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Volumn 34, Issue 8, 2013, Pages 1699-1707

HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1;

EID: 84881539307     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt209     Document Type: Review
Times cited : (146)

References (146)
  • 1
    • 0037076385 scopus 로고    scopus 로고
    • Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
    • Jögi, A. et al. (2002) Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc. Natl Acad. Sci. USA, 99, 7021-7026.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 7021-7026
    • Jögi, A.1
  • 2
    • 38949163338 scopus 로고    scopus 로고
    • Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis
    • Zou, L., et al. (2008) Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis. FASEB J., 22, 355-364.
    • (2008) FASEB J. , vol.22 , pp. 355-364
    • Zou, L.1
  • 3
    • 32944457064 scopus 로고    scopus 로고
    • Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation
    • Awale, S., et al. (2006) Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res., 66, 1751-1757.
    • (2006) Cancer Res. , vol.66 , pp. 1751-1757
    • Awale, S.1
  • 4
    • 34547134517 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
    • Land, S.C., et al. (2007) Hypoxia-inducible factor 1 alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J. Biol. Chem., 282, 20534-20543.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20534-20543
    • Land, S.C.1
  • 5
    • 24744444711 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke
    • Mu, D., et al. (2005) Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke. Exp. Neurol., 195, 407-415.
    • (2005) Exp. Neurol. , vol.195 , pp. 407-415
    • Mu, D.1
  • 6
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G.L., et al. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem., 269, 23757-23763.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.L.1
  • 7
    • 70349570410 scopus 로고    scopus 로고
    • HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms
    • Marín-Hernández, A., et al. (2009) HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms. Mini Rev. Med. Chem., 9, 1084-1101.
    • (2009) Mini Rev. Med. Chem. , vol.9 , pp. 1084-1101
    • Marín-Hernández, A.1
  • 8
    • 79958191830 scopus 로고    scopus 로고
    • Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways
    • Rohwer, N., et al. (2011) Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist. Updat., 14, 191-201.
    • (2011) Drug Resist. Updat. , vol.14 , pp. 191-201
    • Rohwer, N.1
  • 9
    • 69049083600 scopus 로고    scopus 로고
    • Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression
    • Lara, P.C., et al. (2009) Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression. Radiat. Oncol., 4, 29.
    • (2009) Radiat. Oncol. , vol.4 , pp. 29
    • Lara, P.C.1
  • 10
    • 33747366672 scopus 로고    scopus 로고
    • Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment
    • Bracken, C.P., et al. (2006) Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J. Biol. Chem., 281, 22575-22585.
    • (2006) J. Biol. Chem. , vol.281 , pp. 22575-22585
    • Bracken, C.P.1
  • 11
    • 0038282482 scopus 로고    scopus 로고
    • The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
    • Unruh, A., et al. (2003) The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene, 22, 3213-3220.
    • (2003) Oncogene , vol.22 , pp. 3213-3220
    • Unruh, A.1
  • 12
    • 84863062001 scopus 로고    scopus 로고
    • Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1a
    • Schilling, D., et al. (2012) Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1a. PLoS One, 7, e31110.
    • (2012) PLoS One , vol.7
    • Schilling, D.1
  • 13
    • 84862667418 scopus 로고    scopus 로고
    • Basal HIF-1a expression levels are not predictive for radiosensitivity of human cancer cell lines
    • Schilling, D., et al.. (2012) Basal HIF-1a expression levels are not predictive for radiosensitivity of human cancer cell lines. Strahlenther. Onkol., 188, 353-358.
    • (2012) Strahlenther. Onkol. , vol.188 , pp. 353-358
    • Schilling, D.1    et, al..2
  • 14
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst, M.W., et al. (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat. Rev. Cancer, 8, 425-437.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1
  • 15
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases
    • Zhong, H., et al. (1999) Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. Cancer Res., 59, 5830-5835.
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1
  • 16
    • 72949100977 scopus 로고    scopus 로고
    • Prognostic significance of hypoxia-inducible factor- 1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer
    • Hung, J.J., et al. (2009) Prognostic significance of hypoxia-inducible factor- 1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer. Thorax, 64, 1082-1089.
    • (2009) Thorax , vol.64 , pp. 1082-1089
    • Hung, J.J.1
  • 17
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
    • Berra, E., et al. (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J., 22, 4082-4090.
    • (2003) EMBO J. , vol.22 , pp. 4082-4090
    • Berra, E.1
  • 18
    • 12644279862 scopus 로고    scopus 로고
    • Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system
    • Zhou, Y.D., et al. (1997) Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc. Natl Acad. Sci. USA, 94, 713-718.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 713-718
    • Zhou, Y.D.1
  • 19
    • 11144337759 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators
    • Déry, M.A., et al. (2005) Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int. J. Biochem. Cell Biol., 37, 535-540.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 535-540
    • Déry, M.A.1
  • 20
    • 78349272461 scopus 로고    scopus 로고
    • HIF-1 and HIF-2 transcription factors-similar but not identical
    • Loboda, A., et al. (2010) HIF-1 and HIF-2 transcription factors-similar but not identical. Mol. Cells, 29, 435-442.
    • (2010) Mol. Cells , vol.29 , pp. 435-442
    • Loboda, A.1
  • 21
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan, J.D., et al. (2007) HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell, 11, 335-347.
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1
  • 22
    • 73849137521 scopus 로고    scopus 로고
    • On the mechanism of iron sensing by IRP2: new players, new paradigms
    • Takahashi-Makise, N., et al.. (2009) On the mechanism of iron sensing by IRP2: new players, new paradigms. Nat. Chem. Biol., 5, 874-875.
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 874-875
    • Takahashi-Makise, N.1    et, al..2
  • 23
    • 33645735151 scopus 로고    scopus 로고
    • The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha
    • Dayan, F., et al. (2006) The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha. Cancer Res., 66, 3688-3698.
    • (2006) Cancer Res. , vol.66 , pp. 3688-3698
    • Dayan, F.1
  • 24
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1alpha promotes metastasis
    • Yang, M.H., et al. (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat. Cell Biol., 10, 295-305.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 295-305
    • Yang, M.H.1
  • 25
    • 79251478772 scopus 로고    scopus 로고
    • Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility
    • Astuti, D., et al. (2011) Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocr. Relat. Cancer, 18, 73-83.
    • (2011) Endocr. Relat. Cancer , vol.18 , pp. 73-83
    • Astuti, D.1
  • 26
    • 0035812318 scopus 로고    scopus 로고
    • Characterization and comparative analysis of the EGLN gene family
    • Taylor, M.S. (2001) Characterization and comparative analysis of the EGLN gene family. Gene, 275, 125-132.
    • (2001) Gene , vol.275 , pp. 125-132
    • Taylor, M.S.1
  • 27
    • 4644259153 scopus 로고    scopus 로고
    • Cellular oxygen sensing need in CNS function: physiological and pathological implications
    • Acker, T., et al. (2004) Cellular oxygen sensing need in CNS function: physiological and pathological implications. J. Exp. Biol., 207(Pt 18), 3171-3188.
    • (2004) J. Exp. Biol. , vol.207 , Issue.PT 18 , pp. 3171-3188
    • Acker, T.1
  • 28
    • 55349111498 scopus 로고    scopus 로고
    • Expression, purification and characterization of human PHD1 in Escherichia coli
    • Li, X.Y., et al. (2008) Expression, purification and characterization of human PHD1 in Escherichia coli. J. Biochem., 144, 555-561.
    • (2008) J. Biochem. , vol.144 , pp. 555-561
    • Li, X.Y.1
  • 29
    • 4644318828 scopus 로고    scopus 로고
    • Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    • Appelhoff, R.J., et al. (2004) Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem., 279, 38458-38465.
    • (2004) J. Biol. Chem. , vol.279 , pp. 38458-38465
    • Appelhoff, R.J.1
  • 30
    • 2342644926 scopus 로고    scopus 로고
    • Oxygen sensing by HIF hydroxylases
    • Schofield, C.J., et al. (2004) Oxygen sensing by HIF hydroxylases. Nat. Rev. Mol. Cell Biol., 5, 343-354.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 343-354
    • Schofield, C.J.1
  • 31
    • 75149165633 scopus 로고    scopus 로고
    • Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors
    • Henze, A.T., et al. (2010) Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res., 70, 357-366.
    • (2010) Cancer Res. , vol.70 , pp. 357-366
    • Henze, A.T.1
  • 32
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein, A.C., et al. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell, 107, 43-54.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1
  • 33
    • 18844408840 scopus 로고    scopus 로고
    • Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element
    • Metzen, E., et al. (2005) Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Biochem. J., 387(Pt 3), 711-717.
    • (2005) Biochem. J. , vol.387 , Issue.PT 3 , pp. 711-717
    • Metzen, E.1
  • 34
    • 33750976389 scopus 로고    scopus 로고
    • Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2
    • Takeda, K., et al. (2006) Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol. Cell. Biol., 26, 8336-8346.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 8336-8346
    • Takeda, K.1
  • 35
    • 40349098553 scopus 로고    scopus 로고
    • Cytoplasmic location of factor-inhibiting hypoxiainducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer
    • Tan, E.Y., et al. (2007) Cytoplasmic location of factor-inhibiting hypoxiainducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer. Breast Cancer Res., 9, R89.
    • (2007) Breast Cancer Res. , vol.9
    • Tan, E.Y.1
  • 36
    • 22144493866 scopus 로고    scopus 로고
    • Negative and positive regulation of HIF-1: a complex network
    • Bárdos, J.I., et al. (2005) Negative and positive regulation of HIF-1: a complex network. Biochim. Biophys. Acta., 1755, 107-120.
    • (2005) Biochim. Biophys. Acta. , vol.1755 , pp. 107-120
    • Bárdos, J.I.1
  • 37
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando, D., et al. (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev., 16, 1466-1471.
    • (2002) Genes Dev. , vol.16 , pp. 1466-1471
    • Lando, D.1
  • 38
    • 77955284188 scopus 로고    scopus 로고
    • The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
    • Zhang, N., et al. (2010) The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab., 11, 364-378.
    • (2010) Cell Metab. , vol.11 , pp. 364-378
    • Zhang, N.1
  • 40
    • 77958553885 scopus 로고    scopus 로고
    • Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification
    • Cai, Q., et al. (2010) Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS One, 5, e9720.
    • (2010) PLoS One , vol.5
    • Cai, Q.1
  • 41
    • 0034214361 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor targets to mitochondria
    • Shiao, Y.H., et al. (2000) The von Hippel-Lindau tumor suppressor targets to mitochondria. Cancer Res., 60, 2816-2819.
    • (2000) Cancer Res. , vol.60 , pp. 2816-2819
    • Shiao, Y.H.1
  • 42
    • 48649098334 scopus 로고    scopus 로고
    • pVHL: a multipurpose adaptor protein
    • Frew, I.J., et al. (2008) pVHL: a multipurpose adaptor protein. Sci. Signal., 1, pe30.
    • (2008) Sci. Signal. , vol.1
    • Frew, I.J.1
  • 43
    • 0035899491 scopus 로고    scopus 로고
    • The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma
    • Clifford, S.C., et al. (2001) The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma. Oncogene, 20, 5067-5074.
    • (2001) Oncogene , vol.20 , pp. 5067-5074
    • Clifford, S.C.1
  • 44
    • 22244440847 scopus 로고    scopus 로고
    • Proline hydroxylation and gene expression
    • Kaelin, W.G. (2005) Proline hydroxylation and gene expression. Annu. Rev. Biochem., 74, 115-128.
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 115-128
    • Kaelin, W.G.1
  • 45
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin G. Jr (2002) Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer, 2, 673-682.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 673-682
    • Kaelin Jr., W.G.1
  • 46
    • 45749145804 scopus 로고    scopus 로고
    • Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene
    • Wu, S., et al. (2008) Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol. Ther., 16, 1227-1234.
    • (2008) Mol. Ther. , vol.16 , pp. 1227-1234
    • Wu, S.1
  • 47
    • 0029090338 scopus 로고
    • Tumour suppression by the human von Hippel- Lindau gene product
    • Iliopoulos, O., et al. (1995) Tumour suppression by the human von Hippel- Lindau gene product. Nat. Med., 1, 822-826.
    • (1995) Nat. Med. , vol.1 , pp. 822-826
    • Iliopoulos, O.1
  • 48
    • 35548935098 scopus 로고    scopus 로고
    • SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
    • Cheng, J., et al. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell, 131, 584-595.
    • (2007) Cell , vol.131 , pp. 584-595
    • Cheng, J.1
  • 49
    • 34247553146 scopus 로고    scopus 로고
    • Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
    • MacKenzie, E.D., et al. (2007) Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol., 27, 3282-3289.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3282-3289
    • MacKenzie, E.D.1
  • 50
    • 77749270530 scopus 로고    scopus 로고
    • Mutations of the metabolic genes IDH1, IDH2, and SDHAF2 are not major determinants of the pseudohypoxic phenotype of sporadic pheochromocytomas and paragangliomas
    • Yao, L., et al. (2010) Mutations of the metabolic genes IDH1, IDH2, and SDHAF2 are not major determinants of the pseudohypoxic phenotype of sporadic pheochromocytomas and paragangliomas. J. Clin. Endocrinol. Metab., 95, 1469-1472.
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 1469-1472
    • Yao, L.1
  • 51
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim, W.Y., et al. (2004) Role of VHL gene mutation in human cancer. J. Clin. Oncol., 22, 4991-5004.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4991-5004
    • Kim, W.Y.1
  • 52
    • 77449100681 scopus 로고    scopus 로고
    • Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum
    • Schlisio, S. (2009) Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum. J. Cell. Mol. Med., 13, 4104-4112.
    • (2009) J. Cell. Mol. Med. , vol.13 , pp. 4104-4112
    • Schlisio, S.1
  • 53
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Lu, H., et al. (2002) Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J. Biol. Chem., 277, 23111-23115.
    • (2002) J. Biol. Chem. , vol.277 , pp. 23111-23115
    • Lu, H.1
  • 54
    • 78649404935 scopus 로고    scopus 로고
    • Research resource: transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas
    • López-Jiménez, E., et al. (2010) Research resource: transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas. Mol. Endocrinol., 24, 2382-2391.
    • (2010) Mol. Endocrinol. , vol.24 , pp. 2382-2391
    • López-Jiménez, E.1
  • 55
    • 27744606274 scopus 로고    scopus 로고
    • Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions
    • Brière, J.J., et al. (2005) Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions. Hum. Mol. Genet., 14, 3263-3269.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 3263-3269
    • Brière, J.J.1
  • 56
    • 19944433653 scopus 로고    scopus 로고
    • Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
    • Selak, M.A., et al. (2005) Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell, 7, 77-85.
    • (2005) Cancer Cell , vol.7 , pp. 77-85
    • Selak, M.A.1
  • 57
    • 26444570010 scopus 로고    scopus 로고
    • Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
    • Pollard, P.J., et al. (2005) Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum. Mol. Genet., 14, 2231-2239.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2231-2239
    • Pollard, P.J.1
  • 58
    • 79959977075 scopus 로고    scopus 로고
    • Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors
    • Thirstrup, K., et al. (2011) Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors. Pharmacol. Res., 64, 268-273.
    • (2011) Pharmacol. Res. , vol.64 , pp. 268-273
    • Thirstrup, K.1
  • 59
    • 0014622009 scopus 로고
    • The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells
    • Gumaa, K.A., et al. (1969) The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. Biochem. J., 115, 1009-1029.
    • (1969) Biochem. J. , vol.115 , pp. 1009-1029
    • Gumaa, K.A.1
  • 60
    • 33646266734 scopus 로고    scopus 로고
    • Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an overexpressed but strongly product-inhibited hexokinase
    • Marín-Hernández, A., et al. (2006) Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an overexpressed but strongly product-inhibited hexokinase. FEBS J., 273, 1975-1988.
    • (2006) FEBS J. , vol.273 , pp. 1975-1988
    • Marín-Hernández, A.1
  • 61
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    • Koivunen, P., et al. (2007) Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem., 282, 4524-4532.
    • (2007) J. Biol. Chem. , vol.282 , pp. 4524-4532
    • Koivunen, P.1
  • 62
    • 29644442625 scopus 로고    scopus 로고
    • Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
    • Lu, H., et al. (2005) Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J. Biol. Chem., 280, 41928-41939.
    • (2005) J. Biol. Chem. , vol.280 , pp. 41928-41939
    • Lu, H.1
  • 63
    • 0017697003 scopus 로고
    • Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates
    • Tuderman, L., et al. (1977) Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates. Eur. J. Biochem., 80, 341-348.
    • (1977) Eur. J. Biochem. , vol.80 , pp. 341-348
    • Tuderman, L.1
  • 64
    • 34547096729 scopus 로고    scopus 로고
    • Genetics of phaeochromocytoma
    • Maher, E.R. (2006) Genetics of phaeochromocytoma. Br. Med. Bull., 79-80, 141-151.
    • (2006) Br. Med. Bull. , vol.79-80 , pp. 141-151
    • Maher, E.R.1
  • 65
    • 0043234538 scopus 로고    scopus 로고
    • Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
    • Hirsilä,M., et al. (2003) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem., 278, 30772-30780.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30772-30780
    • Hirsilä, M.1
  • 66
    • 0017742181 scopus 로고
    • Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence
    • Myllylä,R., et al. (1977) Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence. Eur. J. Biochem., 80, 349-357.
    • (1977) Eur. J. Biochem. , vol.80 , pp. 349-357
    • Myllylä, R.1
  • 67
    • 77956503391 scopus 로고    scopus 로고
    • Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
    • O'Flaherty, L., et al. (2010) Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Hum. Mol. Genet., 19, 3844-3851.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3844-3851
    • O'Flaherty, L.1
  • 68
    • 18544365098 scopus 로고    scopus 로고
    • Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas
    • Barker, K.T., et al. (2002) Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas. Br. J. Cancer, 87, 446-448.
    • (2002) Br. J. Cancer , vol.87 , pp. 446-448
    • Barker, K.T.1
  • 69
    • 0037102441 scopus 로고    scopus 로고
    • Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families
    • Kiuru, M., et al. (2002) Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families. Cancer Res., 62, 4554-4557.
    • (2002) Cancer Res. , vol.62 , pp. 4554-4557
    • Kiuru, M.1
  • 70
    • 77950553262 scopus 로고    scopus 로고
    • Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response
    • Yogev, O., et al. (2010) Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. PLoS Biol., 8, e1000328.
    • (2010) PLoS Biol. , vol.8
    • Yogev, O.1
  • 71
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    • Zhao, S., et al. (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science, 324, 261-265.
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1
  • 72
    • 69549088424 scopus 로고    scopus 로고
    • SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma
    • Hao, H.X., et al. (2009) SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science, 325, 1139-1142.
    • (2009) Science , vol.325 , pp. 1139-1142
    • Hao, H.X.1
  • 73
    • 77952263737 scopus 로고    scopus 로고
    • The genetic basis of kidney cancer: a metabolic disease
    • Linehan, W.M., et al. (2010) The genetic basis of kidney cancer: a metabolic disease. Nat. Rev. Urol., 7, 277-285.
    • (2010) Nat. Rev. Urol. , vol.7 , pp. 277-285
    • Linehan, W.M.1
  • 74
    • 33746398489 scopus 로고    scopus 로고
    • Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
    • Smith, T.G., et al. (2006) Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med., 3, e290.
    • (2006) PLoS Med. , vol.3
    • Smith, T.G.1
  • 75
    • 77955370669 scopus 로고    scopus 로고
    • Effects of HIF-1alpha and HIF2alpha on growth and metabolism of clear-cell renal cell carcinoma 786-0 xenografts
    • Biswas, S., et al. (2010) Effects of HIF-1alpha and HIF2alpha on growth and metabolism of clear-cell renal cell carcinoma 786-0 xenografts. J. Oncol., 2010, 757908.
    • (2010) J. Oncol. , vol.2010 , pp. 757908
    • Biswas, S.1
  • 76
    • 0023718383 scopus 로고
    • Pathways of succinate formation and their contribution to improvement of cardiac function in the hypoxic rat heart
    • Wiesner, R.J., et al. (1988) Pathways of succinate formation and their contribution to improvement of cardiac function in the hypoxic rat heart. Biochem. Med. Metab. Biol., 40, 19-34.
    • (1988) Biochem. Med. Metab. Biol. , vol.40 , pp. 19-34
    • Wiesner, R.J.1
  • 77
    • 77951432631 scopus 로고    scopus 로고
    • The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation-why mitochondria are targets for cancer therapy
    • Ralph, S.J., et al. (2010) The causes of cancer revisited: et al."mitochondrial malignancy" and ROS-induced oncogenic transformation-why mitochondria are targets for cancer therapy. Mol. Aspects Med., 31, 145-170.
    • (2010) Mol. Aspects Med. , vol.31 , pp. 145-170
    • Ralph, S.J.1
  • 78
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
    • Semenza, G.L. (2012) Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol. Sci., 33, 207-214.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 79
    • 80052755020 scopus 로고    scopus 로고
    • Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress
    • Ito, K., et al. (2011) Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress. Angiogenesis, 14, 293-307.
    • (2011) Angiogenesis , vol.14 , pp. 293-307
    • Ito, K.1
  • 80
    • 0037662638 scopus 로고    scopus 로고
    • Effects of hyperoxia on VEGF, its receptors, and HIF-2alpha in the newborn rat lung
    • Hosford, G.E., et al. (2003) Effects of hyperoxia on VEGF, its receptors, and HIF-2alpha in the newborn rat lung. Am. J. Physiol. Lung Cell. Mol. Physiol., 285, L161-L168.
    • (2003) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.285
    • Hosford, G.E.1
  • 81
    • 67651098992 scopus 로고    scopus 로고
    • Endothelial deletion of hypoxia-inducible factor- 2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis
    • Skuli, N., et al. (2009) Endothelial deletion of hypoxia-inducible factor- 2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood, 114, 469-477.
    • (2009) Blood , vol.114 , pp. 469-477
    • Skuli, N.1
  • 82
    • 79957440998 scopus 로고    scopus 로고
    • The hypoxia-associated factor switches cells from HIF-1a- to HIF-2a-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
    • Koh, M.Y., et al. (2011) The hypoxia-associated factor switches cells from HIF-1a- to HIF-2a-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res., 71, 4015-4027.
    • (2011) Cancer Res. , vol.71 , pp. 4015-4027
    • Koh, M.Y.1
  • 83
    • 77956187907 scopus 로고    scopus 로고
    • Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma
    • Rodríguez-Enríquez, S., et al. (2010) Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma. Int. J. Biochem. Cell Biol., 42, 1744-1751.
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 1744-1751
    • Rodríguez-Enríquez, S.1
  • 84
    • 0031226737 scopus 로고    scopus 로고
    • Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line
    • Chu, Y.W., et al. (1997) Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am. J. Respir. Cell Mol. Biol., 17, 353-360.
    • (1997) Am. J. Respir. Cell Mol. Biol. , vol.17 , pp. 353-360
    • Chu, Y.W.1
  • 85
    • 78149243774 scopus 로고    scopus 로고
    • Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation
    • Louie, E., et al. (2010) Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation. Breast Cancer Res., 12, R94.
    • (2010) Breast Cancer Res. , vol.12
    • Louie, E.1
  • 86
    • 77952490843 scopus 로고    scopus 로고
    • Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells
    • Cho, K.B., et al. (2010) Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells. Cancer Lett., 293, 230-239.
    • (2010) Cancer Lett. , vol.293 , pp. 230-239
    • Cho, K.B.1
  • 87
    • 79952770168 scopus 로고    scopus 로고
    • MYC and metastasis
    • Wolfer, A., et al. (2011) MYC and metastasis. Cancer Res., 71, 2034-2037.
    • (2011) Cancer Res. , vol.71 , pp. 2034-2037
    • Wolfer, A.1
  • 88
    • 61849135453 scopus 로고    scopus 로고
    • Tumor suppressors and cell metabolism: a recipe for cancer growth
    • Jones, R.G., et al. (2009) Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev., 23, 537-548.
    • (2009) Genes Dev. , vol.23 , pp. 537-548
    • Jones, R.G.1
  • 89
    • 33744457297 scopus 로고    scopus 로고
    • HIF-1: hypoxia-inducible factor or dysoxiainducible factor?
    • López-Lázaro, M. (2006) HIF-1: hypoxia-inducible factor or dysoxiainducible factor?. FASEB J., 20, 828-832.
    • (2006) FASEB J. , vol.20 , pp. 828-832
    • López-Lázaro, M.1
  • 90
    • 84870461608 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in oxygen sensing by the carotid body
    • Nurse, C.A., et al.. (eds) Springer, The Netherlands
    • Semenza, G., et al.. (2012) The role of hypoxia-inducible factors in oxygen sensing by the carotid body. In Nurse, C.A., et al.. (eds) Arterial Chemoreception. Springer, The Netherlands, pp. 1-5.
    • (2012) Arterial Chemoreception , pp. 1-5
    • Semenza, G.1    et, al..2
  • 91
    • 79960024581 scopus 로고    scopus 로고
    • Reciprocal influence of the p53 and the hypoxic pathways
    • Sermeus, A., et al. (2011) Reciprocal influence of the p53 and the hypoxic pathways. Cell Death Dis., 2, e164.
    • (2011) Cell Death Dis. , vol.2
    • Sermeus, A.1
  • 92
    • 0036285034 scopus 로고    scopus 로고
    • c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogeneinduced genetic instability
    • Vafa, O., et al. (2002) c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogeneinduced genetic instability. Mol. Cell, 9, 1031-1044.
    • (2002) Mol. Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1
  • 93
    • 84865036227 scopus 로고    scopus 로고
    • Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death
    • Castells, M., et al. (2012) Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. Int. J. Mol. Sci., 13, 9545-9571.
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 9545-9571
    • Castells, M.1
  • 94
    • 0022002156 scopus 로고
    • Migration of tumor cells to organ-derived chemoattractants
    • Hujanen, E.S., et al. (1985) Migration of tumor cells to organ-derived chemoattractants. Cancer Res., 45, 3517-3521.
    • (1985) Cancer Res. , vol.45 , pp. 3517-3521
    • Hujanen, E.S.1
  • 95
    • 79954579633 scopus 로고    scopus 로고
    • EMT: a new vision of hypoxia promoting cancer progression
    • Jiang, J., et al. (2011) EMT: a new vision of hypoxia promoting cancer progression. Cancer Biol. Ther., 11, 714-723.
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 714-723
    • Jiang, J.1
  • 96
    • 84877157115 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling enhances hypoxiainduced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1a signaling
    • Zhang, Q., et al. (2011) Wnt/β-catenin signaling enhances hypoxiainduced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1a signaling. Carcinogenesis, 34, 962-973.
    • (2011) Carcinogenesis , vol.34 , pp. 962-973
    • Zhang, Q.1
  • 97
    • 70449527638 scopus 로고    scopus 로고
    • Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer
    • Lundgren, K., et al. (2009) Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer. Br. J. Cancer, 101, 1769-1781.
    • (2009) Br. J. Cancer , vol.101 , pp. 1769-1781
    • Lundgren, K.1
  • 98
    • 0141760411 scopus 로고    scopus 로고
    • Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    • Imai, T., et al. (2003) Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am. J. Pathol., 163, 1437-1447.
    • (2003) Am. J. Pathol. , vol.163 , pp. 1437-1447
    • Imai, T.1
  • 99
    • 57349164238 scopus 로고    scopus 로고
    • Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells
    • Cannito, S., et al. (2008) Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis, 29, 2267-2278.
    • (2008) Carcinogenesis , vol.29 , pp. 2267-2278
    • Cannito, S.1
  • 100
    • 79959421475 scopus 로고    scopus 로고
    • HIF-1a mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression
    • Yoo, Y.G., et al. (2011) HIF-1a mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression. Sci. Signal., 4, pt4.
    • (2011) Sci. Signal. , vol.4
    • Yoo, Y.G.1
  • 101
    • 44049090235 scopus 로고    scopus 로고
    • Notch signaling mediates hypoxia-induced tumor cell migration and invasion
    • Sahlgren, C., et al. (2008) Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc. Natl Acad. Sci. USA, 105, 6392-6397.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 6392-6397
    • Sahlgren, C.1
  • 102
    • 34248193253 scopus 로고    scopus 로고
    • Immune surveillance of tumors
    • Swann, J.B., et al. (2007) Immune surveillance of tumors. J. Clin. Invest., 117, 1137-1146.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1137-1146
    • Swann, J.B.1
  • 103
    • 77957350018 scopus 로고    scopus 로고
    • Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
    • Doedens, A.L., et al. (2010) Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res., 70, 7465-7475.
    • (2010) Cancer Res. , vol.70 , pp. 7465-7475
    • Doedens, A.L.1
  • 104
    • 68249153389 scopus 로고    scopus 로고
    • Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin
    • Yang, M., et al. (2009) Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin. Immunology, 128(1 suppl.), e237-e249.
    • (2009) Immunology , vol.128 , Issue.1 SUPPL.
    • Yang, M.1
  • 105
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene, A., et al. (2011) Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature, 475, 226-230.
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1
  • 106
    • 10244222236 scopus 로고    scopus 로고
    • Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism
    • Eltzschig, H.K., et al. (2004) Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood, 104, 3986-3992.
    • (2004) Blood , vol.104 , pp. 3986-3992
    • Eltzschig, H.K.1
  • 107
    • 33748357735 scopus 로고    scopus 로고
    • A2A adenosine receptor protects tumors from antitumor T cells
    • Ohta, A., et al. (2006) A2A adenosine receptor protects tumors from antitumor T cells. Proc. Natl Acad. Sci. USA, 103, 13132-13137.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 13132-13137
    • Ohta, A.1
  • 108
    • 24044461733 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies
    • Lewis, C., et al. (2005) Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am. J. Pathol., 167, 627-635.
    • (2005) Am. J. Pathol. , vol.167 , pp. 627-635
    • Lewis, C.1
  • 109
    • 77951134669 scopus 로고    scopus 로고
    • Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?
    • Lee, C.T., et al. (2010) Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer? Int. J. Hyperthermia, 26, 232-246.
    • (2010) Int. J. Hyperthermia , vol.26 , pp. 232-246
    • Lee, C.T.1
  • 110
    • 33749512970 scopus 로고    scopus 로고
    • Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
    • Lukashev, D., et al. (2006) Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J. Immunol., 177, 4962-4965.
    • (2006) J. Immunol. , vol.177 , pp. 4962-4965
    • Lukashev, D.1
  • 111
    • 33144460217 scopus 로고    scopus 로고
    • Galectin-1: a link between tumor hypoxia and tumor immune privilege
    • Le, Q.T., et al. (2005) Galectin-1: a link between tumor hypoxia and tumor immune privilege. J. Clin. Oncol., 23, 8932-8941.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8932-8941
    • Le, Q.T.1
  • 112
    • 84867990611 scopus 로고    scopus 로고
    • Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment
    • Ito, K., et al. (2012) Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment. Cancer and Metastasis Rev., 31, 763-778.
    • (2012) Cancer and Metastasis Rev. , vol.31 , pp. 763-778
    • Ito, K.1
  • 113
    • 0030921103 scopus 로고    scopus 로고
    • c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
    • Shim, H., et al. (1997) c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl Acad. Sci. USA, 94, 6658-6663.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 6658-6663
    • Shim, H.1
  • 114
    • 0034326273 scopus 로고    scopus 로고
    • Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
    • Elson, D.A., et al. (2000) Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res., 60, 6189-6195.
    • (2000) Cancer Res. , vol.60 , pp. 6189-6195
    • Elson, D.A.1
  • 115
    • 79953827951 scopus 로고    scopus 로고
    • Suppression of T-cell responses by tumor metabolites
    • Singer, K., et al. (2011) Suppression of T-cell responses by tumor metabolites. Cancer Immunol. Immunother., 60, 425-431.
    • (2011) Cancer Immunol. Immunother. , vol.60 , pp. 425-431
    • Singer, K.1
  • 116
    • 33645560710 scopus 로고    scopus 로고
    • Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes
    • Castello, P.R., et al. (2006) Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes. Cell Metab., 3, 277-287.
    • (2006) Cell Metab. , vol.3 , pp. 277-287
    • Castello, P.R.1
  • 117
    • 80052426012 scopus 로고    scopus 로고
    • Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival
    • Frezza, C., et al. (2011) Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival. PLoS One, 6, e24411.
    • (2011) PLoS One , vol.6
    • Frezza, C.1
  • 118
    • 34247352844 scopus 로고    scopus 로고
    • Inhibitory effect of tumor cell-derived lactic acid on human T cells
    • Fischer, K., et al. (2007) Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood, 109, 3812-3819.
    • (2007) Blood , vol.109 , pp. 3812-3819
    • Fischer, K.1
  • 119
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • Fyles, A., et al. (2002) Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J. Clin. Oncol., 20, 680-687.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 680-687
    • Fyles, A.1
  • 120
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • Keith, B., et al. (2007) Hypoxia-inducible factors, stem cells, and cancer. Cell, 129, 465-472.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1
  • 121
    • 77649273107 scopus 로고    scopus 로고
    • Hypoxia inducible factors in cancer stem cells
    • Heddleston, J.M., et al. (2010) Hypoxia inducible factors in cancer stem cells. Br. J. Cancer, 102, 789-795.
    • (2010) Br. J. Cancer , vol.102 , pp. 789-795
    • Heddleston, J.M.1
  • 122
    • 84861466196 scopus 로고    scopus 로고
    • The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells
    • Liang, D., et al. (2012) The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells. BMC Cancer, 12, 201.
    • (2012) BMC Cancer , vol.12 , pp. 201
    • Liang, D.1
  • 123
    • 79959908506 scopus 로고    scopus 로고
    • HIF induces human embryonic stem cell markers in cancer cells
    • Mathieu, J., et al. (2011) HIF induces human embryonic stem cell markers in cancer cells. Cancer Res., 71, 4640-4652.
    • (2011) Cancer Res. , vol.71 , pp. 4640-4652
    • Mathieu, J.1
  • 124
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen, J., et al. (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 488, 522-526.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1
  • 125
    • 79955778894 scopus 로고    scopus 로고
    • Breast cancer stem cells: treatment resistance and therapeutic opportunities
    • Al-Ejeh, F., et al. (2011) Breast cancer stem cells: treatment resistance and therapeutic opportunities. Carcinogenesis, 32, 650-658.
    • (2011) Carcinogenesis , vol.32 , pp. 650-658
    • Al-Ejeh, F.1
  • 126
    • 68349133231 scopus 로고    scopus 로고
    • Hypoxic tumor microenvironment and cancer cell differentiation
    • Kim, Y., et al. (2009) Hypoxic tumor microenvironment and cancer cell differentiation. Curr. Mol. Med., 9, 425-434.
    • (2009) Curr. Mol. Med. , vol.9 , pp. 425-434
    • Kim, Y.1
  • 127
    • 84857186454 scopus 로고    scopus 로고
    • Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells
    • Bhaskara, V.K., et al. (2012) Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells. PLoS One, 7, e30905.
    • (2012) PLoS One , vol.7
    • Bhaskara, V.K.1
  • 128
    • 77955640829 scopus 로고    scopus 로고
    • Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells
    • Rizzino, A. (2009) Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells. Wiley Interdiscip. Rev. Syst. Biol. Med., 1, 228-236.
    • (2009) Wiley Interdiscip. Rev. Syst. Biol. Med. , vol.1 , pp. 228-236
    • Rizzino, A.1
  • 129
    • 77950794030 scopus 로고    scopus 로고
    • Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer
    • Peng, S., et al. (2010) Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. Oncogene, 29, 2153-2159.
    • (2010) Oncogene , vol.29 , pp. 2153-2159
    • Peng, S.1
  • 130
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath, I., et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet., 40, 499-507.
    • (2008) Nat. Genet. , vol.40 , pp. 499-507
    • Ben-Porath, I.1
  • 131
    • 84865429409 scopus 로고    scopus 로고
    • Passing the baton: the HIF switch
    • Koh, M.Y., et al. (2012) Passing the baton: the HIF switch. Trends Biochem. Sci., 37, 364-372.
    • (2012) Trends Biochem. Sci. , vol.37 , pp. 364-372
    • Koh, M.Y.1
  • 132
    • 84455174511 scopus 로고    scopus 로고
    • Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2
    • Iida, H., et al. (2012) Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2. Int. J. Oncol., 40, 71-79.
    • (2012) Int. J. Oncol. , vol.40 , pp. 71-79
    • Iida, H.1
  • 133
    • 75849160216 scopus 로고    scopus 로고
    • Human cancers converge at the HIF-2alpha oncogenic axis
    • Franovic, A., et al. (2009) Human cancers converge at the HIF-2alpha oncogenic axis. Proc. Natl Acad. Sci. USA, 106, 21306-21311.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 21306-21311
    • Franovic, A.1
  • 134
    • 34247537076 scopus 로고    scopus 로고
    • Hypoxia and metastasis
    • Chaudary, N., et al. (2007) Hypoxia and metastasis. Clin. Cancer Res., 13, 1947-1949.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1947-1949
    • Chaudary, N.1
  • 135
    • 33646464845 scopus 로고    scopus 로고
    • Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model
    • Hofmann, M., et al. (2006) Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model. Neoplasia, 8, 89-95.
    • (2006) Neoplasia , vol.8 , pp. 89-95
    • Hofmann, M.1
  • 136
    • 0042411985 scopus 로고    scopus 로고
    • Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
    • Shannon, A.M., et al. (2003) Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat. Rev., 29, 297-307.
    • (2003) Cancer Treat. Rev. , vol.29 , pp. 297-307
    • Shannon, A.M.1
  • 137
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow, R.G., et al. (2008) Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat. Rev. Cancer, 8, 180-192.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1
  • 138
    • 33845984533 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention
    • López-Lázaro, M. (2006) Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention. Cancer Epidemiol. Biomarkers Prev., 15, 2332-2335.
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 2332-2335
    • López-Lázaro, M.1
  • 139
    • 23244454418 scopus 로고    scopus 로고
    • New drugs target hypoxia response in tumors
    • Garber, K. (2005) New drugs target hypoxia response in tumors. J. Natl Cancer Inst., 97, 1112-1114.
    • (2005) J. Natl Cancer Inst. , vol.97 , pp. 1112-1114
    • Garber, K.1
  • 140
    • 82255167669 scopus 로고    scopus 로고
    • Targeting hypoxic tumour cells to overcome metastasis
    • Bennewith, K.L., et al. (2011) Targeting hypoxic tumour cells to overcome metastasis. BMC Cancer, 11, 504.
    • (2011) BMC Cancer , vol.11 , pp. 504
    • Bennewith, K.L.1
  • 141
    • 34447122556 scopus 로고    scopus 로고
    • Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104
    • Patterson, A.V., et al. (2007) Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin. Cancer Res., 13, 3922-3932.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3922-3932
    • Patterson, A.V.1
  • 142
    • 84881499668 scopus 로고    scopus 로고
    • FDA approves Proacta IND application for PR610. Pharmaceutical Business Review.(30 August 2012).
    • FDA approves Proacta IND application for PR610. Pharmaceutical Business Review. http://regulatoryaffairs.pharmaceutical-business-review. com/news/fda-approves-proacta-ind-application-for-pr610-300812 (30 August 2012).
  • 143
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson, W.R., et al. (2011) Targeting hypoxia in cancer therapy. Nat. Rev. Cancer, 11, 393-410.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1
  • 144
    • 84861860592 scopus 로고    scopus 로고
    • Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella typhimurium strain
    • Yu, B., et al. (2012) Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella typhimurium strain. Sci. Rep., 2, 436.
    • (2012) Sci. Rep. , vol.2 , pp. 436
    • Yu, B.1
  • 145
    • 53049087992 scopus 로고    scopus 로고
    • Bacterial therapies: completing the cancer treatment toolbox
    • St Jean, A.T., et al. (2008) Bacterial therapies: completing the cancer treatment toolbox. Curr. Opin. Biotechnol., 19, 511-517.
    • (2008) Curr. Opin. Biotechnol. , vol.19 , pp. 511-517
    • St Jean, A.T.1
  • 146
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1


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