-
1
-
-
0037076385
-
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
-
Jögi, A. et al. (2002) Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc. Natl Acad. Sci. USA, 99, 7021-7026.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 7021-7026
-
-
Jögi, A.1
-
2
-
-
38949163338
-
Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis
-
Zou, L., et al. (2008) Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis. FASEB J., 22, 355-364.
-
(2008)
FASEB J.
, vol.22
, pp. 355-364
-
-
Zou, L.1
-
3
-
-
32944457064
-
Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation
-
Awale, S., et al. (2006) Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res., 66, 1751-1757.
-
(2006)
Cancer Res.
, vol.66
, pp. 1751-1757
-
-
Awale, S.1
-
4
-
-
34547134517
-
Hypoxia-inducible factor 1 alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
-
Land, S.C., et al. (2007) Hypoxia-inducible factor 1 alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J. Biol. Chem., 282, 20534-20543.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 20534-20543
-
-
Land, S.C.1
-
5
-
-
24744444711
-
Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke
-
Mu, D., et al. (2005) Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke. Exp. Neurol., 195, 407-415.
-
(2005)
Exp. Neurol.
, vol.195
, pp. 407-415
-
-
Mu, D.1
-
6
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza, G.L., et al. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem., 269, 23757-23763.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
-
7
-
-
70349570410
-
HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms
-
Marín-Hernández, A., et al. (2009) HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms. Mini Rev. Med. Chem., 9, 1084-1101.
-
(2009)
Mini Rev. Med. Chem.
, vol.9
, pp. 1084-1101
-
-
Marín-Hernández, A.1
-
8
-
-
79958191830
-
Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways
-
Rohwer, N., et al. (2011) Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist. Updat., 14, 191-201.
-
(2011)
Drug Resist. Updat.
, vol.14
, pp. 191-201
-
-
Rohwer, N.1
-
9
-
-
69049083600
-
Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression
-
Lara, P.C., et al. (2009) Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression. Radiat. Oncol., 4, 29.
-
(2009)
Radiat. Oncol.
, vol.4
, pp. 29
-
-
Lara, P.C.1
-
10
-
-
33747366672
-
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment
-
Bracken, C.P., et al. (2006) Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J. Biol. Chem., 281, 22575-22585.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 22575-22585
-
-
Bracken, C.P.1
-
11
-
-
0038282482
-
The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
-
Unruh, A., et al. (2003) The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene, 22, 3213-3220.
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
-
12
-
-
84863062001
-
Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1a
-
Schilling, D., et al. (2012) Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1a. PLoS One, 7, e31110.
-
(2012)
PLoS One
, vol.7
-
-
Schilling, D.1
-
13
-
-
84862667418
-
Basal HIF-1a expression levels are not predictive for radiosensitivity of human cancer cell lines
-
Schilling, D., et al.. (2012) Basal HIF-1a expression levels are not predictive for radiosensitivity of human cancer cell lines. Strahlenther. Onkol., 188, 353-358.
-
(2012)
Strahlenther. Onkol.
, vol.188
, pp. 353-358
-
-
Schilling, D.1
et, al..2
-
14
-
-
44349157832
-
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
-
Dewhirst, M.W., et al. (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat. Rev. Cancer, 8, 425-437.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 425-437
-
-
Dewhirst, M.W.1
-
15
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases
-
Zhong, H., et al. (1999) Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. Cancer Res., 59, 5830-5835.
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
-
16
-
-
72949100977
-
Prognostic significance of hypoxia-inducible factor- 1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer
-
Hung, J.J., et al. (2009) Prognostic significance of hypoxia-inducible factor- 1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer. Thorax, 64, 1082-1089.
-
(2009)
Thorax
, vol.64
, pp. 1082-1089
-
-
Hung, J.J.1
-
17
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra, E., et al. (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J., 22, 4082-4090.
-
(2003)
EMBO J.
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
-
18
-
-
12644279862
-
Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system
-
Zhou, Y.D., et al. (1997) Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc. Natl Acad. Sci. USA, 94, 713-718.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 713-718
-
-
Zhou, Y.D.1
-
19
-
-
11144337759
-
Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators
-
Déry, M.A., et al. (2005) Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int. J. Biochem. Cell Biol., 37, 535-540.
-
(2005)
Int. J. Biochem. Cell Biol.
, vol.37
, pp. 535-540
-
-
Déry, M.A.1
-
20
-
-
78349272461
-
HIF-1 and HIF-2 transcription factors-similar but not identical
-
Loboda, A., et al. (2010) HIF-1 and HIF-2 transcription factors-similar but not identical. Mol. Cells, 29, 435-442.
-
(2010)
Mol. Cells
, vol.29
, pp. 435-442
-
-
Loboda, A.1
-
21
-
-
34047156190
-
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
-
Gordan, J.D., et al. (2007) HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell, 11, 335-347.
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
-
22
-
-
73849137521
-
On the mechanism of iron sensing by IRP2: new players, new paradigms
-
Takahashi-Makise, N., et al.. (2009) On the mechanism of iron sensing by IRP2: new players, new paradigms. Nat. Chem. Biol., 5, 874-875.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 874-875
-
-
Takahashi-Makise, N.1
et, al..2
-
23
-
-
33645735151
-
The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha
-
Dayan, F., et al. (2006) The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha. Cancer Res., 66, 3688-3698.
-
(2006)
Cancer Res.
, vol.66
, pp. 3688-3698
-
-
Dayan, F.1
-
24
-
-
40249113328
-
Direct regulation of TWIST by HIF-1alpha promotes metastasis
-
Yang, M.H., et al. (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat. Cell Biol., 10, 295-305.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 295-305
-
-
Yang, M.H.1
-
25
-
-
79251478772
-
Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility
-
Astuti, D., et al. (2011) Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocr. Relat. Cancer, 18, 73-83.
-
(2011)
Endocr. Relat. Cancer
, vol.18
, pp. 73-83
-
-
Astuti, D.1
-
26
-
-
0035812318
-
Characterization and comparative analysis of the EGLN gene family
-
Taylor, M.S. (2001) Characterization and comparative analysis of the EGLN gene family. Gene, 275, 125-132.
-
(2001)
Gene
, vol.275
, pp. 125-132
-
-
Taylor, M.S.1
-
27
-
-
4644259153
-
Cellular oxygen sensing need in CNS function: physiological and pathological implications
-
Acker, T., et al. (2004) Cellular oxygen sensing need in CNS function: physiological and pathological implications. J. Exp. Biol., 207(Pt 18), 3171-3188.
-
(2004)
J. Exp. Biol.
, vol.207
, Issue.PT 18
, pp. 3171-3188
-
-
Acker, T.1
-
28
-
-
55349111498
-
Expression, purification and characterization of human PHD1 in Escherichia coli
-
Li, X.Y., et al. (2008) Expression, purification and characterization of human PHD1 in Escherichia coli. J. Biochem., 144, 555-561.
-
(2008)
J. Biochem.
, vol.144
, pp. 555-561
-
-
Li, X.Y.1
-
29
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
-
Appelhoff, R.J., et al. (2004) Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem., 279, 38458-38465.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
-
30
-
-
2342644926
-
Oxygen sensing by HIF hydroxylases
-
Schofield, C.J., et al. (2004) Oxygen sensing by HIF hydroxylases. Nat. Rev. Mol. Cell Biol., 5, 343-354.
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 343-354
-
-
Schofield, C.J.1
-
31
-
-
75149165633
-
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors
-
Henze, A.T., et al. (2010) Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res., 70, 357-366.
-
(2010)
Cancer Res.
, vol.70
, pp. 357-366
-
-
Henze, A.T.1
-
32
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein, A.C., et al. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell, 107, 43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
-
33
-
-
18844408840
-
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element
-
Metzen, E., et al. (2005) Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Biochem. J., 387(Pt 3), 711-717.
-
(2005)
Biochem. J.
, vol.387
, Issue.PT 3
, pp. 711-717
-
-
Metzen, E.1
-
34
-
-
33750976389
-
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2
-
Takeda, K., et al. (2006) Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol. Cell. Biol., 26, 8336-8346.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8336-8346
-
-
Takeda, K.1
-
35
-
-
40349098553
-
Cytoplasmic location of factor-inhibiting hypoxiainducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer
-
Tan, E.Y., et al. (2007) Cytoplasmic location of factor-inhibiting hypoxiainducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer. Breast Cancer Res., 9, R89.
-
(2007)
Breast Cancer Res.
, vol.9
-
-
Tan, E.Y.1
-
36
-
-
22144493866
-
Negative and positive regulation of HIF-1: a complex network
-
Bárdos, J.I., et al. (2005) Negative and positive regulation of HIF-1: a complex network. Biochim. Biophys. Acta., 1755, 107-120.
-
(2005)
Biochim. Biophys. Acta.
, vol.1755
, pp. 107-120
-
-
Bárdos, J.I.1
-
37
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando, D., et al. (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev., 16, 1466-1471.
-
(2002)
Genes Dev.
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
-
38
-
-
77955284188
-
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
-
Zhang, N., et al. (2010) The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab., 11, 364-378.
-
(2010)
Cell Metab.
, vol.11
, pp. 364-378
-
-
Zhang, N.1
-
40
-
-
77958553885
-
Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification
-
Cai, Q., et al. (2010) Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS One, 5, e9720.
-
(2010)
PLoS One
, vol.5
-
-
Cai, Q.1
-
41
-
-
0034214361
-
The von Hippel-Lindau tumor suppressor targets to mitochondria
-
Shiao, Y.H., et al. (2000) The von Hippel-Lindau tumor suppressor targets to mitochondria. Cancer Res., 60, 2816-2819.
-
(2000)
Cancer Res.
, vol.60
, pp. 2816-2819
-
-
Shiao, Y.H.1
-
42
-
-
48649098334
-
pVHL: a multipurpose adaptor protein
-
Frew, I.J., et al. (2008) pVHL: a multipurpose adaptor protein. Sci. Signal., 1, pe30.
-
(2008)
Sci. Signal.
, vol.1
-
-
Frew, I.J.1
-
43
-
-
0035899491
-
The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma
-
Clifford, S.C., et al. (2001) The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma. Oncogene, 20, 5067-5074.
-
(2001)
Oncogene
, vol.20
, pp. 5067-5074
-
-
Clifford, S.C.1
-
44
-
-
22244440847
-
Proline hydroxylation and gene expression
-
Kaelin, W.G. (2005) Proline hydroxylation and gene expression. Annu. Rev. Biochem., 74, 115-128.
-
(2005)
Annu. Rev. Biochem.
, vol.74
, pp. 115-128
-
-
Kaelin, W.G.1
-
45
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin G. Jr (2002) Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer, 2, 673-682.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 673-682
-
-
Kaelin Jr., W.G.1
-
46
-
-
45749145804
-
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene
-
Wu, S., et al. (2008) Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol. Ther., 16, 1227-1234.
-
(2008)
Mol. Ther.
, vol.16
, pp. 1227-1234
-
-
Wu, S.1
-
47
-
-
0029090338
-
Tumour suppression by the human von Hippel- Lindau gene product
-
Iliopoulos, O., et al. (1995) Tumour suppression by the human von Hippel- Lindau gene product. Nat. Med., 1, 822-826.
-
(1995)
Nat. Med.
, vol.1
, pp. 822-826
-
-
Iliopoulos, O.1
-
48
-
-
35548935098
-
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
-
Cheng, J., et al. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell, 131, 584-595.
-
(2007)
Cell
, vol.131
, pp. 584-595
-
-
Cheng, J.1
-
49
-
-
34247553146
-
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
-
MacKenzie, E.D., et al. (2007) Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol., 27, 3282-3289.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3282-3289
-
-
MacKenzie, E.D.1
-
50
-
-
77749270530
-
Mutations of the metabolic genes IDH1, IDH2, and SDHAF2 are not major determinants of the pseudohypoxic phenotype of sporadic pheochromocytomas and paragangliomas
-
Yao, L., et al. (2010) Mutations of the metabolic genes IDH1, IDH2, and SDHAF2 are not major determinants of the pseudohypoxic phenotype of sporadic pheochromocytomas and paragangliomas. J. Clin. Endocrinol. Metab., 95, 1469-1472.
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 1469-1472
-
-
Yao, L.1
-
51
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim, W.Y., et al. (2004) Role of VHL gene mutation in human cancer. J. Clin. Oncol., 22, 4991-5004.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
-
52
-
-
77449100681
-
Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum
-
Schlisio, S. (2009) Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum. J. Cell. Mol. Med., 13, 4104-4112.
-
(2009)
J. Cell. Mol. Med.
, vol.13
, pp. 4104-4112
-
-
Schlisio, S.1
-
53
-
-
0037189542
-
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
-
Lu, H., et al. (2002) Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J. Biol. Chem., 277, 23111-23115.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23111-23115
-
-
Lu, H.1
-
54
-
-
78649404935
-
Research resource: transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas
-
López-Jiménez, E., et al. (2010) Research resource: transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas. Mol. Endocrinol., 24, 2382-2391.
-
(2010)
Mol. Endocrinol.
, vol.24
, pp. 2382-2391
-
-
López-Jiménez, E.1
-
55
-
-
27744606274
-
Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions
-
Brière, J.J., et al. (2005) Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions. Hum. Mol. Genet., 14, 3263-3269.
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 3263-3269
-
-
Brière, J.J.1
-
56
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
-
Selak, M.A., et al. (2005) Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell, 7, 77-85.
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
-
57
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
-
Pollard, P.J., et al. (2005) Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum. Mol. Genet., 14, 2231-2239.
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 2231-2239
-
-
Pollard, P.J.1
-
58
-
-
79959977075
-
Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors
-
Thirstrup, K., et al. (2011) Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors. Pharmacol. Res., 64, 268-273.
-
(2011)
Pharmacol. Res.
, vol.64
, pp. 268-273
-
-
Thirstrup, K.1
-
59
-
-
0014622009
-
The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells
-
Gumaa, K.A., et al. (1969) The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. Biochem. J., 115, 1009-1029.
-
(1969)
Biochem. J.
, vol.115
, pp. 1009-1029
-
-
Gumaa, K.A.1
-
60
-
-
33646266734
-
Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an overexpressed but strongly product-inhibited hexokinase
-
Marín-Hernández, A., et al. (2006) Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an overexpressed but strongly product-inhibited hexokinase. FEBS J., 273, 1975-1988.
-
(2006)
FEBS J.
, vol.273
, pp. 1975-1988
-
-
Marín-Hernández, A.1
-
61
-
-
33947520506
-
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
-
Koivunen, P., et al. (2007) Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem., 282, 4524-4532.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 4524-4532
-
-
Koivunen, P.1
-
62
-
-
29644442625
-
Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
-
Lu, H., et al. (2005) Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J. Biol. Chem., 280, 41928-41939.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 41928-41939
-
-
Lu, H.1
-
63
-
-
0017697003
-
Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates
-
Tuderman, L., et al. (1977) Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates. Eur. J. Biochem., 80, 341-348.
-
(1977)
Eur. J. Biochem.
, vol.80
, pp. 341-348
-
-
Tuderman, L.1
-
64
-
-
34547096729
-
Genetics of phaeochromocytoma
-
Maher, E.R. (2006) Genetics of phaeochromocytoma. Br. Med. Bull., 79-80, 141-151.
-
(2006)
Br. Med. Bull.
, vol.79-80
, pp. 141-151
-
-
Maher, E.R.1
-
65
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsilä,M., et al. (2003) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem., 278, 30772-30780.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30772-30780
-
-
Hirsilä, M.1
-
66
-
-
0017742181
-
Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence
-
Myllylä,R., et al. (1977) Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence. Eur. J. Biochem., 80, 349-357.
-
(1977)
Eur. J. Biochem.
, vol.80
, pp. 349-357
-
-
Myllylä, R.1
-
67
-
-
77956503391
-
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
-
O'Flaherty, L., et al. (2010) Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Hum. Mol. Genet., 19, 3844-3851.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3844-3851
-
-
O'Flaherty, L.1
-
68
-
-
18544365098
-
Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas
-
Barker, K.T., et al. (2002) Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas. Br. J. Cancer, 87, 446-448.
-
(2002)
Br. J. Cancer
, vol.87
, pp. 446-448
-
-
Barker, K.T.1
-
69
-
-
0037102441
-
Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families
-
Kiuru, M., et al. (2002) Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families. Cancer Res., 62, 4554-4557.
-
(2002)
Cancer Res.
, vol.62
, pp. 4554-4557
-
-
Kiuru, M.1
-
70
-
-
77950553262
-
Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response
-
Yogev, O., et al. (2010) Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. PLoS Biol., 8, e1000328.
-
(2010)
PLoS Biol.
, vol.8
-
-
Yogev, O.1
-
71
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
-
Zhao, S., et al. (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science, 324, 261-265.
-
(2009)
Science
, vol.324
, pp. 261-265
-
-
Zhao, S.1
-
72
-
-
69549088424
-
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma
-
Hao, H.X., et al. (2009) SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science, 325, 1139-1142.
-
(2009)
Science
, vol.325
, pp. 1139-1142
-
-
Hao, H.X.1
-
73
-
-
77952263737
-
The genetic basis of kidney cancer: a metabolic disease
-
Linehan, W.M., et al. (2010) The genetic basis of kidney cancer: a metabolic disease. Nat. Rev. Urol., 7, 277-285.
-
(2010)
Nat. Rev. Urol.
, vol.7
, pp. 277-285
-
-
Linehan, W.M.1
-
74
-
-
33746398489
-
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
-
Smith, T.G., et al. (2006) Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med., 3, e290.
-
(2006)
PLoS Med.
, vol.3
-
-
Smith, T.G.1
-
75
-
-
77955370669
-
Effects of HIF-1alpha and HIF2alpha on growth and metabolism of clear-cell renal cell carcinoma 786-0 xenografts
-
Biswas, S., et al. (2010) Effects of HIF-1alpha and HIF2alpha on growth and metabolism of clear-cell renal cell carcinoma 786-0 xenografts. J. Oncol., 2010, 757908.
-
(2010)
J. Oncol.
, vol.2010
, pp. 757908
-
-
Biswas, S.1
-
76
-
-
0023718383
-
Pathways of succinate formation and their contribution to improvement of cardiac function in the hypoxic rat heart
-
Wiesner, R.J., et al. (1988) Pathways of succinate formation and their contribution to improvement of cardiac function in the hypoxic rat heart. Biochem. Med. Metab. Biol., 40, 19-34.
-
(1988)
Biochem. Med. Metab. Biol.
, vol.40
, pp. 19-34
-
-
Wiesner, R.J.1
-
77
-
-
77951432631
-
The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation-why mitochondria are targets for cancer therapy
-
Ralph, S.J., et al. (2010) The causes of cancer revisited: et al."mitochondrial malignancy" and ROS-induced oncogenic transformation-why mitochondria are targets for cancer therapy. Mol. Aspects Med., 31, 145-170.
-
(2010)
Mol. Aspects Med.
, vol.31
, pp. 145-170
-
-
Ralph, S.J.1
-
78
-
-
84859445000
-
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
-
Semenza, G.L. (2012) Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol. Sci., 33, 207-214.
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 207-214
-
-
Semenza, G.L.1
-
79
-
-
80052755020
-
Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress
-
Ito, K., et al. (2011) Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress. Angiogenesis, 14, 293-307.
-
(2011)
Angiogenesis
, vol.14
, pp. 293-307
-
-
Ito, K.1
-
80
-
-
0037662638
-
Effects of hyperoxia on VEGF, its receptors, and HIF-2alpha in the newborn rat lung
-
Hosford, G.E., et al. (2003) Effects of hyperoxia on VEGF, its receptors, and HIF-2alpha in the newborn rat lung. Am. J. Physiol. Lung Cell. Mol. Physiol., 285, L161-L168.
-
(2003)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.285
-
-
Hosford, G.E.1
-
81
-
-
67651098992
-
Endothelial deletion of hypoxia-inducible factor- 2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis
-
Skuli, N., et al. (2009) Endothelial deletion of hypoxia-inducible factor- 2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood, 114, 469-477.
-
(2009)
Blood
, vol.114
, pp. 469-477
-
-
Skuli, N.1
-
82
-
-
79957440998
-
The hypoxia-associated factor switches cells from HIF-1a- to HIF-2a-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
-
Koh, M.Y., et al. (2011) The hypoxia-associated factor switches cells from HIF-1a- to HIF-2a-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res., 71, 4015-4027.
-
(2011)
Cancer Res.
, vol.71
, pp. 4015-4027
-
-
Koh, M.Y.1
-
83
-
-
77956187907
-
Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma
-
Rodríguez-Enríquez, S., et al. (2010) Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma. Int. J. Biochem. Cell Biol., 42, 1744-1751.
-
(2010)
Int. J. Biochem. Cell Biol.
, vol.42
, pp. 1744-1751
-
-
Rodríguez-Enríquez, S.1
-
84
-
-
0031226737
-
Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line
-
Chu, Y.W., et al. (1997) Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am. J. Respir. Cell Mol. Biol., 17, 353-360.
-
(1997)
Am. J. Respir. Cell Mol. Biol.
, vol.17
, pp. 353-360
-
-
Chu, Y.W.1
-
85
-
-
78149243774
-
Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation
-
Louie, E., et al. (2010) Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation. Breast Cancer Res., 12, R94.
-
(2010)
Breast Cancer Res.
, vol.12
-
-
Louie, E.1
-
86
-
-
77952490843
-
Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells
-
Cho, K.B., et al. (2010) Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells. Cancer Lett., 293, 230-239.
-
(2010)
Cancer Lett.
, vol.293
, pp. 230-239
-
-
Cho, K.B.1
-
87
-
-
79952770168
-
MYC and metastasis
-
Wolfer, A., et al. (2011) MYC and metastasis. Cancer Res., 71, 2034-2037.
-
(2011)
Cancer Res.
, vol.71
, pp. 2034-2037
-
-
Wolfer, A.1
-
88
-
-
61849135453
-
Tumor suppressors and cell metabolism: a recipe for cancer growth
-
Jones, R.G., et al. (2009) Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev., 23, 537-548.
-
(2009)
Genes Dev.
, vol.23
, pp. 537-548
-
-
Jones, R.G.1
-
89
-
-
33744457297
-
HIF-1: hypoxia-inducible factor or dysoxiainducible factor?
-
López-Lázaro, M. (2006) HIF-1: hypoxia-inducible factor or dysoxiainducible factor?. FASEB J., 20, 828-832.
-
(2006)
FASEB J.
, vol.20
, pp. 828-832
-
-
López-Lázaro, M.1
-
90
-
-
84870461608
-
The role of hypoxia-inducible factors in oxygen sensing by the carotid body
-
Nurse, C.A., et al.. (eds) Springer, The Netherlands
-
Semenza, G., et al.. (2012) The role of hypoxia-inducible factors in oxygen sensing by the carotid body. In Nurse, C.A., et al.. (eds) Arterial Chemoreception. Springer, The Netherlands, pp. 1-5.
-
(2012)
Arterial Chemoreception
, pp. 1-5
-
-
Semenza, G.1
et, al..2
-
91
-
-
79960024581
-
Reciprocal influence of the p53 and the hypoxic pathways
-
Sermeus, A., et al. (2011) Reciprocal influence of the p53 and the hypoxic pathways. Cell Death Dis., 2, e164.
-
(2011)
Cell Death Dis.
, vol.2
-
-
Sermeus, A.1
-
92
-
-
0036285034
-
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogeneinduced genetic instability
-
Vafa, O., et al. (2002) c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogeneinduced genetic instability. Mol. Cell, 9, 1031-1044.
-
(2002)
Mol. Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
-
93
-
-
84865036227
-
Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death
-
Castells, M., et al. (2012) Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. Int. J. Mol. Sci., 13, 9545-9571.
-
(2012)
Int. J. Mol. Sci.
, vol.13
, pp. 9545-9571
-
-
Castells, M.1
-
94
-
-
0022002156
-
Migration of tumor cells to organ-derived chemoattractants
-
Hujanen, E.S., et al. (1985) Migration of tumor cells to organ-derived chemoattractants. Cancer Res., 45, 3517-3521.
-
(1985)
Cancer Res.
, vol.45
, pp. 3517-3521
-
-
Hujanen, E.S.1
-
95
-
-
79954579633
-
EMT: a new vision of hypoxia promoting cancer progression
-
Jiang, J., et al. (2011) EMT: a new vision of hypoxia promoting cancer progression. Cancer Biol. Ther., 11, 714-723.
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 714-723
-
-
Jiang, J.1
-
96
-
-
84877157115
-
Wnt/β-catenin signaling enhances hypoxiainduced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1a signaling
-
Zhang, Q., et al. (2011) Wnt/β-catenin signaling enhances hypoxiainduced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1a signaling. Carcinogenesis, 34, 962-973.
-
(2011)
Carcinogenesis
, vol.34
, pp. 962-973
-
-
Zhang, Q.1
-
97
-
-
70449527638
-
Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer
-
Lundgren, K., et al. (2009) Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer. Br. J. Cancer, 101, 1769-1781.
-
(2009)
Br. J. Cancer
, vol.101
, pp. 1769-1781
-
-
Lundgren, K.1
-
98
-
-
0141760411
-
Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
-
Imai, T., et al. (2003) Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am. J. Pathol., 163, 1437-1447.
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 1437-1447
-
-
Imai, T.1
-
99
-
-
57349164238
-
Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells
-
Cannito, S., et al. (2008) Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis, 29, 2267-2278.
-
(2008)
Carcinogenesis
, vol.29
, pp. 2267-2278
-
-
Cannito, S.1
-
100
-
-
79959421475
-
HIF-1a mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression
-
Yoo, Y.G., et al. (2011) HIF-1a mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression. Sci. Signal., 4, pt4.
-
(2011)
Sci. Signal.
, vol.4
-
-
Yoo, Y.G.1
-
101
-
-
44049090235
-
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
-
Sahlgren, C., et al. (2008) Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc. Natl Acad. Sci. USA, 105, 6392-6397.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 6392-6397
-
-
Sahlgren, C.1
-
102
-
-
34248193253
-
Immune surveillance of tumors
-
Swann, J.B., et al. (2007) Immune surveillance of tumors. J. Clin. Invest., 117, 1137-1146.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1137-1146
-
-
Swann, J.B.1
-
103
-
-
77957350018
-
Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
-
Doedens, A.L., et al. (2010) Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res., 70, 7465-7475.
-
(2010)
Cancer Res.
, vol.70
, pp. 7465-7475
-
-
Doedens, A.L.1
-
104
-
-
68249153389
-
Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin
-
Yang, M., et al. (2009) Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin. Immunology, 128(1 suppl.), e237-e249.
-
(2009)
Immunology
, vol.128
, Issue.1 SUPPL.
-
-
Yang, M.1
-
105
-
-
79960393113
-
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
-
Facciabene, A., et al. (2011) Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature, 475, 226-230.
-
(2011)
Nature
, vol.475
, pp. 226-230
-
-
Facciabene, A.1
-
106
-
-
10244222236
-
Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism
-
Eltzschig, H.K., et al. (2004) Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood, 104, 3986-3992.
-
(2004)
Blood
, vol.104
, pp. 3986-3992
-
-
Eltzschig, H.K.1
-
107
-
-
33748357735
-
A2A adenosine receptor protects tumors from antitumor T cells
-
Ohta, A., et al. (2006) A2A adenosine receptor protects tumors from antitumor T cells. Proc. Natl Acad. Sci. USA, 103, 13132-13137.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 13132-13137
-
-
Ohta, A.1
-
108
-
-
24044461733
-
Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies
-
Lewis, C., et al. (2005) Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am. J. Pathol., 167, 627-635.
-
(2005)
Am. J. Pathol.
, vol.167
, pp. 627-635
-
-
Lewis, C.1
-
109
-
-
77951134669
-
Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?
-
Lee, C.T., et al. (2010) Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer? Int. J. Hyperthermia, 26, 232-246.
-
(2010)
Int. J. Hyperthermia
, vol.26
, pp. 232-246
-
-
Lee, C.T.1
-
110
-
-
33749512970
-
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
-
Lukashev, D., et al. (2006) Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J. Immunol., 177, 4962-4965.
-
(2006)
J. Immunol.
, vol.177
, pp. 4962-4965
-
-
Lukashev, D.1
-
111
-
-
33144460217
-
Galectin-1: a link between tumor hypoxia and tumor immune privilege
-
Le, Q.T., et al. (2005) Galectin-1: a link between tumor hypoxia and tumor immune privilege. J. Clin. Oncol., 23, 8932-8941.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 8932-8941
-
-
Le, Q.T.1
-
112
-
-
84867990611
-
Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment
-
Ito, K., et al. (2012) Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment. Cancer and Metastasis Rev., 31, 763-778.
-
(2012)
Cancer and Metastasis Rev.
, vol.31
, pp. 763-778
-
-
Ito, K.1
-
113
-
-
0030921103
-
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
-
Shim, H., et al. (1997) c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl Acad. Sci. USA, 94, 6658-6663.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
-
114
-
-
0034326273
-
Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
-
Elson, D.A., et al. (2000) Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res., 60, 6189-6195.
-
(2000)
Cancer Res.
, vol.60
, pp. 6189-6195
-
-
Elson, D.A.1
-
115
-
-
79953827951
-
Suppression of T-cell responses by tumor metabolites
-
Singer, K., et al. (2011) Suppression of T-cell responses by tumor metabolites. Cancer Immunol. Immunother., 60, 425-431.
-
(2011)
Cancer Immunol. Immunother.
, vol.60
, pp. 425-431
-
-
Singer, K.1
-
116
-
-
33645560710
-
Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes
-
Castello, P.R., et al. (2006) Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes. Cell Metab., 3, 277-287.
-
(2006)
Cell Metab.
, vol.3
, pp. 277-287
-
-
Castello, P.R.1
-
117
-
-
80052426012
-
Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival
-
Frezza, C., et al. (2011) Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival. PLoS One, 6, e24411.
-
(2011)
PLoS One
, vol.6
-
-
Frezza, C.1
-
118
-
-
34247352844
-
Inhibitory effect of tumor cell-derived lactic acid on human T cells
-
Fischer, K., et al. (2007) Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood, 109, 3812-3819.
-
(2007)
Blood
, vol.109
, pp. 3812-3819
-
-
Fischer, K.1
-
119
-
-
0036467638
-
Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
-
Fyles, A., et al. (2002) Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J. Clin. Oncol., 20, 680-687.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 680-687
-
-
Fyles, A.1
-
120
-
-
34247527730
-
Hypoxia-inducible factors, stem cells, and cancer
-
Keith, B., et al. (2007) Hypoxia-inducible factors, stem cells, and cancer. Cell, 129, 465-472.
-
(2007)
Cell
, vol.129
, pp. 465-472
-
-
Keith, B.1
-
121
-
-
77649273107
-
Hypoxia inducible factors in cancer stem cells
-
Heddleston, J.M., et al. (2010) Hypoxia inducible factors in cancer stem cells. Br. J. Cancer, 102, 789-795.
-
(2010)
Br. J. Cancer
, vol.102
, pp. 789-795
-
-
Heddleston, J.M.1
-
122
-
-
84861466196
-
The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells
-
Liang, D., et al. (2012) The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells. BMC Cancer, 12, 201.
-
(2012)
BMC Cancer
, vol.12
, pp. 201
-
-
Liang, D.1
-
123
-
-
79959908506
-
HIF induces human embryonic stem cell markers in cancer cells
-
Mathieu, J., et al. (2011) HIF induces human embryonic stem cell markers in cancer cells. Cancer Res., 71, 4640-4652.
-
(2011)
Cancer Res.
, vol.71
, pp. 4640-4652
-
-
Mathieu, J.1
-
124
-
-
84865203983
-
A restricted cell population propagates glioblastoma growth after chemotherapy
-
Chen, J., et al. (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 488, 522-526.
-
(2012)
Nature
, vol.488
, pp. 522-526
-
-
Chen, J.1
-
125
-
-
79955778894
-
Breast cancer stem cells: treatment resistance and therapeutic opportunities
-
Al-Ejeh, F., et al. (2011) Breast cancer stem cells: treatment resistance and therapeutic opportunities. Carcinogenesis, 32, 650-658.
-
(2011)
Carcinogenesis
, vol.32
, pp. 650-658
-
-
Al-Ejeh, F.1
-
126
-
-
68349133231
-
Hypoxic tumor microenvironment and cancer cell differentiation
-
Kim, Y., et al. (2009) Hypoxic tumor microenvironment and cancer cell differentiation. Curr. Mol. Med., 9, 425-434.
-
(2009)
Curr. Mol. Med.
, vol.9
, pp. 425-434
-
-
Kim, Y.1
-
127
-
-
84857186454
-
Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells
-
Bhaskara, V.K., et al. (2012) Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells. PLoS One, 7, e30905.
-
(2012)
PLoS One
, vol.7
-
-
Bhaskara, V.K.1
-
128
-
-
77955640829
-
Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells
-
Rizzino, A. (2009) Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells. Wiley Interdiscip. Rev. Syst. Biol. Med., 1, 228-236.
-
(2009)
Wiley Interdiscip. Rev. Syst. Biol. Med.
, vol.1
, pp. 228-236
-
-
Rizzino, A.1
-
129
-
-
77950794030
-
Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer
-
Peng, S., et al. (2010) Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. Oncogene, 29, 2153-2159.
-
(2010)
Oncogene
, vol.29
, pp. 2153-2159
-
-
Peng, S.1
-
130
-
-
42649112047
-
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
-
Ben-Porath, I., et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet., 40, 499-507.
-
(2008)
Nat. Genet.
, vol.40
, pp. 499-507
-
-
Ben-Porath, I.1
-
131
-
-
84865429409
-
Passing the baton: the HIF switch
-
Koh, M.Y., et al. (2012) Passing the baton: the HIF switch. Trends Biochem. Sci., 37, 364-372.
-
(2012)
Trends Biochem. Sci.
, vol.37
, pp. 364-372
-
-
Koh, M.Y.1
-
132
-
-
84455174511
-
Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2
-
Iida, H., et al. (2012) Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2. Int. J. Oncol., 40, 71-79.
-
(2012)
Int. J. Oncol.
, vol.40
, pp. 71-79
-
-
Iida, H.1
-
133
-
-
75849160216
-
Human cancers converge at the HIF-2alpha oncogenic axis
-
Franovic, A., et al. (2009) Human cancers converge at the HIF-2alpha oncogenic axis. Proc. Natl Acad. Sci. USA, 106, 21306-21311.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 21306-21311
-
-
Franovic, A.1
-
134
-
-
34247537076
-
Hypoxia and metastasis
-
Chaudary, N., et al. (2007) Hypoxia and metastasis. Clin. Cancer Res., 13, 1947-1949.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 1947-1949
-
-
Chaudary, N.1
-
135
-
-
33646464845
-
Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model
-
Hofmann, M., et al. (2006) Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model. Neoplasia, 8, 89-95.
-
(2006)
Neoplasia
, vol.8
, pp. 89-95
-
-
Hofmann, M.1
-
136
-
-
0042411985
-
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
-
Shannon, A.M., et al. (2003) Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat. Rev., 29, 297-307.
-
(2003)
Cancer Treat. Rev.
, vol.29
, pp. 297-307
-
-
Shannon, A.M.1
-
137
-
-
39749114978
-
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
-
Bristow, R.G., et al. (2008) Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat. Rev. Cancer, 8, 180-192.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 180-192
-
-
Bristow, R.G.1
-
138
-
-
33845984533
-
Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention
-
López-Lázaro, M. (2006) Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention. Cancer Epidemiol. Biomarkers Prev., 15, 2332-2335.
-
(2006)
Cancer Epidemiol. Biomarkers Prev.
, vol.15
, pp. 2332-2335
-
-
López-Lázaro, M.1
-
139
-
-
23244454418
-
New drugs target hypoxia response in tumors
-
Garber, K. (2005) New drugs target hypoxia response in tumors. J. Natl Cancer Inst., 97, 1112-1114.
-
(2005)
J. Natl Cancer Inst.
, vol.97
, pp. 1112-1114
-
-
Garber, K.1
-
140
-
-
82255167669
-
Targeting hypoxic tumour cells to overcome metastasis
-
Bennewith, K.L., et al. (2011) Targeting hypoxic tumour cells to overcome metastasis. BMC Cancer, 11, 504.
-
(2011)
BMC Cancer
, vol.11
, pp. 504
-
-
Bennewith, K.L.1
-
141
-
-
34447122556
-
Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104
-
Patterson, A.V., et al. (2007) Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin. Cancer Res., 13, 3922-3932.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 3922-3932
-
-
Patterson, A.V.1
-
142
-
-
84881499668
-
-
FDA approves Proacta IND application for PR610. Pharmaceutical Business Review.(30 August 2012).
-
FDA approves Proacta IND application for PR610. Pharmaceutical Business Review. http://regulatoryaffairs.pharmaceutical-business-review. com/news/fda-approves-proacta-ind-application-for-pr610-300812 (30 August 2012).
-
-
-
-
143
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
Wilson, W.R., et al. (2011) Targeting hypoxia in cancer therapy. Nat. Rev. Cancer, 11, 393-410.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 393-410
-
-
Wilson, W.R.1
-
144
-
-
84861860592
-
Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella typhimurium strain
-
Yu, B., et al. (2012) Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella typhimurium strain. Sci. Rep., 2, 436.
-
(2012)
Sci. Rep.
, vol.2
, pp. 436
-
-
Yu, B.1
-
145
-
-
53049087992
-
Bacterial therapies: completing the cancer treatment toolbox
-
St Jean, A.T., et al. (2008) Bacterial therapies: completing the cancer treatment toolbox. Curr. Opin. Biotechnol., 19, 511-517.
-
(2008)
Curr. Opin. Biotechnol.
, vol.19
, pp. 511-517
-
-
St Jean, A.T.1
-
146
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan, D., et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
|