, M., Cornils, A., Maier, W., Alcedo, J., and Zhang, Y. (2013). Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans. Neuron 77, 572-585.
    • (2013) elegans. Neuron , vol.77 , pp. 572-585
    • Chen, Z.1    Hendricks, M.2    Cornils, A.3    Maier, W.4    Alcedo, J.5    Zhang, Y.6
  • 32
    • 0035283404 scopus 로고    scopus 로고
    • Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner
    • Chrysis, D., Calikoglu, A. S., Ye, P., and D'Ercole, A. J. (2001). Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. J. Neurosci. 21, 1481-1489.
    • (2001) J. Neurosci. , vol.21 , pp. 1481-1489
    • Chrysis, D.1    Calikoglu, A.S.2    Ye, P.3    D'Ercole, A.J.4
  • 33
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • Cohen, E., Bieschke, J., Perciavalle, R. M., Kelly, J. W., and Dillin, A. (2006). Opposing activities protect against age-onset proteotoxicity. Science 313, 1604-1610.
    • (2006) Science , vol.313 , pp. 1604-1610
    • Cohen, E.1    Bieschke, J.2    Perciavalle, R.M.3    Kelly, J.W.4    Dillin, A.5
  • 35
    • 70349782312 scopus 로고    scopus 로고
    • Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain
    • Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., et al. (2009). Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Curr. Biol. 19, 1591-1598.
    • (2009) Curr. Biol. , vol.19 , pp. 1591-1598
    • Copeland, J.M.1    Cho, J.2    Lo, T.3    Hur, J.H.4    Bahadorani, S.5    Arabyan, T.6
  • 36
    • 79955155505 scopus 로고    scopus 로고
    • Specific insulin-like peptides encode sensory information to regulate distinct developmental processes
    • Cornils, A., Gloeck, M., Chen, Z., Zhang, Y., and Alcedo, J. (2011). Specific insulin-like peptides encode sensory information to regulate distinct developmental processes. Development 138, 1183-1193.
    • (2011) Development , vol.138 , pp. 1183-1193
    • Cornils, A.1    Gloeck, M.2    Chen, Z.3    Zhang, Y.4    Alcedo, J.5
  • 37
    • 77956795163 scopus 로고    scopus 로고
    • Widespread protein aggregation as an inherent part of aging in Celegans.
    • doi:10.1371/journal.pbio.1000450
    • David, D. C., Ollikainen, N., Trinidad, J. C., Cary, M. P., Burlingame, A. L., and Kenyon, C. (2010). Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol. 8:e1000450. doi:10.1371/journal.pbio.1000450
    • (2010) PLoS Biol. , vol.8
    • David, D.C.1    Ollikainen, N.2    Trinidad, J.C.3    Cary, M.P.4    Burlingame, A.L.5    Kenyon, C.6
  • 39
    • 0034779064 scopus 로고    scopus 로고
    • Sex-specific longevity associations defined by tyrosine hydroxylase-insulin-insulin growth factor 2 haplotypes on the 11p15
    • De Luca, M., Rose, G., Bonafè, M., Garasto, S., Greco, V., Weir, B. S., et al. (2001). Sex-specific longevity associations defined by tyrosine hydroxylase-insulin-insulin growth factor 2 haplotypes on the 11p15.5 chromosomal region. Exp. Gerontol. 36, 1663-1671.
    • (2001) chromosomal region. Exp. Gerontol. , vol.36 , pp. 1663-1671
    • De Luca, M.1    Rose, G.2    Bonafè, M.3    Garasto, S.4    Greco, V.5    Weir, B.S.6
  • 41
    • 84870814857 scopus 로고    scopus 로고
    • Comparative biology: looking for a master switch
    • Deweerdt, S. (2012). Comparative biology: looking for a master switch. Nature 492, S10-S11.
    • (2012) Nature , vol.492
    • Deweerdt, S.1
  • 42
    • 0037147103 scopus 로고    scopus 로고
    • Rates of behavior and aging specified by mitochondrial function during development
    • Dillin, A., Hsu, A. L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., et al. (2002a). Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-2401.
    • (2002) Science , vol.298 , pp. 2398-2401
    • Dillin, A.1    Hsu, A.L.2    Arantes-Oliveira, N.3    Lehrer-Graiwer, J.4    Hsin, H.5    Fraser, A.G.6
  • 43
    • 0037174629 scopus 로고    scopus 로고
    • Timing requirements for insulin/IGF-1 signaling in C
    • Dillin, A., Crawford, D. K., and Kenyon, C. (2002b). Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298, 830-834.
    • (2002) elegans. Science , vol.298 , pp. 830-834
    • Dillin, A.1    Crawford, D.K.2    Kenyon, C.3
  • 44
    • 78650944949 scopus 로고    scopus 로고
    • The cell-non-autonomous nature of electron transport chain-mediated longevity
    • Durieux, J., Wolff, S., and Dillin, A. (2011). The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144, 79-91.
    • (2011) Cell , vol.144 , pp. 79-91
    • Durieux, J.1    Wolff, S.2    Dillin, A.3
  • 45
    • 81455157378 scopus 로고    scopus 로고
    • Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-ß toxicity
    • doi:10.1186/alzrt74
    • Eckert, A., Schmitt, K., and Götz, J. (2011). Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-ß toxicity. Alzheimers Res. Ther. 3, 15. doi:10.1186/alzrt74
    • (2011) Alzheimers Res. Ther. , vol.3 , pp. 15
    • Eckert, A.1    Schmitt, K.2    Götz, J.3
  • 46
    • 11244280883 scopus 로고    scopus 로고
    • JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine
    • Eminel, S., Klettner, A., Roemer, L., Herdegen, T., and Waetzig, V. (2004). JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine. J. Biol. Chem. 279, 55385-55392.
    • (2004) J. Biol. Chem. , vol.279 , pp. 55385-55392
    • Eminel, S.1    Klettner, A.2    Roemer, L.3    Herdegen, T.4    Waetzig, V.5
  • 47
    • 78651233673 scopus 로고    scopus 로고
    • Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila
    • doi:10.1371/journal.pone.0015780
    • Enell, L. E., Kapan, N., Söderberg, J. A. E., Kahsai, L., and Nässel, D. R. (2010). Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila. PLoS ONE 5:e15780. doi:10.1371/journal.pone.0015780
    • (2010) PLoS ONE , vol.5
    • Enell, L.E.1    Kapan, N.2    Söderberg, J.A.E.3    Kahsai, L.4    Nässel, D.R.5
  • 49
    • 50049116926 scopus 로고    scopus 로고
    • C. elegans dauer formation and the molecular basis of plasticity
    • Fielenbach, N., and Antebi, A. (2008). C. elegans dauer formation and the molecular basis of plasticity. Genes Dev. 22, 2149-2165.
    • (2008) Genes Dev. , vol.22 , pp. 2149-2165
    • Fielenbach, N.1    Antebi, A.2
  • 52
    • 1542328247 scopus 로고    scopus 로고
    • Assessing natural variation in genes affecting Drosophila lifespan
    • Flatt, T. (2004). Assessing natural variation in genes affecting Drosophila lifespan. Mech. Ageing Dev. 125, 155-159.
    • (2004) Mech. Ageing Dev. , vol.125 , pp. 155-159
    • Flatt, T.1
  • 53
    • 25144508573 scopus 로고    scopus 로고
    • The evolutionary genetics of canalization
    • Flatt, T. (2005). The evolutionary genetics of canalization. Q. Rev. Biol. 80, 287-316.
    • (2005) Q. Rev. Biol. , vol.80 , pp. 287-316
    • Flatt, T.1
  • 55
    • 69949084150 scopus 로고    scopus 로고
    • Integrating evolutionary and molecular genetics of aging
    • Flatt, T., and Schmidt, P. S. (2009). Integrating evolutionary and molecular genetics of aging. Biochim. Biophys. Acta 1790, 951-962.
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 951-962
    • Flatt, T.1    Schmidt, P.S.2
  • 57
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span - from yeast to humans
    • Fontana, L., Partridge, L., and Longo, V. D. (2010). Extending healthy life span - from yeast to humans. Science 328, 321-328.
    • (2010) Science , vol.328 , pp. 321-328
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 58
    • 77953642134 scopus 로고    scopus 로고
    • Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
    • Fridell, Y. W., Hoh, M., Kréneisz, O., Hosier, S., Chang, C., Scantling, D., et al. (2009). Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan. Aging (Albany, NY) 1, 699-713.
    • (2009) Aging (Albany, NY) , vol.1 , pp. 699-713
    • Fridell, Y.W.1    Hoh, M.2    Kréneisz, O.3    Hosier, S.4    Chang, C.5    Scantling, D.6
  • 59
    • 23944494249 scopus 로고    scopus 로고
    • Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly
    • Fridell, Y. W., Sanchez Blanco, A., Silvia, B. A., and Helfand, S. L. (2005). Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. Cell Metab. 1, 145-152.
    • (2005) Cell Metab. , vol.1 , pp. 145-152
    • Fridell, Y.W.1    Sanchez Blanco, A.2    Silvia, B.A.3    Helfand, S.L.4
  • 60
    • 84872023523 scopus 로고    scopus 로고
    • Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans
    • doi:10.1371/journal.pgen.1003133
    • Gaglia, M. M., Jeong, D.-E., Ryu, E.-A., Lee, D., Kenyon, C., and Lee, S.-J. (2012). Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genet. 8:e1003133. doi:10.1371/journal.pgen.1003133
    • (2012) PLoS Genet. , vol.8
    • Gaglia, M.M.1    Jeong, D.-E.2    Ryu, E.-A.3    Lee, D.4    Kenyon, C.5    Lee, S.-J.6
  • 61
    • 84863313468 scopus 로고    scopus 로고
    • Season of birth and exceptional longevity: comparative study of American centenarians, their siblings, and spouses
    • doi:10.4061/2011/104616
    • Gavrilov, L. A., and Gavrilova, N. S. (2011). Season of birth and exceptional longevity: comparative study of American centenarians, their siblings, and spouses. J. Aging Res. 2011:104616. doi:10.4061/2011/104616
    • (2011) J. Aging Res. , vol.2011
    • Gavrilov, L.A.1    Gavrilova, N.S.2
  • 62
    • 1542328246 scopus 로고    scopus 로고
    • Quantitative trait loci affecting natural variation in Drosophila longevity
    • Geiger-Thornsberry, G. L., and Mackay, T. F. C. (2004). Quantitative trait loci affecting natural variation in Drosophila longevity. Mech. Ageing Dev. 125, 179-189.
    • (2004) Mech. Ageing Dev. , vol.125 , pp. 179-189
    • Geiger-Thornsberry, G.L.1    Mackay, T.F.C.2
  • 63
    • 69149110896 scopus 로고    scopus 로고
    • Remote control of insulin secretion by fat cells in Drosophila
    • Geminard, C., Rulifson, E. J., and Leopold, P. (2009). Remote control of insulin secretion by fat cells in Drosophila. Cell Metab. 10, 199-207.
    • (2009) Cell Metab. , vol.10 , pp. 199-207
    • Geminard, C.1    Rulifson, E.J.2    Leopold, P.3
  • 64
    • 0031685525 scopus 로고    scopus 로고
    • Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans
    • Gems, D., Sutton, A. J., Sundermeyer, M. L., Albert, P. S., King, K. V., Edgley, M. L., et al. (1998). Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150, 129-155.
    • (1998) Genetics , vol.150 , pp. 129-155
    • Gems, D.1    Sutton, A.J.2    Sundermeyer, M.L.3    Albert, P.S.4    King, K.V.5    Edgley, M.L.6
  • 66
    • 56849121888 scopus 로고    scopus 로고
    • Age-related behaviors have distinct transcriptional profiles in C
    • Golden, T. R., Hubbard, A., Dando, C., Herren, M., and Melov, S. (2008). Age-related behaviors have distinct transcriptional profiles in C. elegans. Aging Cell 7, 850-865.
    • (2008) elegans. Aging Cell , vol.7 , pp. 850-865
    • Golden, T.R.1    Hubbard, A.2    Dando, C.3    Herren, M.4    Melov, S.5
  • 68
    • 77649195357 scopus 로고    scopus 로고
    • Molecular evolution and functional characterization of Drosophila insulin-like peptides
    • doi:10.1371/journal.pgen.1000857
    • Grönke, S., Clarke, D. F., Broughton, S., Andrews, T. D., and Partridge, L. (2010). Molecular evolution and functional characterization of Drosophila insulin-like peptides. PLoS Genet. 6:e1000857. doi:10.1371/journal.pgen.1000857
    • (2010) PLoS Genet. , vol.6
    • Grönke, S.1    Clarke, D.F.2    Broughton, S.3    Andrews, T.D.4    Partridge, L.5
  • 69
    • 33745553890 scopus 로고    scopus 로고
    • Melatonin stimulates glucose transport via insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells
    • Ha, E., Yim, S.-V., Chung, J.-H., Yoon, K.-S., Kang, I., Cho, Y. H., et al. (2006). Melatonin stimulates glucose transport via insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells. J. Pineal Res. 41, 67-72.
    • (2006) J. Pineal Res. , vol.41 , pp. 67-72
    • Ha, E.1    Yim, S.-V.2    Chung, J.-H.3    Yoon, K.-S.4    Kang, I.5    Cho, Y.H.6
  • 70
    • 77956821499 scopus 로고    scopus 로고
    • Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance
    • Haselton, A., Sharmin, E., Schrader, J., Sah, M., Poon, P., and Fridell, Y. W. (2010). Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance. Cell Cycle 9, 3063-3071.
    • (2010) Cell Cycle , vol.9 , pp. 3063-3071
    • Haselton, A.1    Sharmin, E.2    Schrader, J.3    Sah, M.4    Poon, P.5    Fridell, Y.W.6
  • 73
    • 0034279245 scopus 로고    scopus 로고
    • Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice
    • Ho, N., Liauw, J. A., Blaeser, F., Wei, F., Hanissian, S., Muglia, L. M., et al. (2000). Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J. Neurosci. 20, 6459-6472.
    • (2000) J. Neurosci. , vol.20 , pp. 6459-6472
    • Ho, N.1    Liauw, J.A.2    Blaeser, F.3    Wei, F.4    Hanissian, S.5    Muglia, L.M.6
  • 75
    • 42249108516 scopus 로고    scopus 로고
    • Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    • doi:10.1186/jbiol72
    • Honegger, B., Galic, M., Kohler, K., Wittwer, F., Brogiolo, W., Hafen, E., et al. (2008). Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J. Biol. 7:10. doi:10.1186/jbiol72
    • (2008) J. Biol. , vol.7 , pp. 10
    • Honegger, B.1    Galic, M.2    Kohler, K.3    Wittwer, F.4    Brogiolo, W.5    Hafen, E.6
  • 76
    • 0033609291 scopus 로고    scopus 로고
    • Signals from the reproductive system regulate the lifespan of C
    • Hsin, H., and Kenyon, C. (1999). Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-366.
    • (1999) elegans. Nature , vol.399 , pp. 362-366
    • Hsin, H.1    Kenyon, C.2
  • 77
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu, A. L., Murphy, C. T., and Kenyon, C. (2003). Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300, 1142-1145.
    • (2003) Science , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 78
    • 37849019064 scopus 로고    scopus 로고
    • Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila
    • Hsu, H. J., LaFever, L., and Drummond-Barbosa, D. (2008). Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Dev. Biol. 313, 700-712.
    • (2008) Dev. Biol. , vol.313 , pp. 700-712
    • Hsu, H.J.1    LaFever, L.2    Drummond-Barbosa, D.3
  • 79
    • 84876134967 scopus 로고    scopus 로고
    • The developing, aging neocortex: how genetics and epigenetics influence early developmental patterning and age-related change
    • doi:10.3389/fgene.2012.00212
    • Huffman, K. (2012). The developing, aging neocortex: how genetics and epigenetics influence early developmental patterning and age-related change. Front. Genet. 3:212. doi:10.3389/fgene.2012.00212
    • (2012) Front. Genet. , vol.3 , pp. 212
    • Huffman, K.1
  • 80
    • 64449085187 scopus 로고    scopus 로고
    • Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan
    • Humphrey, D. M., Toivonen, J. M., Giannakou, M., Partridge, L., and Brand, M. D. (2009). Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan. Exp. Gerontol. 44, 316-327.
    • (2009) Exp. Gerontol. , vol.44 , pp. 316-327
    • Humphrey, D.M.1    Toivonen, J.M.2    Giannakou, M.3    Partridge, L.4    Brand, M.D.5
  • 81
    • 33750719067 scopus 로고    scopus 로고
    • Aging: a shift from redox regulation to oxidative damage
    • Humphries, K. M., Szweda, P. A., and Szweda, L. I. (2006). Aging: a shift from redox regulation to oxidative damage. Free Radic. Res. 40, 1239-1243.
    • (2006) Free Radic. Res. , vol.40 , pp. 1239-1243
    • Humphries, K.M.1    Szweda, P.A.2    Szweda, L.I.3
  • 82
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • Hwangbo, D. S., Gershman, B., Tu, M. P., Palmer, M., and Tatar, M. (2004). Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429, 562-566.
    • (2004) Nature , vol.429 , pp. 562-566
    • Hwangbo, D.S.1    Gershman, B.2    Tu, M.P.3    Palmer, M.4    Tatar, M.5
  • 83
    • 33847345896 scopus 로고    scopus 로고
    • Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs
    • Iser, W. B., Gami, M. S., and Wolkow, C. A. (2007). Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs. Dev. Biol. 303, 434-447.
    • (2007) Dev. Biol. , vol.303 , pp. 434-447
    • Iser, W.B.1    Gami, M.S.2    Wolkow, C.A.3
  • 84
    • 84872017766 scopus 로고    scopus 로고
    • Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging
    • doi:10.3389/fgene.2012.00218
    • Jeong, D.-E., Artan, M., Seo, K., and Lee, S.-J. (2012). Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front. Genet. 3:218. doi:10.3389/fgene.2012.00218
    • (2012) Front. Genet. , vol.3 , pp. 218
    • Jeong, D.-E.1    Artan, M.2    Seo, K.3    Lee, S.-J.4
  • 85
    • 54949143977 scopus 로고    scopus 로고
    • Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism
    • doi:10.1371/journal.pbio.0060254
    • Kappeler, L., De Magalhaes Filho, C., Dupont, J., Leneuve, P., Cervera, P., Périn, L., et al. (2008). Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol. 6:e254. doi:10.1371/journal.pbio.0060254
    • (2008) PLoS Biol. , vol.6
    • Kappeler, L.1    De Magalhaes Filho, C.2    Dupont, J.3    Leneuve, P.4    Cervera, P.5    Périn, L.6
  • 86
    • 66149160390 scopus 로고    scopus 로고
    • JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila
    • Karpac, J., Hull-Thompson, J., Falleur, M., and Jasper, H. (2009). JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 8, 288-295.
    • (2009) Aging Cell , vol.8 , pp. 288-295
    • Karpac, J.1    Hull-Thompson, J.2    Falleur, M.3    Jasper, H.4
  • 87
    • 62649089279 scopus 로고    scopus 로고
    • Insulin and JNK: optimizing metabolic homeostasis and lifespan
    • Karpac, J., and Jasper, H. (2009). Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol. Metab. 20, 100-106.
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 100-106
    • Karpac, J.1    Jasper, H.2
  • 88
    • 13944269223 scopus 로고    scopus 로고
    • The plasticity of aging: insights from long-lived mutants
    • Kenyon, C. (2005). The plasticity of aging: insights from long-lived mutants. Cell 120, 449-460.
    • (2005) Cell , vol.120 , pp. 449-460
    • Kenyon, C.1
  • 89
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon, C. (2010). The genetics of ageing. Nature 464, 504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.1
  • 91
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura, K. D., Tissenbaum, H. A., Liu, Y., and Ruvkun, G. (1997). Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-694.
    • (1997) Science , vol.277 , pp. 942-694
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 92
    • 0017763799 scopus 로고
    • Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span
    • Klass, M. R. (1977). Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech. Ageing Dev. 6, 413-429.
    • (1977) Mech. Ageing Dev. , vol.6 , pp. 413-429
    • Klass, M.R.1
  • 93
    • 84867332714 scopus 로고    scopus 로고
    • Small heat-shock proteins protect from heat-stroke-associated neurodegeneration
    • Kourtis, N., Nikoletopoulou, V., and Tavernarakis, N. (2012). Small heat-shock proteins protect from heat-stroke-associated neurodegeneration. Nature 490, 213-218.
    • (2012) Nature , vol.490 , pp. 213-218
    • Kourtis, N.1    Nikoletopoulou, V.2    Tavernarakis, N.3
  • 94
    • 0035178919 scopus 로고    scopus 로고
    • Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night-time glucose concentrations
    • la Fleur, S. E., Kalsbeek, A., Wortel, J., van der Vliet, J., and Buijs, R. M. (2001). Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night-time glucose concentrations. J. Neuroendocrinol. 13, 1025-1032.
    • (2001) J. Neuroendocrinol. , vol.13 , pp. 1025-1032
    • la Fleur, S.E.1    Kalsbeek, A.2    Wortel, J.3    van der Vliet, J.4    Buijs, R.M.5
  • 95
    • 23644444460 scopus 로고    scopus 로고
    • Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila
    • LaFever, L., and Drummond-Barbosa, D. (2005). Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila. Science 309, 1071-1073.
    • (2005) Science , vol.309 , pp. 1071-1073
    • LaFever, L.1    Drummond-Barbosa, D.2
  • 96
    • 77951559453 scopus 로고    scopus 로고
    • Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO
    • Landis, J. N., and Murphy, C. T. (2010). Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev. Dyn. 239, 1405-1412.
    • (2010) Dev. Dyn. , vol.239 , pp. 1405-1412
    • Landis, J.N.1    Murphy, C.T.2
  • 97
    • 84857477619 scopus 로고    scopus 로고
    • Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
    • doi:10.1371/journal.pgen.1002473
    • Larson, K., Yan, S. J., Tsurumi, A., Liu, J., Zhou, J., Gaur, K., et al. (2012). Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet. 8:e1002473. doi:10.1371/journal.pgen.1002473
    • (2012) PLoS Genet. , vol.8
    • Larson, K.1    Yan, S.J.2    Tsurumi, A.3    Liu, J.4    Zhou, J.5    Gaur, K.6
  • 98
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
    • Lee, J., Giordano, S., and Zhang, J. (2012). Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem. J. 441, 523-540.
    • (2012) Biochem. J. , vol.441 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 99
    • 67849119263 scopus 로고    scopus 로고
    • Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster
    • Lee, K. S., Hong, S. H., Kim, A. K., Ju, S. K., Kwon, O. Y., and Yu, K. (2009). Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster. FEBS Lett. 583, 2573-2577.
    • (2009) FEBS Lett. , vol.583 , pp. 2573-2577
    • Lee, K.S.1    Hong, S.H.2    Kim, A.K.3    Ju, S.K.4    Kwon, O.Y.5    Yu, K.6
  • 100
    • 43149111605 scopus 로고    scopus 로고
    • Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
    • Lee, K. S., Kwon, O. Y., Lee, J. H., Kwon, K., Min, K. J., Jung, S. A., et al. (2008). Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling. Nat. Cell Biol. 10, 468-475.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 468-475
    • Lee, K.S.1    Kwon, O.Y.2    Lee, J.H.3    Kwon, K.4    Min, K.J.5    Jung, S.A.6
  • 102
    • 65549165654 scopus 로고    scopus 로고
    • Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans
    • Lee, S. J., and Kenyon, C. (2009). Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr. Biol. 19, 715-722.
    • (2009) Curr. Biol. , vol.19 , pp. 715-722
    • Lee, S.J.1    Kenyon, C.2
  • 103
    • 79952582588 scopus 로고    scopus 로고
    • HIF-1 modulates longevity and healthspan in a temperature-dependent manner
    • Leiser, S. F., Begun, A., and Kaeberlein, M. (2011). HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell 10, 318-326.
    • (2011) Aging Cell , vol.10 , pp. 318-326
    • Leiser, S.F.1    Begun, A.2    Kaeberlein, M.3
  • 104
    • 16844366524 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
    • Lemasters, J. J. (2005). Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res. 8, 3-5.
    • (2005) Rejuvenation Res. , vol.8 , pp. 3-5
    • Lemasters, J.J.1
  • 105
    • 36049044765 scopus 로고    scopus 로고
    • Drosophila and the genetics of the internal milieu
    • Leopold, P., and Perrimon, N. (2007). Drosophila and the genetics of the internal milieu. Nature 450, 186-188.
    • (2007) Nature , vol.450 , pp. 186-188
    • Leopold, P.1    Perrimon, N.2
  • 107
    • 84876280641 scopus 로고    scopus 로고
    • Accelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevity
    • Li, Y., and de Magalhães, J. P. (2011). Accelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevity. Age (Dordr.) 35, 301-314.
    • (2011) Age (Dordr.) , vol.35 , pp. 301-314
    • Li, Y.1    de Magalhães, J.P.2
  • 108
    • 70350359126 scopus 로고    scopus 로고
    • Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations
    • Li, Y., Wang, W. J., Cao, H., Lu, J., Wu, C., Hu, F. Y., et al. (2009). Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum. Mol. Genet. 18, 4897-4904.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 4897-4904
    • Li, Y.1    Wang, W.J.2    Cao, H.3    Lu, J.4    Wu, C.5    Hu, F.Y.6
  • 109
    • 33847259770 scopus 로고    scopus 로고
    • Regulation of Drosophila life span by olfaction and food-derived odors
    • Libert, S., Zwiener, J., Chu, X., VanVoorhies, W., Roman, G., and Pletcher, S. D. (2007). Regulation of Drosophila life span by olfaction and food-derived odors. Science 315, 1133-1137.
    • (2007) Science , vol.315 , pp. 1133-1137
    • Libert, S.1    Zwiener, J.2    Chu, X.3    VanVoorhies, W.4    Roman, G.5    Pletcher, S.D.6
  • 111
    • 84875906572 scopus 로고    scopus 로고
    • Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure
    • Liesa, M., and Shirihai, O. S. (2013). Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. 17, 491-506.
    • (2013) Cell Metab. , vol.17 , pp. 491-506
    • Liesa, M.1    Shirihai, O.S.2
  • 112
    • 84862776753 scopus 로고    scopus 로고
    • The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila
    • Liu, N., Landreh, M., Cao, K., Abe, M., Hendriks, G. J., Kennerdell, J. R., et al. (2012). The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature 482, 519-523.
    • (2012) Nature , vol.482 , pp. 519-523
    • Liu, N.1    Landreh, M.2    Cao, K.3    Abe, M.4    Hendriks, G.J.5    Kennerdell, J.R.6
  • 113
    • 54149092555 scopus 로고    scopus 로고
    • Evolution of the aging brain transcriptome and synaptic regulation
    • doi:10.1371/journal.pone.0003329
    • Loerch, P. M., Lu, T., Dakin, K. A., Vann, J. M., Isaacs, A., Geula, C., et al. (2008). Evolution of the aging brain transcriptome and synaptic regulation. PLoS ONE 3:e3329. doi:10.1371/journal.pone.0003329
    • (2008) PLoS ONE , vol.3
    • Loerch, P.M.1    Lu, T.2    Dakin, K.A.3    Vann, J.M.4    Isaacs, A.5    Geula, C.6
  • 114
    • 84862852400 scopus 로고    scopus 로고
    • Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations
    • Luisi, P., Alvarez-Ponce, D., Dall'Olio, G. M., Sikora, M., Bertranpetit, J., and Laayouni, H. (2012). Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations. Mol. Biol. Evol. 29, 1379-1392.
    • (2012) Mol. Biol. Evol. , vol.29 , pp. 1379-1392
    • Luisi, P.1    Alvarez-Ponce, D.2    Dall'Olio, G.M.3    Sikora, M.4    Bertranpetit, J.5    Laayouni, H.6
  • 115
    • 77952908744 scopus 로고    scopus 로고
    • A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C
    • doi:10.1371/journal.pbio.1000376
    • Maier, W., Adilov, B., Regenass, M., and Alcedo, J. (2010). A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8:e1000376. doi:10.1371/journal.pbio.1000376
    • (2010) elegans lifespan. PLoS Biol. , vol.8
    • Maier, W.1    Adilov, B.2    Regenass, M.3    Alcedo, J.4
  • 116
    • 33947623671 scopus 로고    scopus 로고
    • Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders
    • Mattson, M. P. (2006). Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. Antioxid. Redox Signal. 8, 1997-2006.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 1997-2006
    • Mattson, M.P.1
  • 118
    • 0036678146 scopus 로고    scopus 로고
    • The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    • Morley, J. F., Brignull, H. R., Weyers, J. J., and Morimoto, R. I. (2002). The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 99, 10417-10422.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 10417-10422
    • Morley, J.F.1    Brignull, H.R.2    Weyers, J.J.3    Morimoto, R.I.4
  • 119
    • 0742323000 scopus 로고    scopus 로고
    • Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
    • Morley, J. F., and Morimoto, R. I. (2004). Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol. Biol. Cell 15, 657-664.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 657-664
    • Morley, J.F.1    Morimoto, R.I.2
  • 120
    • 2442649342 scopus 로고    scopus 로고
    • Overexpression of the small mitochondrial Hsp22 extends Drosophila lifespan and increases resistance to oxidative stress
    • Morrow, G., Samson, M., Michaud, S., and Tanguay, R. M. (2004). Overexpression of the small mitochondrial Hsp22 extends Drosophila lifespan and increases resistance to oxidative stress. FASEB J. 18, 598-609.
    • (2004) FASEB J. , vol.18 , pp. 598-609
    • Morrow, G.1    Samson, M.2    Michaud, S.3    Tanguay, R.M.4
  • 121
    • 37649022616 scopus 로고    scopus 로고
    • Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
    • Murphy, C. T., Lee, S. J., and Kenyon, C. (2007). Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 104, 19046-19050.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19046-19050
    • Murphy, C.T.1    Lee, S.J.2    Kenyon, C.3
  • 122
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy, C. T., McCarroll, S., Bargmann, C., Fraser, A., Kamath, R. S., Ahringer, J., et al. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-284.
    • (2003) Nature , vol.424 , pp. 277-284
    • Murphy, C.T.1    McCarroll, S.2    Bargmann, C.3    Fraser, A.4    Kamath, R.S.5    Ahringer, J.6
  • 123
    • 38349192060 scopus 로고    scopus 로고
    • Strong variations of mitochondrial mutation rate across mammals - the longevity hypothesis
    • Nabholz, B., Glémin, S., and Galtier, N. (2008). Strong variations of mitochondrial mutation rate across mammals - the longevity hypothesis. Mol. Biol. Evol. 25, 120-130.
    • (2008) Mol. Biol. Evol. , vol.25 , pp. 120-130
    • Nabholz, B.1    Glémin, S.2    Galtier, N.3
  • 124
    • 84860890706 scopus 로고    scopus 로고
    • Comparative and meta-analytic insights into life-extension via dietary restriction
    • Nakagawa, S., Lagisz, M., Hector, K. L., and Spencer, H. G. (2012). Comparative and meta-analytic insights into life-extension via dietary restriction. Aging Cell 11, 401-409.
    • (2012) Aging Cell , vol.11 , pp. 401-409
    • Nakagawa, S.1    Lagisz, M.2    Hector, K.L.3    Spencer, H.G.4
  • 125
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra, D., Tanaka, A., Suen, D. F., and Youle, R. J. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803.
    • (2008) J. Cell Biol. , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 126
    • 75749156257 scopus 로고    scopus 로고
    • PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
    • doi:10.1371/journal.pbio.1000298
    • Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D. F., Gautier, C. A., Shen, J., et al. (2010). PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 8:e1000298. doi:10.1371/journal.pbio.1000298
    • (2010) PLoS Biol. , vol.8
    • Narendra, D.P.1    Jin, S.M.2    Tanaka, A.3    Suen, D.F.4    Gautier, C.A.5    Shen, J.6
  • 127
    • 77749277117 scopus 로고    scopus 로고
    • Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independent clines on two continents
    • Paaby, A. B., Blacket, M. J., Hoffmann, A. A., and Schmidt, P. S. (2010). Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independent clines on two continents. Mol. Ecol. 19, 760-774.
    • (2010) Mol. Ecol. , vol.19 , pp. 760-774
    • Paaby, A.B.1    Blacket, M.J.2    Hoffmann, A.A.3    Schmidt, P.S.4
  • 128
    • 44849103119 scopus 로고    scopus 로고
    • Functional significance of allelic variation at methuselah, an aging gene in Drosophila
    • doi:10.1371/journal.pone.0001987
    • Paaby, A. B., and Schmidt, P. S. (2008). Functional significance of allelic variation at methuselah, an aging gene in Drosophila. PLoS ONE 3:e1987. doi:10.1371/journal.pone.0001987
    • (2008) PLoS ONE , vol.3
    • Paaby, A.B.1    Schmidt, P.S.2
  • 129
    • 84876335261 scopus 로고    scopus 로고
    • Mitophagy in neurodegeneration and aging
    • doi:10.3389/fgene.2012.00297
    • Palikaras, K., and Tavernarakis, N. (2012). Mitophagy in neurodegeneration and aging. Front. Genet. 3:297. doi:10.3389/fgene.2012.00297
    • (2012) Front. Genet. , vol.3 , pp. 297
    • Palikaras, K.1    Tavernarakis, N.2
  • 130
    • 0036245337 scopus 로고    scopus 로고
    • Mechanisms of ageing: public or private?
    • Partridge, L., and Gems, D. (2002). Mechanisms of ageing: public or private? Nat. Rev. Genet. 3, 165-175.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 165-175
    • Partridge, L.1    Gems, D.2
  • 131
    • 79954628932 scopus 로고    scopus 로고
    • Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
    • Partridge, L., Alic, N., Bjedov, I., and Piper, M. D. W. (2011). Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp. Gerontol. 46, 376-381.
    • (2011) Exp. Gerontol. , vol.46 , pp. 376-381
    • Partridge, L.1    Alic, N.2    Bjedov, I.3    Piper, M.D.W.4
  • 132
    • 13944282128 scopus 로고    scopus 로고
    • Sex and death: what is the connection?
    • Partridge, L., Gems, D., and Withers, D. J. (2005). Sex and death: what is the connection? Cell 120, 461-472.
    • (2005) Cell , vol.120 , pp. 461-472
    • Partridge, L.1    Gems, D.2    Withers, D.J.3
  • 133
    • 67651151249 scopus 로고    scopus 로고
    • Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
    • Pawlikowska, L., Hu, D., Huntsman, S., Sung, A., Chu, C., Chen, J., et al. (2009). Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8, 460-472.
    • (2009) Aging Cell , vol.8 , pp. 460-472
    • Pawlikowska, L.1    Hu, D.2    Huntsman, S.3    Sung, A.4    Chu, C.5    Chen, J.6
  • 135
    • 79955638397 scopus 로고    scopus 로고
    • Changed gene expression for candidate ageing genes in long-lived Bicyclus anynana butterflies
    • Pijpe, J., Pul, N., van Duijn, S., Brakefield, P. M., and Zwaan, B. J. (2011). Changed gene expression for candidate ageing genes in long-lived Bicyclus anynana butterflies. Exp. Gerontol. 46, 426-434.
    • (2011) Exp. Gerontol. , vol.46 , pp. 426-434
    • Pijpe, J.1    Pul, N.2    van Duijn, S.3    Brakefield, P.M.4    Zwaan, B.J.5
  • 136
    • 77951568707 scopus 로고    scopus 로고
    • Developmental biomarkers of aging in Caenorhabditis elegans
    • Pincus, Z., and Slack, F. J. (2010). Developmental biomarkers of aging in Caenorhabditis elegans. Dev. Dyn. 239, 1306-1314.
    • (2010) Dev. Dyn. , vol.239 , pp. 1306-1314
    • Pincus, Z.1    Slack, F.J.2
  • 137
    • 80053446656 scopus 로고    scopus 로고
    • MicroRNA predictors of longevity in Caenorhabditis elegans
    • doi:10.1371/journal.pgen.1002306
    • Pincus, Z., Smith-Vikos, T., and Slack, F. J. (2011). MicroRNA predictors of longevity in Caenorhabditis elegans. PLoS Genet. 7:e1002306. doi:10.1371/journal.pgen.1002306
    • (2011) PLoS Genet. , vol.7
    • Pincus, Z.1    Smith-Vikos, T.2    Slack, F.J.3
  • 138
    • 13944272576 scopus 로고    scopus 로고
    • The role of insulin receptor signaling in the brain
    • Plum, L., Schubert, M., and Bruning, J. C. (2005). The role of insulin receptor signaling in the brain. Trends Endocrinol. Metab. 16, 59-65.
    • (2005) Trends Endocrinol. Metab. , vol.16 , pp. 59-65
    • Plum, L.1    Schubert, M.2    Bruning, J.C.3
  • 139
    • 77951667748 scopus 로고    scopus 로고
    • Hypoxia activates a latent circuit for processing gustatory information in C
    • Pocock, R., and Hobert, O. (2010). Hypoxia activates a latent circuit for processing gustatory information in C. elegans. Nat. Neurosci. 13, 610-614.
    • (2010) elegans. Nat. Neurosci. , vol.13 , pp. 610-614
    • Pocock, R.1    Hobert, O.2
  • 140
    • 77951760782 scopus 로고    scopus 로고
    • Carbon dioxide sensing modulates lifespan and physiology in Drosophila
    • doi:10.1371/journal.pbio.1000356
    • Poon, P. C., Kuo, T.-H., Linford, N. J., Roman, G., and Pletcher, S. D. (2010). Carbon dioxide sensing modulates lifespan and physiology in Drosophila. PLoS Biol. 8:e1000356. doi:10.1371/journal.pbio.1000356
    • (2010) PLoS Biol. , vol.8
    • Poon, P.C.1    Kuo, T.-H.2    Linford, N.J.3    Roman, G.4    Pletcher, S.D.5
  • 141
    • 44049095652 scopus 로고    scopus 로고
    • Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
    • Prahlad, V., Cornelius, T., and Morimoto, R. I. (2008). Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 320, 811-814.
    • (2008) Science , vol.320 , pp. 811-814
    • Prahlad, V.1    Cornelius, T.2    Morimoto, R.I.3
  • 142
    • 80052137410 scopus 로고    scopus 로고
    • Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins
    • Prahlad, V., and Morimoto, R. I. (2011). Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proc. Natl. Acad. Sci. U.S.A. 108, 14204-14209.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 14204-14209
    • Prahlad, V.1    Morimoto, R.I.2
  • 143
    • 0042161896 scopus 로고    scopus 로고
    • Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
    • Puig, O., Marr, M. T. II, Ruhf, M. L., and Tjian, R. (2003). Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17, 2006-2020.
    • (2003) Genes Dev. , vol.17 , pp. 2006-2020
    • Puig, O.1    Marr, M.T.2    Ruhf, M.L.3    Tjian, R.4
  • 144
    • 26944461217 scopus 로고    scopus 로고
    • Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
    • Puig, O., and Tjian, R. (2005). Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 19, 2435-2446.
    • (2005) Genes Dev. , vol.19 , pp. 2435-2446
    • Puig, O.1    Tjian, R.2
  • 145
    • 79960217416 scopus 로고    scopus 로고
    • Drosophila as a model for interorgan communication: lessons from studies on energy homeostasis
    • Rajan, A., and Perrimon, N. (2011). Drosophila as a model for interorgan communication: lessons from studies on energy homeostasis. Dev. Cell 21, 29-31.
    • (2011) Dev. Cell , vol.21 , pp. 29-31
    • Rajan, A.1    Perrimon, N.2
  • 146
    • 0041440219 scopus 로고    scopus 로고
    • A metabolic model for life span determination in Caenorhabditis elegans
    • Rea, S., and Johnson, T. E. (2003). A metabolic model for life span determination in Caenorhabditis elegans. Dev. Cell 5, 197-203.
    • (2003) Dev. Cell , vol.5 , pp. 197-203
    • Rea, S.1    Johnson, T.E.2
  • 147
    • 35648947912 scopus 로고    scopus 로고
    • Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    • doi:10.1371/journal.pbio.0050259
    • Rea, S. L., Ventura, N., and Johnson, T. E. (2007). Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol. 5:e259. doi:10.1371/journal.pbio.0050259
    • (2007) PLoS Biol. , vol.5
    • Rea, S.L.1    Ventura, N.2    Johnson, T.E.3
  • 148
    • 79959344446 scopus 로고    scopus 로고
    • Mitochondria as a therapeutic target for aging and neurodegenerative diseases
    • Reddy, P. H., and Reddy, T. P. (2011). Mitochondria as a therapeutic target for aging and neurodegenerative diseases. Curr. Alzheimer Res. 8, 393-409.
    • (2011) Curr. Alzheimer Res. , vol.8 , pp. 393-409
    • Reddy, P.H.1    Reddy, T.P.2
  • 149
    • 33644874724 scopus 로고    scopus 로고
    • The genetic basis of aging: an evolutionary biologist's perspective
    • Reznick, D. N. (2005). The genetic basis of aging: an evolutionary biologist's perspective. Sci. Aging Knowledge Environ. 2005, e7.
    • (2005) Sci. Aging Knowledge Environ. , vol.2005
    • Reznick, D.N.1
  • 150
    • 33645879802 scopus 로고    scopus 로고
    • Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C
    • Rogers, C., Persson, A., Cheung, B., and de Bono, M. (2006). Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans. Curr. Biol. 16, 649-659.
    • (2006) elegans. Curr. Biol. , vol.16 , pp. 649-659
    • Rogers, C.1    Persson, A.2    Cheung, B.3    de Bono, M.4
  • 151
    • 84455161659 scopus 로고    scopus 로고
    • Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity
    • doi:10.1371/journal.pone.0029650
    • Rose, G., Crocco, P., De Rango, F., Montesanto, A., and Passarino, G. (2011). Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity. PLoS ONE 6:e29650. doi:10.1371/journal.pone.0029650
    • (2011) PLoS ONE , vol.6
    • Rose, G.1    Crocco, P.2    De Rango, F.3    Montesanto, A.4    Passarino, G.5
  • 152
    • 78149455668 scopus 로고    scopus 로고
    • Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study
    • doi:10.1371/journal.pone.0013395
    • Rose, G., Romeo, G., Dato, S., Crocco, P., Bruni, A. C., Hervonen, A., et al. (2010). Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study. PLoS ONE 5:e13395. doi:10.1371/journal.pone.0013395
    • (2010) PLoS ONE , vol.5
    • Rose, G.1    Romeo, G.2    Dato, S.3    Crocco, P.4    Bruni, A.C.5    Hervonen, A.6
  • 153
    • 79952648592 scopus 로고    scopus 로고
    • Annual research review: epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development
    • Roth, T. L., and Sweatt, J. D. (2011). Annual research review: epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development. J. Child Psychol. Psychiatry 52, 398-408.
    • (2011) J. Child Psychol. Psychiatry , vol.52 , pp. 398-408
    • Roth, T.L.1    Sweatt, J.D.2
  • 154
    • 79956306310 scopus 로고    scopus 로고
    • Sex-dependent modulation of longevity by two Drosophila homologues of human apolipoprotein D, GLaz and NLaz
    • Ruiz, M., Sanchez, D., Canal, I., Acebes, A., and Ganfornina, M. D. (2011). Sex-dependent modulation of longevity by two Drosophila homologues of human apolipoprotein D, GLaz and NLaz. Exp. Gerontol. 46, 579-589.
    • (2011) Exp. Gerontol. , vol.46 , pp. 579-589
    • Ruiz, M.1    Sanchez, D.2    Canal, I.3    Acebes, A.4    Ganfornina, M.D.5
  • 155
    • 0037052544 scopus 로고    scopus 로고
    • Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    • Rulifson, E. J., Kim, S. K., and Nusse, R. (2002). Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296, 1118-1120.
    • (2002) Science , vol.296 , pp. 1118-1120
    • Rulifson, E.J.1    Kim, S.K.2    Nusse, R.3
  • 156
    • 77958587538 scopus 로고    scopus 로고
    • A naturally occurring polymorphism at Drosophila melanogaster Lim3 locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan
    • doi:10.1371/journal.pone.0012621
    • Rybina, O. Y., and Pasyukova, E. G. (2010). A naturally occurring polymorphism at Drosophila melanogaster Lim3 locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan. PLoS ONE 5:e12621. doi:10.1371/journal.pone.0012621
    • (2010) PLoS ONE , vol.5
    • Rybina, O.Y.1    Pasyukova, E.G.2
  • 157
    • 84864939940 scopus 로고    scopus 로고
    • Longevity and lifetime reproductive success of barn swallow offspring are predicted by their hatching date and phenotypic quality
    • Saino, N., Romano, M., Ambrosini, R., Rubolini, D., Boncoraglio, G., Caprioli, M., et al. (2012). Longevity and lifetime reproductive success of barn swallow offspring are predicted by their hatching date and phenotypic quality. J. Anim. Ecol. 81, 1004-1012.
    • (2012) J. Anim. Ecol. , vol.81 , pp. 1004-1012
    • Saino, N.1    Romano, M.2    Ambrosini, R.3    Rubolini, D.4    Boncoraglio, G.5    Caprioli, M.6
  • 158
    • 0030272986 scopus 로고    scopus 로고
    • Chemosensory neurons function in parallel to mediate a pheromone response in C
    • Schackwitz, W. S., Inoue, T., and Thomas, J. H. (1996). Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17, 719-728.
    • (1996) elegans. Neuron , vol.17 , pp. 719-728
    • Schackwitz, W.S.1    Inoue, T.2    Thomas, J.H.3
  • 159
    • 0034718541 scopus 로고    scopus 로고
    • Adaptive evolution of a candidate gene for aging in Drosophila
    • Schmidt, P. S., Duvernell, D. D., and Eanes, W. F. (2000). Adaptive evolution of a candidate gene for aging in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 97, 10861-10865.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 10861-10865
    • Schmidt, P.S.1    Duvernell, D.D.2    Eanes, W.F.3
  • 160
    • 0038677013 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis
    • Schroeter, H., Boyd, C. S., Ahmed, R., Spencer, J. P., Duncan, R. F., Rice-Evans, C., et al. (2003). c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem. J. 372, 359-369.
    • (2003) Biochem. J. , vol.372 , pp. 359-369
    • Schroeter, H.1    Boyd, C.S.2    Ahmed, R.3    Spencer, J.P.4    Duncan, R.F.5    Rice-Evans, C.6
  • 162
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., and Ristow, M. (2007). Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6, 280-293.
    • (2007) Cell Metab. , vol.6 , pp. 280-293
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5    Ristow, M.6
  • 163
    • 74549224106 scopus 로고    scopus 로고
    • Identifying sexual differentiation genes that affect Drosophila life span
    • doi:10.1186/1471-2318-9-56
    • Shen, J., Ford, D., Landis, G. N., and Tower, J. (2009). Identifying sexual differentiation genes that affect Drosophila life span. BMC Geriatr. 9:56 doi:10.1186/1471-2318-9-56
    • (2009) BMC Geriatr. , vol.9 , pp. 56
    • Shen, J.1    Ford, D.2    Landis, G.N.3    Tower, J.4
  • 164
    • 77953487311 scopus 로고    scopus 로고
    • Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion
    • Shen, L. L., Du, M., Lin, X. F., Cai, T., and Wang, D. Y. (2010). Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion. Neurosci. Bull. 26, 91-103.
    • (2010) Neurosci. Bull. , vol.26 , pp. 91-103
    • Shen, L.L.1    Du, M.2    Lin, X.F.3    Cai, T.4    Wang, D.Y.5
  • 165
    • 0036678862 scopus 로고    scopus 로고
    • Waddington's canalization revisited: developmental stability and evolution
    • Siegal, M. L., and Bergman, A. (2002). Waddington's canalization revisited: developmental stability and evolution. Proc. Natl. Acad. Sci. U.S.A. 99, 10528-10532.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 10528-10532
    • Siegal, M.L.1    Bergman, A.2
  • 166
    • 41649094265 scopus 로고    scopus 로고
    • Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
    • Smith, E. D., Tsuchiya, M., Fox, L. A., Dang, N., Hu, D., Kerr, E. O., et al. (2008). Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res. 18, 564-570.
    • (2008) Genome Res. , vol.18 , pp. 564-570
    • Smith, E.D.1    Tsuchiya, M.2    Fox, L.A.3    Dang, N.4    Hu, D.5    Kerr, E.O.6
  • 167
    • 78249280592 scopus 로고    scopus 로고
    • Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data
    • Soerensen, M., Dato, S., Christensen, K., McGue, M., Stevnsner, T., Bohr, V. A., et al. (2010). Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 9, 1010-1017.
    • (2010) Aging Cell , vol.9 , pp. 1010-1017
    • Soerensen, M.1    Dato, S.2    Christensen, K.3    McGue, M.4    Stevnsner, T.5    Bohr, V.A.6
  • 170
    • 42149141146 scopus 로고    scopus 로고
    • Functionally significant insulin-like growth factor I receptor mutations in centenarians
    • Suh, Y., Atzmon, G., Cho, M. O., Hwang, D., Liu, B., Leahy, D. J., et al. (2008). Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc. Natl. Acad. Sci. U.S.A. 105, 3438-3442.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 3438-3442
    • Suh, Y.1    Atzmon, G.2    Cho, M.O.3    Hwang, D.4    Liu, B.5    Leahy, D.J.6
  • 171
    • 80053892506 scopus 로고    scopus 로고
    • Brain aging, Alzheimer's disease, and mitochondria
    • Swerdlow, R. H. (2011). Brain aging, Alzheimer's disease, and mitochondria. Biochim. Biophys. Acta 1812, 1630-1639.
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 1630-1639
    • Swerdlow, R.H.1
  • 172
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • Taguchi, A., Wartschow, L. M., and White, M. F. (2007). Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372.
    • (2007) Science , vol.317 , pp. 369-372
    • Taguchi, A.1    Wartschow, L.M.2    White, M.F.3
  • 173
    • 43549122104 scopus 로고    scopus 로고
    • Insulin-like signaling, nutrient homeostasis, and life span
    • Taguchi, A., and White, M. F. (2008). Insulin-like signaling, nutrient homeostasis, and life span. Annu. Rev. Physiol. 70, 191-212.
    • (2008) Annu. Rev. Physiol. , vol.70 , pp. 191-212
    • Taguchi, A.1    White, M.F.2
  • 174
    • 69149105316 scopus 로고    scopus 로고
    • Metabolism by remote control
    • Tatar, M. (2009). Metabolism by remote control. Cell Metab. 10, 164-166.
    • (2009) Cell Metab. , vol.10 , pp. 164-166
    • Tatar, M.1
  • 175
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • Tatar, M., Bartke, A., and Antebi, A. (2003). The endocrine regulation of aging by insulin-like signals. Science 299, 1346-1351.
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 176
    • 66149147947 scopus 로고    scopus 로고
    • Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance
    • doi:10.1371/journal.pgen.1000452
    • Tazearslan, C., Ayyadevara, S., Bharill, P., and Shmookler Reis, R. J. (2009). Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance. PLoS Genet. 5:e1000452. doi:10.1371/journal.pgen.1000452
    • (2009) PLoS Genet. , vol.5
    • Tazearslan, C.1    Ayyadevara, S.2    Bharill, P.3    Shmookler Reis, R.J.4
  • 177
    • 33646249818 scopus 로고    scopus 로고
    • Novel regulators revealed by profiling Drosophila testis stem cells within their niche
    • Terry, N. A., Tulina, N., Matunis, E., and DiNardo, S. (2006). Novel regulators revealed by profiling Drosophila testis stem cells within their niche. Dev. Biol. 294, 246-257.
    • (2006) Dev. Biol. , vol.294 , pp. 246-257
    • Terry, N.A.1    Tulina, N.2    Matunis, E.3    DiNardo, S.4
  • 178
    • 78049425268 scopus 로고    scopus 로고
    • ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans
    • doi:10.1371/journal.pgen.1001125
    • Thyagarajan, B., Blaszczak, A. G., Chandler, K. J., Watts, J. L., Johnson, W. E., and Graves, B. J. (2010). ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. PLoS Genet. 6:e1001125. doi:10.1371/journal.pgen.1001125
    • (2010) PLoS Genet. , vol.6
    • Thyagarajan, B.1    Blaszczak, A.G.2    Chandler, K.J.3    Watts, J.L.4    Johnson, W.E.5    Graves, B.J.6
  • 179
    • 84876078981 scopus 로고    scopus 로고
    • Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration
    • doi:10.3389/fgene.2012.00244
    • Troulinaki, K., and Bano, D. (2012). Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration. Front. Genet. 3:244. doi:10.3389/fgene.2012.00244
    • (2012) Front. Genet. , vol.3 , pp. 244
    • Troulinaki, K.1    Bano, D.2
  • 181
    • 78751668794 scopus 로고    scopus 로고
    • Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases
    • Vermehren-Schmaedick, A., Ainsley, J. A., Johnson, W. A., Davies, S.-A., and Morton, D. B. (2010). Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics 186, 183-196.
    • (2010) Genetics , vol.186 , pp. 183-196
    • Vermehren-Schmaedick, A.1    Ainsley, J.A.2    Johnson, W.A.3    Davies, S.-A.4    Morton, D.B.5
  • 182
    • 0030759780 scopus 로고    scopus 로고
    • The heterochromatin loss model of aging
    • Villeponteau, B. (1997). The heterochromatin loss model of aging. Exp. Gerontol. 32, 383-394.
    • (1997) Exp. Gerontol. , vol.32 , pp. 383-394
    • Villeponteau, B.1
  • 185
    • 17044408768 scopus 로고    scopus 로고
    • JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
    • Wang, M. C., Bohmann, D., and Jasper, H. (2005). JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115-125.
    • (2005) Cell , vol.121 , pp. 115-125
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 186
    • 77953417589 scopus 로고    scopus 로고
    • Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy
    • Waskar, M., Landis, G. N., Shen, J., Curtis, C., Tozer, K., Abdueva, D., et al. (2009). Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging (Albany, NY) 1, 903-936.
    • (2009) Aging (Albany, NY) , vol.1 , pp. 903-936
    • Waskar, M.1    Landis, G.N.2    Shen, J.3    Curtis, C.4    Tozer, K.5    Abdueva, D.6
  • 190
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection, and the evolution of senescence
    • Williams, G. C. (1957). Pleiotropy, natural selection, and the evolution of senescence. Evolution 11, 398-411.
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1
  • 192
    • 0000821951 scopus 로고
    • Melatonin synthesis in the pineal gland: effect of light mediated by the sympathetic nervous system
    • Wurtman, R. J., Axelrod, J., and Fischer, J. E. (1964). Melatonin synthesis in the pineal gland: effect of light mediated by the sympathetic nervous system. Science 143, 1328-1329.
    • (1964) Science , vol.143 , pp. 1328-1329
    • Wurtman, R.J.1    Axelrod, J.2    Fischer, J.E.3
  • 193
    • 0000292185 scopus 로고
    • Melatonin synthesis in the pineal gland: control by light
    • Wurtman, R. J., Axelrod, J., and Phillips, L. S. (1963). Melatonin synthesis in the pineal gland: control by light. Science 142, 1071-1073.
    • (1963) Science , vol.142 , pp. 1071-1073
    • Wurtman, R.J.1    Axelrod, J.2    Phillips, L.S.3
  • 194
    • 84866160403 scopus 로고    scopus 로고
    • Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes
    • doi:10.1371/journal.pgen.1002834
    • Wuttke, D., Connor, R., Vora, C., Craig, T., Li, Y., Wood, S., et al. (2012). Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. PLoS Genet. 8:e1002834. doi:10.1371/journal.pgen.1002834
    • (2012) PLoS Genet. , vol.8
    • Wuttke, D.1    Connor, R.2    Vora, C.3    Craig, T.4    Li, Y.5    Wood, S.6
  • 196
    • 84891787701 scopus 로고    scopus 로고
    • Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration
    • doi:10.1089/ars.2012.4774
    • Yin, F., Boveris, A., and Cadenas, E. (2012). Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid. Redox Signal. doi:10.1089/ars.2012.4774
    • (2012) Antioxid. Redox Signal.
    • Yin, F.1    Boveris, A.2    Cadenas, E.3
  • 197
    • 27744573039 scopus 로고    scopus 로고
    • Olfactory inputs to hypothalamic neurons controlling reproduction and fertility
    • Yoon, H., Enquist, L. W., and Dulac, C. (2005). Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. Cell 123, 669-682.
    • (2005) Cell , vol.123 , pp. 669-682
    • Yoon, H.1    Enquist, L.W.2    Dulac, C.3
  • 198
    • 33748615713 scopus 로고    scopus 로고
    • The neural/cephalic phase reflexes in the physiology of nutrition
    • Zafra, M. A., Molina, F., and Puerto, A. (2006). The neural/cephalic phase reflexes in the physiology of nutrition. Neurosci. Biobehav. Rev. 30, 1032-1044.
    • (2006) Neurosci. Biobehav. Rev. , vol.30 , pp. 1032-1044
    • Zafra, M.A.1    Molina, F.2    Puerto, A.3
  • 200
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    • Zhang, C. Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., et al. (2001). Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105, 745-755.
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1    Baffy, G.2    Perret, P.3    Krauss, S.4    Peroni, O.5    Grujic, D.6
  • 201
    • 68149149835 scopus 로고    scopus 로고
    • The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans
    • doi:10.1371/journal.pone.0006348
    • Zhang, Y., Shao, Z., Zhai, Z., Shen, C., and Powell-Coffman, J. A. (2009). The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS ONE 4:e6348. doi:10.1371/journal.pone.0006348
    • (2009) PLoS ONE , vol.4 , pp. 6348
    • Zhang, Y.1    Shao, Z.2    Zhai, Z.3    Shen, C.4    Powell-Coffman, J.A.5
  • 202
    • 37349081929 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons
    • Zhou, Q., Lam, P. Y., Han, D., and Cadenas, E. (2008). c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons. J. Neurochem. 104, 325-335.
    • (2008) J. Neurochem. , vol.104 , pp. 325-335
    • Zhou, Q.1    Lam, P.Y.2    Han, D.3    Cadenas, E.4
  • 203
    • 62849111251 scopus 로고    scopus 로고
    • Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging
    • Zhou, Q., Lam, P. Y., Han, D., and Cadenas, E. (2009). Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. FEBS Lett. 583, 1132-1140.
    • (2009) FEBS Lett. , vol.583 , pp. 1132-1140
    • Zhou, Q.1    Lam, P.Y.2    Han, D.3    Cadenas, E.4


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