The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis

Annals of the New York Academy of Sciences

Volumn 926, Issue , 2000, Pages 126-131

  Charette, Steve J ^a   Landry, Jacques ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Apoptosis; Ask1; Daxx; Fas; Heat; HSP27; Shock protein

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE; DAXX PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN; GENE PRODUCT; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; CELL NUCLEUS; CELL PROTECTION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CYTOPLASM; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 0034512869     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb05606.x     Document Type: Conference Paper

References (22)

1. Apoptosis by death factor
2. Apoptotic pathways: The roads to ruin
3. Daxx, a novel Fas-binding protein that activates JNK and apoptosis
4. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
5. Inhibition of daxx-mediated apoptosis by heat shock protein 27
6. Inhibition of fas death signals by FLIPs
7. Dissecting Fas signaling with an altered-specificity deathdomain mutant: Requirement of FADD binding for apoptosis but not Jun N- terminal kinase activation
8. Characterization of 45-kDa/54-kDa HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27-kDa heat-shock protein HSP27
9. Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II
10. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
11. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
12. HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus
13. Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation
14. Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis
15. hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells
16. Growth arrest of human B lymphocytes is accompanied by induction of the low molecular weight mammalian heat shock protein (Hsp28)
17. The small heat shock protein hsp25 is accumulated in P19 embryonal carcinoma cells and embryonic stem cells of line BLC6 during differentiation
18. Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurospodne-induced cell death
19. HSP27 inhibits cytochrome c-dependent activation of procaspase-9
20. Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein
21. A dynamic connection between centromeres and ND10 proteins
22. Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death