Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements

Cancer Research

Volumn 66, Issue 22, 2006, Pages 10805-10814

  Dasari, Arvind ^a   Bartholomew, Janine N ^a   Volonte, Daniela ^a   Galbiati, Ferruccio ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN 1; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; QUERCETIN; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CANCER CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOTOXICITY; DNA RESPONSIVE ELEMENT; ENZYME INHIBITION; FIBROBLAST; GC RICH SEQUENCE; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE CONSTRUCT; GENE DELETION; GENE MAPPING; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REPORTER GENE; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIOXIDANTS; CAVEOLIN 1; CELL AGING; CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; HYDROGEN PEROXIDE; MICE; NIH 3T3 CELLS; OXIDANTS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); QUERCETIN; RESPONSE ELEMENTS; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 33845345975     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1236     Document Type: Article

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