Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models

Growth Hormone and IGF Research

Volumn 18, Issue 6, 2008, Pages 455-471

  Berryman, Darlene E ^a   Christiansen, Jens Sandahl ^b   Johannsson, Gudmundur ^c   Thorner, Michael O ^d   Kopchick, John J ^e  

^a Health Services   (United States)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^e OHIO UNIVERSITY   (United States)

Author keywords

Aging; Growth hormone; Healthspan; Insulin like growth factor 1; Intracellular signaling pathways; Lifespan; Longevity genes; Mouse models

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RECEPTOR; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; KLOTHO PROTEIN; PROTEIN P66; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

AGING; CALORIC RESTRICTION; CANCER INCIDENCE; CARCINOGENESIS; COGNITION; DIABETES MELLITUS; EXPERIMENTAL ANIMAL; EXPERIMENTAL DOG; EXPERIMENTAL MOUSE; GENE FUNCTION; GROWTH HORMONE DEFICIENCY; HEALTH STATUS; HORMONE ACTION; HUMAN; HYPOPHYSIS FUNCTION; INSULIN SENSITIVITY; INVERTEBRATE; KIDNEY FUNCTION; LIFESPAN; LONGEVITY; MAMMAL; MUSCULOSKELETAL SYSTEM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; STRESS;

AGING; ANIMALS; CALORIC RESTRICTION; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MODELS, ANIMAL; SIGNAL TRANSDUCTION;

EID: 53249134458     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2008.05.005     Document Type: Review

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