Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic pulmonary fibrosis

Human Pathology

Volumn 41, Issue 3, 2010, Pages 385-391

  Waisberg, Daniel Reis ^a   Barbas Filho, João Valente ^a   Parra, Edwin Roger ^a   Fernezlian, Sandra ^a   Ribeiro de Carvalho, Carlos Roberto ^a   Kairalla, Ronaldo Adib ^a   Capelozzi, Vera Luiza ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Alveolar collapse; Apoptosis; Idiopathic pulmonary fibrosis; Prognosis; Telomerase; Type II alveolar epithelial cells

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; SURFACTANT; TELOMERASE;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL DENSITY; CELL DIVISION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; FIBROSING ALVEOLITIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERSTITIAL PNEUMONIA; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS EPITHELIUM TYPE 2; LUNG BIOPSY; LUNG PARENCHYMA; MALE; MORPHOMETRICS; NICK END LABELING; PROTEIN EXPRESSION; STAINING;

AGED; APOPTOSIS; CELL PROLIFERATION; FEMALE; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; PNEUMOCYTES; PROGNOSIS; RESPIRATORY MUCOSA; TELOMERASE;

EID: 75949125865     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.08.019     Document Type: Article

References (30)

1. Gross T.J., and Hunninghake G.W. Idiopathic pulmonary fibrosis. N Engl J Med 345 (2001) 517-525
2. Raghu G., Weycker D., Edelsberg J., Bradford W.Z., and Oster G. Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 174 (2006) 810-816
3. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med 165 (2002) 277-304
4. Katzenstein A.L., Mukhopadhyay S., and Myers J.L. Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases. Hum Pathol 39 (2008) 1275-1294
5. Selman M., Thannickal V.J., Pardo A., Zisman D.A., Martinez F.J., and Lynch J.P. Idiopathic pulmonary fibrosis: Pathogenesis and therapeutic approaches. Drugs 64 (2004) 405-430
6. King Jr. T.E., Schwarz M.I., Brown K., et al. Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med 164 (2001) 1025-1032
7. Nicholson A.G., Fulford L.G., Colby T.V., du Bois R.M., Hansell D.M., and Wells A.U. The relationship between individual histologic features and disease progression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 166 (2002) 173-177
8. Baptista A.L., Parra E.R., Filho J.V., Kairalla R.A., de Carvalho C.R., and Capelozzi V.L. Structural features of epithelial remodeling in usual interstitial pneumonia histologic pattern. Lung 184 (2006) 239-244
9. Kuwano K., Miyazaki H., Hagimoto N., et al. The involvement of Fas-Fas ligand pathway in fibrosing lung diseases. Am J Respir Cell Mol Biol 20 (1999) 53-60
10. Kuwano K., Hagimoto N., Kawasaki M., et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest 104 (1999) 13-19
11. Barbas-Filho J.V., Ferreira M.A., Sesso A., Kairalla R.A., Carvalho C.R., and Capelozzi V.L. Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IPF) / usual interstitial pneumonia (UIP). J Clin Pathol 54 (2001) 132-138
12. Tsakiri K.D., Cronkhite J.T., Kuan P.J., et al. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A 104 (2007) 7552-7557
13. d 'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., et al. A DNA damage check-point response in telomere-initiated senescence. Nature 426 (2003) 194-198
14. Hemann M.T., Strong M.A., Hao L.Y., and Greider C.W. The shortest telomere not average telomere length, is critical for cell viability and chromosome stability. Cell 107 (2001) 67-77
15. White E.S., Lazar M.H., and Thannickal V.J. Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. J Pathol 201 (2003) 343-354
16. Maher T.M., Wells A.U., and Laurent G.J. Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?. Eur Respir J 30 (2007) 835-839
17. Gavrieli Y., Sherman Y., and Bem-Sasson A.S. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119 (1992) 4993-5501
18. Wijsman J.H., Jonker R.R., Keijzer R., van de Velde C.J., Cornelise C.J., and van Dierendonck J.H. A new method to detect apoptosis in paraffin sections: in situ end labeling of fragmented DNA. J Histochem Cytochem 41 (1993) 7-12
19. Gundersen H.J.G., Bendtesen T.F., Korbo L., et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96 (1988) 379-394
20. 2. Exp Mol Pathol 22 (1975) 142-150
21. Rudolph K.L., Chang S., Millard M., Schreiber-Agus N., and Delpinho R.A. Inhibition of experimental liver cirrohosis in mice by telomerase gene delivery. Science 287 (2000) 1253-1258
22. Driscoll B., Buckley S., Bui K.C., Anderson K.D., and Warburton D. Telomerase in alveolar epithelial development and repair. Am J Physiol Lung Cell Mol Physiol 279 (2000) L1191-L1198
23. Mondello C., and Scovassi A.I. Telomeros, telomerase, and apoptosis. Biochem Cell Biol 82 (2004) 498-507
24. Smith L.L., Coller H.Á., and Roberts J.M. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 5 (2003) 474-479
25. Friendlenger Z.G., Cohen P.Y., Golan O., Arish N., Dayan-Wallach S., and Breuer R. Telomerase activity in alveolar epithelial development and repair. Eur Respir J 30 (2007) 205-213
26. Ramirez R., Carracedo J., Jimenez R., et al. Massive telomere loss is an early event of DNA damage-induced apoptosis. J Biol Chem 278 (2003) 836-842
27. Armanios M., Chin J.L., Chang Y.P., et al. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci U S A 102 (2005) 15960-15964
28. Armanios M.Y., Chen J.L.L.J., Cogan J.D., et al. W.Greider CW, Loyd JE. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med 356 (2007) 1317-1326
29. Cronkhite J.T., Xing C., Raghu G., et al. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med 178 (2008) 729-737
30. Alder J.K., Chen J.J., Lancaster L., et al. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A 105 (2008) 13051-13056