Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

Experimental Gerontology

Volumn 44, Issue 5, 2009, Pages 316-327

  Humphrey, Dickon M ^a   Toivonen, Janne M ^b   Giannakou, Maria ^b   Partridge, Linda ^b   Brand, Martin D ^a,c  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Ageing; Drosophila; Insulin signalling; Lifespan; UCP3; Uncoupling protein

Indexed keywords

MESSENGER RNA; UNCOUPLING PROTEIN 3;

ANIMAL CELL; ARTICLE; CELL ISOLATION; LIFESPAN; MITOCHONDRION; MUSCLE MITOCHONDRION; NERVE CELL; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGING; ANIMALS; DIPTERA; DROSOPHILA; HUMANS; INSULIN-SECRETING CELLS; ION CHANNELS; LONGEVITY; MALE; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

DROSOPHILA MELANOGASTER; RODENTIA;

EID: 64449085187     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2009.02.001     Document Type: Article

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