Roles of mechanical forces and collagen failure in the development of elastase-induced emphysema

American Journal of Respiratory and Critical Care Medicine

Volumn 164, Issue 10 I, 2001, Pages 1920-1926

  Kononov, Stefanida ^a   Brewer, Kelly ^a   Sakai, Hiroaki ^a   Cavalcante, Francisco S A ^a   Sabayanagam, Chandran R ^a   Ingenito, Edward P ^a   Suki, Béla ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Boston University   (United States)

Author keywords

Fluorescent labeling; Lung; Remodeling; Stress strain; Volume reduction

Indexed keywords

COLLAGEN; COLLAGEN FIBER; ELASTASE; ELASTIN; PROTEINASE; PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING MECHANICS; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; LUNG EMPHYSEMA; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; STRESS STRAIN RELATIONSHIP; TECHNIQUE; TISSUE REPAIR;

EID: 0035891566     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.164.10.2101083     Document Type: Article

References (38)

1. Medical progress: Chronic obstructive pulmonary disease
2. Animal models of emphysema
3. Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis
4. The scanning electron microscopy of elastase-induced emphysema. A comparison with emphysema in man
5. The induction of emphysema with elastase. II. Changes in connective tissue
6. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
7. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema
8. Induction of emphysematous lesions in rat lung by beta-o-xyloside, an inhibitor of proteoglycan synthesis
9. Rate of FEV1 change following lung volume reduction surgery
10. Lung volume reduction surgery and airflow limitation
11. Lung function 4 years after lung volume reduction surgery for emphysema
12. Distribution of mechanical stress in the lung, a possible factor in localization of pulmonary disease
13. Effect of temperature on the biaxial mechanics ofexcised lung parenchyma of the dog
14. Airway-parenchymal interdependence after airway contraction in rat lung explants
15. Smoke-induced emphysema in guinea pigs is associated with morphometric evidence of collagen breakdown and repair
16. Dynamic properties of lung parenchyma: Mechanical contributions of fiber network and interstitial cells
17. Alveolar size as a determinant of pulmonary distensibility in mammalian lungs
18. Mild emphysema is associated with reduced elastic recoil and increased lung size but not with air-flow limitation
19. Elastic properties of air- and liquid-filled lung parenchyma
20. Structural and functional characteristics of peripheral pulmonary parenchyma in golden hamster
21. Remodeling of alveolar walls after elastase treatment of hamsters. Results of elastin and collagen mRNA in situ hybridization
22. Cellular and connective tissue changes in alveolar septal walls in emphysema
23. Micromechanical foundations of pulmonary elasticity
24. Measurement and modeling of lung elasticity following remodeling and in vitro digestion
25. Elastase-mediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures. A mechanism for basic fibroblast growth factor (bfgf) release and attenuation of bfgf binding following elastase-induced injury
26. Effects of collagenase and elastase on the mechanical properties of lung tissue strips
27. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
28. Matrix metalloproteinases. Matrix degradation and more
29. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
30. Cleavage of native type I collagen by human neutrophil elastase
31. Clinical significance of serum concentration of interleukin 8 in patients with bronchial asthma or chronic pulmonary emphysema
32. Interleukin-4 and interferongamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets
33. Independent modulation of collagen fibrillogenesis by decorin and lumican
34. Complexity of terminal airspace geometry assessed by lung computed tomography in normal subjects and patients with chronic obstructive pulmonary disease
35. Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease