Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling

Nature Cell Biology

Volumn 10, Issue 4, 2008, Pages 468-475

  Lee, Kyu Sun ^a   Kwon, O Yu ^b   Lee, Joon H ^c   Kwon, Kisang ^b   Min, Kyung Jin ^d   Jung, Sun Ah ^c   Kim, Ae Kyeong ^a   You, Kwan Hee ^e   Tatar, Marc ^d   Yu, Kweon ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

^c Konyang University   (South Korea)

^d BROWN UNIVERSITY   (United States)

^e UNIVERSITY OF ALASKA ANCHORAGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INITIATION FACTOR 4E BINDING PROTEIN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; NEUROPEPTIDE; NEUROPEPTIDE RECEPTOR; NEUROPEPTIDE Y; PROTEIN KINASE B; SHORT NEUROPEPTIDE F; SHORT NEUROPEPTIDE F RECEPTOR 1; TRANSCRIPTION FACTOR FOXO; DIAP2 PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; INSULIN RECEPTOR; ISOPROTEIN; NEUROPEPTIDE F, DROSOPHILA; NEUROPEPTIDE Y RECEPTOR; NPFR1 PROTEIN, DROSOPHILA;

ANIMAL CELL; ARTICLE; BODY SIZE; CELL CULTURE; CELL METABOLISM; CELL SIZE; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOWN REGULATION; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; FAT BODY; FEMALE; GENE OVEREXPRESSION; GENETIC CONSERVATION; GROWTH REGULATION; LARVA; MAMMAL; NERVE CELL GROWTH; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; ORTHOLOGY; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; ANIMAL; BRAIN; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; GENETICS; HISTOLOGY; HUMAN; LIFE EXPECTANCY; METABOLISM; PHYSIOLOGY;

ANIMALIA; DROSOPHILA MELANOGASTER; MAMMALIA; RATTUS;

ANIMALS; BODY SIZE; BRAIN; CELL LINE; CELLS, CULTURED; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INSULIN; LARVA; LIFE EXPECTANCY; NEUROPEPTIDE Y; NEUROPEPTIDES; PROTEIN ISOFORMS; RATS; RECEPTOR, INSULIN; RECEPTORS, NEUROPEPTIDE; RECEPTORS, NEUROPEPTIDE Y; SIGNAL TRANSDUCTION;

EID: 43149111605     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1710     Document Type: Article

References (27)

1. Colombani, J. et al. Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science 310, 667-670 (2005).
2. Ikeya, T., Galic, M., Belawat, P., Nairz, K. & Hafen, E. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr. Biol. 12, 1293-1300 (2002).
3. Rulifson, E. J., Kim, S. K. & Nusse, R. Ablation of insulin-producing neurons in flies: Growth and diabetic phenotypes. Science 296 1118-1120 (2002).
4. Broughton, S.J. et al. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl Acad. Sci. USA 102, 3105-3110 (2005).
5. Tatar, M., Bartke, A. & Antebi, A. The endocrine regulation of aging by insulin-like signals. Science 299, 13461351 (2003).
6. Brogiolo, W. et al. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11, 213221 (2001).
7. Bell, C. G., Walley, A. J. & Froguel, P. The genetics of human obesity. Nature Rev. Genet. 6, 221-234 (2005).
8. Emeson, R. B. & Morabito, M. V. Food fight: The NPY-serotonin link between aggression and feeding behavior. Sci STKE 2005, pe12 (2005).
9. Wahlestedt, C., Pich, E.M., Koob, G.F., Yee, F. & Heilig, M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259, 528-531 (1993).
10. Lee, K. S., You, K. H., Choo, J. K., Han, Y. M. & Yu, K. Drosophila short neuropeptide F regulates food intake and body size. J. Biol. Chem. 279, 50781-50789 (2004).
11. Feng, G. et al. Functional characterization of a neuropeptide F-like receptor from Drosophila melanogaster. Eur. J. Neurosci. 18, 227-238 (2003).
12. Chung, Y. D., Zhu, J., Han, Y. & Kernan, M. J. nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures. Neuron 29, 415-428 (2001).
13. Joiner, M. A. & Griffith, L. C. Mapping of the anatomical circuit of CaM kinase-dependent courtship conditioning in Drosophila. Learn. Mem. 6, 177-192 (1999).
14. Colombani, J. et al. A nutrient sensor mechanism controls Drosophila growth. Cell 114, 739-749 (2003).
15. Hwangbo, D. S., Gershman, B., Tu, M. P., Palmer, M. & Tatar, M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429, 562-566 (2004).
16. Wang, M. C., Bohmann, D. & Jasper, H. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115-125 (2005).
17. Cho, Y. R. & Kim, C. W. Neuropeptide Y promotes beta-cell replication via extracellular signal-regulated kinase activation. Biochem. Biophys. Res. Commun. 314, 773-780 (2004).
18. Kim, M. et al. MKP-3 has essential roles as a negative regulator of the Ras/mitogenactivated protein kinase pathway during Drosophila development. Mol. Cell. Biol. 24, 573-583 (2004).
19. Ui, K. et al. Newly established cell lines from Drosophila larval CNS express neural specific characteristics. In Vitro Cell. Dev. Biol. 30A, 209-216 (1994).
20. Asfari, M. et al. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinol. 130 167-178 (1992).
21. Hay, N. & Sonenberg, N. Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945 (2004).
22. Puig, O., Marr, M. T., Ruhf, M. L. & Tjian, R. Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17, 2006-2020 (2003).
23. Zimanyi, I. A., Fathi, Z. & Poindexter, G. S. Central control of feeding behavior by neuropeptide Y. Curr. Pharm. Des. 4, 349-366 (1998).
24. Wang, S., Tulina, N., Carlin, D. L. & Rulifson, E. J. The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis. Proc. Natl Acad. Sci. USA 104, 19873-19878 (2007).
25. Rubin, G. M. & Spradling, A. C. Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353 (1982).
26. Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415 (1993).
27. Yu, K. et al. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development 127, 2143-2154 (2000).