Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

Journal of Clinical Investigation

Volumn 123, Issue 3, 2013, Pages 1096-1108

  Zhou, Yong ^a   Huang, Xiangwei ^a   Hecker, Louise ^a   Kurundkar, Deepali ^a   Kurundkar, Ashish ^a   Liu, Hui ^a   Jin, Tong Huan ^a   Desai, Leena ^a   Bernard, Karen ^a   Thannickal, Victor J ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYTOCHROME C; F ACTIN; FASUDIL; G ACTIN; MESSENGER RNA; PROTEIN BCL 2; RHO KINASE;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVATION; EX VIVO STUDY; FEMALE; FIBROSING ALVEOLITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LUNG INJURY; MECHANOTRANSDUCTION; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ACTIN CYTOSKELETON; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; DOWN-REGULATION; EXTRACELLULAR MATRIX; FEMALE; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; MYOFIBROBLASTS; ONCOGENE PROTEINS, FUSION; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-BCL-2; PULMONARY FIBROSIS; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84874609382     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI66700     Document Type: Article

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