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Volumn 31, Issue 3-4, 2012, Pages 763-778

Galectin-1 as a potent target for cancer therapy: Role in the tumor microenvironment

Author keywords

Galectin 1; Hypoxia; Immunosuppression; Metastasis; Tumor angiogenesis

Indexed keywords

ALPHA GALACTOMANNAN; ANGINEX; ANGIOGENESIS INHIBITOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GALECTIN 1; GCS 100; GLYCAN; PECTIN; THIODIGALACTOSIDE; UNCLASSIFIED DRUG;

EID: 84867990611     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/s10555-012-9388-2     Document Type: Review
Times cited : (115)

References (152)
  • 1
    • 0028261522 scopus 로고
    • Galectins: A family of animal beta-galactoside-binding lectins
    • 8124704 1:CAS:528:DyaK2cXitlymur8%3D
    • Barondes, S. H.; Castronovo, V.; Cooper, D. N.; Cummings, R. D.; Drickamer, K.; Feizi, T.; et al. (1994). Galectins: a family of animal beta-galactoside-binding lectins. Cell, 76(4), 597-598.
    • (1994) Cell , vol.76 , Issue.4 , pp. 597-598
    • Barondes, S.H.1    Castronovo, V.2    Cooper, D.N.3    Cummings, R.D.4    Drickamer, K.5    Feizi, T.6
  • 2
    • 0037136416 scopus 로고    scopus 로고
    • Galectinomics: Finding themes in complexity
    • 12223271 1:CAS:528:DC%2BD38XmvVagsL4%3D
    • Cooper, D. N. (2002). Galectinomics: finding themes in complexity. Biochimica et Biophysica Acta, 1572(2-3), 209-231.
    • (2002) Biochimica et Biophysica Acta , vol.1572 , Issue.2-3 , pp. 209-231
    • Cooper, D.N.1
  • 5
    • 0027954503 scopus 로고
    • Crystallization and preliminary X-ray diffraction studies of the soluble 14 kDa beta-galactoside-binding lectin from bovine heart
    • 8289301 1:CAS:528:DyaK2cXhvVGltLw%3D
    • Bourne, Y.; Bolgiano, B.; Nesa, M. P.; Penfold, P.; Johnson, D.; Feizi, T.; et al. (1994). Crystallization and preliminary X-ray diffraction studies of the soluble 14 kDa beta-galactoside-binding lectin from bovine heart. Journal of Molecular Biology, 235(2), 787-789.
    • (1994) Journal of Molecular Biology , vol.235 , Issue.2 , pp. 787-789
    • Bourne, Y.1    Bolgiano, B.2    Nesa, M.P.3    Penfold, P.4    Johnson, D.5    Feizi, T.6
  • 6
    • 21444434899 scopus 로고    scopus 로고
    • Structural and functional studies of galectin-1: A novel axonal regeneration-promoting activity for oxidized galectin-1
    • 16026256 1:CAS:528:DC%2BD2MXlslChtL8%3D
    • Kadoya, T.; & Horie, H. (2005). Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-1. Current Drug Targets, 6(4), 375-383.
    • (2005) Current Drug Targets , vol.6 , Issue.4 , pp. 375-383
    • Kadoya, T.1    Horie, H.2
  • 7
    • 69549097373 scopus 로고    scopus 로고
    • Characterisation of oxidized recombinant human galectin-1
    • 19860718 1:CAS:528:DC%2BD1MXhtlentLrN
    • Scott, S. A.; Bugarcic, A.; & Blanchard, H. (2009). Characterisation of oxidized recombinant human galectin-1. Protein and Peptide Letters, 16(10), 1249-1255.
    • (2009) Protein and Peptide Letters , vol.16 , Issue.10 , pp. 1249-1255
    • Scott, S.A.1    Bugarcic, A.2    Blanchard, H.3
  • 8
    • 0034074288 scopus 로고    scopus 로고
    • Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties
    • 10806394 1:CAS:528:DC%2BD3cXjs1Gjs7k%3D
    • Inagaki, Y.; Sohma, Y.; Horie, H.; Nozawa, R.; & Kadoya, T. (2000). Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties. European Journal of Biochemistry, 267(10), 2955-2964.
    • (2000) European Journal of Biochemistry , vol.267 , Issue.10 , pp. 2955-2964
    • Inagaki, Y.1    Sohma, Y.2    Horie, H.3    Nozawa, R.4    Kadoya, T.5
  • 9
    • 10744221890 scopus 로고    scopus 로고
    • Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy
    • 14985427 1:CAS:528:DC%2BD2cXitVWktrk%3D
    • Horie, H.; Kadoya, T.; Hikawa, N.; Sango, K.; Inoue, H.; Takeshita, K.; et al. (2004). Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy. The Journal of Neuroscience, 24(8), 1873-1880.
    • (2004) The Journal of Neuroscience , vol.24 , Issue.8 , pp. 1873-1880
    • Horie, H.1    Kadoya, T.2    Hikawa, N.3    Sango, K.4    Inoue, H.5    Takeshita, K.6
  • 10
    • 68849105996 scopus 로고    scopus 로고
    • Expression of galectin-1 in malignant tumors
    • 19550395 1:CAS:528:DC%2BD1MXhtVWitrjM
    • Demydenko, D.; & Berest, I. (2009). Expression of galectin-1 in malignant tumors. Experimental Oncology, 31(2), 74-79.
    • (2009) Experimental Oncology , vol.31 , Issue.2 , pp. 74-79
    • Demydenko, D.1    Berest, I.2
  • 11
    • 35549003245 scopus 로고    scopus 로고
    • Galectins in the tumor endothelium: Opportunities for combined cancer therapy
    • 17591944 1:CAS:528:DC%2BD2sXht1SmurfP
    • Thijssen, V. L.; Poirier, F.; Baum, L. G.; & Griffioen, A. W. (2007). Galectins in the tumor endothelium: opportunities for combined cancer therapy. Blood, 110(8), 2819-2827.
    • (2007) Blood , vol.110 , Issue.8 , pp. 2819-2827
    • Thijssen, V.L.1    Poirier, F.2    Baum, L.G.3    Griffioen, A.W.4
  • 12
    • 33847376532 scopus 로고    scopus 로고
    • Galectin-1: A key effector of regulation mediated by CD4+ CD25+ T cells
    • 17110462 1:CAS:528:DC%2BD2sXjtFequrw%3D
    • Garin, M. I.; Chu, C. C.; Golshayan, D.; Cernuda-Morollon, E.; Wait, R.; & Lechler, R. I. (2007). Galectin-1: a key effector of regulation mediated by CD4+ CD25+ T cells. Blood, 109(5), 2058-2065.
    • (2007) Blood , vol.109 , Issue.5 , pp. 2058-2065
    • Garin, M.I.1    Chu, C.C.2    Golshayan, D.3    Cernuda-Morollon, E.4    Wait, R.5    Lechler, R.I.6
  • 13
    • 33749556658 scopus 로고    scopus 로고
    • Galectin-1: A small protein with major functions
    • 16840800 1:CAS:528:DC%2BD28XhtVOmurfI
    • Camby, I.; Le Mercier, M.; Lefranc, F.; & Kiss, R. (2006). Galectin-1: a small protein with major functions. Glycobiology, 16(11), 137R-157R.
    • (2006) Glycobiology , vol.16 , Issue.11
    • Camby, I.1    Le Mercier, M.2    Lefranc, F.3    Kiss, R.4
  • 14
    • 0034487883 scopus 로고    scopus 로고
    • Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma
    • 11156213 1:CAS:528:DC%2BD3MXotlentQ%3D%3D
    • Honjo, Y.; Inohara, H.; Akahani, S.; Yoshii, T.; Takenaka, Y.; Yoshida, J.; et al. (2000). Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. Clinical Cancer Research, 6(12), 4635-4640.
    • (2000) Clinical Cancer Research , vol.6 , Issue.12 , pp. 4635-4640
    • Honjo, Y.1    Inohara, H.2    Akahani, S.3    Yoshii, T.4    Takenaka, Y.5    Yoshida, J.6
  • 15
    • 0028986607 scopus 로고
    • Galectin-1, a beta-galactoside-binding lectin in Chinese hamster ovary cells. II. Localization and biosynthesis
    • 7890631 1:CAS:528:DyaK2MXksVSltL8%3D
    • Cho, M.; & Cummings, R. D. (1995). Galectin-1, a beta-galactoside- binding lectin in Chinese hamster ovary cells. II. Localization and biosynthesis. Journal of Biological Chemistry, 270(10), 5207-5212.
    • (1995) Journal of Biological Chemistry , vol.270 , Issue.10 , pp. 5207-5212
    • Cho, M.1    Cummings, R.D.2
  • 16
    • 0028986609 scopus 로고
    • Galectin-1, a beta-galactoside-binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization
    • 7890630 1:CAS:528:DyaK2MXksVSltL4%3D
    • Cho, M.; & Cummings, R. D. (1995). Galectin-1, a beta-galactoside- binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization. The Journal of Biological Chemistry, 270(10), 5198-5206.
    • (1995) The Journal of Biological Chemistry , vol.270 , Issue.10 , pp. 5198-5206
    • Cho, M.1    Cummings, R.D.2
  • 17
    • 0032534494 scopus 로고    scopus 로고
    • Galectin-3 stimulates cell proliferation
    • 9851870 1:CAS:528:DyaK1cXotVWqsLs%3D
    • Inohara, H.; Akahani, S.; & Raz, A. (1998). Galectin-3 stimulates cell proliferation. Experimental Cell Research, 245(2), 294-302.
    • (1998) Experimental Cell Research , vol.245 , Issue.2 , pp. 294-302
    • Inohara, H.1    Akahani, S.2    Raz, A.3
  • 18
    • 33846689832 scopus 로고    scopus 로고
    • Mechano-transduction mediated secretion and uptake of galectin-3 in breast carcinoma cells: Implications in the extracellular functions of the lectin
    • 17184769 1:CAS:528:DC%2BD2sXhs1Cnurs%3D
    • Baptiste, T. A.; James, A.; Saria, M.; & Ochieng, J. (2007). Mechano-transduction mediated secretion and uptake of galectin-3 in breast carcinoma cells: implications in the extracellular functions of the lectin. Experimental Cell Research, 313(4), 652-664.
    • (2007) Experimental Cell Research , vol.313 , Issue.4 , pp. 652-664
    • Baptiste, T.A.1    James, A.2    Saria, M.3    Ochieng, J.4
  • 19
    • 40249088785 scopus 로고    scopus 로고
    • Varied expression and localization of multiple galectins in different cancer cell lines
    • 18288388 1:CAS:528:DC%2BD1cXjs1emu7Y%3D
    • Satelli, A.; Rao, P. S.; Gupta, P. K.; Lockman, P. R.; Srivenugopal, K. S.; & Rao, U. S. (2008). Varied expression and localization of multiple galectins in different cancer cell lines. Oncology Reports, 19(3), 587-594.
    • (2008) Oncology Reports , vol.19 , Issue.3 , pp. 587-594
    • Satelli, A.1    Rao, P.S.2    Gupta, P.K.3    Lockman, P.R.4    Srivenugopal, K.S.5    Rao, U.S.6
  • 20
    • 21844468743 scopus 로고    scopus 로고
    • Unconventional secretory routes: Direct protein export across the plasma membrane of mammalian cells
    • 15998317 1:CAS:528:DC%2BD2MXmsVeitbY%3D
    • Nickel, W. (2005). Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells. Traffic, 6(8), 607-614.
    • (2005) Traffic , vol.6 , Issue.8 , pp. 607-614
    • Nickel, W.1
  • 21
    • 79953043430 scopus 로고    scopus 로고
    • Clinical significance of circulating galectins as colorectal cancer markers
    • 21369702
    • Watanabe, M.; Takemasa, I.; Kaneko, N.; Yokoyama, Y.; Matsuo, E.; Iwasa, S.; et al. (2011). Clinical significance of circulating galectins as colorectal cancer markers. Oncology Reports, 25(5), 1217-1226.
    • (2011) Oncology Reports , vol.25 , Issue.5 , pp. 1217-1226
    • Watanabe, M.1    Takemasa, I.2    Kaneko, N.3    Yokoyama, Y.4    Matsuo, E.5    Iwasa, S.6
  • 22
    • 80054728440 scopus 로고    scopus 로고
    • Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients
    • 22028908 1:CAS:528:DC%2BC3MXhsVCjur3K
    • Carlsson, M. C.; Cederfur, C.; Schaar, V.; Balog, C. I.; Lepur, A.; Touret, F.; et al. (2011). Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients. PLoS One, 6(10), e26560.
    • (2011) PLoS One , vol.6 , Issue.10 , pp. 26560
    • Carlsson, M.C.1    Cederfur, C.2    Schaar, V.3    Balog, C.I.4    Lepur, A.5    Touret, F.6
  • 23
    • 37049015985 scopus 로고    scopus 로고
    • The determination of the levels of circulating galectin-1 and -3 in HNSCC patients could be used to monitor tumor progression and/or responses to therapy
    • 17350328 1:CAS:528:DC%2BD2sXhsVCjtL3I
    • Saussez, S.; Lorfevre, F.; Lequeux, T.; Laurent, G.; Chantrain, G.; Vertongen, F.; et al. (2008). The determination of the levels of circulating galectin-1 and -3 in HNSCC patients could be used to monitor tumor progression and/or responses to therapy. Oral Oncology, 44(1), 86-93.
    • (2008) Oral Oncology , vol.44 , Issue.1 , pp. 86-93
    • Saussez, S.1    Lorfevre, F.2    Lequeux, T.3    Laurent, G.4    Chantrain, G.5    Vertongen, F.6
  • 24
    • 47549102018 scopus 로고    scopus 로고
    • Serum galectin-1 and galectin-3 levels in benign and malignant nodular thyroid disease
    • 18630998 1:CAS:528:DC%2BD1cXos1ChsLY%3D
    • Saussez, S.; Glinoer, D.; Chantrain, G.; Pattou, F.; Carnaille, B.; Andre, S.; et al. (2008). Serum galectin-1 and galectin-3 levels in benign and malignant nodular thyroid disease. Thyroid, 18(7), 705-712.
    • (2008) Thyroid , vol.18 , Issue.7 , pp. 705-712
    • Saussez, S.1    Glinoer, D.2    Chantrain, G.3    Pattou, F.4    Carnaille, B.5    Andre, S.6
  • 25
    • 81255138301 scopus 로고    scopus 로고
    • Serum galectins -2, -4 and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium
    • Barrow, H.; Guo, X.; Wandall, H. H.; Pedersen, J. W.; Fu, B.; Zhao, Q.; et al. (2011). Serum galectins -2, -4 and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium. Clinical Cancer Research, 15;17(22):7035-7046
    • (2011) Clinical Cancer Research , vol.15-17 , Issue.22 , pp. 7035-7046
    • Barrow, H.1    Guo, X.2    Wandall H., .H.3    Pedersen J., .W.4    Fu, B.5    Zhao, Q.6
  • 26
    • 42049121650 scopus 로고    scopus 로고
    • The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation
    • 1:CAS:528:DC%2BD1cXktlWnsbY%3D
    • Pacienza, N.; Pozner, R. G.; Bianco, G. A.; D'Atri, L. P.; Croci, D. O.; Negrotto, S.; et al. (2008). The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation. The FASEB Journal, 22(4), 1113-1123.
    • (2008) The FASEB Journal , vol.22 , Issue.4 , pp. 1113-1123
    • Pacienza, N.1    Pozner, R.G.2    Bianco, G.A.3    D'Atri, L.P.4    Croci, D.O.5    Negrotto, S.6
  • 27
    • 40749138127 scopus 로고    scopus 로고
    • Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma
    • 17588803 1:CAS:528:DC%2BD1cXjtl2qsLw%3D
    • Chiang, W. F.; Liu, S. Y.; Fang, L. Y.; Lin, C. N.; Wu, M. H.; Chen, Y. C.; et al. (2008). Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma. Oral Oncology, 44(4), 325-334.
    • (2008) Oral Oncology , vol.44 , Issue.4 , pp. 325-334
    • Chiang, W.F.1    Liu, S.Y.2    Fang, L.Y.3    Lin, C.N.4    Wu, M.H.5    Chen, Y.C.6
  • 28
    • 84864117886 scopus 로고    scopus 로고
    • High galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion
    • in press
    • Kim, H. J.; Jeon, H. K.; Cho, Y. J.; Park, Y. A.; Choi, J. J.; Do, I. G.; et al. (2012). High galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion. European Journal Cancer (in press)
    • (2012) European Journal Cancer
    • Kim H., .J.1    Jeon H., .K.2    Cho Y., .J.3    Park Y., .A.4    Choi J., .J.5    Do I., .G.6
  • 29
    • 33745228107 scopus 로고    scopus 로고
    • Galectin 7 (p53-induced gene 1): A new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer
    • 16788763
    • Saussez, S.; Cucu, D. R.; Decaestecker, C.; Chevalier, D.; Kaltner, H.; Andre, S.; et al. (2006). Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer. Annals of Surgical Oncology, 13(7), 999-1009.
    • (2006) Annals of Surgical Oncology , vol.13 , Issue.7 , pp. 999-1009
    • Saussez, S.1    Cucu, D.R.2    Decaestecker, C.3    Chevalier, D.4    Kaltner, H.5    Andre, S.6
  • 30
    • 0029589620 scopus 로고
    • Apoptosis of T cells mediated by galectin-1
    • 7501023 1:CAS:528:DyaK2MXhtVSnt7vI
    • Perillo, N. L.; Pace, K. E.; Seilhamer, J. J.; & Baum, L. G. (1995). Apoptosis of T cells mediated by galectin-1. Nature, 378(6558), 736-739.
    • (1995) Nature , vol.378 , Issue.6558 , pp. 736-739
    • Perillo, N.L.1    Pace, K.E.2    Seilhamer, J.J.3    Baum, L.G.4
  • 31
    • 3042742399 scopus 로고    scopus 로고
    • The role of galectins in the initiation, amplification and resolution of the inflammatory response
    • 15191517 1:CAS:528:DC%2BD2cXmtlSnurw%3D
    • Rubinstein, N.; Ilarregui, J. M.; Toscano, M. A.; & Rabinovich, G. A. (2004). The role of galectins in the initiation, amplification and resolution of the inflammatory response. Tissue Antigens, 64(1), 1-12.
    • (2004) Tissue Antigens , vol.64 , Issue.1 , pp. 1-12
    • Rubinstein, N.1    Ilarregui, J.M.2    Toscano, M.A.3    Rabinovich, G.A.4
  • 32
    • 67649781736 scopus 로고    scopus 로고
    • T-cell growth, cell surface organization, and the galectin-glycoprotein lattice
    • 1:CAS:528:DC%2BD1MXhsFGls7fE
    • Grigorian, A.; Torossian, S.; & Demetriou, M. (2009). T-cell growth, cell surface organization, and the galectin-glycoprotein lattice. Immunology Reviews, 230(1), 232-246.
    • (2009) Immunology Reviews , vol.230 , Issue.1 , pp. 232-246
    • Grigorian, A.1    Torossian, S.2    Demetriou, M.3
  • 33
    • 0035889895 scopus 로고    scopus 로고
    • CD45 modulates galectin-1-induced T cell death: Regulation by expression of core 2 O-glycans
    • 11698442 1:CAS:528:DC%2BD3MXotlamtLk%3D
    • Nguyen, J. T.; Evans, D. P.; Galvan, M.; Pace, K. E.; Leitenberg, D.; Bui, T. N.; et al. (2001). CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans. The Journal of Immunology, 167(10), 5697-5707.
    • (2001) The Journal of Immunology , vol.167 , Issue.10 , pp. 5697-5707
    • Nguyen, J.T.1    Evans, D.P.2    Galvan, M.3    Pace, K.E.4    Leitenberg, D.5    Bui, T.N.6
  • 34
    • 0034267915 scopus 로고    scopus 로고
    • CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death
    • 10946254 1:CAS:528:DC%2BD3cXmtFOrsbs%3D
    • Pace, K. E.; Hahn, H. P.; Pang, M.; Nguyen, J. T.; & Baum, L. G. (2000). CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. The Journal of Immunology, 165(5), 2331-2334.
    • (2000) The Journal of Immunology , vol.165 , Issue.5 , pp. 2331-2334
    • Pace, K.E.1    Hahn, H.P.2    Pang, M.3    Nguyen, J.T.4    Baum, L.G.5
  • 35
    • 33749514807 scopus 로고    scopus 로고
    • Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death
    • 17015718 1:CAS:528:DC%2BD28XhtVansrnK
    • Hernandez, J. D.; Nguyen, J. T.; He, J.; Wang, W.; Ardman, B.; Green, J. M.; et al. (2006). Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. The Journal of Immunology, 177(8), 5328-5336.
    • (2006) The Journal of Immunology , vol.177 , Issue.8 , pp. 5328-5336
    • Hernandez, J.D.1    Nguyen, J.T.2    He, J.3    Wang, W.4    Ardman, B.5    Green, J.M.6
  • 36
    • 70349252237 scopus 로고    scopus 로고
    • Galectin-1 induced activation of the mitochondrial apoptotic pathway: Evidence for a connection between death-receptor and mitochondrial pathways in human Jurkat T lymphocytes
    • 19381674 1:CAS:528:DC%2BD1MXovFajtbw%3D
    • Lange, F.; Brandt, B.; Tiedge, M.; Jonas, L.; Jeschke, U.; Pohland, R.; et al. (2009). Galectin-1 induced activation of the mitochondrial apoptotic pathway: evidence for a connection between death-receptor and mitochondrial pathways in human Jurkat T lymphocytes. Histochemistry and Cell Biology, 132(2), 211-223.
    • (2009) Histochemistry and Cell Biology , vol.132 , Issue.2 , pp. 211-223
    • Lange, F.1    Brandt, B.2    Tiedge, M.3    Jonas, L.4    Jeschke, U.5    Pohland, R.6
  • 37
    • 79959979001 scopus 로고    scopus 로고
    • Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death
    • 1:STN:280:DC%2BC3M3jtVKlug%3D%3D
    • Brandt, B.; Abou-Eladab, E. F.; Tiedge, M.; & Walzel, H. (2010). Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death. Cell Death Diseases, 1, e23.
    • (2010) Cell Death Diseases , vol.1 , pp. 23
    • Brandt, B.1    Abou-Eladab, E.F.2    Tiedge, M.3    Walzel, H.4
  • 38
    • 0033555408 scopus 로고    scopus 로고
    • Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation
    • 9916701 1:CAS:528:DyaK1MXovFOrsg%3D%3D
    • Vespa, G. N.; Lewis, L. A.; Kozak, K. R.; Moran, M.; Nguyen, J. T.; Baum, L. G.; et al. (1999). Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation. The Journal of Immunology, 162(2), 799-806.
    • (1999) The Journal of Immunology , vol.162 , Issue.2 , pp. 799-806
    • Vespa, G.N.1    Lewis, L.A.2    Kozak, K.R.3    Moran, M.4    Nguyen, J.T.5    Baum, L.G.6
  • 39
    • 0034292424 scopus 로고    scopus 로고
    • Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction
    • 11034377 1:CAS:528:DC%2BD3cXntVyisrg%3D
    • Chung, C. D.; Patel, V. P.; Moran, M.; Lewis, L. A.; & Miceli, M. C. (2000). Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction. The Journal of Immunology, 165(7), 3722-3729.
    • (2000) The Journal of Immunology , vol.165 , Issue.7 , pp. 3722-3729
    • Chung, C.D.1    Patel, V.P.2    Moran, M.3    Lewis, L.A.4    Miceli, M.C.5
  • 40
    • 14844334137 scopus 로고    scopus 로고
    • Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission
    • 15556941 1:CAS:528:DC%2BD2MXhsV2qtbw%3D
    • Matarrese, P.; Tinari, A.; Mormone, E.; Bianco, G. A.; Toscano, M. A.; Ascione, B.; et al. (2005). Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. The Journal of Biological Chemistry, 280(8), 6969-6985.
    • (2005) The Journal of Biological Chemistry , vol.280 , Issue.8 , pp. 6969-6985
    • Matarrese, P.1    Tinari, A.2    Mormone, E.3    Bianco, G.A.4    Toscano, M.A.5    Ascione, B.6
  • 41
    • 4644305974 scopus 로고    scopus 로고
    • Human galectin-2: Novel inducer of T cell apoptosis with distinct profile of caspase activation
    • 15356130 1:CAS:528:DC%2BD2cXnsVWksr0%3D
    • Sturm, A.; Lensch, M.; Andre, S.; Kaltner, H.; Wiedenmann, B.; Rosewicz, S.; et al. (2004). Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. The Journal of Immunology, 173(6), 3825-3837.
    • (2004) The Journal of Immunology , vol.173 , Issue.6 , pp. 3825-3837
    • Sturm, A.1    Lensch, M.2    Andre, S.3    Kaltner, H.4    Wiedenmann, B.5    Rosewicz, S.6
  • 42
    • 9944222484 scopus 로고    scopus 로고
    • Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death
    • 15297883 1:CAS:528:DC%2BD2cXpslWitbg%3D
    • Hahn, H. P.; Pang, M.; He, J.; Hernandez, J. D.; Yang, R. Y.; Li, L. Y.; et al. (2004). Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death and Differentiation, 11(12), 1277-1286.
    • (2004) Cell Death and Differentiation , vol.11 , Issue.12 , pp. 1277-1286
    • Hahn, H.P.1    Pang, M.2    He, J.3    Hernandez, J.D.4    Yang, R.Y.5    Li, L.Y.6
  • 44
    • 0345734273 scopus 로고    scopus 로고
    • CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis
    • 14678989 1:CAS:528:DC%2BD3sXpvVagtL4%3D
    • Fukumori, T.; Takenaka, Y.; Yoshii, T.; Kim, H. R.; Hogan, V.; Inohara, H.; et al. (2003). CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis. Cancer Research, 63(23), 8302-8311.
    • (2003) Cancer Research , vol.63 , Issue.23 , pp. 8302-8311
    • Fukumori, T.1    Takenaka, Y.2    Yoshii, T.3    Kim, H.R.4    Hogan, V.5    Inohara, H.6
  • 45
    • 0037470066 scopus 로고    scopus 로고
    • The ST6Gal i sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death
    • 12499376 1:CAS:528:DC%2BD3sXhsVKitLo%3D
    • Amano, M.; Galvan, M.; He, J.; & Baum, L. G. (2003). The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. The Journal of Biological Chemistry, 278(9), 7469-7475.
    • (2003) The Journal of Biological Chemistry , vol.278 , Issue.9 , pp. 7469-7475
    • Amano, M.1    Galvan, M.2    He, J.3    Baum, L.G.4
  • 46
    • 33947724303 scopus 로고    scopus 로고
    • Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation
    • 17418791 1:CAS:528:DC%2BD2sXkvVeltLk%3D
    • Lau, K. S.; Partridge, E. A.; Grigorian, A.; Silvescu, C. I.; Reinhold, V. N.; Demetriou, M.; et al. (2007). Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell, 129(1), 123-134.
    • (2007) Cell , vol.129 , Issue.1 , pp. 123-134
    • Lau, K.S.1    Partridge, E.A.2    Grigorian, A.3    Silvescu, C.I.4    Reinhold, V.N.5    Demetriou, M.6
  • 48
    • 34547099820 scopus 로고    scopus 로고
    • Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death
    • 17589510 1:CAS:528:DC%2BD2sXnvFejsLo%3D
    • Toscano, M. A.; Bianco, G. A.; Ilarregui, J. M.; Croci, D. O.; Correale, J.; Hernandez, J. D.; et al. (2007). Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nature Immunology, 8(8), 825-834.
    • (2007) Nature Immunology , vol.8 , Issue.8 , pp. 825-834
    • Toscano, M.A.1    Bianco, G.A.2    Ilarregui, J.M.3    Croci, D.O.4    Correale, J.5    Hernandez, J.D.6
  • 49
    • 33646491737 scopus 로고    scopus 로고
    • Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses
    • 16670344 1:CAS:528:DC%2BD28XktVWns7w%3D
    • Toscano, M. A.; Commodaro, A. G.; Ilarregui, J. M.; Bianco, G. A.; Liberman, A.; Serra, H. M.; et al. (2006). Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses. The Journal of Immunology, 176(10), 6323-6332.
    • (2006) The Journal of Immunology , vol.176 , Issue.10 , pp. 6323-6332
    • Toscano, M.A.1    Commodaro, A.G.2    Ilarregui, J.M.3    Bianco, G.A.4    Liberman, A.5    Serra, H.M.6
  • 50
    • 0034599742 scopus 로고    scopus 로고
    • Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans
    • 10748241 1:CAS:528:DC%2BD3cXit1ygu7w%3D
    • Harrington, L. E.; Galvan, M.; Baum, L. G.; Altman, J. D.; & Ahmed, R. (2000). Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. The Journal of Experimental Medicine, 191(7), 1241-1246.
    • (2000) The Journal of Experimental Medicine , vol.191 , Issue.7 , pp. 1241-1246
    • Harrington, L.E.1    Galvan, M.2    Baum, L.G.3    Altman, J.D.4    Ahmed, R.5
  • 51
    • 0034595685 scopus 로고    scopus 로고
    • Expression of a specific glycosyltransferase enzyme regulates T cell death mediated by galectin-1
    • 10747988 1:CAS:528:DC%2BD3cXjvFCnu7k%3D
    • Galvan, M.; Tsuboi, S.; Fukuda, M.; & Baum, L. G. (2000). Expression of a specific glycosyltransferase enzyme regulates T cell death mediated by galectin-1. The Journal of Biological Chemistry, 275(22), 16730-16737.
    • (2000) The Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 16730-16737
    • Galvan, M.1    Tsuboi, S.2    Fukuda, M.3    Baum, L.G.4
  • 52
    • 80052755020 scopus 로고    scopus 로고
    • Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress. [Research Support, Non-U.S. Gov't]
    • 21523436 1:CAS:528:DC%2BC3MXhtVagtrjN
    • Ito, K.; Scott, S. A.; Cutler, S.; Dong, L. F.; Neuzil, J.; Blanchard, H.; et al. (2011). Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress. [Research Support, Non-U.S. Gov't]. Angiogenesis, 14(3), 293-307.
    • (2011) Angiogenesis , vol.14 , Issue.3 , pp. 293-307
    • Ito, K.1    Scott, S.A.2    Cutler, S.3    Dong, L.F.4    Neuzil, J.5    Blanchard, H.6
  • 53
    • 79959887879 scopus 로고    scopus 로고
    • Tumor Galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis
    • 21546572 1:CAS:528:DC%2BC3MXotlersbw%3D
    • Banh, A.; Zhang, J.; Cao, H.; Bouley, D. M.; Kwok, S.; Kong, C.; et al. (2011). Tumor Galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis. Cancer Research, 71(13), 4423-4431.
    • (2011) Cancer Research , vol.71 , Issue.13 , pp. 4423-4431
    • Banh, A.1    Zhang, J.2    Cao, H.3    Bouley, D.M.4    Kwok, S.5    Kong, C.6
  • 54
    • 43749112760 scopus 로고    scopus 로고
    • Vascular normalization in Rgs5-deficient tumours promotes immune destruction
    • 18418378 1:CAS:528:DC%2BD1cXlvV2qtL4%3D
    • Hamzah, J.; Jugold, M.; Kiessling, F.; Rigby, P.; Manzur, M.; Marti, H. H.; et al. (2008). Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature, 453(7193), 410-414.
    • (2008) Nature , vol.453 , Issue.7193 , pp. 410-414
    • Hamzah, J.1    Jugold, M.2    Kiessling, F.3    Rigby, P.4    Manzur, M.5    Marti, H.H.6
  • 55
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • 21742796 1:CAS:528:DC%2BC3MXhtFyjurzO
    • Goel, S.; Duda, D. G.; Xu, L.; Munn, L. L.; Boucher, Y.; Fukumura, D.; et al. (2011). Normalization of the vasculature for treatment of cancer and other diseases. Physiological Reviews, 91(3), 1071-1121.
    • (2011) Physiological Reviews , vol.91 , Issue.3 , pp. 1071-1121
    • Goel, S.1    Duda, D.G.2    Xu, L.3    Munn, L.L.4    Boucher, Y.5    Fukumura, D.6
  • 56
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • 20631075 1:CAS:528:DC%2BC3cXpsVCntLk%3D
    • Shrimali, R. K.; Yu, Z.; Theoret, M. R.; Chinnasamy, D.; Restifo, N. P.; & Rosenberg, S. A. (2010). Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Research, 70(15), 6171-6180.
    • (2010) Cancer Research , vol.70 , Issue.15 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 57
    • 0034090097 scopus 로고    scopus 로고
    • Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
    • 10835101 1:CAS:528:DC%2BD3cXks1SksLw%3D
    • Griffioen, A. W.; & Molema, G. (2000). Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacological Reviews, 52(2), 237-268.
    • (2000) Pharmacological Reviews , vol.52 , Issue.2 , pp. 237-268
    • Griffioen, A.W.1    Molema, G.2
  • 58
    • 20344379950 scopus 로고    scopus 로고
    • Disrupting tumour blood vessels
    • 15928673 1:CAS:528:DC%2BD2MXks1Gmsr0%3D
    • Tozer, G. M.; Kanthou, C.; & Baguley, B. C. (2005). Disrupting tumour blood vessels. Nature Reviews Cancer, 5(6), 423-435.
    • (2005) Nature Reviews Cancer , vol.5 , Issue.6 , pp. 423-435
    • Tozer, G.M.1    Kanthou, C.2    Baguley, B.C.3
  • 59
    • 36048982445 scopus 로고    scopus 로고
    • Tumor blood vessels, a difficult hurdle for infiltrating leukocytes
    • 17888580 1:CAS:528:DC%2BD2sXht12hsLzN
    • Castermans, K.; & Griffioen, A. W. (2007). Tumor blood vessels, a difficult hurdle for infiltrating leukocytes. Biochimica et Biophysica Acta, 1776(2), 160-174.
    • (2007) Biochimica et Biophysica Acta , vol.1776 , Issue.2 , pp. 160-174
    • Castermans, K.1    Griffioen, A.W.2
  • 60
    • 39549084700 scopus 로고    scopus 로고
    • The galectin profile of the endothelium: Altered expression and localization in activated and tumor endothelial cells
    • 18202194 1:CAS:528:DC%2BD1cXis1aisL0%3D
    • Thijssen, V. L.; Hulsmans, S.; & Griffioen, A. W. (2008). The galectin profile of the endothelium: altered expression and localization in activated and tumor endothelial cells. The American Journal of Pathology, 172(2), 545-553.
    • (2008) The American Journal of Pathology , vol.172 , Issue.2 , pp. 545-553
    • Thijssen, V.L.1    Hulsmans, S.2    Griffioen, A.W.3
  • 61
    • 77955347056 scopus 로고    scopus 로고
    • Tumor cells secrete galectin-1 to enhance endothelial cell activity
    • 20647324 1:CAS:528:DC%2BC3cXpsVCntb8%3D
    • Thijssen, V. L.; Barkan, B.; Shoji, H.; Aries, I. M.; Mathieu, V.; Deltour, L.; et al. (2010). Tumor cells secrete galectin-1 to enhance endothelial cell activity. Cancer Research, 70(15), 6216-6224.
    • (2010) Cancer Research , vol.70 , Issue.15 , pp. 6216-6224
    • Thijssen, V.L.1    Barkan, B.2    Shoji, H.3    Aries, I.M.4    Mathieu, V.5    Deltour, L.6
  • 62
    • 65949100404 scopus 로고    scopus 로고
    • Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression
    • 19412433
    • Le Mercier, M.; Fortin, S.; Mathieu, V.; Roland, I.; Spiegl-Kreinecker, S.; Haibe-Kains, B.; et al. (2009). Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression. Neoplasia, 11(5), 485-496.
    • (2009) Neoplasia , vol.11 , Issue.5 , pp. 485-496
    • Le Mercier, M.1    Fortin, S.2    Mathieu, V.3    Roland, I.4    Spiegl-Kreinecker, S.5    Haibe-Kains, B.6
  • 63
    • 0037344258 scopus 로고    scopus 로고
    • Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin
    • 12649338
    • van den Brule, F.; Califice, S.; Garnier, F.; Fernandez, P. L.; Berchuck, A.; & Castronovo, V. (2003). Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. Laboratory Investigation, 83(3), 377-386.
    • (2003) Laboratory Investigation , vol.83 , Issue.3 , pp. 377-386
    • Van Den Brule, F.1    Califice, S.2    Garnier, F.3    Fernandez, P.L.4    Berchuck, A.5    Castronovo, V.6
  • 64
    • 0027465761 scopus 로고
    • Altered glycosylation of beta 1 integrins associated with reduced adhesiveness to fibronectin and laminin
    • 1:CAS:528:DyaK3sXkt1Gmurk%3D
    • Kawano, T.; Takasaki, S.; Tao, T. W.; & Kobata, A. (1993). Altered glycosylation of beta 1 integrins associated with reduced adhesiveness to fibronectin and laminin. International Journal of Cancer, 53(1), 91-96.
    • (1993) International Journal of Cancer , vol.53 , Issue.1 , pp. 91-96
    • Kawano, T.1    Takasaki, S.2    Tao, T.W.3    Kobata, A.4
  • 65
    • 33746320397 scopus 로고    scopus 로고
    • Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
    • 16763549 1:CAS:528:DC%2BD28XmvFajtL4%3D
    • Shintani, Y.; Takashima, S.; Asano, Y.; Kato, H.; Liao, Y.; Yamazaki, S.; et al. (2006). Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling. The EMBO Journal, 25(13), 3045-3055.
    • (2006) The EMBO Journal , vol.25 , Issue.13 , pp. 3045-3055
    • Shintani, Y.1    Takashima, S.2    Asano, Y.3    Kato, H.4    Liao, Y.5    Yamazaki, S.6
  • 66
    • 79954559053 scopus 로고    scopus 로고
    • Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
    • 21306301 1:CAS:528:DC%2BC3MXkslGkur4%3D
    • Pellet-Many, C.; Frankel, P.; Evans, I. M.; Herzog, B.; Junemann-Ramirez, M.; & Zachary, I. C. (2011). Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas. The Biochemical Journal, 435(3), 609-618.
    • (2011) The Biochemical Journal , vol.435 , Issue.3 , pp. 609-618
    • Pellet-Many, C.1    Frankel, P.2    Evans, I.M.3    Herzog, B.4    Junemann-Ramirez, M.5    Zachary, I.C.6
  • 67
    • 45949085841 scopus 로고    scopus 로고
    • Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells
    • 18223683 1:CAS:528:DC%2BD1cXntVCmsrg%3D
    • Hsieh, S. H.; Ying, N. W.; Wu, M. H.; Chiang, W. F.; Hsu, C. L.; Wong, T. Y.; et al. (2008). Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells. Oncogene, 27(26), 3746-3753.
    • (2008) Oncogene , vol.27 , Issue.26 , pp. 3746-3753
    • Hsieh, S.H.1    Ying, N.W.2    Wu, M.H.3    Chiang, W.F.4    Hsu, C.L.5    Wong, T.Y.6
  • 68
    • 77952901022 scopus 로고    scopus 로고
    • Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs
    • 20378772 1:CAS:528:DC%2BC3cXmtFCnsb4%3D
    • Sugahara, K. N.; Teesalu, T.; Karmali, P. P.; Kotamraju, V. R.; Agemy, L.; Greenwald, D. R.; et al. (2010). Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science, 328(5981), 1031-1035.
    • (2010) Science , vol.328 , Issue.5981 , pp. 1031-1035
    • Sugahara, K.N.1    Teesalu, T.2    Karmali, P.P.3    Kotamraju, V.R.4    Agemy, L.5    Greenwald, D.R.6
  • 69
    • 34547135687 scopus 로고    scopus 로고
    • Hypoxia and cancer
    • 17404692 1:CAS:528:DC%2BD2sXotFWrtLs%3D
    • Semenza, G. L. (2007). Hypoxia and cancer. Cancer and Metastasis Reviews, 26(2), 223-224.
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 223-224
    • Semenza, G.L.1
  • 70
    • 0034855105 scopus 로고    scopus 로고
    • Hypoxia and oxidative stress in breast cancer. Oxidative stress: Its effects on the growth, metastatic potential and response to therapy of breast cancer
    • 11597322 1:CAS:528:DC%2BD3MXntlegsLk%3D
    • Brown, N. S.; & Bicknell, R. (2001). Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Research, 3(5), 323-327.
    • (2001) Breast Cancer Research , vol.3 , Issue.5 , pp. 323-327
    • Brown, N.S.1    Bicknell, R.2
  • 71
    • 78650387484 scopus 로고    scopus 로고
    • Imaging cycling tumor hypoxia
    • 21159626 1:CAS:528:DC%2BC3cXhsFGrt7zK
    • Matsumoto, S.; Yasui, H.; Mitchell, J. B.; & Krishna, M. C. (2010). Imaging cycling tumor hypoxia. Cancer Research, 70(24), 10019-10023.
    • (2010) Cancer Research , vol.70 , Issue.24 , pp. 10019-10023
    • Matsumoto, S.1    Yasui, H.2    Mitchell, J.B.3    Krishna, M.C.4
  • 72
    • 33846204728 scopus 로고    scopus 로고
    • Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: Implications for anticancer therapies
    • 17178869 1:CAS:528:DC%2BD28Xhtlagu7%2FM
    • Martinive, P.; Defresne, F.; Bouzin, C.; Saliez, J.; Lair, F.; Grégoire, V.; et al. (2006). Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies. Cancer Research, 66(24), 11736-11744.
    • (2006) Cancer Research , vol.66 , Issue.24 , pp. 11736-11744
    • Martinive, P.1    Defresne, F.2    Bouzin, C.3    Saliez, J.4    Lair, F.5    Grégoire, V.6
  • 73
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • 18500244 1:CAS:528:DC%2BD1cXmt1Oksbo%3D
    • Dewhirst, M. W.; Cao, Y.; & Moeller, B. (2008). Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nature Reviews Cancer, 8(6), 425-437.
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 74
    • 54049134838 scopus 로고    scopus 로고
    • Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis
    • 18458121 1:CAS:528:DC%2BD1cXotFaisbg%3D
    • Vaupel, P. (2008). Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. The Oncologist, 13(Suppl 3), 21-26.
    • (2008) The Oncologist , vol.13 , Issue.SUPPL. 3 , pp. 21-26
    • Vaupel, P.1
  • 76
    • 33749512970 scopus 로고    scopus 로고
    • Cutting edge: Hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
    • 17015677 1:CAS:528:DC%2BD28XhtVansr3I
    • Lukashev, D.; Klebanov, B.; Kojima, H.; Grinberg, A.; Ohta, A.; Berenfeld, L.; et al. (2006). Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. The Journal of Immunology, 177(8), 4962-4965.
    • (2006) The Journal of Immunology , vol.177 , Issue.8 , pp. 4962-4965
    • Lukashev, D.1    Klebanov, B.2    Kojima, H.3    Grinberg, A.4    Ohta, A.5    Berenfeld, L.6
  • 77
    • 65449154326 scopus 로고    scopus 로고
    • The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis
    • 19265129 1:CAS:528:DC%2BD1MXis12it7Y%3D
    • Noman, M. Z.; Buart, S.; Van Pelt, J.; Richon, C.; Hasmim, M.; Leleu, N.; et al. (2009). The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. The Journal of Immunology, 182(6), 3510-3521.
    • (2009) The Journal of Immunology , vol.182 , Issue.6 , pp. 3510-3521
    • Noman, M.Z.1    Buart, S.2    Van Pelt, J.3    Richon, C.4    Hasmim, M.5    Leleu, N.6
  • 78
    • 10244222236 scopus 로고    scopus 로고
    • Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: Coordination by extracellular nucleotide metabolism
    • 15319286 1:CAS:528:DC%2BD2cXhtFaju7vK
    • Eltzschig, H. K.; Thompson, L. F.; Karhausen, J.; Cotta, R. J.; Ibla, J. C.; Robson, S. C.; et al. (2004). Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood, 104(13), 3986-3992.
    • (2004) Blood , vol.104 , Issue.13 , pp. 3986-3992
    • Eltzschig, H.K.1    Thompson, L.F.2    Karhausen, J.3    Cotta, R.J.4    Ibla, J.C.5    Robson, S.C.6
  • 80
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • 21753853 1:CAS:528:DC%2BC3MXovFegs7g%3D
    • Facciabene, A.; Peng, X.; Hagemann, I. S.; Balint, K.; Barchetti, A.; Wang, L. P.; et al. (2011). Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature, 475(7355), 226-230.
    • (2011) Nature , vol.475 , Issue.7355 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3    Balint, K.4    Barchetti, A.5    Wang, L.P.6
  • 81
    • 77955387572 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 mediates expression of galectin-1: The potential role in migration/invasion of colorectal cancer cells
    • 20525878 1:CAS:528:DC%2BC3cXpvFWqsLw%3D
    • Zhao, X. Y.; Chen, T. T.; Xia, L.; Guo, M.; Xu, Y.; Yue, F.; et al. (2010). Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis, 31(8), 1367-1375.
    • (2010) Carcinogenesis , vol.31 , Issue.8 , pp. 1367-1375
    • Zhao, X.Y.1    Chen, T.T.2    Xia, L.3    Guo, M.4    Xu, Y.5    Yue, F.6
  • 82
    • 33144460217 scopus 로고    scopus 로고
    • Galectin-1: A link between tumor hypoxia and tumor immune privilege
    • 16219933 1:CAS:528:DC%2BD28XktVCgtQ%3D%3D
    • Le, Q. T.; Shi, G.; Cao, H.; Nelson, D. W.; Wang, Y.; Chen, E. Y.; et al. (2005). Galectin-1: a link between tumor hypoxia and tumor immune privilege. Journal of Clinical Oncology, 23(35), 8932-8941.
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.35 , pp. 8932-8941
    • Le, Q.T.1    Shi, G.2    Cao, H.3    Nelson, D.W.4    Wang, Y.5    Chen, E.Y.6
  • 83
    • 80052661201 scopus 로고    scopus 로고
    • Melanoma-associated genes, MXI1, FN1, and NME1, are hypoxia responsive in murine and human melanoma cells
    • 21912348 1:CAS:528:DC%2BC3MXhtFGiu7rO
    • Olbryt, M.; Habryka, A.; Tyszkiewicz, T.; Rusin, A.; Cichon, T.; Jarzab, M.; et al. (2011). Melanoma-associated genes, MXI1, FN1, and NME1, are hypoxia responsive in murine and human melanoma cells. Melanoma Research, 21(5), 417-425.
    • (2011) Melanoma Research , vol.21 , Issue.5 , pp. 417-425
    • Olbryt, M.1    Habryka, A.2    Tyszkiewicz, T.3    Rusin, A.4    Cichon, T.5    Jarzab, M.6
  • 85
    • 35748954051 scopus 로고    scopus 로고
    • Tumor-endothelial cell interactions: Therapeutic potential
    • 17498748 1:CAS:528:DC%2BD2sXht1ykur7O
    • Iiizumi, M.; Mohinta, S.; Bandyopadhyay, S.; & Watabe, K. (2007). Tumor-endothelial cell interactions: therapeutic potential. Microvascular Research, 74(2-3), 114-120.
    • (2007) Microvascular Research , vol.74 , Issue.2-3 , pp. 114-120
    • Iiizumi, M.1    Mohinta, S.2    Bandyopadhyay, S.3    Watabe, K.4
  • 86
    • 44349193400 scopus 로고    scopus 로고
    • Stepping out of the flow: Capillary extravasation in cancer metastasis
    • 1:CAS:528:DC%2BD1cXptVSqu7o%3D
    • Miles, F. L.; Pruitt, F. L.; van Golen, K. L.; & Cooper, C. R. (2008). Stepping out of the flow: capillary extravasation in cancer metastasis. Clinical & Experimental Metastasis, 25(4), 305-324.
    • (2008) Clinical & Experimental Metastasis , vol.25 , Issue.4 , pp. 305-324
    • Miles, F.L.1    Pruitt, F.L.2    Van Golen, K.L.3    Cooper, C.R.4
  • 88
    • 0031959770 scopus 로고    scopus 로고
    • Galectins: Versatile modulators of cell adhesion, cell proliferation, and cell death
    • 1:CAS:528:DyaK1cXjsleku7k%3D
    • Perillo, N. L.; Marcus, M. E.; & Baum, L. G. (1998). Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. Journal Molecular Medica (Berliner), 76(6), 402-412.
    • (1998) Journal Molecular Medica (Berliner) , vol.76 , Issue.6 , pp. 402-412
    • Perillo, N.L.1    Marcus, M.E.2    Baum, L.G.3
  • 89
    • 84863718828 scopus 로고    scopus 로고
    • Inhibiting galectin-1 reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence
    • doi: 10.1007/s10585-012-9471-7
    • Ito, K.; & Ralph, S. J. (2012). Inhibiting galectin-1 reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence. Clinical and Experimental Metastasis. doi: 10.1007/s10585-012- 9471-7.
    • (2012) Clinical and Experimental Metastasis
    • Ito, K.1    Ralph S., .J.2
  • 90
    • 34447136940 scopus 로고    scopus 로고
    • Galectins: Matricellular glycan-binding proteins linking cell adhesion, migration, and survival
    • 17497244 1:CAS:528:DC%2BD2sXos1Crsr0%3D
    • Elola, M. T.; Wolfenstein-Todel, C.; Troncoso, M. F.; Vasta, G. R.; & Rabinovich, G. A. (2007). Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Cellular and Molecular Life Sciences, 64(13), 1679-1700.
    • (2007) Cellular and Molecular Life Sciences , vol.64 , Issue.13 , pp. 1679-1700
    • Elola, M.T.1    Wolfenstein-Todel, C.2    Troncoso, M.F.3    Vasta, G.R.4    Rabinovich, G.A.5
  • 92
    • 84858977200 scopus 로고    scopus 로고
    • Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor associated dendritic cells by expressing HB-EGF
    • 9753-9764
    • Kuo, P. L.; Huang, M. S.; Cheng, D. E.; Hung, J. Y.; Yang, C. J.; & Chou, S. H. (2012). Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor associated dendritic cells by expressing HB-EGF. Journal of Biological Chemistry, 23;287(13):9753-9764.
    • (2012) Journal of Biological Chemistry , vol.23 , Issue.13 , pp. 287
    • Kuo P., .L.1    Huang M., .S.2    Cheng D., .E.3    Hung J., .Y.4    Yang C., .J.5    Chou S., .H.6
  • 93
    • 84863138173 scopus 로고    scopus 로고
    • A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells
    • 22237208
    • Huang, E. Y.; Chen, Y. F.; Chen, Y. M.; Lin, I. H.; Wang, C. C.; Su, W. H.; et al. (2012). A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells. Cell Death Disease, 3, e251.
    • (2012) Cell Death Disease , vol.3 , pp. 251
    • Huang, E.Y.1    Chen, Y.F.2    Chen, Y.M.3    Lin, I.H.4    Wang, C.C.5    Su, W.H.6
  • 94
    • 0037205398 scopus 로고    scopus 로고
    • Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species
    • 11884408 1:CAS:528:DC%2BD38XksVWltLc%3D
    • Cho, H. J.; Jeong, H. G.; Lee, J. S.; Woo, E. R.; Hyun, J. W.; Chung, M. H.; et al. (2002). Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species. The Journal of Biological Chemistry, 277(22), 19358-19366.
    • (2002) The Journal of Biological Chemistry , vol.277 , Issue.22 , pp. 19358-19366
    • Cho, H.J.1    Jeong, H.G.2    Lee, J.S.3    Woo, E.R.4    Hyun, J.W.5    Chung, M.H.6
  • 95
    • 0037542854 scopus 로고    scopus 로고
    • Ras proteins: Different signals from different locations
    • 12728271 1:CAS:528:DC%2BD3sXjtlalt7g%3D
    • Hancock, J. F. (2003). Ras proteins: different signals from different locations. Nature Reviews Molecular Cell Biology, 4(5), 373-384.
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.5 , pp. 373-384
    • Hancock, J.F.1
  • 96
    • 2342508517 scopus 로고    scopus 로고
    • Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP
    • 15126348 1:CAS:528:DC%2BD2cXjs1ehtrg%3D
    • Rotblat, B.; Niv, H.; Andre, S.; Kaltner, H.; Gabius, H. J.; & Kloog, Y. (2004). Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP. Cancer Research, 64(9), 3112-3118.
    • (2004) Cancer Research , vol.64 , Issue.9 , pp. 3112-3118
    • Rotblat, B.1    Niv, H.2    Andre, S.3    Kaltner, H.4    Gabius, H.J.5    Kloog, Y.6
  • 97
    • 0035829731 scopus 로고    scopus 로고
    • Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation
    • 11709720 1:CAS:528:DC%2BD3MXovVyrt70%3D
    • Paz, A.; Haklai, R.; Elad-Sfadia, G.; Ballan, E.; & Kloog, Y. (2001). Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene, 20(51), 7486-7493.
    • (2001) Oncogene , vol.20 , Issue.51 , pp. 7486-7493
    • Paz, A.1    Haklai, R.2    Elad-Sfadia, G.3    Ballan, E.4    Kloog, Y.5
  • 98
    • 23944500772 scopus 로고    scopus 로고
    • C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: Efficient lectin inhibition through double arginine-arene interactions
    • 1:CAS:528:DC%2BD2MXps12hsLk%3D
    • Cumpstey, I.; Sundin, A.; Leffler, H.; & Nilsson, U. J. (2005). C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions. Angewandte Chemie (International Ed. in English), 44(32), 5110-5112.
    • (2005) Angewandte Chemie (International Ed. in English) , vol.44 , Issue.32 , pp. 5110-5112
    • Cumpstey, I.1    Sundin, A.2    Leffler, H.3    Nilsson, U.J.4
  • 99
    • 34548118303 scopus 로고    scopus 로고
    • Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters
    • 17631664 1:CAS:528:DC%2BD2sXps1altLo%3D
    • Cumpstey, I.; Salomonsson, E.; Sundin, A.; Leffler, H.; & Nilsson, U. J. (2007). Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters. Chembiochem, 8(12), 1389-1398.
    • (2007) Chembiochem , vol.8 , Issue.12 , pp. 1389-1398
    • Cumpstey, I.1    Salomonsson, E.2    Sundin, A.3    Leffler, H.4    Nilsson, U.J.5
  • 105
    • 79954601101 scopus 로고    scopus 로고
    • The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins
    • 21372130 1:CAS:528:DC%2BC3MXkslWjt7o%3D
    • Salomonsson, E.; Thijssen, V. L.; Griffioen, A. W.; Nilsson, U. J.; & Leffler, H. (2011). The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins. The Journal of Biological Chemistry, 286(16), 13801-13804.
    • (2011) The Journal of Biological Chemistry , vol.286 , Issue.16 , pp. 13801-13804
    • Salomonsson, E.1    Thijssen, V.L.2    Griffioen, A.W.3    Nilsson, U.J.4    Leffler, H.5
  • 106
    • 0028916852 scopus 로고
    • Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin
    • 7853416 1:CAS:528:DyaK2MXkslGisrk%3D
    • Pienta, K. J.; Naik, H.; Akhtar, A.; Yamazaki, K.; Replogle, T. S.; Lehr, J.; et al. (1995). Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. Journal of the National Cancer Institute, 87(5), 348-353.
    • (1995) Journal of the National Cancer Institute , vol.87 , Issue.5 , pp. 348-353
    • Pienta, K.J.1    Naik, H.2    Akhtar, A.3    Yamazaki, K.4    Replogle, T.S.5    Lehr, J.6
  • 107
    • 79958708479 scopus 로고    scopus 로고
    • Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment
    • 21368866 1:STN:280:DC%2BC3M3jsVWgtg%3D%3D
    • Wang, Y.; Nangia-Makker, P.; Balan, V.; Hogan, V.; & Raz, A. (2010). Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment. Cell Death Dis, 1, e101.
    • (2010) Cell Death Dis , vol.1 , pp. 101
    • Wang, Y.1    Nangia-Makker, P.2    Balan, V.3    Hogan, V.4    Raz, A.5
  • 108
    • 63449129739 scopus 로고    scopus 로고
    • Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model
    • 19109874 1:CAS:528:DC%2BD1MXktlKmt7c%3D
    • Liu, H. Y.; Huang, Z. L.; Yang, G. H.; Lu, W. Q.; & Yu, N. R. (2008). Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model. World Journal of Gastroenterology, 14(48), 7386-7391.
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.48 , pp. 7386-7391
    • Liu, H.Y.1    Huang, Z.L.2    Yang, G.H.3    Lu, W.Q.4    Yu, N.R.5
  • 109
    • 84867994052 scopus 로고    scopus 로고
    • Structural Features for alpha-galactomannan binding to galectin-1
    • Miller, M. C.; Klyosov, A.; & Mayo, K. H. (2011). Structural Features for alpha-galactomannan binding to galectin-1. Glycobiology
    • (2011) Glycobiology
    • Miller M., .C.1    Klyosov, A.2    Mayo K., .H.3
  • 111
    • 0037136406 scopus 로고    scopus 로고
    • Oligosaccharide specificity of galectins: A search by frontal affinity chromatography
    • 12223272 1:CAS:528:DC%2BD38XmvVagsLw%3D
    • Hirabayashi, J.; Hashidate, T.; Arata, Y.; Nishi, N.; Nakamura, T.; Hirashima, M.; et al. (2002). Oligosaccharide specificity of galectins: a search by frontal affinity chromatography. Biochimica et Biophysica Acta, 1572(2-3), 232-254.
    • (2002) Biochimica et Biophysica Acta , vol.1572 , Issue.2-3 , pp. 232-254
    • Hirabayashi, J.1    Hashidate, T.2    Arata, Y.3    Nishi, N.4    Nakamura, T.5    Hirashima, M.6
  • 112
    • 0033215424 scopus 로고    scopus 로고
    • Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1
    • 10490978 1:CAS:528:DyaK1MXmt1yjurg%3D
    • Pace, K. E.; Lee, C.; Stewart, P. L.; & Baum, L. G. (1999). Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. The Journal of Immunology, 163(7), 3801-3811.
    • (1999) The Journal of Immunology , vol.163 , Issue.7 , pp. 3801-3811
    • Pace, K.E.1    Lee, C.2    Stewart, P.L.3    Baum, L.G.4
  • 113
    • 53049084874 scopus 로고    scopus 로고
    • N-Glycans in cancer progression
    • 18701722 1:CAS:528:DC%2BD1cXhtFOgtL3O
    • Lau, K. S.; & Dennis, J. W. (2008). N-Glycans in cancer progression. Glycobiology, 18(10), 750-760.
    • (2008) Glycobiology , vol.18 , Issue.10 , pp. 750-760
    • Lau, K.S.1    Dennis, J.W.2
  • 114
    • 84857740465 scopus 로고    scopus 로고
    • Human prostate cancer in a clinically relevant xenograft mouse model: Identification of β(1,6)-branched oligosaccharides as a marker of tumor progression
    • Lange, T.; Ullrich, S.; Müller, I.; Nentwich, M. F.; Stübke, K.; Feldhaus, S.; et al. (2012). Human prostate cancer in a clinically relevant xenograft mouse model: identification of β(1,6)-branched oligosaccharides as a marker of tumor progression. Clinical Cancer Research, 18(5), 1-10.
    • (2012) Clinical Cancer Research , vol.18 , Issue.5 , pp. 1-10
    • Lange, T.1    Ullrich, S.2    Müller, I.3    Nentwich, M.F.4    Stübke, K.5    Feldhaus, S.6
  • 115
    • 84859378239 scopus 로고    scopus 로고
    • Vascular normalization by loss of Siah2-/- results in increased chemotherapeutic efficacy
    • 22354750 1:CAS:528:DC%2BC38XkvVelsLk%3D
    • Wong, C. S.; Sceneay, J. E.; House, C. M.; Halse, H. M.; Liu, M. C.; George, J.; et al. (2012). Vascular normalization by loss of Siah2-/- results in increased chemotherapeutic efficacy. Cancer Research, 72, 1694-1704.
    • (2012) Cancer Research , vol.72 , pp. 1694-1704
    • Wong, C.S.1    Sceneay, J.E.2    House, C.M.3    Halse, H.M.4    Liu, M.C.5    George, J.6
  • 116
    • 33947512932 scopus 로고    scopus 로고
    • Antiangiogenesis therapy using a novel angiogenesis inhibitor, anginex, following radiation causes tumor growth delay
    • 17380440
    • Amano, M.; Suzuki, M.; Andoh, S.; Monzen, H.; Terai, K.; Williams, B.; et al. (2007). Antiangiogenesis therapy using a novel angiogenesis inhibitor, anginex, following radiation causes tumor growth delay. International Journal of Clinical Oncology, 12(1), 42-47.
    • (2007) International Journal of Clinical Oncology , vol.12 , Issue.1 , pp. 42-47
    • Amano, M.1    Suzuki, M.2    Andoh, S.3    Monzen, H.4    Terai, K.5    Williams, B.6
  • 117
    • 0037439824 scopus 로고    scopus 로고
    • The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin
    • 12543791 1:CAS:528:DC%2BD3sXnt1Krsw%3D%3D
    • Dings, R. P.; Yokoyama, Y.; Ramakrishnan, S.; Griffioen, A. W.; & Mayo, K. H. (2003). The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin. Cancer Research, 63(2), 382-385.
    • (2003) Cancer Research , vol.63 , Issue.2 , pp. 382-385
    • Dings, R.P.1    Yokoyama, Y.2    Ramakrishnan, S.3    Griffioen, A.W.4    Mayo, K.H.5
  • 118
    • 74949118349 scopus 로고    scopus 로고
    • Inhibiting tumor growth by targeting tumor vasculature with galectin-1 antagonist anginex conjugated to the cytotoxic acylfulvene, 6- hydroxylpropylacylfulvene
    • 20020769 1:CAS:528:DC%2BD1MXhsFOrtrvL
    • Dings, R. P.; Van Laar, E. S.; Loren, M.; Webber, J.; Zhang, Y.; Waters, S. J.; et al. (2010). Inhibiting tumor growth by targeting tumor vasculature with galectin-1 antagonist anginex conjugated to the cytotoxic acylfulvene, 6-hydroxylpropylacylfulvene. Bioconjugate Chemistry, 21(1), 20-27.
    • (2010) Bioconjugate Chemistry , vol.21 , Issue.1 , pp. 20-27
    • Dings, R.P.1    Van Laar, E.S.2    Loren, M.3    Webber, J.4    Zhang, Y.5    Waters, S.J.6
  • 119
    • 33646857224 scopus 로고    scopus 로고
    • Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration
    • 16607379 1:CAS:528:DC%2BD28Xkslemu7k%3D
    • He, J.; & Baum, L. G. (2006). Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration. Laboratory Investigation, 86(6), 578-590.
    • (2006) Laboratory Investigation , vol.86 , Issue.6 , pp. 578-590
    • He, J.1    Baum, L.G.2
  • 120
    • 78049310747 scopus 로고    scopus 로고
    • Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
    • 20826047 1:CAS:528:DC%2BC3cXhtlKhs7jM
    • Stannard, K. A.; Collins, P. M.; Ito, K.; Sullivan, E. M.; Scott, S. A.; Gabutero, E.; et al. (2010). Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Letters, 299(2), 95-110.
    • (2010) Cancer Letters , vol.299 , Issue.2 , pp. 95-110
    • Stannard, K.A.1    Collins, P.M.2    Ito, K.3    Sullivan, E.M.4    Scott, S.A.5    Gabutero, E.6
  • 121
    • 0035017215 scopus 로고    scopus 로고
    • Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures
    • 11414198 1:CAS:528:DC%2BD3MXjt1Chsrg%3D
    • Lahm, H.; Andre, S.; Hoeflich, A.; Fischer, J. R.; Sordat, B.; Kaltner, H.; et al. (2001). Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. Journal of Cancer Research and Clinical Oncology, 127(6), 375-386.
    • (2001) Journal of Cancer Research and Clinical Oncology , vol.127 , Issue.6 , pp. 375-386
    • Lahm, H.1    Andre, S.2    Hoeflich, A.3    Fischer, J.R.4    Sordat, B.5    Kaltner, H.6
  • 122
    • 0037142179 scopus 로고    scopus 로고
    • Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance
    • 1:CAS:528:DC%2BD38XksVajs7o%3D
    • Kageshita, T.; Kashio, Y.; Yamauchi, A.; Seki, M.; Abedin, M. J.; Nishi, N.; et al. (2002). Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance. International Journal of Cancer, 99(6), 809-816.
    • (2002) International Journal of Cancer , vol.99 , Issue.6 , pp. 809-816
    • Kageshita, T.1    Kashio, Y.2    Yamauchi, A.3    Seki, M.4    Abedin, M.J.5    Nishi, N.6
  • 123
    • 34848896271 scopus 로고    scopus 로고
    • Galectin-1 knockdown increases sensitivity to temozolomide in a B16F10 mouse metastatic melanoma model
    • 17495956 1:CAS:528:DC%2BD2sXhtVeisb7F
    • Mathieu, V.; Le Mercier, M.; De Neve, N.; Sauvage, S.; Gras, T.; Roland, I.; et al. (2007). Galectin-1 knockdown increases sensitivity to temozolomide in a B16F10 mouse metastatic melanoma model. The Journal of Investigative Dermatology, 127(10), 2399-2410.
    • (2007) The Journal of Investigative Dermatology , vol.127 , Issue.10 , pp. 2399-2410
    • Mathieu, V.1    Le Mercier, M.2    De Neve, N.3    Sauvage, S.4    Gras, T.5    Roland, I.6
  • 125
    • 79955154452 scopus 로고    scopus 로고
    • Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue
    • 1:CAS:528:DC%2BC3MXltFyjt7g%3D
    • Alves, P. M.; Godoy, G. P.; Gomes, D. Q.; Medeiros, A. M.; de Souza, L. B.; da Silveira, E. J.; et al. (2011). Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue. Pathology Research and Practice, 207(4), 236-240.
    • (2011) Pathology Research and Practice , vol.207 , Issue.4 , pp. 236-240
    • Alves, P.M.1    Godoy, G.P.2    Gomes, D.Q.3    Medeiros, A.M.4    De Souza, L.B.5    Da Silveira, E.J.6
  • 126
    • 12144285871 scopus 로고    scopus 로고
    • Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege
    • 15050916 1:CAS:528:DC%2BD2cXjtVartbY%3D
    • Rubinstein, N.; Alvarez, M.; Zwirner, N. W.; Toscano, M. A.; Ilarregui, J. M.; Bravo, A.; et al. (2004). Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; a potential mechanism of tumor-immune privilege. Cancer Cell, 5(3), 241-251.
    • (2004) Cancer Cell , vol.5 , Issue.3 , pp. 241-251
    • Rubinstein, N.1    Alvarez, M.2    Zwirner, N.W.3    Toscano, M.A.4    Ilarregui, J.M.5    Bravo, A.6
  • 127
    • 45949102754 scopus 로고    scopus 로고
    • Novel insights into the inhibitory effects of galectin-1 on neutrophil recruitment under flow
    • 18372340 1:CAS:528:DC%2BD1cXntVelsbw%3D
    • Cooper, D.; Norling, L. V.; & Perretti, M. (2008). Novel insights into the inhibitory effects of galectin-1 on neutrophil recruitment under flow. Journal of Leukocyte Biology, 83(6), 1459-1466.
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.6 , pp. 1459-1466
    • Cooper, D.1    Norling, L.V.2    Perretti, M.3
  • 128
    • 0034101698 scopus 로고    scopus 로고
    • Concentrations of galectin-3 in the sera of normal controls and cancer patients
    • 10778968 1:CAS:528:DC%2BD3cXjtVOqt7k%3D
    • Iurisci, I.; Tinari, N.; Natoli, C.; Angelucci, D.; Cianchetti, E.; & Iacobelli, S. (2000). Concentrations of galectin-3 in the sera of normal controls and cancer patients. Clinical Cancer Research, 6(4), 1389-1393.
    • (2000) Clinical Cancer Research , vol.6 , Issue.4 , pp. 1389-1393
    • Iurisci, I.1    Tinari, N.2    Natoli, C.3    Angelucci, D.4    Cianchetti, E.5    Iacobelli, S.6
  • 130
  • 131
    • 0344559105 scopus 로고    scopus 로고
    • Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting
    • 12673710
    • Nagy, N.; Legendre, H.; Engels, O.; Andre, S.; Kaltner, H.; Wasano, K.; et al. (2003). Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting. Cancer, 97(8), 1849-1858.
    • (2003) Cancer , vol.97 , Issue.8 , pp. 1849-1858
    • Nagy, N.1    Legendre, H.2    Engels, O.3    Andre, S.4    Kaltner, H.5    Wasano, K.6
  • 132
    • 84855170684 scopus 로고    scopus 로고
    • Transient gene silencing of galectin-3 suppresses pancreatic cancer cell migration and invasion through degradation of beta-catenin
    • 1:CAS:528:DC%2BC3MXhtlKgurrP
    • Kobayashi, T.; Shimura, T.; Yajima, T.; Kubo, N.; Araki, K.; Tsutsumi, S.; et al. (2011). Transient gene silencing of galectin-3 suppresses pancreatic cancer cell migration and invasion through degradation of beta-catenin. International Journal of Cancer, 129(12), 2775-2786.
    • (2011) International Journal of Cancer , vol.129 , Issue.12 , pp. 2775-2786
    • Kobayashi, T.1    Shimura, T.2    Yajima, T.3    Kubo, N.4    Araki, K.5    Tsutsumi, S.6
  • 133
    • 77951939167 scopus 로고    scopus 로고
    • Evidence of heavy methylation in the galectin 3 promoter in early stages of prostate adenocarcinoma: Development and validation of a methylated marker for early diagnosis of prostate cancer
    • 19701499
    • Ahmed, H.; Cappello, F.; Rodolico, V.; & Vasta, G. R. (2009). Evidence of heavy methylation in the galectin 3 promoter in early stages of prostate adenocarcinoma: development and validation of a methylated marker for early diagnosis of prostate cancer. Translational Oncology, 2(3), 146-156.
    • (2009) Translational Oncology , vol.2 , Issue.3 , pp. 146-156
    • Ahmed, H.1    Cappello, F.2    Rodolico, V.3    Vasta, G.R.4
  • 134
    • 0343962593 scopus 로고    scopus 로고
    • Alteration of the cytoplasmic/nuclear expression pattern of galectin-3 correlates with prostate carcinoma progression
    • van den Brule, F. A.; Waltregny, D.; Liu, F. T.; & Castronovo, V. (2000). Alteration of the cytoplasmic/nuclear expression pattern of galectin-3 correlates with prostate carcinoma progression. International Journal of Cancer, 89(4), 361-367.
    • (2000) International Journal of Cancer , vol.89 , Issue.4 , pp. 361-367
    • Van Den Brule, F.A.1    Waltregny, D.2    Liu, F.T.3    Castronovo, V.4
  • 135
    • 52049118288 scopus 로고    scopus 로고
    • Tumor-associated galectin-3 modulates the function of tumor-reactive T cells
    • 18757439 1:CAS:528:DC%2BD1cXhtVCrsL7K
    • Peng, W.; Wang, H. Y.; Miyahara, Y.; Peng, G.; & Wang, R. F. (2008). Tumor-associated galectin-3 modulates the function of tumor-reactive T cells.
    • (2008) Cancer Research , vol.68 , Issue.17 , pp. 7228-7236
    • Peng, W.1    Wang, H.Y.2    Miyahara, Y.3    Peng, G.4    Wang, R.F.5
  • 136
    • 22944478661 scopus 로고    scopus 로고
    • Galectin-3 expression is a potent prognostic marker in colorectal cancer
    • 16080575 1:CAS:528:DC%2BD2MXpt1Wrur4%3D
    • Endo, K.; Kohnoe, S.; Tsujita, E.; Watanabe, A.; Nakashima, H.; Baba, H.; et al. (2005). Galectin-3 expression is a potent prognostic marker in colorectal cancer. Anticancer Research, 25(4), 3117-3121.
    • (2005) Anticancer Research , vol.25 , Issue.4 , pp. 3117-3121
    • Endo, K.1    Kohnoe, S.2    Tsujita, E.3    Watanabe, A.4    Nakashima, H.5    Baba, H.6
  • 137
    • 79955522603 scopus 로고    scopus 로고
    • Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells
    • 1:CAS:528:DC%2BC3MXltFegtrw%3D
    • Kobayashi, T.; Shimura, T.; Yajima, T.; Kubo, N.; Araki, K.; Wada, W.; et al. (2011). Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells. Clinical & Experimental Metastasis, 28(4), 367-376.
    • (2011) Clinical & Experimental Metastasis , vol.28 , Issue.4 , pp. 367-376
    • Kobayashi, T.1    Shimura, T.2    Yajima, T.3    Kubo, N.4    Araki, K.5    Wada, W.6
  • 138
    • 71849116316 scopus 로고    scopus 로고
    • Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents
    • 19843071 1:CAS:528:DC%2BC3cXnvVKqtw%3D%3D
    • Cheong, T. C.; Shin, J. Y.; & Chun, K. H. (2010). Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents. Cancer Science, 101(1), 94-102.
    • (2010) Cancer Science , vol.101 , Issue.1 , pp. 94-102
    • Cheong, T.C.1    Shin, J.Y.2    Chun, K.H.3
  • 139
    • 37449015117 scopus 로고    scopus 로고
    • Involvement of decreased galectin-3 expression in the pathogenesis and progression of prostate cancer
    • 18008332
    • Merseburger, A. S.; Kramer, M. W.; Hennenlotter, J.; Simon, P.; Knapp, J.; Hartmann, J. T.; et al. (2008). Involvement of decreased galectin-3 expression in the pathogenesis and progression of prostate cancer. The Prostate, 68(1), 72-77.
    • (2008) The Prostate , vol.68 , Issue.1 , pp. 72-77
    • Merseburger, A.S.1    Kramer, M.W.2    Hennenlotter, J.3    Simon, P.4    Knapp, J.5    Hartmann, J.T.6
  • 140
    • 0034235223 scopus 로고    scopus 로고
    • Decreased galectin-3 expression in prostate cancer
    • 10881021 1:CAS:528:DC%2BD3cXltFOmtL8%3D
    • Pacis, R. A.; Pilat, M. J.; Pienta, K. J.; Wojno, K.; Raz, A.; Hogan, V.; et al. (2000). Decreased galectin-3 expression in prostate cancer. The Prostate, 44(2), 118-123.
    • (2000) The Prostate , vol.44 , Issue.2 , pp. 118-123
    • Pacis, R.A.1    Pilat, M.J.2    Pienta, K.J.3    Wojno, K.4    Raz, A.5    Hogan, V.6
  • 143
    • 34250834372 scopus 로고    scopus 로고
    • Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries
    • 16822880 1:CAS:528:DC%2BD2sXot1CqsLg%3D
    • Heinzelmann-Schwarz, V. A.; Scolyer, R. A.; Scurry, J. P.; Smith, A. N.; Gardiner-Garden, M.; Biankin, A. V.; et al. (2007). Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries. Journal of Clinical Pathology, 60(6), 622-626.
    • (2007) Journal of Clinical Pathology , vol.60 , Issue.6 , pp. 622-626
    • Heinzelmann-Schwarz, V.A.1    Scolyer, R.A.2    Scurry, J.P.3    Smith, A.N.4    Gardiner-Garden, M.5    Biankin, A.V.6
  • 144
    • 34047256445 scopus 로고    scopus 로고
    • Galectin-7 in lymphoma: Elevated expression in human lymphoid malignancies and decreased lymphoma dissemination by antisense strategies in experimental model
    • 17363605 1:CAS:528:DC%2BD2sXivV2nsb0%3D
    • Demers, M.; Biron-Pain, K.; Hebert, J.; Lamarre, A.; Magnaldo, T.; & St-Pierre, Y. (2007). Galectin-7 in lymphoma: elevated expression in human lymphoid malignancies and decreased lymphoma dissemination by antisense strategies in experimental model. Cancer Research, 67(6), 2824-2829.
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2824-2829
    • Demers, M.1    Biron-Pain, K.2    Hebert, J.3    Lamarre, A.4    Magnaldo, T.5    St-Pierre, Y.6
  • 145
    • 0037398950 scopus 로고    scopus 로고
    • Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype
    • 12682633 1:CAS:528:DC%2BD3sXis12isb8%3D
    • Moisan, S.; Demers, M.; Mercier, J.; Magnaldo, T.; Potworowski, E. F.; & St-Pierre, Y. (2003). Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype. Leukemia, 17(4), 751-759.
    • (2003) Leukemia , vol.17 , Issue.4 , pp. 751-759
    • Moisan, S.1    Demers, M.2    Mercier, J.3    Magnaldo, T.4    Potworowski, E.F.5    St-Pierre, Y.6
  • 146
    • 2142749539 scopus 로고    scopus 로고
    • P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells
    • 12883691 1:CAS:528:DC%2BD3sXmvFWgurk%3D
    • Liang, X. Q.; Cao, E. H.; Zhang, Y.; & Qin, J. F. (2003). P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells. Oncology Reports, 10(5), 1265-1269.
    • (2003) Oncology Reports , vol.10 , Issue.5 , pp. 1265-1269
    • Liang, X.Q.1    Cao, E.H.2    Zhang, Y.3    Qin, J.F.4
  • 147
    • 0036175965 scopus 로고    scopus 로고
    • Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor
    • 11839721 1:CAS:528:DC%2BD38XitFegsLo%3D
    • Nagy, N.; Bronckart, Y.; Camby, I.; Legendre, H.; Lahm, H.; Kaltner, H.; et al. (2002). Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor. Gut, 50(3), 392-401.
    • (2002) Gut , vol.50 , Issue.3 , pp. 392-401
    • Nagy, N.1    Bronckart, Y.2    Camby, I.3    Legendre, H.4    Lahm, H.5    Kaltner, H.6
  • 148
    • 61849139471 scopus 로고    scopus 로고
    • Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
    • 19005181 1:CAS:528:DC%2BD1MXivVaqsbk%3D
    • Klibi, J.; Niki, T.; Riedel, A.; Pioche-Durieu, C.; Souquere, S.; Rubinstein, E.; et al. (2009). Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood, 113(9), 1957-1966.
    • (2009) Blood , vol.113 , Issue.9 , pp. 1957-1966
    • Klibi, J.1    Niki, T.2    Riedel, A.3    Pioche-Durieu, C.4    Souquere, S.5    Rubinstein, E.6
  • 149
    • 33748355382 scopus 로고    scopus 로고
    • Galectin-9, a novel prognostic factor with antimetastatic potential in breast cancer
    • 16959001
    • Yamauchi, A.; Kontani, K.; Kihara, M.; Nishi, N.; Yokomise, H.; & Hirashima, M. (2006). Galectin-9, a novel prognostic factor with antimetastatic potential in breast cancer. The Breast Journal, 12(5 Suppl 2), S196-S200.
    • (2006) The Breast Journal , vol.12 , Issue.5 SUPPL. 2
    • Yamauchi, A.1    Kontani, K.2    Kihara, M.3    Nishi, N.4    Yokomise, H.5    Hirashima, M.6
  • 150
    • 20244382990 scopus 로고    scopus 로고
    • Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer
    • 15837748 1:CAS:528:DC%2BD2MXjtlejt7c%3D
    • Irie, A.; Yamauchi, A.; Kontani, K.; Kihara, M.; Liu, D.; Shirato, Y.; et al. (2005). Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer. Clinical Cancer Research, 11(8), 2962-2968.
    • (2005) Clinical Cancer Research , vol.11 , Issue.8 , pp. 2962-2968
    • Irie, A.1    Yamauchi, A.2    Kontani, K.3    Kihara, M.4    Liu, D.5    Shirato, Y.6
  • 151
    • 0035827555 scopus 로고    scopus 로고
    • Cell cycle regulation by galectin-12, a new member of the galectin superfamily
    • 11283015 1:CAS:528:DC%2BD3MXktlKntr4%3D
    • Yang, R. Y.; Hsu, D. K.; Yu, L.; Ni, J.; & Liu, F. T. (2001). Cell cycle regulation by galectin-12, a new member of the galectin superfamily. The Journal of Biological Chemistry, 276(23), 20252-20260.
    • (2001) The Journal of Biological Chemistry , vol.276 , Issue.23 , pp. 20252-20260
    • Yang, R.Y.1    Hsu, D.K.2    Yu, L.3    Ni, J.4    Liu, F.T.5
  • 152
    • 79958708727 scopus 로고    scopus 로고
    • Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation
    • 21493714 1:CAS:528:DC%2BC3MXntlOrsLo%3D
    • Barthel, S. R.; Antonopoulos, A.; Cedeno-Laurent, F.; Schaffer, L.; Hernandez, G.; Patil, S. A.; et al. (2011). Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation. The Journal of Biological Chemistry, 286(24), 21717-21731.
    • (2011) The Journal of Biological Chemistry , vol.286 , Issue.24 , pp. 21717-21731
    • Barthel, S.R.1    Antonopoulos, A.2    Cedeno-Laurent, F.3    Schaffer, L.4    Hernandez, G.5    Patil, S.A.6


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