Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging

FEBS Letters

Volumn 583, Issue 7, 2009, Pages 1132-1140

  Zhou, Qiongqiong ^b   Lam, Philip Y ^a   Han, Derick ^c   Cadenas, Enrique ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Brain aging; JNK; Mitochondria; Neurodegeneration; Pyruvate dehydrogenase

Indexed keywords

ADENOSINE TRIPHOSPHATE; LACTIC ACID; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE 2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOENERGY; BRAIN CELL; CELL AGING; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY TRANSFER; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLYCOLYSIS; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ADENOSINE TRIPHOSPHATE; AGING; ANAEROBIOSIS; ANIMALS; BRAIN; CATALYTIC DOMAIN; GLYCOLYSIS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTIC ACID; MALE; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN TRANSPORT; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, INBRED F344; SIGNAL TRANSDUCTION;

RATTUS;

EID: 62849111251     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.02.043     Document Type: Article

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