Transgenic mice with a reduced core body temperature have an increased life span

Science

Volumn 314, Issue 5800, 2006, Pages 825-828

  Conti, Bruno ^a   Sanchez Alavez, Manuel ^a   Winsky Sommerer, Raphaelle ^a,b   Morale, Maria Concetta ^a,c   Lucero, Jacinta ^a   Brownell, Sara ^a,d   Fabre, Veronique ^a,e   Huitron Resendiz, Salvador ^a   Henriksen, Steven ^a,f   Zorrilla, Eric P ^a   De Lecea, Luis ^a,g   Bartfai, Tamas ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c OASI RESEARCH INSTITUTE IRCCS   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e INSERM   (France)

^f WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENERGY EFFICIENCY; THERMAL EFFECTS; THERMOSTATS;

CALORIE RESTRICTION (CR); CORE BODY TEMPERATURE; HOMEOTHERMS;

LIVING SYSTEMS STUDIES;

UNCOUPLING PROTEIN 2;

BODY TEMPERATURE; EXPERIMENTAL STUDY; LIFE CYCLE; RODENT;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CALORIC INTAKE; CALORIC RESTRICTION; CONTROLLED STUDY; FEMALE; HYPOTHALAMUS; LIFESPAN; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AGING; ANIMALS; BODY TEMPERATURE; BODY TEMPERATURE REGULATION; BODY WEIGHT; CIRCADIAN RHYTHM; DRINKING; EATING; ENERGY METABOLISM; FEMALE; HYPOTHALAMIC AREA, LATERAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ION CHANNELS; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; NEURONS; NEUROPEPTIDES; PREOPTIC AREA; THERMOGENESIS;

MUS MUSCULUS;

EID: 33750681712     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132191     Document Type: Article

References (30)

1. J. A. Boulant, Clin. Infect. Dis. 31 (suppl. 5), 5157 (2000).
2. D. Ricquier, F. Bouillaud, Biochem. J. 345, 161 (2000).
3. J. G. Sutcliffe, L. de Lecea, Nat. Rev. Neurosci. 3, 339 (2002).
4. J. T. Willie, R. M. Chemelli, C. M. Sinton, M. Yanagisawa, Annu. Rev. Neurosci. 24, 429 (2001).
5. E. Mignot, S. Taheri, S. Nishino, Nat. Neurosci. 5 (suppl.), 1071 (2002).
6. L. de Lecea et al., Proc. Natl. Acad. Sci. U.S.A. 95, 322 (1998).
7. M. Jaszberenyi, E. Bujdoso, E. Kiss, I. Pataki, G. Telegdy, Regul. Pept. 104, 55 (2002).
8. M. Monda, A. Viggiano, F. Fuccio, V. De Luca, Brain Res. 1018, 265 (2004).
9. M. Szekely, E. Petervari, M. Balasko, I. Hernadi, B. Uzsoki, Regul. Pept. 104, 47 (2002).
10. G. Yoshimichi, H. Yoshimatsu, T. Masaki, T. Sakata, Exp. Biol. Med. 226, 468 (2001).
11. J. Hara et al., Neuron 30, 345 (2001).
12. H. C. Chen, Z. Ladha, S. J. Smith, R. V. Farese Jr., Am. J. Physiol. Endocrinol. Metab. 284, E213 (2003).
13. R. Liu, R. Walford, Nature 212, 1277 (1966).
14. C. McCay, M. Cromwell, L. Maynard, J. Nutr. 10, 63 (1935).
15. R. Weindruch, R. L. Walford, S. Fligiel, D. Guthrie, J. Nutr. 116, 641 (1986).
16. P. H. Duffy, J. E. Leakey, J. L. Pipkin, A. Turturro, R. W. Hart, Environ. Res. 73, 242 (1997).
17. A. Koizumi, M. Tsukada, Y. Wada, H. Masuda, R. Weindruch, J. Nutr. 122, 1446 (1992).
18. W. Duan, M. P. Mattson, J. Neurosci. Res. 57, 195 (1999).
19. D. K. Ingram, R. Weindruch, E. L. Spangler, J. R. Freeman, R. L. Walford, J. Gerontol. 42, 78 (1987).
20. M. P. Mattson, Brain Res. 886, 47 (2000).
21. H. Zhu, Q. Guo, M. P. Mattson, Brain Res. 842, 224 (1999).
22. J. W. Vaupel, K. G. Manton, E. Stallard, Demography 16, 439 (1979).
23. L. Partridge, S. D. Pletcher, W. Mair, Mech. Ageing Dev. 126, 35 (2005).
24. W. Mair, P. Goymer, S. D. Pletcher, L. Partridge, Science 301, 1731 (2003).
25. J. Miquel, P. R. Lundgren, K. G. Bensch, H. Atlan, Mech. Ageing Dev. 5, 347 (1976).
26. M. Parmar, D. Machin, Eds., Survival Analysis: A Practical Approach (Wiley, New York, 1995).
27. S. D. Pletcher et al., Curr. Biol. 12, 712 (2002).
28. M. Tatar, Senescence, in C. W. Fox, D. A. Roff, D. J. Fairbain, Eds., Evolutionary Ecology: Concepts and Case Studies (Oxford Univ. Press, Oxford, 2001), pp. 128-141.
29. S. N. Austad, D. M. Kristan, Aging Cell 2, 201 (2003).
30. We thank J. Buxbaum, M. Behrens, M. Brennan, E. Crawford, C. Davis, K. Eusko, R. Fernandez, J. Koziol, M. Martes, T. Hurtado de Mendoza, J. Pemberton, M. Sabbatini, V. Zhukov, and D. Wills for their input and assistance; T. Sakurai for providing the orexin ataxin 3 mice; and M. Tatar for assistance with survival analysis. This work was supported by the Harold Dorris Neurological Research Institute, The Ellison Medical Foundation, NS043S01 and MH58543.