Aging, telomeres and heart failure

Heart Failure Reviews

Volumn 15, Issue 5, 2010, Pages 479-486

  Wong, Liza S M ^a   Van Der Harst, Pim ^a   De Boer, Rudolf A ^a   Huzen, Jardi ^a   Van Gilst, Wiek H ^a   Van Veldhuisen, Dirk J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Aging; DNA; Genetics; Heart failure; Telomerase; Telomere

Indexed keywords

DNA; LIPOFUSCIN; MYOSIN; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 2; TROPONIN;

AGING; APOPTOSIS; CELL AGING; CELL COUNT; CELL FUNCTION; CELL STRUCTURE; CIGARETTE SMOKING; DISEASE ASSOCIATION; DNA DAMAGE; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; REVIEW; TELOMERE; TISSUE INJURY; ULTRAVIOLET RADIATION;

AGING; DISEASE PROGRESSION; HEART FAILURE; HUMANS; MYOCYTES, CARDIAC; PROGNOSIS; RISK FACTORS; TELOMERASE; TELOMERE;

EID: 77955716077     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10741-010-9173-7     Document Type: Review

References (68)

1. K Dickstein A Cohen-Solal G Filippatos JJ McMurray P Ponikowski PA Poole-Wilson A Stromberg DJ van Veldhuisen D Atar AW Hoes A Keren A Mebazaa M Nieminen SG Priori K Swedberg A Vahanian J Camm CR De V Dean K Dickstein G Filippatos C Funck-Brentano I Hellemans SD Kristensen K McGregor U Sechtem S Silber M Tendera P Widimsky JL Zamorano M Tendera A Auricchio J Bax M Bohm U Corra BP Della PM Elliott F Follath M Gheorghiade Y Hasin A Hernborg T Jaarsma M Komajda R Kornowski M Piepoli B Prendergast L Tavazzi JL Vachiery FW Verheugt JL Zamorano F Zannad 2008 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European society of cardiology, developed in collaboration with the heart failure association of the ESC (HFA) and endorsed by the European society of intensive care medicine (ESICM) Eur J Heart Fail 10 933 989 10.1016/j.ejheart.2008.08.005 18826876
2. WB Kannel 2000 Incidence and epidemiology of heart failure Heart Fail Rev 5 167 173 10.1023/A:1009884820941 1:STN:280:DC%2BD2MrltVeluw%3D%3D 16228142
3. DW Kitzman 2002 Diastolic heart failure in the elderly Heart Fail Rev 7 17 27 10.1023/A:1013745705318 11790920
4. LS Wong RA de Boer NJ Samani DJ van Veldhuisen P van der Harst 2008 Telomere biology in heart failure Eur J Heart Fail 10 1049 1056 10.1016/j.ejheart.2008.08.007 1:CAS:528:DC%2BD1cXht1Knsr%2FP 18815070
5. NJ Samani P van der Harst 2008 Biological ageing and cardiovascular disease Heart 94 537 539 10.1136/hrt.2007.136010 1:CAS:528:DC%2BD1cXmsl2qtr8%3D 18411343
6. EG Lakatta 2002 Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons Heart Fail Rev 7 29 49 10.1023/A:1013797722156 11790921
7. KG Pugh JY Wei 2001 Clinical implications of physiological changes in the aging heart Drugs Aging 18 263 276 10.2165/00002512-200118040-00004 1:CAS:528:DC%2BD3MXjvVyntLs%3D 11341474
8. SP Schulman EG Lakatta JL Fleg L Lakatta LC Becker G Gerstenblith 1992 Age-related decline in left ventricular filling at rest and exercise Am J Physiol 263 H1932 H1938 1:STN:280:DyaK3s7ivVGisg%3D%3D 1362335
9. JR Stratton WC Levy MD Cerqueira RS Schwartz IB Abrass 1994 Cardiovascular responses to exercise Effects of aging and exercise training in healthy men. Circulation 89 1648 1655 1:STN:280:DyaK2c7pvFOgsg%3D%3D
10. EG Lakatta G Gerstenblith CS Angell NW Shock ML Weisfeldt 1975 Diminished inotropic response of aged myocardium to catecholamines Circ Res 36 262 269 1:CAS:528:DyaE2MXpsF2htQ%3D%3D 1116236
11. MR McLean PB Goldberg J Roberts 1983 An ultrastructural study of the effects of age on sympathetic innervation and atrial tissue in the rat J Mol Cell Cardiol 15 75 92 10.1016/0022-2828(83)90284-5 1:STN:280: DyaL3s3hs1WlsA%3D%3D 6854660
12. HU Rehman 1999 Age and the cardiovascular system Hosp Med 60 645 652 1:STN:280:DC%2BD3c%2FoslKksg%3D%3D 10621790
13. LM Buja D Vela 2008 Cardiomyocyte death and renewal in the normal and diseased heart Cardiovasc Pathol 17 349 374 10.1016/j.carpath.2008.02.004 18402842
14. G Olivetti M Melissari JM Capasso P Anversa 1991 Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy Circ Res 68 1560 1568 1:STN:280:DyaK3M3ktlaqtw%3D%3D 2036710
15. ML Burgess JC McCrea HL Hedrick 2001 Age-associated changes in cardiac matrix and integrins Mech Ageing Dev 122 1739 1756 10.1016/S0047-6374(01)00296-2 1:CAS:528:DC%2BD3MXms12lsb0%3D 11557277
16. K Pandya HS Kim O Smithies 2006 Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo Proc Natl Acad Sci U S A 103 16864 16869 10.1073/pnas.0607700103 1:CAS:528:DC%2BD28Xht1egurrF 17068123
17. JT Lie PI Hammond 1988 Pathology of the senescent heart: anatomic observations on 237 autopsy studies of patients 90 to 105 years old Mayo Clin Proc 63 552 564 1:STN:280:DyaL1c3jtFOqtA%3D%3D 3374172
18. D Bernhard G Laufer 2008 The aging cardiomyocyte: a mini-review Gerontology 54 24 31 10.1159/000113503 1:CAS:528:DC%2BD1cXlsVWqurw%3D 18196923
19. V Raizada D Pathak TM Blomquist R Minser B Woodfin 1993 Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine Cardiovasc Res 27 1869 1872 10.1093/cvr/27.10.1869 1:CAS:528:DyaK2cXhvVaktrw%3D 8275537
20. JM Dhahbi T Tsuchiya HJ Kim PL Mote SR Spindler 2006 Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction J Gerontol A Biol Sci Med Sci 61 218 231 16567370
21. C Muscari C Finelli C Stefanelli F Flamigni C Guarnieri CM Caldarera 1993 Age-dependent differences of ATP breakdown and ATP-catabolite release in ischemic and reperfused hearts Mech Ageing Dev 67 1 11 10.1016/0047-6374(93) 90107-3 1:CAS:528:DyaK3sXks12gurw%3D 8469022
22. O Bergmann RD Bhardwaj S Bernard S Zdunek F Barnabe-Heider S Walsh J Zupicich K Alkass BA Buchholz H Druid S Jovinge J Frisen 2009 Evidence for cardiomyocyte renewal in humans Science 324 98 102 10.1126/science.1164680 1:CAS:528:DC%2BD1MXjvVajsbc%3D 19342590
23. PC Hsieh VF Segers ME Davis C MacGillivray J Gannon JD Molkentin J Robbins RT Lee 2007 Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury Nat Med 13 970 974 10.1038/nm1618 1:CAS:528:DC%2BD2sXos1Cjsbk%3D 17660827
24. S Dimmeler A Leri 2008 Aging and disease as modifiers of efficacy of cell therapy Circ Res 102 1319 1330 10.1161/CIRCRESAHA.108.175943 1:CAS:528:DC%2BD1cXmt1yht74%3D 18535269
25. JM Edelberg L Tang K Hattori D Lyden S Rafii 2002 Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function Circ Res 90 E89 E93 10.1161/01.RES.0000020861.20064.7E 1:CAS:528:DC%2BD38XktlSntr8%3D 12039806
26. S Jiang HH Kh RP Ahmed NM Idris A Salim M Ashraf 2008 Transcriptional profiling of young and old mesenchymal stem cells in response to oxygen deprivation and reparability of the infarcted myocardium J Mol Cell Cardiol 44 582 596 10.1016/j.yjmcc.2007.11.014 1:CAS:528:DC%2BD1cXjtl2lsb8%3D 18199451
27. N Werner S Kosiol T Schiegl P Ahlers K Walenta A Link M Bohm G Nickenig 2005 Circulating endothelial progenitor cells and cardiovascular outcomes N Engl J Med 353 999 1007 10.1056/NEJMoa043814 1:CAS:528:DC%2BD2MXpvVOisbw%3D 16148285
28. CK Kissel R Lehmann B Assmus A Aicher J Honold U Fischer-Rasokat C Heeschen I Spyridopoulos S Dimmeler AM Zeiher 2007 Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with post infarction heart failure J Am Coll Cardiol 49 2341 2349 10.1016/j.jacc.2007.01.095 17572250
29. M Vasa S Fichtlscherer A Aicher K Adler C Urbich H Martin AM Zeiher S Dimmeler 2001 Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease Circ Res 89 E1 E7 10.1161/hh1301.093953 1:CAS:528:DC%2BD3MXltlSmt7k%3D 11440984
30. T von Zglinicki 2002 Oxidative stress shortens telomeres Trends Biochem Sci 27 339 344 10.1016/S0968-0004(02)02110-2
31. JV Grobelny M Kulp-McEliece D Broccoli 2001 Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway Hum Mol Genet 10 1953 1961 10.1093/hmg/10.18.1953 1:CAS:528:DC%2BD3MXntlSgsbk%3D 11555632
32. CM Azzalin P Reichenbach L Khoriauli E Giulotto J Lingner 2007 Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends Science 318 798 801 10.1126/science.1147182 1:CAS:528:DC%2BD2sXht1elsrfM 17916692
33. S Schoeftner MA Blasco 2008 Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II Nat Cell Biol 10 228 236 10.1038/ncb1685 1:CAS:528:DC%2BD1cXhs1Kiur0%3D 18157120
34. PE Slagboom S Droog DI Boomsma 1994 Genetic determination of telomere size in humans: a twin study of three age groups Am J Hum Genet 55 876 882 1:STN:280:DyaK2M%2Fmsl2msA%3D%3D 7977349
35. OT Njajou RM Cawthon CM Damcott SH Wu S Ott MJ Garant EH Blackburn BD Mitchell AR Shuldiner WC Hsueh 2007 Telomere length is paternally inherited and is associated with parental lifespan Proc Natl Acad Sci U S A 104 12135 12139 10.1073/pnas.0702703104 1:CAS:528:DC%2BD2sXosVWmtb8%3D 17623782
36. M Vasa-Nicotera S Brouilette M Mangino JR Thompson P Braund JR Clemitson A Mason CL Bodycote SM Raleigh E Louis NJ Samani 2005 Mapping of a major locus that determines telomere length in humans Am J Hum Genet 76 147 151 10.1086/426734 1:CAS:528:DC%2BD2MXhtVyksg%3D%3D 15520935
37. T Andrew A Aviv M Falchi GL Surdulescu JP Gardner X Lu M Kimura BS Kato AM Valdes TD Spector 2006 Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs Am J Hum Genet 78 480 486 10.1086/500052 1:CAS:528:DC%2BD28XitVWqtLg%3D 16400618
38. M Mangino JB Richards N Soranzo G Zhai A Aviv AM Valdes NJ Samani P Deloukas TD Spector 2009 A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length J Med Genet 46 451 454 10.1136/jmg.2008.064956 1:CAS:528:DC%2BD1MXpslyjsr4%3D 19359265
39. V Codd M Mangino P van der Harst PS Braund M Kaiser AJ Beveridge S Rafelt J Moore C Nelson N Soranzo G Zhai AM Valdes H Blackburn LI Mateo RA de Boer AH Goodall W Ouwehand DJ van Veldhuisen WH van Gilst G Navis PR Burton MD Tobin AS Hall JR Thompson T Spector NJ Samani 2010 Common variants near TERC are associated with mean telomere length Nat Genet 42 197 199 10.1038/ng.532 1:CAS:528:DC%2BC3cXhs1Onsb0%3D 20139977
40. AM Valdes T Andrew JP Gardner M Kimura E Oelsner LF Cherkas A Aviv TD Spector 2005 Obesity, cigarette smoking, and telomere length in women Lancet 366 662 664 10.1016/S0140-6736(05)66630-5 1:CAS:528:DC%2BD2MXosVajsbo%3D 16112303
41. S Oikawa S Tada-Oikawa S Kawanishi 2001 Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening Biochemistry 40 4763 4768 10.1021/bi002721g 1:CAS:528:DC%2BD3MXitVyrsrY%3D 11294644
42. E Jeanclos NJ Schork KO Kyvik M Kimura JH Skurnick A Aviv 2000 Telomere length inversely correlates with pulse pressure and is highly familial Hypertension 36 195 200 1:CAS:528:DC%2BD3cXmtlers7k%3D 10948077
43. E Jeanclos A Krolewski J Skurnick M Kimura H Aviv JH Warram A Aviv 1998 Shortened telomere length in white blood cells of patients with IDDM Diabetes 47 482 486 10.2337/diabetes.47.3.482 1:CAS:528:DyaK1cXhs1aqurc%3D 9519758
44. S Brouilette RK Singh JR Thompson AH Goodall NJ Samani 2003 White cell telomere length and risk of premature myocardial infarction Arterioscler Thromb Vasc Biol 23 842 846 10.1161/01.ATV.0000067426.96344.32 1:CAS:528: DC%2BD3sXjtlaktb0%3D 12649083
45. RS Vasan S Demissie M Kimura LA Cupples N Rifai C White TJ Wang JP Gardner X Cao EJ Benjamin D Levy A Aviv 2008 Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system. The framingham heart study Circulation 117 1138 1144 10.1161/CIRCULATIONAHA.107. 731794 1:CAS:528:DC%2BD1cXitlyrsL4%3D 18268147
46. P van der Harst G van der Steege RA de Boer AA Voors AS Hall MJ Mulder WH van Gilst DJ van Veldhuisen 2007 Telomere length of circulating leukocytes is decreased in patients with chronic heart failure J Am Coll Cardiol 49 1459 1464 10.1016/j.jacc.2007.01.027 17397675
47. P van der Harst RA de Boer NJ Samani LS Wong J Huzen V Codd HL Hillege AA Voors WH van Gilst T Jaarsma DJ van Veldhuisen 2010 Telomere length and outcome in heart failure Ann Med 42 36 44 10.3109/07853890903233887 19941413
48. FW Asselbergs P van der Harst GA Jessurun RA Tio WH van Gilst 2005 Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins Vascul Pharmacol 42 125 140 10.1016/j.vph.2005.01.009 1:CAS:528:DC%2BD2MXisFGrtrg%3D 15792930
49. TD Smilde K Damman P van der Harst G Navis WB Daan AA Voors F Boomsma DJ van Veldhuisen HL Hillege 2009 Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure Clin Res Cardiol 98 121 129 10.1007/s00392-008-0732-z 1:CAS:528: DC%2BD1MXhvF2nu7c%3D 18979056
50. P van der Harst TD Smilde H Buikema AA Voors G Navis DJ van Veldhuisen WH van Gilst 2006 Vascular function and mild renal impairment in stable coronary artery disease Arterioscler Thromb Vasc Biol 26 379 384 10.1161/01.ATV. 0000197844.06411.22 16306429
51. van der Harst P, Wong LS, de Boer RA, Brouilette SW, van der SG, Voors AA, Hall AS, Samani NJ, Wikstrand J, van Gilst WH, van Veldhuisen DJ (2008) Possible association between telomere length and renal dysfunction in patients with chronic heart failure. Am J Cardiol 102:207-210
52. LS Wong P van der Harst RA de Boer V Codd J Huzen NJ Samani HL Hillege AA Voors WH van Gilst T Jaarsma DJ van Veldhuisen 2008 Renal dysfunction is associated with shorter telomere length in patients with heart failure Clin Res Cardiol 98 629 634 10.1007/s00392-009-0048-7
53. J Collerton C Martin-Ruiz A Kenny K Barrass T von Zglinicki T Kirkwood B Keavney 2007 Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85 + study Eur Heart J 28 172 176 10.1093/eurheartj/ehl437 1:CAS:528:DC%2BD2sXjtlKqsb0%3D 17215319
54. H Oh SC Wang A Prahash M Sano CS Moravec GE Taffet LH Michael KA Youker ML Entman MD Schneider 2003 Telomere attrition and Chk2 activation in human heart failure Proc Natl Acad Sci U S A 100 5378 5383 10.1073/pnas.0836098100 1:CAS:528:DC%2BD3sXjs1yitL0%3D 12702777
55. C Chimenti J Kajstura D Torella K Urbanek H Heleniak C Colussi F Di Meglio B Nadal-Ginard A Frustaci A Leri A Maseri P Anversa 2003 Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure Circ Res 93 604 613 10.1161/01.RES.0000093985.76901.AF 1:CAS:528:DC%2BD3sXnsFSgs7o%3D 12958145
56. I Spyridopoulos Y Erben TH Brummendorf J Haendeler K Dietz F Seeger C Kissel H Martin J Hoffmann B Assmus AM Zeiher S Dimmeler 2008 Telomere gap between granulocytes and lymphocytes is a determinant for haematopoetic progenitor cell impairment in patients with previous myocardial infarction Arterioscler Thromb Vasc Biol 28 968 974 10.1161/ATVBAHA.107.160846 1:CAS:528:DC%2BD1cXktlymu7c%3D 18276909
57. P van der Harst DJ van Veldhuisen NJ Samani 2008 Expanding the concept of telomere dysfunction in cardiovascular disease Arterioscler Thromb Vasc Biol 28 807 808 10.1161/ATVBAHA.108.164434 18421006
58. Westenbrink BD, Voors AA, de Boer RA, Schuringa JJ, Klinkenberg T, van der Harst P, Vellenga E, van Veldhuisen DJ, van Gilst WH (2010) Bone marrow dysfunction in chronic heart failure patients. Eur J Heart Fail. In press
59. A Leri S Franco A Zacheo L Barlucchi S Chimenti F Limana B Nadal-Ginard J Kajstura P Anversa MA Blasco 2003 Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation EMBO J 22 131 139 10.1093/emboj/cdg013 1:CAS:528:DC%2BD3sXovFartw%3D%3D 12505991
60. C Werner M Hanhoun T Widmann A Kazakov A Semenov J Poss J Bauersachs T Thum M Pfreundschuh P Muller J Haendeler M Bohm U Laufs 2008 Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis J Am Coll Cardiol 52 470 482 10.1016/j.jacc.2008.04.034 1:CAS:528:DC%2BD1cXpt1GrsLw%3D 18672169
61. P van der Harst AA Voors M Volbeda H Buikema DJ van Veldhuisen WH van Gilst 2006 Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting Am J Cardiol 97 1697 1701 10.1016/j.amjcard.2006.01.030 16765116
62. P van der Harst AA Voors WH van Gilst M Bohm DJ van Veldhuisen 2006 Statins in the treatment of chronic heart failure: biological and clinical considerations Cardiovasc Res 71 443 454 10.1016/j.cardiores.2006.04.011 16730683
63. J Kjekshus E Apetrei V Barrios M Bohm JG Cleland JH Cornel P Dunselman C Fonseca A Goudev P Grande L Gullestad A Hjalmarson J Hradec A Janosi G Kamensky M Komajda J Korewicki T Kuusi F Mach V Mareev JJ McMurray N Ranjith M Schaufelberger J Vanhaecke DJ van Veldhuisen F Waagstein H Wedel J Wikstrand 2007 Rosuvastatin in older patients with systolic heart failure N Engl J Med 357 2248 2261 10.1056/NEJMoa0706201 1:CAS:528:DC%2BD2sXhsVSlsLvI 17984166
64. P van der Harst AA Voors WH van Gilst M Bohm DJ van Veldhuisen 2006 Statins in the treatment of chronic heart failure: a systematic review PLoS Med 3 e333 10.1371/journal.pmed.0030333 16933967
65. E Lipsic BD Westenbrink P van der Meer P van der Harst AA Voors DJ van Veldhuisen RG Schoemaker WH van Gilst 2008 Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit Eur J Heart Fail 10 22 29 10.1016/j.ejheart.2007.10.008 1:CAS:528: DC%2BD1cXisl2jsg%3D%3D 18077209
66. BD Westenbrink E Lipsic P van der Meer P van der Harst H Oeseburg GJ Du Marchie Sarvaas J Koster AA Voors DJ van Veldhuisen WH van Gilst RG Schoemaker 2007 Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization Eur Heart J 28 2018 2027 10.1093/eurheartj/ehm177 1:CAS:528:DC%2BD2sXhtV2mtbzM 17576662
67. BD Westenbrink H Oeseburg L Kleijn P van der Harst AM Belonje AA Voors RG Schoemaker RA de Boer DJ van Veldhuisen WH van Gilst 2008 Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia Cardiovasc Drugs Ther 22 265 274 10.1007/s10557-008-6094-y 1:CAS:528: DC%2BD1cXovV2gsLc%3D 18327705
68. J Huzen DJ van Veldhuisen WH van Gilst P van der Harst 2008 Telomeres and biological ageing in cardiovascular disease Ned Tijdschr Geneeskd 152 1265 1270 1:STN:280:DC%2BD1cvitFaquw%3D%3D 18590060