Mechanical stretching induces osteoprotegerin in differentiating C2C12 precursor cells through noncanonical Wnt pathways

Journal of Bone and Mineral Research

Volumn 25, Issue 5, 2010, Pages 1128-1137

  Yu, Hsiao Chi ^a   Wu, Tzu Chin ^a   Chen, Mei Ru ^a   Liu, Shan Wen ^a   Chen, Jen Hao ^b   Lin, Kurt Ming Chao ^a,c  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Arrays; Mechanical loading; Molecular pathways; OPG; Osteoblasts; Osteoporosis; Stress strain; WNT FRZ LRP5

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; BIOLOGICAL MARKER; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SMALL INTERFERING RNA; WNT PROTEIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; BONE REMODELING; COMPETITIVE INHIBITION; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION; MACROPHAGE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOUSE; MYOBLAST; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL; UPREGULATION;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; MICE; OSTEOCLASTS; OSTEOPROTEGERIN; STRESS, MECHANICAL; WNT PROTEINS;

EID: 77953501417     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.9     Document Type: Article

References (67)

1. Jakob F, Seefried L, Ebert R. [Pathophysiology of bone metabolism]. Internist (Berl). 2008;49:1159-1160 1162, 1164 passim.
2. Reid P, Holen I. Pathophysiological roles of osteoprotegerin (OPG). Eur J Cell Biol. 2009;88:1-17.
3. Baldock PA, Thomas GP, Hodge JM, et al. Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast. J Bone Miner Res. 2006;21:1618-1626.
4. Zallone A. Direct and indirect estrogen actions on osteoblasts and osteoclasts. Ann N Y Acad Sci. 2006;1068:173-179. (Pubitemid 43824147)
5. Silvestrini G, Ballanti P, Leopizzi M, et al. Effects of the administration of corticosterone, parathyroid hormone, or both, and of their withdrawal, on rat bone and cartilage histomorphometric parameters, and on osteoprotegerin and RANKL mRNA expression and proteins. J Mol Histol. 2007;38:215-226. (Pubitemid 46980555)
6. Kreja L, Liedert A, Hasni S, Claes L, Ignatius A. Mechanical regulation of osteoclastic genes in human osteoblasts. Biochem Biophys Res Commun. 2008;368:582-7.
7. Kim CH, You L, Yellowley CE, Jacobs CR. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone. 2006;39:1043-7. (Pubitemid 44528376)
8. Kanzaki H, Chiba M, Sato A, et al. Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction. J Dent Res. 2006;85:457-62. (Pubitemid 43799265)
9. Saunders MM, Taylor AF, Du C, Zhou Z, Pellegrini VD Jr, Donahue HJ. Mechanical stimulation effects on functional end effectors in osteoblastic MG-63 cells. J Biomech. 2006;39:1419-27.
10. Lin JM, Callon KE, Lin CQ, et al. Alteration of bone cell function by RANKL and OPG in different in vitro models. Eur J Clin Invest. 2007;37:407-15.
11. De Toni EN, Thieme SE, Herbst A, et al. OPG is regulated by β-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer. Clin Cancer Res. 2008;14:4713-8.
12. Bu G, Lu W, Liu CC, et al. Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. Int J Cancer. 2008;123:1034-42.
13. Ling L, Nurcombe V, Cool SM. Wnt signaling controls the fate of mesenchymal stem cells. Gene. 2009;433:1-7.
14. Clevers H. 2006Wnt/β-catenin signaling in development and disease. Cell. 127:469-80.
15. Baron R, Rawadi G. Targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology. 2007;148:2635-43. (Pubitemid 46984775)
16. Gregory CA, Green A, Lee N, Rao A, Gunn W. The promise of canonical Wnt signaling modulators in enhancing bone repair. Drug News Perspect. 2006;19:445-52. (Pubitemid 46050818)
17. Glass DA 2nd, Bialek P, Ahn JD, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005;8:751-64. (Pubitemid 40585297)
18. Daoussis D, Andonopoulos AP, Liossis SN. Wnt Pathway and IL-17: Novel Regulators of Joint Remodeling in Rheumatic Diseases. Looking Beyond the RANK-RANKL-OPG Axis. Semin Arthritis Rheum. 2008.
19. Holmen SL, Zylstra CR, Mukherjee A, et al. Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem. 2005;280:21162-8. (Pubitemid 40805677)
20. Boland GM, Perkins G, Hall DJ, Tuan RS. Wnt3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem. 2004;93:1210-30. (Pubitemid 44264134)
21. Nakashima A, Katagiri T, Tamura M. Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts. J Biol Chem. 2005;280:37660-8.
22. Sato MM, Nakashima A, Nashimoto M, Yawaka Y, Tamura M. Bone morphogenetic protein-2 enhances Wnt/β-catenin signaling-induced osteoprotegerin expression. Genes Cells. 2009;14:141-53.
23. Bennett CN, Longo KA, Wright WS, et al. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci USA. 2005;102:3324-9.
24. Sheldahl LC, Park M, Malbon CC, Moon RT. Protein kinase C is differentially stimulated by Wnt and Frizzled homologues in a Gprotein-dependent manner. Curr Biol. 1999;9:695-8. (Pubitemid 29332351)
25. Zhong N, Gersch RP, Hadjiargyrou M. Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Bone. 2006;39:5-16.
26. Etheridge SL, Spencer GJ, Heath DJ, Genever PG. Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells. Stem Cells. 2004;22:849-60.
27. Lu W, Yamamoto V, Ortega B, Baltimore D. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 2004;119:97-108.
28. Liu F, Kohlmeier S, Wang CY. Wnt signaling and skeletal development. Cell Signal. 2008;20:999-1009.
29. Oishi I, Suzuki H, Onishi N, et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells. 2003;8:645-54.
30. 2-terminal kinase (JNK) prevents nuclear β-catenin accumulation and regulates axis formation in Xenopus embryos. Proc Natl Acad Sci U S A. 2006;103:16313-8.
31. Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol. 2003;13:680-5. (Pubitemid 36453318)
32. Kohn AD, Moon RT. Wnt and calcium signaling: β-catenin-independent pathways. Cell Calcium. 2005;38:439-46.
33. Anakwe K, Robson L, Hadley J, et al. Wnt signalling regulates myogenic differentiation in the developing avian wing. Development. 2003;130:3503-14. (Pubitemid 37010013)
34. Ishitani T, Ninomiya-Tsuji J, Matsumoto K. Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/betacatenin signaling. Mol Cell Biol. 2003;23:1379-89. (Pubitemid 36177046)
35. 2+ pathway to antagonize Wnt/β-catenin signaling. Mol Cell Biol. 2003;23:131-9.
36. Saneyoshi T, Kume S, Amasaki Y, Mikoshiba K. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature. 2002;417:295-9. (Pubitemid 34534712)
37. Snow-Harter C, Bouxsein ML, Lewis BT, Carter DR, Marcus R. Effects of resistance and endurance exercise on bone mineral status of young women: a randomized exercise intervention trial. J Bone Miner Res. 1992;7:761-9.
38. Dhamrait SS, James L, Brull DJ, et al. Cortical bone resorption during exercise is interleukin-6 genotype-dependent. Eur J Appl Physiol. 2003;89:21-5. (Pubitemid 36748710)
39. Kesavan C, Mohan S, Oberholtzer S, Wergedal JE, Baylink DJ. Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains. J Appl Physiol. 2005;99:1951-7. (Pubitemid 41547196)
40. Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ. Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density. Bone. 2005;36:111-22.
41. Kesavan C, Mohan S, Srivastava AK, et al. Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross. Bone. 2006;39:634-43. (Pubitemid 44149279)
42. Robling AG, Li J, Shultz KL, Beamer WG, Turner CH. Evidence for a skeletal mechanosensitivity gene on mouse chromosome 4. FASEB J. 2003;17:324-6.
43. Armstrong VJ, Muzylak M, Sunters A, et al. 2007Wnt/β-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem. 282:20715-27.
44. Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, et al. 2006Wnt/β-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem. 281:31720-8.
45. Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res. 2005;20:1103-13. (Pubitemid 40863798)
46. Robling AG, Niziolek PJ, Baldridge LA, et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem. 2008;283:5866-75.
47. Kuo CK, Tuan RS. Mechanoactive tenogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A. 2008;14:1615-27.
48. Liu J, Zou L, Wang J, et al. Hydrostatic pressure promotes Wnt10b and Wnt4 expression dependent and independent on ERK signaling in early-osteoinduced MSCs. Biochem Biophys Res Commun. 2009;379:505-9.
49. Yamaguchi A. Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-β superfamily. Semin Cell Biol. 1995;6:165-73.
50. Takada I, Mihara M, Suzawa M, et al. A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation. Nat Cell Biol. 2007;9:1273-85.
51. Wawrzak D, Metioui M, Willems E, Hendrickx M, de Genst E, Leyns L. Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun. 357: 2007; 1119-23.
52. Chung YS, Baylink DJ, Srivastava AK, et al. Effects of secreted Frizzled-related protein 3 on osteoblasts in vitro. J Bone Miner Res. 2004;19:1395-402.
53. Zhao B, Katagiri T, Toyoda H, et al. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J Biol Chem. 2006;281:23246-53.
54. Chien S. Mechanotransduction and endothelial cell homeostasis: the wisdomof the cell. AmJ Physiol Heart Circ Physiol. 2007;292:H1209-24.
55. Lin K, Hsu PP, Chen BP, et al. Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A. 2000;97:9385-9.
56. Lee WC, Maul TM, Vorp DA, Rubin JP, Marra KG. Effects of uniaxial cyclic strain on adipose-derived stem cell morphology, proliferation, and differentiation. Biomech Model Mechanobiol. 2007;6:265-73.
57. Case N, Ma M, Sen B, Xie Z, Gross TS, Rubin J. Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem. 2008;283:29196-205.
58. Akimoto T, Ushida T, Miyaki S, et al. Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling. Biochem Biophys Res Commun. 2005;329:381-5.
59. Fili S, Karalaki M, Schaller B. Mechanism of bone metastasis: the role of osteoprotegerin and of the host-tissue microenvironment-related survival factors. Cancer Lett. 2009.
60. Holen I, Shipman CM. Role of osteoprotegerin (OPG) in cancer. Clin Sci (Lond). 2006;110:279-91.
61. Herman S, Kronke G, Schett G. Molecular mechanisms of inflammatory bone damage: emerging targets for therapy. Trends Mol Med. 2008;14:245-53.
62. Kotake S, Udagawa N, Takahashi N, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 1999;103:1345-52.
63. Kim KJ, Kotake S, Udagawa N, et al. Osteoprotegerin inhibits in vitro mouse osteoclast formation induced by joint fluid from failed total hip arthroplasty. J Biomed Mater Res. 2001;58:393-400. (Pubitemid 32643187)
64. Arnsdorf EJ, Tummala P, Jacobs CR. Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS One. 2009;4:e5388.
65. Han Y, Cowin SC, Schaffler MB, Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci U S A. 2004;101:16689-94. (Pubitemid 39557774)
66. Wang Y, McNamara LM, Schaffler MB, Weinbaum S. Strain amplification and integrin based signaling in osteocytes. J Musculoskelet Neuronal Interact. 2008;8:332-4.
67. Nicolella DP, Moravits DE, Gale AM, Bonewald LF, Lankford J. Osteocyte lacunae tissue strain in cortical bone. J Biomech. 2006;39:1735-43. (Pubitemid 43817023)