Mitochondrial succinate is instrumental for HIF1α nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

Human Molecular Genetics

Volumn 14, Issue 21, 2005, Pages 3263-3269

  Brière, Jean Jacques ^a   Favier, Judith ^b   Bénit, Paule ^a   El Ghouzzi, Vincent ^a   Lorenzato, Annalisa ^c   Rabier, Daniel ^d   Di Renzo, Maria Flavia ^c   Gimenez Roqueplo, Anne Paule ^b,e   Rustin, Pierre ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b INSERM   (France)

^c UNIVERSITY OF TURIN   (Italy)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATASE; CARBOXYLIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN SUBUNIT; SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE A; SUCCINATE DEHYDROGENASE B; SUCCINATE DEHYDROGENASE C; SUCCINATE DEHYDROGENASE D; SUCCINIC ACID; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CASE REPORT; CELL HYPOXIA; CELL MUTANT; CELL NUCLEUS; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MITOCHONDRION; MUTATIONAL ANALYSIS; NEUROENDOCRINE TUMOR; PARAGANGLIOMA; PRIORITY JOURNAL; PROTEIN TRANSPORT; SKIN FIBROBLAST; TUMOR SUPPRESSOR GENE;

BLOTTING, WESTERN; DNA PRIMERS; FIBROBLASTS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; ISOENZYMES; KETOGLUTARIC ACIDS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MUTATION; PROTEIN TRANSPORT; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; SUPEROXIDES;

EID: 27744606274     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddi359     Document Type: Article

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