Aberrant innate immune sensing leads to the rapid progression of idiopathic pulmonary fibrosis

Fibrogenesis and Tissue Repair

Volumn 5, Issue SUPPL.1, 2012, Pages

  Hogaboam, Cory M ^a   Trujillo, Glenda ^b   Martinez, Fernando J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; TOLL LIKE RECEPTOR 9;

ADOPTIVE TRANSFER; ARTICLE; CPG ISLAND; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE EXACERBATION; DNA METHYLATION; FIBROBLAST; FIBROSING ALVEOLITIS; HUMAN; IMMUNE RESPONSE; IN VIVO STUDY; INNATE IMMUNITY; LUNG BIOPSY; LUNG FUNCTION; LUNG LOBE; MAJOR CLINICAL STUDY; MORTALITY; PHENOTYPE;

EID: 84880998606     PISSN: None     EISSN: 17551536     Source Type: Journal    
DOI: 10.1186/1755-1536-5-S1-S3     Document Type: Article

References (8)

1. Trujillo G, Meneghin A, Flaherty KR, Sholl LM, Myers JL, Kazerooni EA, Gross BH, Oak SR, Coelho AL, Evanoff H, et al. TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis. Sci Transl Med 2010, 2:57ra82. 10.1126/scitranslmed.3001510, 3235647, 21068441.
2. Flaherty KR, Thwaite EL, Kazerooni EA, Gross BH, Toews GB, Colby TV, Travis WD, Mumford JA, Murray S, Flint A, et al. Radiological versus histological diagnosis in UIP and NSIP: survival implications. Thorax 2003, 58:143-148. 10.1136/thorax.58.2.143, 1746568, 12554898.
3. Martinez FJ, Safrin S, Weycker D, Starko KM, Bradford WZ, King TE, Flaherty KR, Schwartz DA, Noble PW, Raghu G, et al. The clinical course of patients with idiopathic pulmonary fibrosis. Ann Intern Med 2005, 142:963-967.
4. Jakubzick C, Choi ES, Carpenter KJ, Kunkel SL, Evanoff H, Martinez FJ, Flaherty KR, Toews GB, Colby TV, Travis WD, et al. Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Am J Pathol 2004, 164:1989-2001. 10.1016/S0002-9440(10)63759-5, 1615781, 15161635.
5. Smith RE, Strieter RM, Zhang K, Phan SH, Standiford TJ, Lukacs NW, Kunkel SL. A role for C-C chemokines in fibrotic lung disease. J Leukoc Biol 1995, 57:782-787.
6. Gharaee-Kermani M, McCullumsmith RE, Charo IF, Kunkel SL, and Phan SH. CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis. Cytokine 2003, 24:266-276. 10.1016/j.cyto.2003.08.003, 14609568.
7. Inoshima I, Kuwano K, Hamada N, Hagimoto N, Yoshimi M, Maeyama T, Takeshita A, Kitamoto S, Egashira K, and Hara N. Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 2004, 286:L1038-1044.
8. Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, and Hogaboam CM. Therapeutic Targeting of CC Ligand 21 or CC Chemokine Receptor 7 Abrogates Pulmonary Fibrosis Induced by the Adoptive Transfer of Human Pulmonary Fibroblasts to Immunodeficient Mice. Am J Pathol 2007, 170:1152-1164. 10.2353/ajpath.2007.060649, 1829450, 17392156.