Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 3, 2012, Pages 340-348

  Huang, Xiangwei ^a   Yang, Naiheng ^a   Fiore, Vincent F ^b   Barker, Thomas H ^b   Sun, Yi ^c   Morris, Stephan W ^c   Ding, Qiang ^a   Thannickal, Victor J ^a   Zhou, Yong ^a  

^a University of Alabama at Birmingham   (United States)

^b Emory University   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

smooth muscle actin; Lung fibrosis; Transcription factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COMPLEMENTARY DNA; GUANOSINE TRIPHOSPHATASE; MEGAKARYOBLASTIC LEUKEMIA FACTOR 1; MYOSIN LIGHT CHAIN; POLYACRYLAMIDE GEL; PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CHROMATIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MECHANOTRANSDUCTION; MOUSE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; POLYMERIZATION; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; YOUNG MODULUS;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELLS, CULTURED; DNA PRIMERS; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, KNOCKOUT; MYOFIBROBLASTS; ONCOGENE PROTEINS, FUSION; PHOSPHORYLATION;

EID: 84865121019     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0050OC     Document Type: Article

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