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Volumn 8, Issue 11-12, 2006, Pages 1997-2006

Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; ANTIOXIDANT; CASPASE; CHAPERONE; HUNTINGTIN; NEUROTROPHIC FACTOR; TAU PROTEIN;

EID: 33947623671     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2006.8.1997     Document Type: Review
Times cited : (187)

References (148)
  • 1
    • 0028153174 scopus 로고
    • Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis
    • Alexianu ME, Mohamed AH, Smith RG, Colom LV, and Appel SH. Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis. J Neurochem 63:2365-2368, 1994.
    • (1994) J Neurochem , vol.63 , pp. 2365-2368
    • Alexianu, M.E.1    Mohamed, A.H.2    Smith, R.G.3    Colom, L.V.4    Appel, S.H.5
  • 3
    • 0028793257 scopus 로고
    • Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
    • Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Arrenius S, Lipton S, and Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973, 1995.
    • (1995) Neuron , vol.15 , pp. 961-973
    • Ankarcrona, M.1    Dypbukt, J.M.2    Bonfoco, E.3    Zhivotovsky, B.4    Arrenius, S.5    Lipton, S.6    Nicotera, P.7
  • 4
    • 0035910918 scopus 로고    scopus 로고
    • Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats
    • Ay I, Sugimori H, and Finklestein SP. Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats. Mol Brain Res 87: 71-80, 2001.
    • (2001) Mol Brain Res , vol.87 , pp. 71-80
    • Ay, I.1    Sugimori, H.2    Finklestein, S.P.3
  • 6
    • 0037361388 scopus 로고    scopus 로고
    • Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease
    • Barzilai A and Melamed E. Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease. Trends Mol Med 9: 126-132, 2003.
    • (2003) Trends Mol Med , vol.9 , pp. 126-132
    • Barzilai, A.1    Melamed, E.2
  • 7
    • 4043075622 scopus 로고    scopus 로고
    • Lessons from models of SOD1-linked familial ALS
    • Bendotti C and Carri MT. Lessons from models of SOD1-linked familial ALS. Trends Mol Med 10: 393-400, 2004.
    • (2004) Trends Mol Med , vol.10 , pp. 393-400
    • Bendotti, C.1    Carri, M.T.2
  • 8
    • 0033134890 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: Signal transduction cascades and site of ethanol action
    • Bhave SV, Ghoda L, and Hoffman PL. Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: signal transduction cascades and site of ethanol action. J Neurosci 19: 3277-3286, 1999.
    • (1999) J Neurosci , vol.19 , pp. 3277-3286
    • Bhave, S.V.1    Ghoda, L.2    Hoffman, P.L.3
  • 9
    • 0344825875 scopus 로고    scopus 로고
    • Boehning D, Patterson RL, and Sedaghat L, et al. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol 5: 1051-1061, 2003.
    • Boehning D, Patterson RL, and Sedaghat L, et al. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol 5: 1051-1061, 2003.
  • 11
    • 26844505808 scopus 로고    scopus 로고
    • Toxin-induced models of Parkinson's disease
    • Bove J, Prou D, Perier C, and Przedborski S. Toxin-induced models of Parkinson's disease. NeuroRx 2: 484-494, 2005.
    • (2005) NeuroRx , vol.2 , pp. 484-494
    • Bove, J.1    Prou, D.2    Perier, C.3    Przedborski, S.4
  • 12
    • 0033786442 scopus 로고    scopus 로고
    • Apoptosis: Overview and signal transduction pathways
    • Bredesen DE. Apoptosis: overview and signal transduction pathways. J Neurotrauma 17: 801-810, 2000.
    • (2000) J Neurotrauma , vol.17 , pp. 801-810
    • Bredesen, D.E.1
  • 13
    • 0032925851 scopus 로고    scopus 로고
    • Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults
    • Bruce-Keller AJ, Umberger G, McFall R, and Mattson MP. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol 45: 8-15, 1999.
    • (1999) Ann Neurol , vol.45 , pp. 8-15
    • Bruce-Keller, A.J.1    Umberger, G.2    McFall, R.3    Mattson, M.P.4
  • 14
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • Bruijn LE, Miller TM, and Cleveland DW. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 27: 723-749, 2004.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 723-749
    • Bruijn, L.E.1    Miller, T.M.2    Cleveland, D.W.3
  • 16
    • 0028233227 scopus 로고
    • The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development
    • Buj-Bello A, Pinon LG, Davies AM. The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development. Development 120: 1573-1580, 1994.
    • (1994) Development , vol.120 , pp. 1573-1580
    • Buj-Bello, A.1    Pinon, L.G.2    Davies, A.M.3
  • 17
    • 33745661717 scopus 로고    scopus 로고
    • Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: The evidence to date
    • Bullock R. Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date. Alzheimer Dis Assoc Disord 20:23-29, 2006.
    • (2006) Alzheimer Dis Assoc Disord , vol.20 , pp. 23-29
    • Bullock, R.1
  • 18
    • 20444457553 scopus 로고    scopus 로고
    • Suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-kappaB
    • Camandola S, Cutler RG, Gary DS, Mulhavet O, Mattson MP. Suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-kappaB. J Biol Chem 280: 22287-22296, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 22287-22296
    • Camandola, S.1    Cutler, R.G.2    Gary, D.S.3    Mulhavet, O.4    Mattson, M.P.5
  • 19
    • 0034651104 scopus 로고    scopus 로고
    • Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis
    • Canu N, Barbato C, Ciotti MT, Serafino A, Dus L, Calissano P. Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis. J Neurosci 20: 589-599, 2000.
    • (2000) J Neurosci , vol.20 , pp. 589-599
    • Canu, N.1    Barbato, C.2    Ciotti, M.T.3    Serafino, A.4    Dus, L.5    Calissano, P.6
  • 20
    • 0036452908 scopus 로고    scopus 로고
    • Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12
    • Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiol Dis 11: 2-19, 2002.
    • (2002) Neurobiol Dis , vol.11 , pp. 2-19
    • Chan, S.L.1    Culmsee, C.2    Haughey, N.3    Klapper, W.4    Mattson, M.P.5
  • 21
    • 0043173995 scopus 로고    scopus 로고
    • Alternating metabolic pathways in NGF-deprived sympathetic neurons affect caspase-independent death
    • Chang LK, Schmidt RE, Johnson EM Jr. Alternating metabolic pathways in NGF-deprived sympathetic neurons affect caspase-independent death. J Cell Biol 162: 245-256, 2003.
    • (2003) J Cell Biol , vol.162 , pp. 245-256
    • Chang, L.K.1    Schmidt, R.E.2    Johnson Jr., E.M.3
  • 22
    • 0026334402 scopus 로고
    • NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis
    • Cheng B and Mattson MP. NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron 7: 1031-1041, 1991.
    • (1991) Neuron , vol.7 , pp. 1031-1041
    • Cheng, B.1    Mattson, M.P.2
  • 23
    • 0026521942 scopus 로고
    • IGF-I and 1GF-1I protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage
    • Cheng B and Mattson MP. IGF-I and 1GF-1I protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage. J Neurosci 12: 1558-1566, 1992.
    • (1992) J Neurosci , vol.12 , pp. 1558-1566
    • Cheng, B.1    Mattson, M.P.2
  • 26
    • 23244439603 scopus 로고    scopus 로고
    • Manganese porphyrin given at symptom onset markedly extends survival of ALS mice
    • Crow JP, Calingasan NY, Chen J, Hill JL, and Beal MF. Manganese porphyrin given at symptom onset markedly extends survival of ALS mice. Ann Neurol 58: 258-265, 2005.
    • (2005) Ann Neurol , vol.58 , pp. 258-265
    • Crow, J.P.1    Calingasan, N.Y.2    Chen, J.3    Hill, J.L.4    Beal, M.F.5
  • 28
    • 0036789845 scopus 로고    scopus 로고
    • Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis
    • Cutler RG, Pedersen WA, Camandola S, Rothstein JD, and Mattson MP. Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Ann Neurol 52: 448- 457, 2002.
    • (2002) Ann Neurol , vol.52 , pp. 448-457
    • Cutler, R.G.1    Pedersen, W.A.2    Camandola, S.3    Rothstein, J.D.4    Mattson, M.P.5
  • 29
    • 1242338183 scopus 로고    scopus 로고
    • Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
    • Cutler RG, Kelly J, and Pedersen WA, et al. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A 101: 2070-2075, 2004.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2070-2075
    • Cutler, R.G.1    Kelly, J.2    Pedersen, W.A.3
  • 30
    • 0030831489 scopus 로고    scopus 로고
    • Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease
    • De la Monte SM, Sohn YK, and Wands JR. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci 152: 73-83, 1997.
    • (1997) J Neurol Sci , vol.152 , pp. 73-83
    • De la Monte, S.M.1    Sohn, Y.K.2    Wands, J.R.3
  • 33
    • 13144276266 scopus 로고    scopus 로고
    • Apoptosis, neurotrophic factors and neurodegeneration
    • Dragunow M, MacGibbon GA, and Lawlor P, et al. Apoptosis, neurotrophic factors and neurodegeneration. Rev Neurosci 8: 223-265, 1997.
    • (1997) Rev Neurosci , vol.8 , pp. 223-265
    • Dragunow, M.1    MacGibbon, G.A.2    Lawlor, P.3
  • 34
    • 0032833041 scopus 로고    scopus 로고
    • Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease
    • Duan W, Zhang Z, Gash DM, and Mattson MP. Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease. Ann Neurol 46: 587-597, 1999.
    • (1999) Ann Neurol , vol.46 , pp. 587-597
    • Duan, W.1    Zhang, Z.2    Gash, D.M.3    Mattson, M.P.4
  • 36
    • 0037418339 scopus 로고    scopus 로고
    • Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
    • Duan W, Guo Z, Jiang H, Ware M, Li XJ, and Mattson MP. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A 100: 2911-2916, 2003.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2911-2916
    • Duan, W.1    Guo, Z.2    Jiang, H.3    Ware, M.4    Li, X.J.5    Mattson, M.P.6
  • 39
    • 26844527655 scopus 로고    scopus 로고
    • Genetic mouse models of parkinsonism: Strengths and limitations
    • Fleming SM, Fernagut PO, and Chesselet MF. Genetic mouse models of parkinsonism: strengths and limitations. NeuroRx 2: 495-503, 2005.
    • (2005) NeuroRx , vol.2 , pp. 495-503
    • Fleming, S.M.1    Fernagut, P.O.2    Chesselet, M.F.3
  • 41
    • 0037417220 scopus 로고    scopus 로고
    • Apoptosis and caspases in neurodegenerative diseases
    • Friedlander RM. Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 348: 1365-1375, 2003.
    • (2003) N Engl J Med , vol.348 , pp. 1365-1375
    • Friedlander, R.M.1
  • 42
    • 10244255083 scopus 로고    scopus 로고
    • Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases
    • Gibson GE and Huang HM. Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases. J Bioenerg Biomembr 36: 335-340, 2004.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 335-340
    • Gibson, G.E.1    Huang, H.M.2
  • 44
    • 0042831025 scopus 로고    scopus 로고
    • Do apoptotic mechanisms regulate synaptic plasticity and growth cone motility?
    • Gilman CP and Mattson MP. Do apoptotic mechanisms regulate synaptic plasticity and growth cone motility? Neuromol Med 2: 197-214, 2002.
    • (2002) Neuromol Med , vol.2 , pp. 197-214
    • Gilman, C.P.1    Mattson, M.P.2
  • 46
    • 24144494527 scopus 로고    scopus 로고
    • The physiology and pathophysiology of nitric oxide in the brain
    • Guix FX, Uribesalgo I, Coma M, Munoz FJ. The physiology and pathophysiology of nitric oxide in the brain. Prog Neurobiol 76: 126-152, 2005.
    • (2005) Prog Neurobiol , vol.76 , pp. 126-152
    • Guix, F.X.1    Uribesalgo, I.2    Coma, M.3    Munoz, F.J.4
  • 47
    • 0030917601 scopus 로고    scopus 로고
    • Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: Involvement of calcium and oxyradicals
    • Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, and Mattson MP. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J Neurosci 17: 4212-4222, 1997.
    • (1997) J Neurosci , vol.17 , pp. 4212-4222
    • Guo, Q.1    Sopher, B.L.2    Furukawa, K.3    Pham, D.G.4    Robinson, N.5    Martin, G.M.6    Mattson, M.P.7
  • 49
    • 0033616796 scopus 로고    scopus 로고
    • Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation
    • Guo Q, Sebastian L, Sopher BL, Miller MW, Glazner GW, Ware CB, Martin GM, and Mattson MP. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc Natl Acad Sci U S A 96: 4125-4130, 1999.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4125-4130
    • Guo, Q.1    Sebastian, L.2    Sopher, B.L.3    Miller, M.W.4    Glazner, G.W.5    Ware, C.B.6    Martin, G.M.7    Mattson, M.P.8
  • 50
    • 0033009194 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: Central roles of superoxide production and caspase activation
    • Guo Q, Sebastian L, Sopher BL, Miller MW, Ware CB, Martin GM, and Mattson MP. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J Neurochem 72: 1019-1029, 1999.
    • (1999) J Neurochem , vol.72 , pp. 1019-1029
    • Guo, Q.1    Sebastian, L.2    Sopher, B.L.3    Miller, M.W.4    Ware, C.B.5    Martin, G.M.6    Mattson, M.P.7
  • 52
    • 0029670980 scopus 로고    scopus 로고
    • Hassouna I, Wickert H, Zimmermann M, and Gillardon F. Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment of mice. Neurosci Lett 204: 85-88, 1996.
    • Hassouna I, Wickert H, Zimmermann M, and Gillardon F. Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment of mice. Neurosci Lett 204: 85-88, 1996.
  • 53
    • 0037376680 scopus 로고    scopus 로고
    • Hickey MA and Chesselet MF. Apoptosis in Huntington's disease. Prog Neuropsychopharmacol Biol Psychiatry 27: 255-265, 2003.
    • Hickey MA and Chesselet MF. Apoptosis in Huntington's disease. Prog Neuropsychopharmacol Biol Psychiatry 27: 255-265, 2003.
  • 54
    • 33750568802 scopus 로고    scopus 로고
    • Life-long caloric restriction counteracts apoptotic effects of aging in the brain and bolsters the action of apoptosis inhibitors
    • Epub ahead of print
    • Hiona A and Leeuwenburgh C. Life-long caloric restriction counteracts apoptotic effects of aging in the brain and bolsters the action of apoptosis inhibitors. Neurobiol Aging 26: [Epub ahead of print], 2005.
    • (2005) Neurobiol Aging , pp. 26
    • Hiona, A.1    Leeuwenburgh, C.2
  • 55
    • 0141642104 scopus 로고    scopus 로고
    • Glutathione peroxidase overexpression inhibits cytochrome c release and proapoptotic mediators to protect neurons from experimental stroke
    • Hoehn B, Yenari MA, Sapolsky RM, and Steinberg GK. Glutathione peroxidase overexpression inhibits cytochrome c release and proapoptotic mediators to protect neurons from experimental stroke. Stroke 34: 2489-2494, 2003.
    • (2003) Stroke , vol.34 , pp. 2489-2494
    • Hoehn, B.1    Yenari, M.A.2    Sapolsky, R.M.3    Steinberg, G.K.4
  • 57
    • 0035336658 scopus 로고    scopus 로고
    • Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
    • Jana NR, Zemskov EA, Wang GH, and Nukina N. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum Mol Genet 10: 1049-1059, 2001.
    • (2001) Hum Mol Genet , vol.10 , pp. 1049-1059
    • Jana, N.R.1    Zemskov, E.A.2    Wang, G.H.3    Nukina, N.4
  • 58
    • 23244458906 scopus 로고    scopus 로고
    • The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons
    • Jiang X, Tian F, Mearow K, Okagaki P, Lipsky RH, and Marini AM. The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons. J Neurochem 94: 713-722, 2005.
    • (2005) J Neurochem , vol.94 , pp. 713-722
    • Jiang, X.1    Tian, F.2    Mearow, K.3    Okagaki, P.4    Lipsky, R.H.5    Marini, A.M.6
  • 59
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar BK, Llado J, Sherkat N, Rothstein JD, and Gage FH. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 301: 839-842, 2003.
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 60
    • 17344371804 scopus 로고    scopus 로고
    • ndrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
    • Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Germeyer A, Steiner SM, Bruce-Keller AJ, Hutchins JB, and Mattson MP. ndrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 18: 687-697, 1998.
    • (1998) J Neurosci , vol.18 , pp. 687-697
    • Keller, J.N.1    Kindy, M.S.2    Holtsberg, F.W.3    St Clair, D.K.4    Yen, H.C.5    Germeyer, A.6    Steiner, S.M.7    Bruce-Keller, A.J.8    Hutchins, J.B.9    Mattson, M.P.10
  • 62
    • 0033601995 scopus 로고    scopus 로고
    • Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity
    • Klevenyi P, Andreassen O, Ferrante RJ, Schleicher JR Jr., Friedlander RM, and Beal MF. Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport 10: 635-638, 1999.
    • (1999) Neuroreport , vol.10 , pp. 635-638
    • Klevenyi, P.1    Andreassen, O.2    Ferrante, R.J.3    Schleicher Jr., J.R.4    Friedlander, R.M.5    Beal, M.F.6
  • 64
    • 0030986669 scopus 로고    scopus 로고
    • Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
    • Kruman I, Bruce-Keller AJ, Bredesen E, Waeg G, and Mattson MP. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci 17: 5089-5100, 1997.
    • (1997) J Neurosci , vol.17 , pp. 5089-5100
    • Kruman, I.1    Bruce-Keller, A.J.2    Bredesen, E.3    Waeg, G.4    Mattson, M.P.5
  • 65
    • 0032731637 scopus 로고    scopus 로고
    • ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis
    • Kruman II, Pedersen WA, Springer JE, and Mattson MP. ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp Neurol 160: 28-39, 1999.
    • (1999) Exp Neurol , vol.160 , pp. 28-39
    • Kruman, I.I.1    Pedersen, W.A.2    Springer, J.E.3    Mattson, M.P.4
  • 66
    • 0036523032 scopus 로고    scopus 로고
    • Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease
    • Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, and Mattson MP. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 22: 1752-1762, 2002.
    • (2002) J Neurosci , vol.22 , pp. 1752-1762
    • Kruman, I.I.1    Kumaravel, T.S.2    Lohani, A.3    Pedersen, W.A.4    Cutler, R.G.5    Kruman, Y.6    Haughey, N.7    Lee, J.8    Evans, M.9    Mattson, M.P.10
  • 70
    • 0036734833 scopus 로고    scopus 로고
    • Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    • Lee J, Duan W, and Mattson MP. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82: 1367-1375, 2000.
    • (2000) J Neurochem , vol.82 , pp. 1367-1375
    • Lee, J.1    Duan, W.2    Mattson, M.P.3
  • 72
    • 13544249779 scopus 로고    scopus 로고
    • Defining the role of the Bcl-2 family of proteins in the nervous system
    • Lindsten T, Zong WX, and Thompson CB. Defining the role of the Bcl-2 family of proteins in the nervous system. Neuroscientist 11: 10-15, 2005.
    • (2005) Neuroscientist , vol.11 , pp. 10-15
    • Lindsten, T.1    Zong, W.X.2    Thompson, C.B.3
  • 74
    • 0033545925 scopus 로고    scopus 로고
    • Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, and Dawson TM. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci U S A 96: 5774-5779, 1999.
    • Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, and Dawson TM. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci U S A 96: 5774-5779, 1999.
  • 75
    • 0032896327 scopus 로고    scopus 로고
    • Neuronal death in amyotrophic lateral sclerosis is apoptosis: Possible contribution of a programmed cell death mechanism
    • Martin LJ. Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism. J Neuropathol Exp Neurol 58: 459-471, 1999.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 459-471
    • Martin, L.J.1
  • 76
    • 0034517935 scopus 로고    scopus 로고
    • p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis
    • Martin LJ. p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis. Neurobiol Dis 7: 613-622, 2000.
    • (2000) Neurobiol Dis , vol.7 , pp. 613-622
    • Martin, L.J.1
  • 78
    • 0029150526 scopus 로고
    • Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
    • Mattson MP, Lovell MA, Furukawa K, and Markesbery WR. Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem 65: 1740-1751, 1995.
    • (1995) J Neurochem , vol.65 , pp. 1740-1751
    • Mattson, M.P.1    Lovell, M.A.2    Furukawa, K.3    Markesbery, W.R.4
  • 79
    • 0032487648 scopus 로고    scopus 로고
    • Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites
    • Mattson MP, Partin J, and Begley JG. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites. Brain Res 807: 167-176, 1998.
    • (1998) Brain Res , vol.807 , pp. 167-176
    • Mattson, M.P.1    Partin, J.2    Begley, J.G.3
  • 80
    • 0034329742 scopus 로고    scopus 로고
    • Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 1: 120-129, 2000.
    • Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 1: 120-129, 2000.
  • 81
    • 0033913058 scopus 로고    scopus 로고
    • Apoptotic and antiapoptotic mechanisms in stroke
    • Mattson MP, Culmsee C, and Yu ZF. Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res 301: 173-187, 2000.
    • (2000) Cell Tissue Res , vol.301 , pp. 173-187
    • Mattson, M.P.1    Culmsee, C.2    Yu, Z.F.3
  • 82
    • 0036304650 scopus 로고    scopus 로고
    • Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior
    • Mattson MP, Chan SL, and Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev 82: 637-672, 2002.
    • (2002) Physiol Rev , vol.82 , pp. 637-672
    • Mattson, M.P.1    Chan, S.L.2    Duan, W.3
  • 83
    • 0013198976 scopus 로고    scopus 로고
    • Mitochondria in cell death: Novel targets for neuro- and cardio-protection
    • Mattson MP and Kroemer G. Mitochondria in cell death: novel targets for neuro- and cardio-protection. Trends Mol Med 9: 196-205, 2003.
    • (2003) Trends Mol Med , vol.9 , pp. 196-205
    • Mattson, M.P.1    Kroemer, G.2
  • 84
    • 0043180531 scopus 로고    scopus 로고
    • Excitotoxic and excitoprotective mechanisms: Abundant targets for the prevention and treatment of neurodegenerative disorders
    • Mattson MP. Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders. Neuromol Med 3: 65-94, 2003.
    • (2003) Neuromol Med , vol.3 , pp. 65-94
    • Mattson, M.P.1
  • 85
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 430: 631-639, 2004.
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 86
    • 4544328810 scopus 로고    scopus 로고
    • BDNF and 5-HT: A dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
    • Mattson MP, Maudsley S, and Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27: 589-594, 2004.
    • (2004) Trends Neurosci , vol.27 , pp. 589-594
    • Mattson, M.P.1    Maudsley, S.2    Martin, B.3
  • 87
    • 33646010041 scopus 로고    scopus 로고
    • Roles for NF-kappaB in nerve cell survival, plasticity, and disease
    • Epub ahead of print
    • Mattson MP and Meffert MK. Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 6: [Epub ahead of print], 2006.
    • (2006) Cell Death Differ , pp. 6
    • Mattson, M.P.1    Meffert, M.K.2
  • 88
    • 0041856595 scopus 로고    scopus 로고
    • Epidemiology of neurodegeneration
    • Mayeux R. Epidemiology of neurodegeneration. Annu Rev Neurosci 26: 81-104, 2003.
    • (2003) Annu Rev Neurosci , vol.26 , pp. 81-104
    • Mayeux, R.1
  • 90
    • 20444471551 scopus 로고    scopus 로고
    • Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype
    • Mirochnitchenko O. Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J Biol Chem 280: 22530-22539, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 22530-22539
    • Mirochnitchenko, O.1
  • 91
    • 0032953541 scopus 로고    scopus 로고
    • Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis
    • Moechars D, Lorent K, and Van Leuven F. Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience 91: 819-830, 1999.
    • (1999) Neuroscience , vol.91 , pp. 819-830
    • Moechars, D.1    Lorent, K.2    Van Leuven, F.3
  • 92
    • 0345832418 scopus 로고    scopus 로고
    • Absence of prostate apoptosis response-4 protein in substantia nigra of Parkinson's disease autopsies
    • Moos T and Jensen PH. Absence of prostate apoptosis response-4 protein in substantia nigra of Parkinson's disease autopsies. Acta Neuropathol (Berl) 107: 23-26, 2004.
    • (2004) Acta Neuropathol (Berl) , vol.107 , pp. 23-26
    • Moos, T.1    Jensen, P.H.2
  • 93
    • 0029787513 scopus 로고    scopus 로고
    • Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons
    • Mu Z, He J, Anderson DW, Trojanowski JQ, and Springer JE. Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons. Ann Neurol 40: 379-386, 1996.
    • (1996) Ann Neurol , vol.40 , pp. 379-386
    • Mu, Z.1    He, J.2    Anderson, D.W.3    Trojanowski, J.Q.4    Springer, J.E.5
  • 94
    • 0035027777 scopus 로고    scopus 로고
    • Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance
    • Nandagopal K, Dawson TM, and Dawson VL. Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance. J Pharmacol Exp Ther 297: 474-478, 2001.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 474-478
    • Nandagopal, K.1    Dawson, T.M.2    Dawson, V.L.3
  • 95
    • 0035341498 scopus 로고    scopus 로고
    • Neuroprotection mediated by glial cell line-derived neurotrophic factor: Involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway
    • Nicole O, Ali C, Docagne F, Plawinski L, MacKenzie ET, Vivien D, and Buisson A. Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway. J Neurosci 21: 3024-3033, 2001.
    • (2001) J Neurosci , vol.21 , pp. 3024-3033
    • Nicole, O.1    Ali, C.2    Docagne, F.3    Plawinski, L.4    MacKenzie, E.T.5    Vivien, D.6    Buisson, A.7
  • 96
    • 0035869351 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner
    • Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K, and Nishimoto I. Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. J Neurosci 21: 1902-1910, 2001.
    • (2001) J Neurosci , vol.21 , pp. 1902-1910
    • Niikura, T.1    Hashimoto, Y.2    Okamoto, T.3    Abe, Y.4    Yasukawa, T.5    Kawasumi, M.6    Hiraki, T.7    Kita, Y.8    Terashita, K.9    Kouyama, K.10    Nishimoto, I.11
  • 98
    • 0032510758 scopus 로고    scopus 로고
    • Offen D, Beart PM, Cheung NS, Pascoe CJ, Hochman A, Gorodin S, Melamed E, Bernard R, and Bernard O. Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity. Proc Natl Acad Sci U S A 95: 5789-5794, 1998.
    • Offen D, Beart PM, Cheung NS, Pascoe CJ, Hochman A, Gorodin S, Melamed E, Bernard R, and Bernard O. Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity. Proc Natl Acad Sci U S A 95: 5789-5794, 1998.
  • 99
    • 0037173038 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: A proposed mechanism
    • Okado-Matsumoto A and Fridovich I. Amyotrophic lateral sclerosis: a proposed mechanism. Proc Natl Acad Sci U S A 99: 9010-9014, 2002.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9010-9014
    • Okado-Matsumoto, A.1    Fridovich, I.2
  • 101
    • 0029860523 scopus 로고    scopus 로고
    • Amyloid beta peptide of Alzheimer's disease down-regulates Bcl-2 and upregulates bax expression in human neurons
    • Paradis E, Douillard H, Koutroumanis M, Goodyer C, and LeBlanc A. Amyloid beta peptide of Alzheimer's disease down-regulates Bcl-2 and upregulates bax expression in human neurons. J Neurosci 16: 7533-7539, 1996.
    • (1996) J Neurosci , vol.16 , pp. 7533-7539
    • Paradis, E.1    Douillard, H.2    Koutroumanis, M.3    Goodyer, C.4    LeBlanc, A.5
  • 102
    • 0032430185 scopus 로고    scopus 로고
    • Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase
    • Pasinelli P, Borchelt DR, Houseweart MK, Cleveland DW, and Brown RH Jr. Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc Natl Acad Sci U S A 95: 15763-15768, 1998.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15763-15768
    • Pasinelli, P.1    Borchelt, D.R.2    Houseweart, M.K.3    Cleveland, D.W.4    Brown Jr., R.H.5
  • 103
    • 3242703300 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
    • Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, and Brown RH Jr. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron 43: 19-30, 2004.
    • (2004) Neuron , vol.43 , pp. 19-30
    • Pasinelli, P.1    Belford, M.E.2    Lennon, N.3    Bacskai, B.J.4    Hyman, B.T.5    Trotti, D.6    Brown Jr., R.H.7
  • 105
    • 0031768026 scopus 로고    scopus 로고
    • Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
    • Pedersen WA, Fu W, Keller JN, Markesbery WR, Appel S, Smith RG, Kasarskis E, and Mattson MP. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann Neurol 44: 819-824, 1998.
    • (1998) Ann Neurol , vol.44 , pp. 819-824
    • Pedersen, W.A.1    Fu, W.2    Keller, J.N.3    Markesbery, W.R.4    Appel, S.5    Smith, R.G.6    Kasarskis, E.7    Mattson, M.P.8
  • 106
    • 0034063728 scopus 로고    scopus 로고
    • A mechanism for the neuroprotective effect of apolipoprotein E: Isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal
    • Pedersen WA, Chan SL, and Mattson MP. A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J Neurochem 74: 1426-1433, 2000.
    • (2000) J Neurochem , vol.74 , pp. 1426-1433
    • Pedersen, W.A.1    Chan, S.L.2    Mattson, M.P.3
  • 107
    • 0036169480 scopus 로고    scopus 로고
    • IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo
    • Perrelet D, Ferri A, Liston P, Muzzin P, Korneluk RG, and Kato AC. IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo. Nat Cell Biol 4: 175-179, 2002.
    • (2002) Nat Cell Biol , vol.4 , pp. 175-179
    • Perrelet, D.1    Ferri, A.2    Liston, P.3    Muzzin, P.4    Korneluk, R.G.5    Kato, A.C.6
  • 108
    • 33947646743 scopus 로고    scopus 로고
    • Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis
    • Nov 10; [Epub ahead of print
    • Petri S, Kiaei M, Kipiani K, Chen J, Calingasan NY, Crow JP, and Beal MF. Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2005 Nov 10; [Epub ahead of print]
    • (2005) Neurobiol Dis
    • Petri, S.1    Kiaei, M.2    Kipiani, K.3    Chen, J.4    Calingasan, N.Y.5    Crow, J.P.6    Beal, M.F.7
  • 109
    • 0029072690 scopus 로고
    • Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
    • Portera-Cailliau C, Hedreen JC, Price DL, and Koliatosos VE. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J Neurosci 15: 3775-3787, 1995.
    • (1995) J Neurosci , vol.15 , pp. 3775-3787
    • Portera-Cailliau, C.1    Hedreen, J.C.2    Price, D.L.3    Koliatosos, V.E.4
  • 110
    • 1642514774 scopus 로고    scopus 로고
    • Men are but worms: Neuronal cell death in C. elegans and vertebrates
    • Putcha GV and Johnson EM Jr. Men are but worms: neuronal cell death in C. elegans and vertebrates. Cell Death Differ 11: 38-48, 2004.
    • (2004) Cell Death Differ , vol.11 , pp. 38-48
    • Putcha, G.V.1    Johnson Jr., E.M.2
  • 111
    • 3042736860 scopus 로고    scopus 로고
    • Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
    • Reddy PH, McWeeney S, Park BS, Manczak M, Gutala RV, Partovi D, Jung Y, Yau V, Searles R, Mori M, and Quinn J. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum Mol Genet 13: 1225-1240, 2004.
    • (2004) Hum Mol Genet , vol.13 , pp. 1225-1240
    • Reddy, P.H.1    McWeeney, S.2    Park, B.S.3    Manczak, M.4    Gutala, R.V.5    Partovi, D.6    Jung, Y.7    Yau, V.8    Searles, R.9    Mori, M.10    Quinn, J.11
  • 112
    • 0033579301 scopus 로고    scopus 로고
    • Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
    • Riccio A, Ahn S, Davenport CM, Blendy JA, and Ginty DD. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286: 2358-2361, 1999.
    • (1999) Science , vol.286 , pp. 2358-2361
    • Riccio, A.1    Ahn, S.2    Davenport, C.M.3    Blendy, J.A.4    Ginty, D.D.5
  • 114
    • 0035141757 scopus 로고    scopus 로고
    • Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease
    • Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, and Cribbs DH. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol 158: 189-198, 2001.
    • (2001) Am J Pathol , vol.158 , pp. 189-198
    • Rohn, T.T.1    Head, E.2    Su, J.H.3    Anderson, A.J.4    Bahr, B.A.5    Cotman, C.W.6    Cribbs, D.H.7
  • 115
    • 0036968953 scopus 로고    scopus 로고
    • Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain
    • Rohn T, Rissman RA, Davis MC, Kim YE, Cotman CW, and Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis 11: 341-354, 2002.
    • (2002) Neurobiol Dis , vol.11 , pp. 341-354
    • Rohn, T.1    Rissman, R.A.2    Davis, M.C.3    Kim, Y.E.4    Cotman, C.W.5    Head, E.6
  • 116
    • 0036533795 scopus 로고    scopus 로고
    • Lessons from animal models of Huntington's disease
    • Rubinsztein DC. Lessons from animal models of Huntington's disease. Trends Genet 18: 202-209, 2002.
    • (2002) Trends Genet , vol.18 , pp. 202-209
    • Rubinsztein, D.C.1
  • 117
    • 2142697164 scopus 로고    scopus 로고
    • Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: A role for the insulin-like growth factor system
    • Russo VC, Kobayashi K, Najdovska S, Baker NL, and Werther GA. Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: a role for the insulin-like growth factor system. Brain Res 1009: 40-53, 2004.
    • (2004) Brain Res , vol.1009 , pp. 40-53
    • Russo, V.C.1    Kobayashi, K.2    Najdovska, S.3    Baker, N.L.4    Werther, G.A.5
  • 122
    • 0035067438 scopus 로고    scopus 로고
    • The selective vulnerability of nerve cells in Huntington's disease
    • Sieradzan KA and Mann DM. The selective vulnerability of nerve cells in Huntington's disease. Neuropathol Appl Neurobiol 27: 1-21, 2001.
    • (2001) Neuropathol Appl Neurobiol , vol.27 , pp. 1-21
    • Sieradzan, K.A.1    Mann, D.M.2
  • 123
    • 13544273998 scopus 로고    scopus 로고
    • Caspase-dependent and -independent neuronal death: Two distinct pathways to neuronal injury
    • Stefanis L. Caspase-dependent and -independent neuronal death: two distinct pathways to neuronal injury. Neuroscientist 11: 50-62, 2005.
    • (2005) Neuroscientist , vol.11 , pp. 50-62
    • Stefanis, L.1
  • 124
    • 4444255624 scopus 로고    scopus 로고
    • Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: Support for the amyloid hypothesis
    • Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, and Johnson JA. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 24: 7707-7717, 2004.
    • (2004) J Neurosci , vol.24 , pp. 7707-7717
    • Stein, T.D.1    Anders, N.J.2    DeCarli, C.3    Chan, S.L.4    Mattson, M.P.5    Johnson, J.A.6
  • 125
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression, and brain pathology
    • Su JH, Deng G, and Cotman CW. Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J Neuropathol Exp Neurol 56: 86-93, 1997.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 86-93
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 127
    • 25644446864 scopus 로고    scopus 로고
    • Dieldrin induces ubiquitin-proteasome dysfunction in alphα-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death
    • Sun F, Anatharam V, Latchoumycandane C, Kanthasamy A, and Kanthasamy AG. Dieldrin induces ubiquitin-proteasome dysfunction in alphα-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. J Pharmacol Exp Ther 315: 69-79, 2005.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 69-79
    • Sun, F.1    Anatharam, V.2    Latchoumycandane, C.3    Kanthasamy, A.4    Kanthasamy, A.G.5
  • 131
    • 0033756901 scopus 로고    scopus 로고
    • Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease
    • Tatton NA. Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp Neurol 166: 29-43, 2000.
    • (2000) Exp Neurol , vol.166 , pp. 29-43
    • Tatton, N.A.1
  • 132
    • 0037378897 scopus 로고    scopus 로고
    • Tatton WG, Chalmers-Redman R, Brown D, and Tatton N. Apoptosis in Parkinson's disease: signals for neuronal degradation. Ann Neurol 53: S61-S70, 2003.
    • Tatton WG, Chalmers-Redman R, Brown D, and Tatton N. Apoptosis in Parkinson's disease: signals for neuronal degradation. Ann Neurol 53: S61-S70, 2003.
  • 134
    • 24144492380 scopus 로고    scopus 로고
    • Lesions and dysfunctions of the nucleus basalis as Alzheimer's disease models: General and critical overview and analysis of the long-term changes in several excitotoxic models
    • Toledano A and Alvarez MI. Lesions and dysfunctions of the nucleus basalis as Alzheimer's disease models: general and critical overview and analysis of the long-term changes in several excitotoxic models. Curr Alzheimer Res 1: 189-214, 2004.
    • (2004) Curr Alzheimer Res , vol.1 , pp. 189-214
    • Toledano, A.1    Alvarez, M.I.2
  • 135
    • 0038205745 scopus 로고    scopus 로고
    • Targeting programmed cell death in neurodegenerative diseases
    • Vila M and Przedborski S. Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci 4: 365-375, 2003.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 365-375
    • Vila, M.1    Przedborski, S.2
  • 136
    • 0035956874 scopus 로고    scopus 로고
    • Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, and Przedborski S. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 98: 2837-2842, 2001.
    • Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, and Przedborski S. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 98: 2837-2842, 2001.
  • 138
  • 139
    • 0037377189 scopus 로고    scopus 로고
    • Prospects for antiapoptotic drug therapy of neurodegenerative disorders
    • Waldmeier PC. Prospects for antiapoptotic drug therapy of neurodegenerative disorders. Prog Neuropsychopharmacol Biol Psychiatry 27: 303-321, 2003.
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 303-321
    • Waldmeier, P.C.1
  • 143
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16: 921-932, 1996.
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1
  • 144
    • 0033015485 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: Suppression of oxidative stress and stabilization of calcium homeostasis
    • Yu Z, Luo H, Fu W, and Mattson MP. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol 155: 302-314, 1999.
    • (1999) Exp Neurol , vol.155 , pp. 302-314
    • Yu, Z.1    Luo, H.2    Fu, W.3    Mattson, M.P.4
  • 145
    • 0034486561 scopus 로고    scopus 로고
    • Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease
    • Yu Z, Zhou D, Cheng G, and Mattson MP. Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease. J Mol Neurosci 15: 31-44, 2000.
    • (2000) J Mol Neurosci , vol.15 , pp. 31-44
    • Yu, Z.1    Zhou, D.2    Cheng, G.3    Mattson, M.P.4
  • 146
    • 0141884305 scopus 로고    scopus 로고
    • Yuan Y, Lipinski M, and Degterev A. Diversity in the mechanisms of neuronal cell death. Neuron 40: 401-413, 2003.
    • Yuan Y, Lipinski M, and Degterev A. Diversity in the mechanisms of neuronal cell death. Neuron 40: 401-413, 2003.
  • 147
    • 0344013490 scopus 로고    scopus 로고
    • Cellular and molecular events underlying ischemia-induced neuronal apoptosis
    • Zheng Z, Zhao H, Steinberg GK, and Yenari MA. Cellular and molecular events underlying ischemia-induced neuronal apoptosis. Drug News Perspect 16: 497-503, 2003.
    • (2003) Drug News Perspect , vol.16 , pp. 497-503
    • Zheng, Z.1    Zhao, H.2    Steinberg, G.K.3    Yenari, M.A.4
  • 148
    • 28344432799 scopus 로고    scopus 로고
    • Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alphα-synuclein
    • Zhou ZD, Yap BP, Gung AY, Leong SM, Ang ST, and Lim TM. Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alphα-synuclein. Exp Cell Res 312: 156-170, 2006.
    • (2006) Exp Cell Res , vol.312 , pp. 156-170
    • Zhou, Z.D.1    Yap, B.P.2    Gung, A.Y.3    Leong, S.M.4    Ang, S.T.5    Lim, T.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.