Functional Wnt signaling is increased in idiopathic pulmonary fibrosis

PLoS ONE

Volumn 3, Issue 5, 2008, Pages

  Königshoff, Melanie ^a   Balsara, Nisha ^a   Pfaff, Eva Maria ^a   Kramer, Monika ^a   Chrobak, Izabella ^a   Seeger, Werner ^a   Eickelberg, Oliver ^a  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; COLLAGEN; CYCLIN D1; FIBRONECTIN; FRIZZLED PROTEIN; GROWTH FACTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYMPHOID ENHANCER FACTOR 1; MATRILYSIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 3; TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR 7; WNT PROTEIN; WNT1 PROTEIN; WNT10B PROTEIN; WNT3A PROTEIN; WNT7B PROTEIN; MESSENGER RNA;

ADULT; AGED; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL STRAIN 3T3; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; MALE; MYOFIBROBLAST; NUCLEOTIDE SEQUENCE; ORGAN DONOR; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL LINE; GENE EXPRESSION PROFILING; GENETICS; LUNG FIBROSIS; METABOLISM; MIDDLE AGED; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; BETA CATENIN; BLOTTING, WESTERN; CELL LINE; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PULMONARY FIBROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 47749101725     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002142     Document Type: Article

References (45)

1. Kim DS, Collard HR, King TE Jr (2006) Classification and natural history of the idiopathic interstitial pneumonias. Proc Am Thorac Soc 3: 285-292.
2. Taskar VS, Coultas DB (2006) Is idiopathic pulmonary fibrosis an environmental disease? Proc Am Thorac Soc 3: 293-298.
3. (2002) American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med 165: 277-304.
4. Martinez FJ, Safrin S, Weycker D, Starko KM, Bradford WZ, et al. (2005) The clinical course of patients with idiopathic pulmonary fibrosis. Ann Intern Med 142: 963-967.
5. Walter N, Collard HR, King TE Jr (2006) Current perspectives on the treatment of idiopathic pulmonary fibrosis. Proc Am Thorac Soc 3: 330-338.
6. Visscher DW, Myers JL (2006) Histologic spectrum of idiopathic interstitial pneumonias. Proc Am Thorac Soc 3: 322-329.
7. AL, Myers JL (1998) Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med 157: 1301-1315.
8. King TE Jr, Schwarz MI, Brown K, Tooze JA, Colby TV, et al. (2001) Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med 164: 1025-1032.
9. Noble PW, Homer RJ (2005) Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 33: 113-120.
10. Selman M, King TE, Pardo A (2001) Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134: 136-151.
11. Moon RT, Kohn AD, De Ferrari GV, Kaykas A (2004) WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet 5: 691-701.
12. Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20: 781-810.
13. Johnson ML, Rajamannan N (2006) Diseases of Wnt signaling. Rev Endocr Metab Disord 7: 41-49.
14. Chilosi M, Poletti V, Zamo A, Lestani M, Montagna L, et al. (2003) Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 162: 1495-1502.
15. Yang IV, Burch LH, Steele MP, Savov JD, Hollingsworth JW, et al. (2007) Gene expression profiling of familial and sporadic interstitial pneumonia. Am J Respir Crit Care Med 175: 45-54.
16. Selman M, Pardo A, Barrera L, Estrada A, Watson SR, et al. (2006) Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med 173: 188-198.
17. Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, et al. (2008) Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med 177: 376-87.
18. White ES, Lazar MH, Thannickal VJ (2003) Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. J Pathol 201: 343-354.
19. Chua F, Gauldie J, Laurent GJ (2005) Pulmonary fibrosis: searching for model answers. Am J Respir Cell Mol Biol 33: 9-13.
20. Scotton CJ, Chambers RC (2007) Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 132: 1311-1321.
21. Nusse R (2005) Wnt signaling in disease and in development. Cell Res 15: 28-32.
22. Selman M, Pardo A, Kaminski N (2008) Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs? PLoS Med 5: e62.
23. Morrisey EE (2003) Wnt signaling and pulmonary fibrosis. Am J Pathol 162: 1393-1397.
24. Mucenski ML, Wert SE, Nation JM, Loudy DE, Huelsken J, et al. (2003) beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem 278: 40231-40238.
25. Mucenski ML, Nation JM, Thitoff AR, Besnard V, Xu Y, et al. (2005) Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 289: L971-979.
26. Li C, Xiao J, Hormi K, Borok Z, Minoo P (2002) Wnt5a participates in distal lung morphogenesis. Dev Biol 248: 68-81.
27. Shu W, Jiang YQ, Lu MM, Morrisey EE (2002) Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development 129: 4831-4842.
28. Lu W, Yamamoto V, Ortega B, Baltimore D (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119: 97-108.
29. Szeto W, Jiang W, Tice DA, Rubinfeld B, Hollingshead PG, et al. (2001) Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer Res 61: 4197-4205.
30. Taneyhill L, Pennica D (2004) Identification of Wnt responsive genes using a murine mammary epithelial cell line model system. BMC Dev Biol 4: 6.
31. Kikuchi A, Yamamoto H, Kishida S (2007) Multiplicity of the interactions of Wnt proteins and their receptors. Cell Signal 19: 659-671.
32. Mikels AJ, Nusse R (2006) Wnts as ligands: processing, secretion and reception. Oncogene 25: 7461-7468.
33. Rulifson EJ, Wu CH, Nusse R (2000) Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless. Mol Cell 6: 117-126.
34. Cadigan KM, Liu YI (2006) Wnt signaling: complexity at the surface. J Cell Sci 119: 395-402.
35. Guo X, Ramirez A, Waddell DS, Li Z, Liu X, et al. (2008) Axin and GSK3-control Smad3 protein stability and modulate TGF- signaling. Genes Dev 22: 106-120.
36. Brembeck FH, Rosario M, Birchmeier W (2006) Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 16: 51-59.
37. Perez-Moreno M, Fuchs E (2006) Catenins: keeping cells from getting their signals crossed. Dev Cell 11: 601-612.
38. Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, et al. (2007) Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 316: 1619-1622.
39. Forde JE, Dale TC (2007) Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 64: 1930-1944.
40. Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, et al. (2002) Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci U S A 99: 6292-6297.
41. Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, et al. (2008) An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis. Am J Respir Crit Care Med 177: 638-45.
42. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, et al. (2006) Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol 290: L242-249.
43. Konigshoff M, Wilhelm A, Jahn A, Sedding D, Amarie OV, et al. (2007) The angiotensin II receptor 2 is expressed and mediates angiotensin II signaling in lung fibrosis. Am J Respir Cell Mol Biol 37: 640-650.
44. Kitowska K, Zakrzewicz D, Konigshoff M, Chrobak I, Grimminger F, et al. (2008) Functional Role and Species-specific Contribution of Arginases in Pulmonary Fibrosis. Am J Physiol Lung Cell Mol Physiol 294: L34-45.
45. Hochberg Y, Benjamini Y (1990) More powerful procedures for multiple significance testing. Stat Med 9: 811-818.