메뉴 건너뛰기




Volumn 162, Issue 3, 2013, Pages 156-173

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BETA GALACTOSIDE; BONE MORPHOGENETIC PROTEIN; CYCLIN D1; HEAT SHOCK PROTEIN 27; KALININ; MATRILYSIN; NOTCH RECEPTOR; SCLEROPROTEIN; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 84882925367     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2013.06.004     Document Type: Review
Times cited : (238)

References (258)
  • 1
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • M. Collado, M.A. Blasco, and M. Serrano Cellular senescence in cancer and aging Cell 130 2007 223 233
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 2
    • 18044398540 scopus 로고    scopus 로고
    • Telomeres as biomarkers for ageing and age-related diseases
    • T. von Zglinicki, and C.M. Martin-Ruiz Telomeres as biomarkers for ageing and age-related diseases Curr Mol Med 5 2005 197 203
    • (2005) Curr Mol Med , vol.5 , pp. 197-203
    • Von Zglinicki, T.1    Martin-Ruiz, C.M.2
  • 3
    • 34548660457 scopus 로고    scopus 로고
    • Global initiative for chronic obstructive lung disease: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    • K.F. Rabe, S. Hurd, and A. Anzueto Global initiative for chronic obstructive lung disease: global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary Am J Respir Crit Care Med 176 2007 532 555
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 532-555
    • Rabe, K.F.1    Hurd, S.2    Anzueto, A.3
  • 4
    • 82755161052 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis
    • T.E. King Jr., A. Pardo, and M. Selman Idiopathic pulmonary fibrosis Lancet 378 2011 1949 1961
    • (2011) Lancet , vol.378 , pp. 1949-1961
    • King, Jr.T.E.1    Pardo, A.2    Selman, M.3
  • 5
    • 70350223450 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study
    • J. Koshiol, M. Rotunno, and D. Consonni Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study PLoS One 4 2009 e7380
    • (2009) PLoS One , vol.4 , pp. 7380
    • Koshiol, J.1    Rotunno, M.2    Consonni, D.3
  • 6
    • 0033983168 scopus 로고    scopus 로고
    • Lung cancer and cryptogenic fibrosing alveolitis: A population-based cohort study
    • R. Hubbard, A. Venn, S. Lewis, and J. Britton Lung cancer and cryptogenic fibrosing alveolitis: a population-based cohort study Am J Respir Crit Care Med 161 2000 5 8
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 5-8
    • Hubbard, R.1    Venn, A.2    Lewis, S.3    Britton, J.4
  • 7
    • 84855614159 scopus 로고    scopus 로고
    • The pathogenesis of COPD and IPF: Distinct horns of the same devil?
    • M. Chilosi, V. Poletti, and A. Rossi The pathogenesis of COPD and IPF: distinct horns of the same devil? Respir Res 13 2012 3
    • (2012) Respir Res , vol.13 , pp. 3
    • Chilosi, M.1    Poletti, V.2    Rossi, A.3
  • 8
    • 84865121012 scopus 로고    scopus 로고
    • Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
    • R. Faner, M. Rojas, W. Macnee, and A. Agustí Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis Am J Respir Crit Care Med 186 2012 306 313
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 306-313
    • Faner, R.1    Rojas, M.2    Macnee, W.3    Agustí, A.4
  • 9
    • 70349129549 scopus 로고    scopus 로고
    • Accelerated lung aging: A novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
    • W. MacNee Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD) Biochem Soc Trans 37 2009 819 823
    • (2009) Biochem Soc Trans , vol.37 , pp. 819-823
    • Macnee, W.1
  • 10
    • 80051720737 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Update on genetic discoveries
    • C.K. Garcia Idiopathic pulmonary fibrosis: update on genetic discoveries Proc Am Thorac Soc 8 2011 158 162
    • (2011) Proc Am Thorac Soc , vol.8 , pp. 158-162
    • Garcia, C.K.1
  • 11
    • 79958788032 scopus 로고    scopus 로고
    • New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis
    • Q. Ding, T. Luckhardt, and L. Hecker New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis Drugs 71 2011 981 1001
    • (2011) Drugs , vol.71 , pp. 981-1001
    • Ding, Q.1    Luckhardt, T.2    Hecker, L.3
  • 12
    • 0034133548 scopus 로고    scopus 로고
    • American Thoracic Society. Idiopathic pulmonary fibrosis: Diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS)
    • American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS) Am J Respir Crit Care Med 161 2000 646 664
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 646-664
  • 13
    • 0035931973 scopus 로고    scopus 로고
    • A mutation in the surfactant protein C gene associated with familial interstitial lung disease
    • L.M. Nogee, A.E. Dunbar 3rd, S.E. Wert, F. Askin, A. Hamvas, and J.A. Whitsett A mutation in the surfactant protein C gene associated with familial interstitial lung disease N Engl J Med 344 2001 573 579
    • (2001) N Engl J Med , vol.344 , pp. 573-579
    • Nogee, L.M.1    Dunbar III, A.E.2    Wert, S.E.3    Askin, F.4    Hamvas, A.5    Whitsett, J.A.6
  • 14
    • 0036570052 scopus 로고    scopus 로고
    • Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred
    • A.Q. Thomas, K. Lane, and J. Phillips 3rd Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred Am J Respir Crit Care Med 165 2002 1322 1328
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1322-1328
    • Thomas, A.Q.1    Lane, K.2    Phillips III, J.3
  • 15
    • 58149159548 scopus 로고    scopus 로고
    • Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer
    • Y. Wang, P.J. Kuan, and C. Xing Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer Am J Hum Genet 84 2009 52 59
    • (2009) Am J Hum Genet , vol.84 , pp. 52-59
    • Wang, Y.1    Kuan, P.J.2    Xing, C.3
  • 16
    • 0242690510 scopus 로고    scopus 로고
    • Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis
    • M. Selman, H.M. Lin, and M. Montaño Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis Hum Genet 113 2003 542 550
    • (2003) Hum Genet , vol.113 , pp. 542-550
    • Selman, M.1    Lin, H.M.2    Montaño, M.3
  • 17
    • 8544245673 scopus 로고    scopus 로고
    • Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF
    • W.E. Lawson, S.W. Grant, and V. Ambrosini Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF Thorax 59 2004 977 980
    • (2004) Thorax , vol.59 , pp. 977-980
    • Lawson, W.E.1    Grant, S.W.2    Ambrosini, V.3
  • 18
    • 33846236874 scopus 로고    scopus 로고
    • Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias
    • P. Markart, C. Ruppert, and M. Wygrecka Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias Eur Respir J 29 2007 134 137
    • (2007) Eur Respir J , vol.29 , pp. 134-137
    • Markart, P.1    Ruppert, C.2    Wygrecka, M.3
  • 19
    • 34047188508 scopus 로고    scopus 로고
    • Telomerase mutations in families with idiopathic pulmonary fibrosis
    • M.Y. Armanios, J.J. Chen, and J.D. Cogan Telomerase mutations in families with idiopathic pulmonary fibrosis N Engl J Med 356 2007 1317 1326
    • (2007) N Engl J Med , vol.356 , pp. 1317-1326
    • Armanios, M.Y.1    Chen, J.J.2    Cogan, J.D.3
  • 20
    • 34250614359 scopus 로고    scopus 로고
    • Adult-onset pulmonary fibrosis caused by mutations in telomerase
    • K.D. Tsakiri, J.T. Cronkhite, and P.J. Kuan Adult-onset pulmonary fibrosis caused by mutations in telomerase Proc Natl Acad Sci U S A 104 2007 7552 7557
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7552-7557
    • Tsakiri, K.D.1    Cronkhite, J.T.2    Kuan, P.J.3
  • 21
    • 51349113450 scopus 로고    scopus 로고
    • Short telomeres are a risk factor for idiopathic pulmonary fibrosis
    • J.K. Alder, J.J. Chen, and L. Lancaster Short telomeres are a risk factor for idiopathic pulmonary fibrosis Proc Natl Acad Sci U S A 105 2008 13051 13056
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13051-13056
    • Alder, J.K.1    Chen, J.J.2    Lancaster, L.3
  • 22
    • 52749083873 scopus 로고    scopus 로고
    • Telomere shortening in familial and sporadic pulmonary fibrosis
    • J.T. Cronkhite, C. Xing, and G. Raghu Telomere shortening in familial and sporadic pulmonary fibrosis Am J Respir Crit Care Med 178 2008 729 737
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 729-737
    • Cronkhite, J.T.1    Xing, C.2    Raghu, G.3
  • 23
    • 84860882713 scopus 로고    scopus 로고
    • HTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms
    • A.R. Tsang, H.D. Wyatt, N.S. Ting, and T.L. Beattie hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms Aging Cell 11 2012 482 490
    • (2012) Aging Cell , vol.11 , pp. 482-490
    • Tsang, A.R.1    Wyatt, H.D.2    Ting, N.S.3    Beattie, T.L.4
  • 24
    • 33744935773 scopus 로고    scopus 로고
    • The genetic approach in pulmonary fibrosis: Can it provide clues to this complex disease?
    • W.E. Lawson, and J.E. Loyd The genetic approach in pulmonary fibrosis: can it provide clues to this complex disease? Proc Am Thorac Soc 3 2006 345 349
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 345-349
    • Lawson, W.E.1    Loyd, J.E.2
  • 25
    • 84872054447 scopus 로고    scopus 로고
    • Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis
    • J.A. Kropski, W.E. Lawson, L.R. Young, and T.S. Blackwell Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis Dis Model Mech 6 2013 9 17
    • (2013) Dis Model Mech , vol.6 , pp. 9-17
    • Kropski, J.A.1    Lawson, W.E.2    Young, L.R.3    Blackwell, T.S.4
  • 27
    • 70949087815 scopus 로고    scopus 로고
    • A spectrum of severe familial liver disorders associated with telomerase mutations
    • R.T. Calado, J.A. Regal, and D.E. Kleiner A spectrum of severe familial liver disorders associated with telomerase mutations PLoS One 4 2009 e7926
    • (2009) PLoS One , vol.4 , pp. 7926
    • Calado, R.T.1    Regal, J.A.2    Kleiner, D.E.3
  • 29
    • 64249090973 scopus 로고    scopus 로고
    • Dyskeratosis congenita, stem cells and telomeres
    • M. Kirwan, and I. Dokal Dyskeratosis congenita, stem cells and telomeres Biochim Biophys Acta 1792 2009 371 379
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 371-379
    • Kirwan, M.1    Dokal, I.2
  • 30
    • 0033518188 scopus 로고    scopus 로고
    • A telomerase component is defective in the human disease dyskeratosis congenita
    • J.R. Mitchell, E. Wood, and K. Collins A telomerase component is defective in the human disease dyskeratosis congenita Nature 402 1999 551 555
    • (1999) Nature , vol.402 , pp. 551-555
    • Mitchell, J.R.1    Wood, E.2    Collins, K.3
  • 32
    • 79959282291 scopus 로고    scopus 로고
    • Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
    • L.F. Batista, M.F. Pech, and F.L. Zhong Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells Nature 474 2011 399 402
    • (2011) Nature , vol.474 , pp. 399-402
    • Batista, L.F.1    Pech, M.F.2    Zhong, F.L.3
  • 33
    • 27644548532 scopus 로고    scopus 로고
    • Dyskeratosis congenita: A disorder of defective telomere maintenance?
    • A.J. Walne, A. Marrone, and I. Dokal Dyskeratosis congenita: a disorder of defective telomere maintenance? Int J Hematol 82 2005 184 189
    • (2005) Int J Hematol , vol.82 , pp. 184-189
    • Walne, A.J.1    Marrone, A.2    Dokal, I.3
  • 34
    • 0028412593 scopus 로고
    • Dyskeratosis congenita showing usual interstitial pneumonia
    • S. Imokawa, A. Sato, and M. Toyoshima Dyskeratosis congenita showing usual interstitial pneumonia Intern Med 33 1994 226 230
    • (1994) Intern Med , vol.33 , pp. 226-230
    • Imokawa, S.1    Sato, A.2    Toyoshima, M.3
  • 35
    • 20044379963 scopus 로고    scopus 로고
    • Usual interstitial pneumonia complicating dyskeratosis congenita
    • J.P. Utz, J.H. Ryu, J.L. Myers, and V.V. Michels Usual interstitial pneumonia complicating dyskeratosis congenita Mayo Clin Proc 80 2005 817 821
    • (2005) Mayo Clin Proc , vol.80 , pp. 817-821
    • Utz, J.P.1    Ryu, J.H.2    Myers, J.L.3    Michels, V.V.4
  • 36
    • 67749086830 scopus 로고    scopus 로고
    • Genetic and environmental factors influencing human diseases with telomere dysfunction
    • H. Ly Genetic and environmental factors influencing human diseases with telomere dysfunction Int J Clin Exp Med 2 2009 114 130
    • (2009) Int J Clin Exp Med , vol.2 , pp. 114-130
    • Ly, H.1
  • 37
    • 77956289135 scopus 로고    scopus 로고
    • Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations
    • A. Diaz de Leon, J.T. Cronkhite, and A.L. Katzenstein Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations PLoS One 5 2010 e10680
    • (2010) PLoS One , vol.5 , pp. 10680
    • Diaz De Leon, A.1    Cronkhite, J.T.2    Katzenstein, A.L.3
  • 40
    • 75949125865 scopus 로고    scopus 로고
    • Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic pulmonary fibrosis
    • D.R. Waisberg, J.V. Barbas-Filho, and E.R. Parra Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic pulmonary fibrosis Hum Pathol 41 2010 385 391
    • (2010) Hum Pathol , vol.41 , pp. 385-391
    • Waisberg, D.R.1    Barbas-Filho, J.V.2    Parra, E.R.3
  • 41
    • 48949119341 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: Association with altered surfactant protein processing and herpesvirus infection
    • W.E. Lawson, P.F. Crossno, and V.V. Polosukhin Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection Am J Physiol Lung Cell Mol Physiol 294 2008 L1119 L1126
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Lawson, W.E.1    Crossno, P.F.2    Polosukhin, V.V.3
  • 42
    • 79960570500 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs
    • W.E. Lawson, D.S. Cheng, and A.L. Degryse Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs Proc Natl Acad Sci U S A 108 2011 10562 10567
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 10562-10567
    • Lawson, W.E.1    Cheng, D.S.2    Degryse, A.L.3
  • 43
    • 13844314302 scopus 로고    scopus 로고
    • Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis
    • M. Plataki, A.V. Koutsopoulos, K. Darivianaki, G. Delides, N.M. Siafakas, and D. Bouros Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis Chest 127 2005 266 274
    • (2005) Chest , vol.127 , pp. 266-274
    • Plataki, M.1    Koutsopoulos, A.V.2    Darivianaki, K.3    Delides, G.4    Siafakas, N.M.5    Bouros, D.6
  • 44
    • 80052540057 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: Effects of misfolded surfactant protein
    • Q. Zhong, B. Zhou, and D.K. Ann Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein Am J Respir Cell Mol Biol 45 2011 498 509
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 498-509
    • Zhong, Q.1    Zhou, B.2    Ann, D.K.3
  • 45
    • 54049115076 scopus 로고    scopus 로고
    • Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
    • M. Korfei, C. Ruppert, and P. Mahavadi Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis Am J Respir Crit Care Med 178 2008 838 846
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 838-846
    • Korfei, M.1    Ruppert, C.2    Mahavadi, P.3
  • 46
    • 79955789007 scopus 로고    scopus 로고
    • Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs
    • M. Korfei, S. Schmitt, and C. Ruppert Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs J Proteome Res 10 2011 2185 2205
    • (2011) J Proteome Res , vol.10 , pp. 2185-2205
    • Korfei, M.1    Schmitt, S.2    Ruppert, C.3
  • 47
    • 51049112958 scopus 로고    scopus 로고
    • Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells
    • E. Jorgensen, A. Stinson, L. Shan, J. Yang, D. Gietl, and A.P. Albino Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells BMC Cancer 8 2008 229
    • (2008) BMC Cancer , vol.8 , pp. 229
    • Jorgensen, E.1    Stinson, A.2    Shan, L.3    Yang, J.4    Gietl, D.5    Albino, A.P.6
  • 48
    • 42949118737 scopus 로고    scopus 로고
    • Cigarette smoke induces an unfolded protein response in the human lung: A proteomic approach
    • S.G. Kelsen, X. Duan, R. Ji, O. Perez, C. Liu, and S. Merali Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach Am J Respir Cell Mol Biol 38 2008 541 550
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 541-550
    • Kelsen, S.G.1    Duan, X.2    Ji, R.3    Perez, O.4    Liu, C.5    Merali, S.6
  • 49
    • 39949085603 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival
    • A. Hengstermann, and T. Müller Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival Free Radic Biol Med 44 2008 1097 1107
    • (2008) Free Radic Biol Med , vol.44 , pp. 1097-1107
    • Hengstermann, A.1    Müller, T.2
  • 50
    • 9744272376 scopus 로고    scopus 로고
    • Cigarette smoke induces senescence in alveolar epithelial cells
    • T. Tsuji, K. Aoshiba, and A. Nagai Cigarette smoke induces senescence in alveolar epithelial cells Am J Respir Cell Mol Biol 31 2004 643 649
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 643-649
    • Tsuji, T.1    Aoshiba, K.2    Nagai, A.3
  • 52
    • 84857758730 scopus 로고    scopus 로고
    • Right place, right time: The evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis
    • J.A. Kropski, W.E. Lawson, and T.S. Blackwell Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol 302 2012 L441 L444
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302
    • Kropski, J.A.1    Lawson, W.E.2    Blackwell, T.S.3
  • 53
    • 22544487197 scopus 로고    scopus 로고
    • HHV-8 and EBV are not commonly found in idiopathic pulmonary fibrosis
    • A. Zamò, V. Poletti, and D. Reghellin HHV-8 and EBV are not commonly found in idiopathic pulmonary fibrosis Sarcoidosis Vasc Diffuse Lung Dis 22 2005 123 128
    • (2005) Sarcoidosis Vasc Diffuse Lung Dis , vol.22 , pp. 123-128
    • Zamò, A.1    Poletti, V.2    Reghellin, D.3
  • 54
    • 84860573175 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis may be a disease of recurrent, tractional injury to the periphery of the aging lung: A unifying hypothesis regarding etiology and pathogenesis
    • K.O. Leslie Idiopathic pulmonary fibrosis may be a disease of recurrent, tractional injury to the periphery of the aging lung: a unifying hypothesis regarding etiology and pathogenesis Arch Pathol Lab Med 136 2012 591 600
    • (2012) Arch Pathol Lab Med , vol.136 , pp. 591-600
    • Leslie, K.O.1
  • 56
    • 79961042772 scopus 로고    scopus 로고
    • Cyclic stretch induces alveolar epithelial barrier dysfunction via calpain-mediated degradation of p120-catenin
    • Y. Wang, R.D. Minshall, D.E. Schwartz, and G. Hu Cyclic stretch induces alveolar epithelial barrier dysfunction via calpain-mediated degradation of p120-catenin Am J Physiol Lung Cell Mol Physiol 301 2011 L197 L206
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301
    • Wang, Y.1    Minshall, R.D.2    Schwartz, D.E.3    Hu, G.4
  • 58
    • 72149113857 scopus 로고    scopus 로고
    • Recent advances and new opportunities in lung mechanobiology
    • D.J. Tschumperlin, F. Boudreault, and F. Liu Recent advances and new opportunities in lung mechanobiology J Biomech 43 2010 99 107
    • (2010) J Biomech , vol.43 , pp. 99-107
    • Tschumperlin, D.J.1    Boudreault, F.2    Liu, F.3
  • 59
    • 84878221108 scopus 로고    scopus 로고
    • Heterogeneous distribution of mechanical stress in human lung: A mathematical approach to evaluate abnormal remodeling in IPF
    • Carloni A, Poletti V, Bellomo N, Fermo L, Chilosi M. Heterogeneous distribution of mechanical stress in human lung: a mathematical approach to evaluate abnormal remodeling in IPF. J Theor Biol 2013;332:136-40.
    • (2013) J Theor Biol , vol.332 , pp. 136-140
    • Carloni, A.1    Poletti, V.2    Bellomo, N.3    Fermo, L.4    Chilosi, M.5
  • 60
    • 65549114494 scopus 로고    scopus 로고
    • Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate
    • E.J. Arnsdorf, P. Tummala, and C.R. Jacobs Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate PLoS One 4 2009 e5388
    • (2009) PLoS One , vol.4 , pp. 5388
    • Arnsdorf, E.J.1    Tummala, P.2    Jacobs, C.R.3
  • 61
    • 77951465571 scopus 로고    scopus 로고
    • Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colon
    • J. Whitehead, D. Vignjevic, C. Fütterer, E. Beaurepaire, S. Robine, and E. Farge Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colon HFSP J 2 2008 286 294
    • (2008) HFSP J , vol.2 , pp. 286-294
    • Whitehead, J.1    Vignjevic, D.2    Fütterer, C.3    Beaurepaire, E.4    Robine, S.5    Farge, E.6
  • 62
    • 84856133737 scopus 로고    scopus 로고
    • Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition
    • N.E. Cabrera-Benítez, M. Parotto, and M. Post Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition Crit Care Med 40 2012 510 517
    • (2012) Crit Care Med , vol.40 , pp. 510-517
    • Cabrera-Benítez, N.E.1    Parotto, M.2    Post, M.3
  • 63
    • 79955967161 scopus 로고    scopus 로고
    • Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity
    • R.L. Heise, V. Stober, C. Cheluvaraju, J.W. Hollingsworth, and S. Garantziotis Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity J Biol Chem 286 2011 17435 17444
    • (2011) J Biol Chem , vol.286 , pp. 17435-17444
    • Heise, R.L.1    Stober, V.2    Cheluvaraju, C.3    Hollingsworth, J.W.4    Garantziotis, S.5
  • 64
    • 77953501417 scopus 로고    scopus 로고
    • Mechanical stretching induces osteoprotegerin in differentiating C2C12 precursor cells through noncanonical Wnt pathways
    • H.C. Yu, T.C. Wu, M.R. Chen, S.W. Liu, J.H. Chen, and K.M. Lin Mechanical stretching induces osteoprotegerin in differentiating C2C12 precursor cells through noncanonical Wnt pathways J Bone Miner Res 25 2010 1128 1137
    • (2010) J Bone Miner Res , vol.25 , pp. 1128-1137
    • Yu, H.C.1    Wu, T.C.2    Chen, M.R.3    Liu, S.W.4    Chen, J.H.5    Lin, K.M.6
  • 65
    • 84886943235 scopus 로고    scopus 로고
    • Role of TAZ as mediator of Wnt signaling
    • L. Azzolin, F. Zanconato, and S. Bresolin Role of TAZ as mediator of Wnt signaling Cell 151 2012 1443 1456
    • (2012) Cell , vol.151 , pp. 1443-1456
    • Azzolin, L.1    Zanconato, F.2    Bresolin, S.3
  • 66
    • 84865411430 scopus 로고    scopus 로고
    • Transduction of mechanical and cytoskeletal cues by YAP and TAZ
    • G. Halder, S. Dupont, and S. Piccolo Transduction of mechanical and cytoskeletal cues by YAP and TAZ Nat Rev Mol Cell Biol 13 2012 591 600
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 591-600
    • Halder, G.1    Dupont, S.2    Piccolo, S.3
  • 67
    • 84879094799 scopus 로고    scopus 로고
    • YAP/TEAD-mediated transcription controls cellular senescence
    • Q. Xie, J. Chen, and H. Feng YAP/TEAD-mediated transcription controls cellular senescence Cancer Res 73 2013 3615 3624
    • (2013) Cancer Res , vol.73 , pp. 3615-3624
    • Xie, Q.1    Chen, J.2    Feng, H.3
  • 68
    • 0242500879 scopus 로고    scopus 로고
    • Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis
    • M. Chilosi, V. Poletti, and A. Zamò Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis Am J Pathol 162 2003 1495 1502
    • (2003) Am J Pathol , vol.162 , pp. 1495-1502
    • Chilosi, M.1    Poletti, V.2    Zamò, A.3
  • 69
    • 47749101725 scopus 로고    scopus 로고
    • Functional Wnt signaling is increased in idiopathic pulmonary fibrosis
    • M. Königshoff, N. Balsara, and E.M. Pfaff Functional Wnt signaling is increased in idiopathic pulmonary fibrosis PLoS One 3 2008 e2142
    • (2008) PLoS One , vol.3 , pp. 2142
    • Königshoff, M.1    Balsara, N.2    Pfaff, E.M.3
  • 70
    • 65249088418 scopus 로고    scopus 로고
    • WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
    • M. Königshoff, M. Kramer, and N. Balsara WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis J Clin Invest 119 2009 772 787
    • (2009) J Clin Invest , vol.119 , pp. 772-787
    • Königshoff, M.1    Kramer, M.2    Balsara, N.3
  • 71
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • W.Y. Kim, and N.E. Sharpless The regulation of INK4/ARF in cancer and aging Cell 127 2006 265 275
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 72
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • J. Campisi Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors Cell 120 2005 513 522
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 73
    • 34548211521 scopus 로고    scopus 로고
    • The DNA damage signaling pathway connects oncogenic stress to cellular senescence
    • F.A. Mallette, and G. Ferbeyre The DNA damage signaling pathway connects oncogenic stress to cellular senescence Cell Cycle 6 2007 1831 1836
    • (2007) Cell Cycle , vol.6 , pp. 1831-1836
    • Mallette, F.A.1    Ferbeyre, G.2
  • 74
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: Cellular senescence as a DNA-damage response
    • F. d'Adda di Fagagna Living on a break: cellular senescence as a DNA-damage response Nat Rev Cancer 8 2008 512 522
    • (2008) Nat Rev Cancer , vol.8 , pp. 512-522
    • D'Adda Di Fagagna, F.1
  • 76
    • 7044231343 scopus 로고    scopus 로고
    • The p16INK4a-RB pathway: Molecular link between cellular senescence and tumor suppression
    • N. Ohtani, K. Yamakoshi, A. Takahashi, and E. Hara The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression J Med Invest 51 2004 146 153
    • (2004) J Med Invest , vol.51 , pp. 146-153
    • Ohtani, N.1    Yamakoshi, K.2    Takahashi, A.3    Hara, E.4
  • 77
    • 78549268199 scopus 로고    scopus 로고
    • Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo
    • S. Takeuchi, A. Takahashi, and N. Motoi Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo Cancer Res 70 2010 9381 9390
    • (2010) Cancer Res , vol.70 , pp. 9381-9390
    • Takeuchi, S.1    Takahashi, A.2    Motoi, N.3
  • 78
    • 79955047394 scopus 로고    scopus 로고
    • Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
    • S. Minagawa, J. Araya, and T. Numata Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells Am J Physiol Lung Cell Mol Physiol 300 2011 L391 L401
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300
    • Minagawa, S.1    Araya, J.2    Numata, T.3
  • 79
    • 0030215822 scopus 로고    scopus 로고
    • P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis
    • K. Kuwano, R. Kunitake, and M. Kawasaki P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis Am J Respir Crit Care Med 154 1996 477 483
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 477-483
    • Kuwano, K.1    Kunitake, R.2    Kawasaki, M.3
  • 80
    • 84856706398 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers
    • N.J. Lomas, K.L. Watts, K.M. Akram, N.R. Forsyth, and M.A. Spiteri Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers Int J Clin Exp Pathol 5 2012 58 71
    • (2012) Int J Clin Exp Pathol , vol.5 , pp. 58-71
    • Lomas, N.J.1    Watts, K.L.2    Akram, K.M.3    Forsyth, N.R.4    Spiteri, M.A.5
  • 81
    • 33746977705 scopus 로고    scopus 로고
    • Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosis
    • M. Chilosi, A. Zamò, and C. Doglioni Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosis Respir Res 7 2006 95
    • (2006) Respir Res , vol.7 , pp. 95
    • Chilosi, M.1    Zamò, A.2    Doglioni, C.3
  • 82
    • 76749165460 scopus 로고    scopus 로고
    • Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis
    • T.H. Sisson, M. Mendez, and K. Choi Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis Am J Respir Crit Care Med 181 2010 254 263
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 254-263
    • Sisson, T.H.1    Mendez, M.2    Choi, K.3
  • 84
    • 79951542163 scopus 로고    scopus 로고
    • Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2
    • E.T. Domyan, E. Ferretti, K. Throckmorton, Y. Mishina, S.K. Nicolis, and X. Sun Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2 Development 138 2011 971 981
    • (2011) Development , vol.138 , pp. 971-981
    • Domyan, E.T.1    Ferretti, E.2    Throckmorton, K.3    Mishina, Y.4    Nicolis, S.K.5    Sun, X.6
  • 85
    • 41549108935 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Aberrant recapitulation of developmental programs?
    • M. Selman, A. Pardo, and N. Kaminski Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med 5 2008 e62
    • (2008) PLoS Med , vol.5 , pp. 62
    • Selman, M.1    Pardo, A.2    Kaminski, N.3
  • 86
    • 77957576439 scopus 로고    scopus 로고
    • Epithelial stem cell exhaustion in the pathogenesis of idiopathic pulmonary fibrosis
    • M. Chilosi, C. Doglioni, B. Murer, and V. Poletti Epithelial stem cell exhaustion in the pathogenesis of idiopathic pulmonary fibrosis Sarcoidosis Vasc Diffuse Lung Dis 27 2010 7 18
    • (2010) Sarcoidosis Vasc Diffuse Lung Dis , vol.27 , pp. 7-18
    • Chilosi, M.1    Doglioni, C.2    Murer, B.3    Poletti, V.4
  • 87
    • 77956288500 scopus 로고    scopus 로고
    • Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
    • W.R. Henderson Jr., E.Y. Chi, and X. Ye Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis Proc Natl Acad Sci U S A 107 2010 14309 14314
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14309-14314
    • Henderson, Jr.W.R.1    Chi, E.Y.2    Ye, X.3
  • 88
    • 79958822662 scopus 로고    scopus 로고
    • Blockade of the Wnt/β-catenin pathway attenuates bleomycin-induced pulmonary fibrosis
    • T.H. Kim, S.H. Kim, and J.Y. Seo Blockade of the Wnt/β-catenin pathway attenuates bleomycin-induced pulmonary fibrosis Tohoku J Exp Med 223 2011 45 54
    • (2011) Tohoku J Exp Med , vol.223 , pp. 45-54
    • Kim, T.H.1    Kim, S.H.2    Seo, J.Y.3
  • 89
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: The dark side of tumor suppression
    • J.P. Coppé, P.Y. Desprez, A. Krtolica, and J. Campisi The senescence-associated secretory phenotype: the dark side of tumor suppression Annu Rev Pathol 5 2010 99 118
    • (2010) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppé, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 90
    • 58849154235 scopus 로고    scopus 로고
    • Senescence-messaging secretome: SMS-ing cellular stress
    • T. Kuilman, and D.S. Peeper Senescence-messaging secretome: SMS-ing cellular stress Nat Rev Cancer 9 2009 81 94
    • (2009) Nat Rev Cancer , vol.9 , pp. 81-94
    • Kuilman, T.1    Peeper, D.S.2
  • 91
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion
    • F. Rodier, J.P. Coppé, and C.K. Patil Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion Nat Cell Biol 11 2009 973 979
    • (2009) Nat Cell Biol , vol.11 , pp. 973-979
    • Rodier, F.1    Coppé, J.P.2    Patil, C.K.3
  • 92
    • 84876100085 scopus 로고    scopus 로고
    • Molecular basis for the tissue specificity of β-catenin oncogenesis
    • A. Sharma, and J.M. Sen Molecular basis for the tissue specificity of β-catenin oncogenesis Oncogene 32 2013 1901 1909
    • (2013) Oncogene , vol.32 , pp. 1901-1909
    • Sharma, A.1    Sen, J.M.2
  • 93
    • 40749092119 scopus 로고    scopus 로고
    • Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo
    • M. Xu, Q. Yu, R. Subrahmanyam, M.J. Difilippantonio, T. Ried, and J.M. Sen Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo Mol Cell Biol 28 2008 1713 1723
    • (2008) Mol Cell Biol , vol.28 , pp. 1713-1723
    • Xu, M.1    Yu, Q.2    Subrahmanyam, R.3    Difilippantonio, M.J.4    Ried, T.5    Sen, J.M.6
  • 94
    • 80052196384 scopus 로고    scopus 로고
    • Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress
    • H. Tanjore, D.S. Cheng, and A.L. Degryse Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress J Biol Chem 286 2011 30972 30980
    • (2011) J Biol Chem , vol.286 , pp. 30972-30980
    • Tanjore, H.1    Cheng, D.S.2    Degryse, A.L.3
  • 95
    • 84859740294 scopus 로고    scopus 로고
    • Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis
    • H. Tanjore, T.S. Blackwell, and W.E. Lawson Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol 302 2012 L721 L729
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302
    • Tanjore, H.1    Blackwell, T.S.2    Lawson, W.E.3
  • 96
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: Potential role in idiopathic pulmonary fibrosis
    • B.C. Willis, J.M. Liebler, and K. Luby-Phelps Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis Am J Pathol 166 2005 1321 1332
    • (2005) Am J Pathol , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3
  • 97
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • J.P. Thiery, H. Acloque, and R.Y. Huang Epithelial-mesenchymal transitions in development and disease Cell 139 2009 871 890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3
  • 98
    • 77955497665 scopus 로고    scopus 로고
    • The role of the miR-200 family in epithelial-mesenchymal transition
    • P.S. Mongroo, and A.K. Rustgi The role of the miR-200 family in epithelial-mesenchymal transition Cancer Biol Ther 10 2010 219 222
    • (2010) Cancer Biol Ther , vol.10 , pp. 219-222
    • Mongroo, P.S.1    Rustgi, A.K.2
  • 99
    • 84856006423 scopus 로고    scopus 로고
    • Participation of miR-200 in pulmonary fibrosis
    • S. Yang, S. Banerjee, and A. de Freitas Participation of miR-200 in pulmonary fibrosis Am J Pathol 180 2012 484 493
    • (2012) Am J Pathol , vol.180 , pp. 484-493
    • Yang, S.1    Banerjee, S.2    De Freitas, A.3
  • 100
    • 0035026949 scopus 로고    scopus 로고
    • Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression
    • C. Ramos, M. Montaño, and J. García-Alvarez Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression Am J Respir Cell Mol Biol 24 2001 591 598
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 591-598
    • Ramos, C.1    Montaño, M.2    García-Alvarez, J.3
  • 102
    • 84859015820 scopus 로고    scopus 로고
    • STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF
    • D.V. Pechkovsky, C.M. Prêle, and J. Wong STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF Am J Pathol 180 2012 1398 1412
    • (2012) Am J Pathol , vol.180 , pp. 1398-1412
    • Pechkovsky, D.V.1    Prêle, C.M.2    Wong, J.3
  • 103
    • 84865824048 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: An altered fibroblast proliferation linked to cancer biology
    • C. Vancheri Idiopathic pulmonary fibrosis: an altered fibroblast proliferation linked to cancer biology Proc Am Thorac Soc 9 2012 153 157
    • (2012) Proc Am Thorac Soc , vol.9 , pp. 153-157
    • Vancheri, C.1
  • 104
    • 84875985279 scopus 로고    scopus 로고
    • FoxO3a (forkhead box O3a) deficiency protects idiopathic pulmonary fibrosis (IPF) fibroblasts from type i polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas
    • R.S. Nho, M. Peterson, P. Hergert, and C.A. Henke FoxO3a (forkhead box O3a) deficiency protects idiopathic pulmonary fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas PLoS One 8 2013 e61017
    • (2013) PLoS One , vol.8 , pp. 61017
    • Nho, R.S.1    Peterson, M.2    Hergert, P.3    Henke, C.A.4
  • 105
    • 84865121019 scopus 로고    scopus 로고
    • Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction
    • X. Huang, N. Yang, and V.F. Fiore Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction Am J Respir Cell Mol Biol 47 2012 340 348
    • (2012) Am J Respir Cell Mol Biol , vol.47 , pp. 340-348
    • Huang, X.1    Yang, N.2    Fiore, V.F.3
  • 106
    • 84874609382 scopus 로고    scopus 로고
    • Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis
    • Y. Zhou, X. Huang, and L. Hecker Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis J Clin Invest 123 2013 1096 1108
    • (2013) J Clin Invest , vol.123 , pp. 1096-1108
    • Zhou, Y.1    Huang, X.2    Hecker, L.3
  • 107
    • 33845899411 scopus 로고    scopus 로고
    • Caveolin-1: A critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
    • X.M. Wang, Y. Zhang, and H.P. Kim Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis J Exp Med 203 2006 2895 2906
    • (2006) J Exp Med , vol.203 , pp. 2895-2906
    • Wang, X.M.1    Zhang, Y.2    Kim, H.P.3
  • 108
    • 77953188523 scopus 로고    scopus 로고
    • Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis
    • H. Xia, W. Khalil, J. Kahm, J. Jessurun, J. Kleidon, and C.A. Henke Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis Am J Pathol 176 2010 2626 2637
    • (2010) Am J Pathol , vol.176 , pp. 2626-2637
    • Xia, H.1    Khalil, W.2    Kahm, J.3    Jessurun, J.4    Kleidon, J.5    Henke, C.A.6
  • 110
    • 84879171327 scopus 로고    scopus 로고
    • Knock down of caveolin-1 affects morphological and functional hallmarks of human endothelial cells
    • L. Madaro, F. Antonangeli, and A. Favia Knock down of caveolin-1 affects morphological and functional hallmarks of human endothelial cells J Cell Biochem 114 2013 1843 1851
    • (2013) J Cell Biochem , vol.114 , pp. 1843-1851
    • Madaro, L.1    Antonangeli, F.2    Favia, A.3
  • 111
    • 84855893320 scopus 로고    scopus 로고
    • Caveolin-1, cellular senescence and age-related diseases
    • H. Zou, E. Stoppani, D. Volonte, and F. Galbiati Caveolin-1, cellular senescence and age-related diseases Mech Ageing Dev 132 2011 533 542
    • (2011) Mech Ageing Dev , vol.132 , pp. 533-542
    • Zou, H.1    Stoppani, E.2    Volonte, D.3    Galbiati, F.4
  • 112
    • 66149127739 scopus 로고    scopus 로고
    • Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway
    • J.N. Bartholomew, D. Volonte, and F. Galbiati Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway Cancer Res 69 2009 2878 2886
    • (2009) Cancer Res , vol.69 , pp. 2878-2886
    • Bartholomew, J.N.1    Volonte, D.2    Galbiati, F.3
  • 113
    • 33845345975 scopus 로고    scopus 로고
    • Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements
    • A. Dasari, J.N. Bartholomew, D. Volonte, and F. Galbiati Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements Cancer Res 66 2006 10805 10814
    • (2006) Cancer Res , vol.66 , pp. 10805-10814
    • Dasari, A.1    Bartholomew, J.N.2    Volonte, D.3    Galbiati, F.4
  • 114
    • 34548238224 scopus 로고    scopus 로고
    • Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells
    • A. Linge, K. Weinhold, R. Bläsche, M. Kasper, and K. Barth Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells Int J Biochem Cell Biol 39 2007 1964 1974
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1964-1974
    • Linge, A.1    Weinhold, K.2    Bläsche, R.3    Kasper, M.4    Barth, K.5
  • 116
    • 0036798845 scopus 로고    scopus 로고
    • Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary fibrosis: The role of deltaN-p63
    • M. Chilosi, V. Poletti, and B. Murer Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary fibrosis: the role of deltaN-p63 Lab Invest 82 2002 1335 1345
    • (2002) Lab Invest , vol.82 , pp. 1335-1345
    • Chilosi, M.1    Poletti, V.2    Murer, B.3
  • 117
    • 77957589550 scopus 로고    scopus 로고
    • Usual interstitial pneumonia
    • S. Zander, H.H. Popper, J. Jagirdar, A.K. Haque, P.T. Cagle, R. Barrios, Springer
    • M. Chilosi, B. Murer, and V. Poletti Usual interstitial pneumonia S. Zander, H.H. Popper, J. Jagirdar, A.K. Haque, P.T. Cagle, R. Barrios, Molecular pathology of lung diseases 2008 Springer 607 615
    • (2008) Molecular Pathology of Lung Diseases , pp. 607-615
    • Chilosi, M.1    Murer, B.2    Poletti, V.3
  • 118
    • 80054030182 scopus 로고    scopus 로고
    • Epithelial progenitor cells in lung development, maintenance, repair, and disease
    • J.R. Rock, and B.L. Hogan Epithelial progenitor cells in lung development, maintenance, repair, and disease Annu Rev Cell Dev Biol 27 2011 493 512
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 493-512
    • Rock, J.R.1    Hogan, B.L.2
  • 119
    • 0141994029 scopus 로고    scopus 로고
    • Beta-catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    • M.L. Mucenski, S.E. Wert, and J.M. Nation Beta-catenin is required for specification of proximal/distal cell fate during lung morphogenesis J Biol Chem 278 2003 40231 40238
    • (2003) J Biol Chem , vol.278 , pp. 40231-40238
    • Mucenski, M.L.1    Wert, S.E.2    Nation, J.M.3
  • 120
    • 20444445954 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    • W. Shu, S. Guttentag, and Z. Wang Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung Dev Biol 283 2005 226 239
    • (2005) Dev Biol , vol.283 , pp. 226-239
    • Shu, W.1    Guttentag, S.2    Wang, Z.3
  • 121
    • 0035071913 scopus 로고    scopus 로고
    • Constitutive p63 expression in airway basal cells: A molecular target in diffuse lung diseases
    • M. Chilosi, and C. Doglioni Constitutive p63 expression in airway basal cells: a molecular target in diffuse lung diseases Sarcoidosis Vasc Diffuse Lung Dis 18 2001 23 26
    • (2001) Sarcoidosis Vasc Diffuse Lung Dis , vol.18 , pp. 23-26
    • Chilosi, M.1    Doglioni, C.2
  • 122
    • 69149106207 scopus 로고    scopus 로고
    • Basal cells as stem cells of the mouse trachea and human airway epithelium
    • J.R. Rock, M.W. Onaitis, and E.L. Rawlins Basal cells as stem cells of the mouse trachea and human airway epithelium Proc Natl Acad Sci U S A 106 2009 12771 12775
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12771-12775
    • Rock, J.R.1    Onaitis, M.W.2    Rawlins, E.L.3
  • 123
    • 77956538031 scopus 로고    scopus 로고
    • Airway basal stem cells: A perspective on their roles in epithelial homeostasis and remodeling
    • J.R. Rock, S.H. Randell, and B.L. Hogan Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling Dis Model Mech 3 2010 545 556
    • (2010) Dis Model Mech , vol.3 , pp. 545-556
    • Rock, J.R.1    Randell, S.H.2    Hogan, B.L.3
  • 124
    • 1542319868 scopus 로고    scopus 로고
    • Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium
    • K.U. Hong, S.D. Reynolds, and S. Watkins Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium Am J Pathol 164 2004 577 588
    • (2004) Am J Pathol , vol.164 , pp. 577-588
    • Hong, K.U.1    Reynolds, S.D.2    Watkins, S.3
  • 125
    • 84856692365 scopus 로고    scopus 로고
    • β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial- mesenchymal transition
    • A. Giangreco, L. Lu, and C. Vickers β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition J Pathol 226 2012 575 587
    • (2012) J Pathol , vol.226 , pp. 575-587
    • Giangreco, A.1    Lu, L.2    Vickers, C.3
  • 126
    • 73349088166 scopus 로고    scopus 로고
    • TAp63 induces senescence and suppresses tumorigenesis in vivo
    • X. Guo, W.M. Keyes, and C. Papazoglu TAp63 induces senescence and suppresses tumorigenesis in vivo Nat Cell Biol 11 2009 1451 1457
    • (2009) Nat Cell Biol , vol.11 , pp. 1451-1457
    • Guo, X.1    Keyes, W.M.2    Papazoglu, C.3
  • 127
    • 34247511981 scopus 로고    scopus 로고
    • P63 Is essential for the proliferative potential of stem cells in stratified epithelia
    • M. Senoo, F. Pinto, C.P. Crum, and F. McKeon p63 Is essential for the proliferative potential of stem cells in stratified epithelia Cell 129 2007 523 536
    • (2007) Cell , vol.129 , pp. 523-536
    • Senoo, M.1    Pinto, F.2    Crum, C.P.3    McKeon, F.4
  • 128
    • 34347379049 scopus 로고    scopus 로고
    • P63: Revving up epithelial stem-cell potential
    • C. Blanpain, and E. Fuchs p63: revving up epithelial stem-cell potential Nat Cell Biol 9 2007 731 733
    • (2007) Nat Cell Biol , vol.9 , pp. 731-733
    • Blanpain, C.1    Fuchs, E.2
  • 129
    • 2942677539 scopus 로고    scopus 로고
    • Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium
    • Y. Daniely, G. Liao, and D. Dixon Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium Am J Physiol Cell Physiol 287 2004 C171 C181
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Daniely, Y.1    Liao, G.2    Dixon, D.3
  • 130
    • 10744221856 scopus 로고    scopus 로고
    • Significance of p63 amplification and overexpression in lung cancer development and prognosis
    • P.P. Massion, P.M. Taflan, and S.M. Jamshedur Rahman Significance of p63 amplification and overexpression in lung cancer development and prognosis Cancer Res 63 2003 7113 7121
    • (2003) Cancer Res , vol.63 , pp. 7113-7121
    • Massion, P.P.1    Taflan, P.M.2    Jamshedur Rahman, S.M.3
  • 131
    • 79551607574 scopus 로고    scopus 로고
    • Δnp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis
    • W.M. Keyes, M. Pecoraro, and V. Aranda ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis Cell Stem Cell 8 2011 164 176
    • (2011) Cell Stem Cell , vol.8 , pp. 164-176
    • Keyes, W.M.1    Pecoraro, M.2    Aranda, V.3
  • 132
    • 32244434160 scopus 로고    scopus 로고
    • P63: A new link between senescence and aging
    • W.M. Keyes, and A.A. Mills p63: a new link between senescence and aging Cell Cycle 5 2006 260 265
    • (2006) Cell Cycle , vol.5 , pp. 260-265
    • Keyes, W.M.1    Mills, A.A.2
  • 133
    • 24344447780 scopus 로고    scopus 로고
    • P63 Deficiency activates a program of cellular senescence and leads to accelerated aging
    • W.M. Keyes, Y. Wu, H. Vogel, X. Guo, S.W. Lowe, and A.A. Mills p63 Deficiency activates a program of cellular senescence and leads to accelerated aging Genes Dev 19 2005 1986 1999
    • (2005) Genes Dev , vol.19 , pp. 1986-1999
    • Keyes, W.M.1    Wu, Y.2    Vogel, H.3    Guo, X.4    Lowe, S.W.5    Mills, A.A.6
  • 135
    • 84875456720 scopus 로고    scopus 로고
    • A localized Wnt signal orients asymmetric stem cell division in vitro
    • S.J. Habib, B.C. Chen, and F.C. Tsai A localized Wnt signal orients asymmetric stem cell division in vitro Science 339 2013 1445 1448
    • (2013) Science , vol.339 , pp. 1445-1448
    • Habib, S.J.1    Chen, B.C.2    Tsai, F.C.3
  • 136
    • 80054793413 scopus 로고    scopus 로고
    • Wnt/Myc interactions in intestinal cancer: Partners in crime
    • K. Myant, and O.J. Sansom Wnt/Myc interactions in intestinal cancer: partners in crime Exp Cell Res 317 2011 2725 2731
    • (2011) Exp Cell Res , vol.317 , pp. 2725-2731
    • Myant, K.1    Sansom, O.J.2
  • 137
    • 0033992481 scopus 로고    scopus 로고
    • The Yin-Yang of TCF/beta-catenin signaling
    • N. Barker, P.J. Morin, and H. Clevers The Yin-Yang of TCF/beta-catenin signaling Adv Cancer Res 77 2000 1 24
    • (2000) Adv Cancer Res , vol.77 , pp. 1-24
    • Barker, N.1    Morin, P.J.2    Clevers, H.3
  • 138
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • T.C. He, C.A.B. Sparks, and C.H. Rago Identification of c-MYC as a target of the APC pathway Science 281 1998 1509 1512
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, C.A.B.2    Rago, C.H.3
  • 139
    • 0029840701 scopus 로고    scopus 로고
    • C-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways
    • G. Packham, C.W. Porter, and J.L. Cleveland c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways Oncogene 13 1996 461 469
    • (1996) Oncogene , vol.13 , pp. 461-469
    • Packham, G.1    Porter, C.W.2    Cleveland, J.L.3
  • 140
    • 2642510818 scopus 로고    scopus 로고
    • Cancer cell biology: Myc wins the competition
    • T.D. Donaldson, and R.J. Duronio Cancer cell biology: Myc wins the competition Curr Biol 14 2004 R425 R427
    • (2004) Curr Biol , vol.14
    • Donaldson, T.D.1    Duronio, R.J.2
  • 141
    • 1842665674 scopus 로고    scopus 로고
    • DMyc transforms cells into super-competitors
    • E. Moreno, and K. Basler dMyc transforms cells into super-competitors Cell 117 2004 117 129
    • (2004) Cell , vol.117 , pp. 117-129
    • Moreno, E.1    Basler, K.2
  • 142
    • 1842816486 scopus 로고    scopus 로고
    • Drosophila myc regulates organ size by inducing cell competition
    • C. de la Cova, M. Abril, P. Bellosta, P. Gallant, and L.A. Johnston Drosophila myc regulates organ size by inducing cell competition Cell 117 2004 107 116
    • (2004) Cell , vol.117 , pp. 107-116
    • De La Cova, C.1    Abril, M.2    Bellosta, P.3    Gallant, P.4    Johnston, L.A.5
  • 143
    • 84875729306 scopus 로고    scopus 로고
    • Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation
    • G. Wettstein, P.S. Bellaye, and M. Kolb Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation FASEB J 27 2013 1549 1560
    • (2013) FASEB J , vol.27 , pp. 1549-1560
    • Wettstein, G.1    Bellaye, P.S.2    Kolb, M.3
  • 144
    • 0034512869 scopus 로고    scopus 로고
    • The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis
    • S.J. Charette, and J. Landry The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis Ann N Y Acad Sci 926 2000 126 131
    • (2000) Ann N y Acad Sci , vol.926 , pp. 126-131
    • Charette, S.J.1    Landry, J.2
  • 145
    • 0034282104 scopus 로고    scopus 로고
    • Hsp27 negatively regulates cell death by interacting with cytochrome c
    • J.M. Bruey, C. Ducasse, and P. Bonniaud Hsp27 negatively regulates cell death by interacting with cytochrome c Nat Cell Biol 2: 2000 645 652
    • (2000) Nat Cell Biol , vol.2 , pp. 645-652
    • Bruey, J.M.1    Ducasse, C.2    Bonniaud, P.3
  • 146
    • 70349507340 scopus 로고    scopus 로고
    • The shock of aging: Molecular chaperones and the heat shock response in longevity and aging: A mini-review
    • S.K. Calderwood, A. Murshid, and T. Prince The shock of aging: molecular chaperones and the heat shock response in longevity and aging: a mini-review Gerontology 55 2009 550 558
    • (2009) Gerontology , vol.55 , pp. 550-558
    • Calderwood, S.K.1    Murshid, A.2    Prince, T.3
  • 147
    • 0034858859 scopus 로고    scopus 로고
    • Heat shock response and ageing: Mechanisms and applications
    • P. Verbeke, J. Fonager, B.F. Clark, and S.I. Rattan Heat shock response and ageing: mechanisms and applications Cell Biol Int 25 2001 845 857
    • (2001) Cell Biol Int , vol.25 , pp. 845-857
    • Verbeke, P.1    Fonager, J.2    Clark, B.F.3    Rattan, S.I.4
  • 148
    • 37549025455 scopus 로고    scopus 로고
    • Hsp27 modulates p53 signaling and suppresses cellular senescence
    • C. O'Callaghan-Sunol, V.L. Gabai, and M.Y. Sherman Hsp27 modulates p53 signaling and suppresses cellular senescence Cancer Res 67 2007 11779 11788
    • (2007) Cancer Res , vol.67 , pp. 11779-11788
    • O'Callaghan-Sunol, C.1    Gabai, V.L.2    Sherman, M.Y.3
  • 149
    • 77956518441 scopus 로고    scopus 로고
    • Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: Implications for age-related macular degeneration
    • M. Pons, S.W. Cousins, K.G. Csaky, G. Striker, and M.E. Marin-Castaño Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration Am J Pathol 177 2010 1198 1213
    • (2010) Am J Pathol , vol.177 , pp. 1198-1213
    • Pons, M.1    Cousins, S.W.2    Csaky, K.G.3    Striker, G.4    Marin-Castaño, M.E.5
  • 150
    • 0033516660 scopus 로고    scopus 로고
    • Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation
    • T. Rogalla, M. Ehrnsperger, and X. Preville Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation J Biol Chem 274 1999 18947 18956
    • (1999) J Biol Chem , vol.274 , pp. 18947-18956
    • Rogalla, T.1    Ehrnsperger, M.2    Preville, X.3
  • 151
    • 0028176312 scopus 로고
    • The alpha 6 beta 4 integrin is a receptor for both laminin and kalinin
    • C.M. Niessen, F. Hogervorst, and L.H. Jaspars The alpha 6 beta 4 integrin is a receptor for both laminin and kalinin Exp Cell Res 211 1994 360 367
    • (1994) Exp Cell Res , vol.211 , pp. 360-367
    • Niessen, C.M.1    Hogervorst, F.2    Jaspars, L.H.3
  • 152
    • 3042749811 scopus 로고    scopus 로고
    • Epithelial cell motility on laminin-5: Regulation by matrix assembly, proteolysis, integrins and erbB receptors
    • E. Hintermann, and V. Quaranta Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors Matrix Biol 23 2004 75 85
    • (2004) Matrix Biol , vol.23 , pp. 75-85
    • Hintermann, E.1    Quaranta, V.2
  • 153
    • 0036787804 scopus 로고    scopus 로고
    • Distribution of laminin 5, integrin receptors, and branching morphogenesis during human fetal lung development
    • C. Coraux, G. Meneguzzi, P. Rousselle, E. Puchelle, and D. Gaillard Distribution of laminin 5, integrin receptors, and branching morphogenesis during human fetal lung development Dev Dyn 225 2002 176 185
    • (2002) Dev Dyn , vol.225 , pp. 176-185
    • Coraux, C.1    Meneguzzi, G.2    Rousselle, P.3    Puchelle, E.4    Gaillard, D.5
  • 154
    • 0035890760 scopus 로고    scopus 로고
    • Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin
    • F. Hlubek, A. Jung, N. Kotzor, T. Kirchner, and T. Brabletz Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin Cancer Res 61 2001 8089 8093
    • (2001) Cancer Res , vol.61 , pp. 8089-8093
    • Hlubek, F.1    Jung, A.2    Kotzor, N.3    Kirchner, T.4    Brabletz, T.5
  • 155
    • 0028173385 scopus 로고
    • The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers
    • C. Pyke, J. Romer, and P. Kallunki The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers Am J Pathol 145 1994 782 791
    • (1994) Am J Pathol , vol.145 , pp. 782-791
    • Pyke, C.1    Romer, J.2    Kallunki, P.3
  • 156
    • 33744732501 scopus 로고    scopus 로고
    • A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence
    • E. Natarajan, J.D. Omobono II, and Z. Guo A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence Am J Pathol 168 2006 1821 1837
    • (2006) Am J Pathol , vol.168 , pp. 1821-1837
    • Natarajan, E.1    Omobono, I.I.J.D.2    Guo, Z.3
  • 157
    • 79955146233 scopus 로고    scopus 로고
    • A common MUC5B promoter polymorphism and pulmonary fibrosis
    • M.A. Seibold, A.L. Wise, and M.C. Speer A common MUC5B promoter polymorphism and pulmonary fibrosis N Engl J Med 364 2011 1503 1512
    • (2011) N Engl J Med , vol.364 , pp. 1503-1512
    • Seibold, M.A.1    Wise, A.L.2    Speer, M.C.3
  • 158
    • 79960612606 scopus 로고    scopus 로고
    • Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis
    • L. Plantier, B. Crestani, and S.E. Wert Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis Thorax 66 2011 651 657
    • (2011) Thorax , vol.66 , pp. 651-657
    • Plantier, L.1    Crestani, B.2    Wert, S.E.3
  • 159
    • 84875176842 scopus 로고    scopus 로고
    • The idiopathic pulmonary fibrosis honeycomb cyst contains a mucociliary pseudostratified epithelium
    • M.A. Seibold, R.W. Smith, and C. Urbanek The idiopathic pulmonary fibrosis honeycomb cyst contains a mucociliary pseudostratified epithelium PLoS One 8 2013 e58658
    • (2013) PLoS One , vol.8 , pp. 58658
    • Seibold, M.A.1    Smith, R.W.2    Urbanek, C.3
  • 160
    • 37549060070 scopus 로고    scopus 로고
    • Accelerated variant of idiopathic pulmonary fibrosis: Clinical behavior and gene expression pattern
    • M. Selman, G. Carrillo, and A. Estrada Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern PLoS One 2 2007 e482
    • (2007) PLoS One , vol.2 , pp. 482
    • Selman, M.1    Carrillo, G.2    Estrada, A.3
  • 161
    • 0242467564 scopus 로고    scopus 로고
    • Acute exacerbation of idiopathic pulmonary fibrosis: Report of a series
    • V. Ambrosini, A. Cancellieri, and M. Chilosi Acute exacerbation of idiopathic pulmonary fibrosis: report of a series Eur Respir J 22 2003 821 826
    • (2003) Eur Respir J , vol.22 , pp. 821-826
    • Ambrosini, V.1    Cancellieri, A.2    Chilosi, M.3
  • 162
    • 34547132777 scopus 로고    scopus 로고
    • Immunosenescence: Deficits in adaptive immunity in the elderly
    • F.T. Hakim, and R.E. Gress Immunosenescence: deficits in adaptive immunity in the elderly Tissue Antigens 70 2007 179 189
    • (2007) Tissue Antigens , vol.70 , pp. 179-189
    • Hakim, F.T.1    Gress, R.E.2
  • 163
    • 84864017351 scopus 로고    scopus 로고
    • Role of CD8 T cell replicative senescence in human aging and in HIV-mediated immunosenescence
    • J.N. Dock, and R.B. Effros Role of CD8 T cell replicative senescence in human aging and in HIV-mediated immunosenescence Aging Dis 2 2011 382 397
    • (2011) Aging Dis , vol.2 , pp. 382-397
    • Dock, J.N.1    Effros, R.B.2
  • 164
    • 39649085837 scopus 로고    scopus 로고
    • Inflammaging as a major characteristic of old people: Can it be prevented or cured?
    • C. Franceschi Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr Rev 65 2007 S173 S176
    • (2007) Nutr Rev , vol.65
    • Franceschi, C.1
  • 165
    • 84880998606 scopus 로고    scopus 로고
    • Aberrant innate immune sensing leads to the rapid progression of idiopathic pulmonary fibrosis
    • C.M. Hogaboam, G. Trujillo, and F.J. Martinez Aberrant innate immune sensing leads to the rapid progression of idiopathic pulmonary fibrosis Fibrogenesis Tissue Rep 5 2012 S3
    • (2012) Fibrogenesis Tissue Rep , vol.5 , pp. 3
    • Hogaboam, C.M.1    Trujillo, G.2    Martinez, F.J.3
  • 166
    • 78349285513 scopus 로고    scopus 로고
    • TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis
    • G. Trujillo, A. Meneghin, and K.R. Flaherty TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis Sci Transl Med 2 2010 57ra82
    • (2010) Sci Transl Med , vol.2
    • Trujillo, G.1    Meneghin, A.2    Flaherty, K.R.3
  • 167
    • 77952489797 scopus 로고    scopus 로고
    • CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis
    • S.R. Gilani, L.J. Vuga, and K.O. Lindell CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis PLoS One 5 2010 e8959
    • (2010) PLoS One , vol.5 , pp. 8959
    • Gilani, S.R.1    Vuga, L.J.2    Lindell, K.O.3
  • 168
    • 84875075526 scopus 로고    scopus 로고
    • Toll like receptor signaling in "inflammaging": MicroRNA as new players
    • F. Olivieri, M.R. Rippo, and F. Prattichizzo Toll like receptor signaling in "inflammaging": microRNA as new players Immun Ageing 10 2013 11
    • (2013) Immun Ageing , vol.10 , pp. 11
    • Olivieri, F.1    Rippo, M.R.2    Prattichizzo, F.3
  • 169
    • 84858019892 scopus 로고    scopus 로고
    • T-cell biology in aging, with a focus on lung disease
    • N. Lee, M.S. Shin, and I. Kang T-cell biology in aging, with a focus on lung disease J Gerontol A Biol Sci Med Sci 67 2012 254 263
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 254-263
    • Lee, N.1    Shin, M.S.2    Kang, I.3
  • 170
    • 67649407892 scopus 로고    scopus 로고
    • CD28(-) T cells: Their role in the age-associated decline of immune function
    • N.P. Weng, A.N. Akbar, and J. Goronzy CD28(-) T cells: their role in the age-associated decline of immune function Trends Immunol 30 2009 306 312
    • (2009) Trends Immunol , vol.30 , pp. 306-312
    • Weng, N.P.1    Akbar, A.N.2    Goronzy, J.3
  • 171
    • 34848884629 scopus 로고    scopus 로고
    • Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis
    • C.A. Feghali-Bostwick, C.G. Tsai, and V.G. Valentine Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis J Immunol 179 2007 2592 2599
    • (2007) J Immunol , vol.179 , pp. 2592-2599
    • Feghali-Bostwick, C.A.1    Tsai, C.G.2    Valentine, V.G.3
  • 172
    • 47949115533 scopus 로고    scopus 로고
    • Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis
    • K. Kurosu, Y. Takiguchi, and O. Okada Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis J Immunol 181 2008 756 767
    • (2008) J Immunol , vol.181 , pp. 756-767
    • Kurosu, K.1    Takiguchi, Y.2    Okada, O.3
  • 173
    • 34548693221 scopus 로고    scopus 로고
    • Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis
    • T. Takahashi, I. Wada, Y. Ohtsuka, M. Munakata, Y. Homma, and Y. Kuroki Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis Respirology 12 2007 642 653
    • (2007) Respirology , vol.12 , pp. 642-653
    • Takahashi, T.1    Wada, I.2    Ohtsuka, Y.3    Munakata, M.4    Homma, Y.5    Kuroki, Y.6
  • 174
    • 84875864680 scopus 로고    scopus 로고
    • Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses
    • R.A. Kahloon, J. Xue, and A. Bhargava Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses Am J Respir Crit Care Med 187 2013 768 775
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 768-775
    • Kahloon, R.A.1    Xue, J.2    Bhargava, A.3
  • 175
    • 33646481327 scopus 로고    scopus 로고
    • Cutting edge: Nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis
    • J. Marchal-Sommé, Y. Uzunhan, and S. Marchand-Adam Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis J Immunol 176 2006 5735 5739
    • (2006) J Immunol , vol.176 , pp. 5735-5739
    • Marchal-Sommé, J.1    Uzunhan, Y.2    Marchand-Adam, S.3
  • 176
    • 84864776533 scopus 로고    scopus 로고
    • Pathogenesis of chronic obstructive pulmonary disease
    • R.M. Tuder, and I. Petrache Pathogenesis of chronic obstructive pulmonary disease J Clin Invest 122 2012 2749 2755
    • (2012) J Clin Invest , vol.122 , pp. 2749-2755
    • Tuder, R.M.1    Petrache, I.2
  • 177
    • 73149099640 scopus 로고    scopus 로고
    • Mechanisms of lung development: Contribution to adult lung disease and relevance to chronic obstructive pulmonary disease
    • W. Shi, F. Chen, and W.V. Cardoso Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease Proc Am Thorac Soc 6 2009 558 563
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 558-563
    • Shi, W.1    Chen, F.2    Cardoso, W.V.3
  • 178
    • 73449092528 scopus 로고    scopus 로고
    • Early life origins of chronic obstructive pulmonary disease
    • C. Svanes, J. Sunyer, and E. Plana Early life origins of chronic obstructive pulmonary disease Thorax 65 2010 14 20
    • (2010) Thorax , vol.65 , pp. 14-20
    • Svanes, C.1    Sunyer, J.2    Plana, E.3
  • 179
    • 84864604353 scopus 로고    scopus 로고
    • Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease
    • G.K. Acquaah-Mensah, D. Malhotra, M. Vulimiri, J.E. McDermott, and S. Biswal Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease PLoS Comput Biol 8 2012 e1002597
    • (2012) PLoS Comput Biol , vol.8 , pp. 1002597
    • Acquaah-Mensah, G.K.1    Malhotra, D.2    Vulimiri, M.3    McDermott, J.E.4    Biswal, S.5
  • 180
    • 34547628244 scopus 로고    scopus 로고
    • Genetic predisposition to accelerated decline of lung function in COPD
    • N.A. Molfino Genetic predisposition to accelerated decline of lung function in COPD Int J Chron Obstruct Pulmon Dis 2 2007 117 119
    • (2007) Int J Chron Obstruct Pulmon Dis , vol.2 , pp. 117-119
    • Molfino, N.A.1
  • 181
    • 58249099942 scopus 로고    scopus 로고
    • COPD as a disease of accelerated lung aging
    • K. Ito, and P.J. Barnes COPD as a disease of accelerated lung aging Chest 135 2009 173 180
    • (2009) Chest , vol.135 , pp. 173-180
    • Ito, K.1    Barnes, P.J.2
  • 182
    • 71549166705 scopus 로고    scopus 로고
    • Telomere length and chronic obstructive pulmonary disease: Evidence of accelerated aging
    • T.S. Mui, J.M. Man, and J.E. McElhaney Telomere length and chronic obstructive pulmonary disease: evidence of accelerated aging J Am Geriatr Soc 57 2009 2372 2374
    • (2009) J Am Geriatr Soc , vol.57 , pp. 2372-2374
    • Mui, T.S.1    Man, J.M.2    McElhaney, J.E.3
  • 183
    • 58249084014 scopus 로고    scopus 로고
    • Telomere shortening in chronic obstructive pulmonary disease
    • J.M. Houben, E.M. Mercken, and H.B. Ketelslegers Telomere shortening in chronic obstructive pulmonary disease Respir Med 103 2009 230 236
    • (2009) Respir Med , vol.103 , pp. 230-236
    • Houben, J.M.1    Mercken, E.M.2    Ketelslegers, H.B.3
  • 184
    • 65249172518 scopus 로고    scopus 로고
    • Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease
    • L. Savale, A. Chaouat, and S. Bastuji-Garin Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 179 2009 566 571
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 566-571
    • Savale, L.1    Chaouat, A.2    Bastuji-Garin, S.3
  • 185
    • 78651431729 scopus 로고    scopus 로고
    • Systemic manifestations of COPD
    • Y. Nussbaumer-Ochsner, and K.F. Rabe Systemic manifestations of COPD Chest 139 2011 165 173
    • (2011) Chest , vol.139 , pp. 165-173
    • Nussbaumer-Ochsner, Y.1    Rabe, K.F.2
  • 187
    • 84875847989 scopus 로고    scopus 로고
    • Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease
    • L.E. Vanfleteren, M.A. Spruit, and M. Groenen Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 187 2013 728 735
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 728-735
    • Vanfleteren, L.E.1    Spruit, M.A.2    Groenen, M.3
  • 188
    • 67649224269 scopus 로고    scopus 로고
    • Progression of chronic obstructive pulmonary disease: Impact of inflammation, comorbidities and therapeutic intervention
    • R.A. Stockley Progression of chronic obstructive pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention Curr Med Res Opin 25 2009 1235 1245
    • (2009) Curr Med Res Opin , vol.25 , pp. 1235-1245
    • Stockley, R.A.1
  • 189
    • 33747876876 scopus 로고    scopus 로고
    • Telomere shortening and mood disorders: Preliminary support for a chronic stress model of accelerated aging
    • N.M. Simon, J.W. Smoller, and K.L. McNamara Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging Biol Psychiatry 60 2006 432 435
    • (2006) Biol Psychiatry , vol.60 , pp. 432-435
    • Simon, N.M.1    Smoller, J.W.2    McNamara, K.L.3
  • 190
    • 80054715764 scopus 로고    scopus 로고
    • Telomere length is a determinant of emphysema susceptibility
    • J.K. Alder, N. Guo, and F. Kembou Telomere length is a determinant of emphysema susceptibility Am J Respir Crit Care Med 184 2011 904 912
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 904-912
    • Alder, J.K.1    Guo, N.2    Kembou, F.3
  • 191
    • 84866145918 scopus 로고    scopus 로고
    • The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD)
    • J. Lee, A.J. Sandford, and J.E. Connett The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD) PLoS One 7 2012 e35567
    • (2012) PLoS One , vol.7 , pp. 35567
    • Lee, J.1    Sandford, A.J.2    Connett, J.E.3
  • 193
    • 33645781050 scopus 로고    scopus 로고
    • Lung fibroblasts from patients with emphysema show markers of senescence in vitro
    • K.C. Müller, L. Welker, and K. Paasch Lung fibroblasts from patients with emphysema show markers of senescence in vitro Respir Res 7 2006 32
    • (2006) Respir Res , vol.7 , pp. 32
    • Müller, K.C.1    Welker, L.2    Paasch, K.3
  • 194
    • 48249116344 scopus 로고    scopus 로고
    • Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms
    • S. Togo, O. Holz, and X. Liu Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms Am J Respir Crit Care Med 178 2008 248 260
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 248-260
    • Togo, S.1    Holz, O.2    Liu, X.3
  • 195
    • 0033660171 scopus 로고    scopus 로고
    • Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
    • Y. Kasahara, R.M. Tuder, and L. Taraseviciene-Stewart Inhibition of VEGF receptors causes lung cell apoptosis and emphysema J Clin Invest 106 2000 1311 1319
    • (2000) J Clin Invest , vol.106 , pp. 1311-1319
    • Kasahara, Y.1    Tuder, R.M.2    Taraseviciene-Stewart, L.3
  • 196
    • 0035077330 scopus 로고    scopus 로고
    • Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema
    • Y. Kasahara, R.M. Tuder, C.D. Cool, D.A. Lynch, S.C. Flores, and N.F. Voelkel Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema Am J Respir Crit Care Med 163 2001 737 744
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 737-744
    • Kasahara, Y.1    Tuder, R.M.2    Cool, C.D.3    Lynch, D.A.4    Flores, S.C.5    Voelkel, N.F.6
  • 198
    • 0037823489 scopus 로고    scopus 로고
    • Different proliferative capacity of lung fibroblasts obtained from control subjects and patients with emphysema
    • J.A. Noordhoek, D.S. Postma, and L.L. Chong Different proliferative capacity of lung fibroblasts obtained from control subjects and patients with emphysema Exp Lung Res 29 2003 291 302
    • (2003) Exp Lung Res , vol.29 , pp. 291-302
    • Noordhoek, J.A.1    Postma, D.S.2    Chong, L.L.3
  • 199
    • 84857138582 scopus 로고    scopus 로고
    • 59 Endothelial colony forming cells (ECFC) are senescent and dysfunctional in COPD due to reduced sirtuin-1 levels
    • K. Paschalaki, R.D. Starke, N. Mercado, D.O. Haskard, P.J. Barnes, and A.M. Randi 59 Endothelial colony forming cells (ECFC) are senescent and dysfunctional in COPD due to reduced sirtuin-1 levels Heart 97 2011 e7
    • (2011) Heart , vol.97 , pp. 7
    • Paschalaki, K.1    Starke, R.D.2    Mercado, N.3    Haskard, D.O.4    Barnes, P.J.5    Randi, A.M.6
  • 200
    • 57649221004 scopus 로고    scopus 로고
    • Targeted induction of lung endothelial cell apoptosis causes emphysemalike changes in the mouse
    • R.J. Giordano, J. Lahdenranta, and L. Zhen Targeted induction of lung endothelial cell apoptosis causes emphysemalike changes in the mouse J Biol Chem 283 2008 29447 29460
    • (2008) J Biol Chem , vol.283 , pp. 29447-29460
    • Giordano, R.J.1    Lahdenranta, J.2    Zhen, L.3
  • 201
    • 60549097786 scopus 로고    scopus 로고
    • Smad gene expression in pulmonary fibroblasts: Indications for defective ECM repair in COPD
    • A. Zandvoort, D.S. Postma, M.R. Jonker, J.A. Noordhoek, J.T. Vos, and W. Timens Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD Respir Res 9 2008 83
    • (2008) Respir Res , vol.9 , pp. 83
    • Zandvoort, A.1    Postma, D.S.2    Jonker, M.R.3    Noordhoek, J.A.4    Vos, J.T.5    Timens, W.6
  • 202
    • 77956672918 scopus 로고    scopus 로고
    • Altered fibroblast proteoglycan production in COPD
    • O. Hallgren, K. Nihlberg, and M. Dahlbäck Altered fibroblast proteoglycan production in COPD Respir Res 11 2010 55
    • (2010) Respir Res , vol.11 , pp. 55
    • Hallgren, O.1    Nihlberg, K.2    Dahlbäck, M.3
  • 203
    • 79954527594 scopus 로고    scopus 로고
    • Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD
    • R. Wang, J. Ahmed, and G. Wang Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD PLoS One 6 2011 e14793
    • (2011) PLoS One , vol.6 , pp. 14793
    • Wang, R.1    Ahmed, J.2    Wang, G.3
  • 204
    • 79952715657 scopus 로고    scopus 로고
    • Activation of the WNT/β-catenin pathway attenuates experimental emphysema
    • N. Kneidinger, A.Ö. Yildirim, and J. Callegari Activation of the WNT/β-catenin pathway attenuates experimental emphysema Am J Respir Crit Care Med 183 2011 723 733
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 723-733
    • Kneidinger, N.1    Yildirim, A.Ö.2    Callegari, J.3
  • 206
    • 84885938266 scopus 로고    scopus 로고
    • Decreased serum transforming growth factor-β1 concentration with aging is associated with the severity of emphysema in chronic obstructive pulmonary disease
    • K. Kamio, T. Ishii, and T. Motegi Decreased serum transforming growth factor-β1 concentration with aging is associated with the severity of emphysema in chronic obstructive pulmonary disease Geriatr Gerontol Int 2013
    • (2013) Geriatr Gerontol Int
    • Kamio, K.1    Ishii, T.2    Motegi, T.3
  • 207
    • 0035891566 scopus 로고    scopus 로고
    • Roles of mechanical forces and collagen failure in the development of elastase-induced emphysema
    • S. Kononov, K. Brewer, and H. Sakai Roles of mechanical forces and collagen failure in the development of elastase-induced emphysema Am J Respir Crit Care Med 164 2001 1920 1926
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1920-1926
    • Kononov, S.1    Brewer, K.2    Sakai, H.3
  • 208
    • 63249129198 scopus 로고    scopus 로고
    • Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease
    • A.E. Tilley, B.G. Harvey, and A. Heguy Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease Am J Respir Crit Care Med 179 2009 457 466
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 457-466
    • Tilley, A.E.1    Harvey, B.G.2    Heguy, A.3
  • 209
    • 59649100796 scopus 로고    scopus 로고
    • Wnt signaling controls the fate of mesenchymal stem cells
    • L. Ling, V. Nurcombe, and S.M. Cool Wnt signaling controls the fate of mesenchymal stem cells Gene 433 2009 1 7
    • (2009) Gene , vol.433 , pp. 1-7
    • Ling, L.1    Nurcombe, V.2    Cool, S.M.3
  • 210
    • 73549084930 scopus 로고    scopus 로고
    • Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis
    • K. Xu, E. Nieuwenhuis, and B.L. Cohen Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis Am J Physiol Lung Cell Mol Physiol 298 2010 L45 L56
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.298
    • Xu, K.1    Nieuwenhuis, E.2    Cohen, B.L.3
  • 211
    • 43049144313 scopus 로고    scopus 로고
    • Wnt signaling and stem cell control
    • R. Nusse Wnt signaling and stem cell control Cell Res 18 2008 523 527
    • (2008) Cell Res , vol.18 , pp. 523-527
    • Nusse, R.1
  • 212
    • 70450245198 scopus 로고    scopus 로고
    • Roles of Wnt/beta-catenin signaling in epithelial differentiation of mesenchymal stem cells
    • Y. Wang, Z. Sun, X. Qiu, Y. Li, J. Qin, and X. Han Roles of Wnt/beta-catenin signaling in epithelial differentiation of mesenchymal stem cells Biochem Biophys Res Commun 390 2009 1309 1314
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 1309-1314
    • Wang, Y.1    Sun, Z.2    Qiu, X.3    Li, Y.4    Qin, J.5    Han, X.6
  • 213
    • 34547908461 scopus 로고    scopus 로고
    • Augmented Wnt signaling in a mammalian model of accelerated aging
    • H. Liu, M.M. Fergusson, and R.M. Castilho Augmented Wnt signaling in a mammalian model of accelerated aging Science 317 2007 803 806
    • (2007) Science , vol.317 , pp. 803-806
    • Liu, H.1    Fergusson, M.M.2    Castilho, R.M.3
  • 214
    • 42049090788 scopus 로고    scopus 로고
    • Gone with the Wnt/Notch: Stem cells in laminopathies, progeria, and aging
    • E. Meshorer, and Y. Gruenbaum Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging J Cell Biol 181 2008 9 13
    • (2008) J Cell Biol , vol.181 , pp. 9-13
    • Meshorer, E.1    Gruenbaum, Y.2
  • 215
    • 77956636550 scopus 로고    scopus 로고
    • Caveolin-1, cellular senescence and pulmonary emphysema
    • D. Volonte, and F. Galbiati Caveolin-1, cellular senescence and pulmonary emphysema Aging (Albany NY) 1 2009 831 835
    • (2009) Aging (Albany NY) , vol.1 , pp. 831-835
    • Volonte, D.1    Galbiati, F.2
  • 216
    • 65549125935 scopus 로고    scopus 로고
    • Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway
    • D. Volonte, B. Kahkonen, S. Shapiro, Y. Di, and F. Galbiati Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway J Biol Chem 284 2009 5462 5466
    • (2009) J Biol Chem , vol.284 , pp. 5462-5466
    • Volonte, D.1    Kahkonen, B.2    Shapiro, S.3    Di, Y.4    Galbiati, F.5
  • 217
    • 0036323674 scopus 로고    scopus 로고
    • Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts
    • D. Volonte, K. Zhang, M.P. Lisanti, and F. Galbiati Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts Mol Biol Cell 13 2002 2502 2517
    • (2002) Mol Biol Cell , vol.13 , pp. 2502-2517
    • Volonte, D.1    Zhang, K.2    Lisanti, M.P.3    Galbiati, F.4
  • 218
    • 66149093072 scopus 로고    scopus 로고
    • The pathology of chronic obstructive pulmonary disease
    • J.C. Hogg, and W. Timens The pathology of chronic obstructive pulmonary disease Annu Rev Pathol 4 2009 435 459
    • (2009) Annu Rev Pathol , vol.4 , pp. 435-459
    • Hogg, J.C.1    Timens, W.2
  • 219
    • 33751207741 scopus 로고    scopus 로고
    • Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?
    • L. Taraseviciene-Stewart, I.S. Douglas, and P.S. Nana-Sinkam Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease? Proc Am Thorac Soc 3 2006 687 690
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 687-690
    • Taraseviciene-Stewart, L.1    Douglas, I.S.2    Nana-Sinkam, P.S.3
  • 220
    • 42949090409 scopus 로고    scopus 로고
    • Phenotypic characterisation of T-lymphocytes in COPD: Abnormal CD4+ CD25+ regulatory T-lymphocyte response to tobacco smoking
    • B. Barceló, J. Pons, J.M. Ferrer, J. Sauleda, A. Fuster, and A.G. Agustí Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+ CD25+ regulatory T-lymphocyte response to tobacco smoking Eur Respir J 31 2008 555 562
    • (2008) Eur Respir J , vol.31 , pp. 555-562
    • Barceló, B.1    Pons, J.2    Ferrer, J.M.3    Sauleda, J.4    Fuster, A.5    Agustí, A.G.6
  • 221
    • 42949098935 scopus 로고    scopus 로고
    • To reg or not to reg: That is the question in COPD
    • S. Baraldo, and M. Saetta To reg or not to reg: that is the question in COPD Eur Respir J 31 2008 486 488
    • (2008) Eur Respir J , vol.31 , pp. 486-488
    • Baraldo, S.1    Saetta, M.2
  • 222
    • 77954722942 scopus 로고    scopus 로고
    • Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice
    • G.T. Motz, B.L. Eppert, S.C. Wesselkamper, J.L. Flury, and M.T. Borchers Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice Am J Respir Crit Care Med 181 2010 1223 1233
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 1223-1233
    • Motz, G.T.1    Eppert, B.L.2    Wesselkamper, S.C.3    Flury, J.L.4    Borchers, M.T.5
  • 223
    • 66649127821 scopus 로고    scopus 로고
    • Immunologic aspects of chronic obstructive pulmonary disease
    • M.G. Cosio, M. Saetta, and A. Agusti Immunologic aspects of chronic obstructive pulmonary disease N Engl J Med 360 2009 2445 2454
    • (2009) N Engl J Med , vol.360 , pp. 2445-2454
    • Cosio, M.G.1    Saetta, M.2    Agusti, A.3
  • 224
    • 84871916713 scopus 로고    scopus 로고
    • Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
    • S. Fujii, H. Hara, and J. Araya Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease Oncoimmunology 1 2012 630 641
    • (2012) Oncoimmunology , vol.1 , pp. 630-641
    • Fujii, S.1    Hara, H.2    Araya, J.3
  • 225
    • 79958120387 scopus 로고    scopus 로고
    • Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
    • F. Zhou, S. Onizawa, A. Nagai, and K. Aoshiba Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury Respir Res 12 2011 78
    • (2011) Respir Res , vol.12 , pp. 78
    • Zhou, F.1    Onizawa, S.2    Nagai, A.3    Aoshiba, K.4
  • 226
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • S. Aggarwal, and M.F. Pittenger Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 105 2005 1815 1822
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 228
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • A. Uccelli, L. Moretta, and V. Pistoia Mesenchymal stem cells in health and disease Nat Rev Immunol 8 2008 726 736
    • (2008) Nat Rev Immunol , vol.8 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 229
    • 36249009667 scopus 로고    scopus 로고
    • Immune regulation by mesenchymal stem cells derived from adult spleen and thymus
    • M. Krampera, S. Sartoris, and F. Liotta Immune regulation by mesenchymal stem cells derived from adult spleen and thymus Stem Cells Dev 16 2007 797 810
    • (2007) Stem Cells Dev , vol.16 , pp. 797-810
    • Krampera, M.1    Sartoris, S.2    Liotta, F.3
  • 230
    • 34548442823 scopus 로고    scopus 로고
    • Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation
    • K.A. Keyser, K.E. Beagles, and H.P. Kiem Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation Cell Transplant 16 2007 555 562
    • (2007) Cell Transplant , vol.16 , pp. 555-562
    • Keyser, K.A.1    Beagles, K.E.2    Kiem, H.P.3
  • 231
    • 84860437339 scopus 로고    scopus 로고
    • Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrow
    • M. Ricciardi, G. Malpeli, and F. Bifari Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrow PLoS One 7 2012 e35639
    • (2012) PLoS One , vol.7 , pp. 35639
    • Ricciardi, M.1    Malpeli, G.2    Bifari, F.3
  • 232
    • 47249135404 scopus 로고    scopus 로고
    • Airway epithelial cell senescence in the lung allograft
    • S.M. Parker, M.R. Goriwiec, and L.A. Borthwick Airway epithelial cell senescence in the lung allograft Am J Transplant 8 2008 1544 1549
    • (2008) Am J Transplant , vol.8 , pp. 1544-1549
    • Parker, S.M.1    Goriwiec, M.R.2    Borthwick, L.A.3
  • 234
    • 43049158102 scopus 로고    scopus 로고
    • An international collaborative pathologic study of surgical lung biopsies from mustard gas-exposed patients
    • M. Ghanei, H.D. Tazelaar, and M. Chilosi An international collaborative pathologic study of surgical lung biopsies from mustard gas-exposed patients Respir Med 102 2008 825 830
    • (2008) Respir Med , vol.102 , pp. 825-830
    • Ghanei, M.1    Tazelaar, H.D.2    Chilosi, M.3
  • 235
    • 58149141748 scopus 로고    scopus 로고
    • Constrictive bronchiolitis associated with paraneoplastic autoimmune multi-organ syndrome
    • F. Maldonado, M.R. Pittelkow, and J.H. Ryu Constrictive bronchiolitis associated with paraneoplastic autoimmune multi-organ syndrome Respirology 14 2009 129 133
    • (2009) Respirology , vol.14 , pp. 129-133
    • Maldonado, F.1    Pittelkow, M.R.2    Ryu, J.H.3
  • 236
    • 84455207428 scopus 로고    scopus 로고
    • Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease
    • V. Amsellem, G. Gary-Bobo, and E. Marcos Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease Am J Respir Crit Care Med 184 2011 1358 1366
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1358-1366
    • Amsellem, V.1    Gary-Bobo, G.2    Marcos, E.3
  • 237
    • 84869879700 scopus 로고    scopus 로고
    • Repair of tracheal epithelium by basal cells after chlorine-induced injury
    • S. Musah, J. Chen, and G.W. Hoyle Repair of tracheal epithelium by basal cells after chlorine-induced injury Respir Res 13 2012 107
    • (2012) Respir Res , vol.13 , pp. 107
    • Musah, S.1    Chen, J.2    Hoyle, G.W.3
  • 238
    • 73149118480 scopus 로고    scopus 로고
    • The aging immune system and its relationship to the development of chronic obstructive pulmonary disease
    • G. Sharma, N.A. Hanania, and Y.M. Shim The aging immune system and its relationship to the development of chronic obstructive pulmonary disease Proc Am Thorac Soc 6 2009 573 580
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 573-580
    • Sharma, G.1    Hanania, N.A.2    Shim, Y.M.3
  • 239
    • 33747600439 scopus 로고    scopus 로고
    • Systemic inflammation in patients with COPD and pulmonary hypertension
    • P. Joppa, D. Petrasova, B. Stancak, and R. Tkacova Systemic inflammation in patients with COPD and pulmonary hypertension Chest 130 2006 326 333
    • (2006) Chest , vol.130 , pp. 326-333
    • Joppa, P.1    Petrasova, D.2    Stancak, B.3    Tkacova, R.4
  • 240
    • 84867162444 scopus 로고    scopus 로고
    • Role of histone deacetylase 2 in epigenetics and cellular senescence: Implications in lung inflammaging and COPD
    • H. Yao, and I. Rahman Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD Am J Physiol Lung Cell Mol Physiol 303 2012 L557 L566
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.303
    • Yao, H.1    Rahman, I.2
  • 241
    • 73149091434 scopus 로고    scopus 로고
    • Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease
    • K. Aoshiba, and A. Nagai Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease Proc Am Thorac Soc 6 2009 596 601
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 596-601
    • Aoshiba, K.1    Nagai, A.2
  • 242
    • 26844449508 scopus 로고    scopus 로고
    • Combined pulmonary fibrosis and emphysema: A distinct underrecognised entity
    • V. Cottin, H. Nunes, and P.Y. Brillet Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity Eur Respir J 26 2005 586 593
    • (2005) Eur Respir J , vol.26 , pp. 586-593
    • Cottin, V.1    Nunes, H.2    Brillet, P.Y.3
  • 243
    • 75149155845 scopus 로고    scopus 로고
    • Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome
    • V. Cottin, J. Le Pavec, and G. Prévot Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome Eur Respir J 35 2010 105 111
    • (2010) Eur Respir J , vol.35 , pp. 105-111
    • Cottin, V.1    Le Pavec, J.2    Prévot, G.3
  • 244
    • 84867903345 scopus 로고    scopus 로고
    • Combined pulmonary fibrosis and emphysema syndrome in systemic sclerosis
    • C. Lubatti, S. Zeni, and F. Ingegnoli Combined pulmonary fibrosis and emphysema syndrome in systemic sclerosis Int J Rheum Dis 15 2012 e122 e123
    • (2012) Int J Rheum Dis , vol.15
    • Lubatti, C.1    Zeni, S.2    Ingegnoli, F.3
  • 245
    • 84864768081 scopus 로고    scopus 로고
    • Combined pulmonary fibrosis and emphysema associated with microscopic polyangiitis
    • A. Tzouvelekis, G. Zacharis, and A. Oikonomou Combined pulmonary fibrosis and emphysema associated with microscopic polyangiitis Eur Respir J 40 2012 505 507
    • (2012) Eur Respir J , vol.40 , pp. 505-507
    • Tzouvelekis, A.1    Zacharis, G.2    Oikonomou, A.3
  • 246
    • 84864869958 scopus 로고    scopus 로고
    • Combined pulmonary fibrosis and emphysema in connective tissue disease
    • V. Cottin, and J.F. Cordier Combined pulmonary fibrosis and emphysema in connective tissue disease Curr Opin Pulmon Med 18 2012 418 427
    • (2012) Curr Opin Pulmon Med , vol.18 , pp. 418-427
    • Cottin, V.1    Cordier, J.F.2
  • 247
    • 84880082256 scopus 로고    scopus 로고
    • Clinical features and outcomes in combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis
    • C.J. Ryerson, T. Hartman, and B.M. Elicker Clinical features and outcomes in combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis Chest 144 2013 234 240
    • (2013) Chest , vol.144 , pp. 234-240
    • Ryerson, C.J.1    Hartman, T.2    Elicker, B.M.3
  • 248
    • 84866111123 scopus 로고    scopus 로고
    • Characteristics of pulmonary inflammation in combined pulmonary fibrosis and emphysema
    • Y. Zhao, A. Cui, and F. Wang Characteristics of pulmonary inflammation in combined pulmonary fibrosis and emphysema Chin Med J (Engl) 125 2012 3015 3021
    • (2012) Chin Med J (Engl) , vol.125 , pp. 3015-3021
    • Zhao, Y.1    Cui, A.2    Wang, F.3
  • 249
    • 80053250869 scopus 로고    scopus 로고
    • Combined pulmonary fibrosis and emphysema syndrome associated with familial SFTPC mutation
    • V. Cottin, P. Reix, C. Khouatra, F. Thivolet-Béjui, D. Feldmann, and J.F. Cordier Combined pulmonary fibrosis and emphysema syndrome associated with familial SFTPC mutation Thorax 66 2011 918 919
    • (2011) Thorax , vol.66 , pp. 918-919
    • Cottin, V.1    Reix, P.2    Khouatra, C.3    Thivolet-Béjui, F.4    Feldmann, D.5    Cordier, J.F.6
  • 250
    • 84880571140 scopus 로고    scopus 로고
    • Reversing T cell immunosenescence: Why, who, and how
    • P.O. Lang, S. Govind, and R. Aspinall Reversing T cell immunosenescence: why, who, and how Age (Dordr) 35 2013 609 620
    • (2013) Age (Dordr) , vol.35 , pp. 609-620
    • Lang, P.O.1    Govind, S.2    Aspinall, R.3
  • 251
  • 252
    • 84876124887 scopus 로고    scopus 로고
    • Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases
    • I.K. Sundar, H. Yao, and I. Rahman Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases Antioxid Redox Signal 18 2013 1956 1971
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1956-1971
    • Sundar, I.K.1    Yao, H.2    Rahman, I.3
  • 253
    • 84860880317 scopus 로고    scopus 로고
    • SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
    • I. Rahman, V.L. Kinnula, V. Gorbunova, and H. Yao SIRT1 as a therapeutic target in inflammaging of the pulmonary disease Prev Med 54 2012 S20 S28
    • (2012) Prev Med , vol.54
    • Rahman, I.1    Kinnula, V.L.2    Gorbunova, V.3    Yao, H.4
  • 254
    • 77956241957 scopus 로고    scopus 로고
    • Stem cells and cell therapy approaches in lung biology and diseases
    • V. Sueblinvong, and D.J. Weiss Stem cells and cell therapy approaches in lung biology and diseases Transl Res 156 2010 188 205
    • (2010) Transl Res , vol.156 , pp. 188-205
    • Sueblinvong, V.1    Weiss, D.J.2
  • 255
    • 79959461779 scopus 로고    scopus 로고
    • Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute lung injury by expanding CD4+ CD25+ forkhead box p3 (FOXP3)+ regulatory T cells and balancing anti- and pro-inflammatory factors
    • J. Sun, Z.B. Han, and W. Liao Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute lung injury by expanding CD4+ CD25+ forkhead box p3 (FOXP3)+ regulatory T cells and balancing anti- and pro-inflammatory factors Cell Physiol Biochem 27 2011 587 596
    • (2011) Cell Physiol Biochem , vol.27 , pp. 587-596
    • Sun, J.1    Han, Z.B.2    Liao, W.3
  • 256
    • 84875186801 scopus 로고    scopus 로고
    • Pluripotent stem cells and gene therapy
    • P. Simara, J.A. Motl, and D.S. Kaufman Pluripotent stem cells and gene therapy Transl Res 161 2013 284 292
    • (2013) Transl Res , vol.161 , pp. 284-292
    • Simara, P.1    Motl, J.A.2    Kaufman, D.S.3
  • 257
    • 84873116668 scopus 로고    scopus 로고
    • Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions
    • A.I. Papaioannou, C. Rossios, K. Kostikas, and K. Ito Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions Curr Drug Targets 14 2013 149 157
    • (2013) Curr Drug Targets , vol.14 , pp. 149-157
    • Papaioannou, A.I.1    Rossios, C.2    Kostikas, K.3    Ito, K.4
  • 258
    • 84872231816 scopus 로고    scopus 로고
    • Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease
    • K. Ito, T. Colley, and N. Mercado Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease Int J Chron Obstruct Pulmon Dis 7 2012 641 652
    • (2012) Int J Chron Obstruct Pulmon Dis , vol.7 , pp. 641-652
    • Ito, K.1    Colley, T.2    Mercado, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.