Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism

PLoS Biology

Volumn 6, Issue 10, 2008, Pages 2144-2153

  Kappeler, Laurent ^a   De Magalhaes Filho, Carlos ^a,b   Dupont, Joëlle ^c   Leneuve, Patricia ^a   Cervera, Pascale ^a   Périn, Laurence ^a   Loudes, Catherine ^d   Blaise, Annick ^a,b   Klein, Rüdiger ^e   Epelbaum, Jacques ^d   Le Bouc, Yves ^a,b   Holzenberger, Martin ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c CEMAGREF   (France)

^d CENTRE PAUL BROCA   (France)

^e MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIRTH; BRAIN; CONTROLLED STUDY; DEVELOPMENT; FEMALE; GROWTH; GROWTH RETARDATION; LIFESPAN; MALE; MAMMAL; METABOLIC DISORDER; MORTALITY; MOUSE; NEUROENDOCRINE DEVELOPMENT; NEUROENDOCRINE SYSTEM; NONHUMAN; PLASTICITY; RISK; ANIMAL; BODY TEMPERATURE; C57BL MOUSE; ENERGY METABOLISM; FERTILITY; GENETICS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LONGEVITY; METABOLISM; NEUROSECRETION; NEWBORN; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MAMMALIA; MUS; NEMATODA; VERTEBRATA;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BODY TEMPERATURE; BRAIN; ENERGY METABOLISM; FEMALE; FERTILITY; GROWTH HORMONE; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROSECRETORY SYSTEMS; RECEPTOR, IGF TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 54949143977     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0060254     Document Type: Article

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