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Volumn 293, Issue 2, 2010, Pages 230-239

Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells

Author keywords

C myc; Epithelial mesenchymal transition; Extracellular signal regulated kinase; Glycogen synthase kinase 3 ; Snail

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; GREEN FLUORESCENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

EID: 77952490843     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.01.013     Document Type: Article
Times cited : (109)

References (42)
  • 3
    • 0031806044 scopus 로고    scopus 로고
    • The molecular role of Myc in growth and transformation: recent discoveries lead to new insights
    • Facchini L.M., Penn L.Z. The molecular role of Myc in growth and transformation: recent discoveries lead to new insights. FASEB J. 1998, 12:633-651.
    • (1998) FASEB J. , vol.12 , pp. 633-651
    • Facchini, L.M.1    Penn, L.Z.2
  • 5
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber M.A., Kraut N., Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 2005, 17:548-558.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 6
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol. 2003, 15:740-746.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 8
    • 42249109021 scopus 로고    scopus 로고
    • Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells
    • Uttamsingh S., Bao X., Nguyen K.T., Bhanot M., Gong J., Chan J.L., Liu F., Chu T.T., Wang L.H. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene 2008, 27:2626-2634.
    • (2008) Oncogene , vol.27 , pp. 2626-2634
    • Uttamsingh, S.1    Bao, X.2    Nguyen, K.T.3    Bhanot, M.4    Gong, J.5    Chan, J.L.6    Liu, F.7    Chu, T.T.8    Wang, L.H.9
  • 9
    • 0035899466 scopus 로고    scopus 로고
    • IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition
    • Morali O.G., Delmas V., Moore R., Jeanney C., Thiery J.P., Larue L. IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene 2001, 20:4942-4950.
    • (2001) Oncogene , vol.20 , pp. 4942-4950
    • Morali, O.G.1    Delmas, V.2    Moore, R.3    Jeanney, C.4    Thiery, J.P.5    Larue, L.6
  • 10
    • 0036676174 scopus 로고    scopus 로고
    • Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway
    • Janda E., Litos G., Grunert S., Downward J., Beug H. Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway. Oncogene 2002, 21:5148-5159.
    • (2002) Oncogene , vol.21 , pp. 5148-5159
    • Janda, E.1    Litos, G.2    Grunert, S.3    Downward, J.4    Beug, H.5
  • 11
    • 29244476148 scopus 로고    scopus 로고
    • C-erbB2-induced epithelial-mesenchymal transition in mammary epithelial cells is suppressed by cell-cell contact and initiated prior to E-cadherin downregulation
    • Jenndahl L.E., Isakson P., Baeckstrom D. c-erbB2-induced epithelial-mesenchymal transition in mammary epithelial cells is suppressed by cell-cell contact and initiated prior to E-cadherin downregulation. Int. J. Oncol. 2005, 27:439-448.
    • (2005) Int. J. Oncol. , vol.27 , pp. 439-448
    • Jenndahl, L.E.1    Isakson, P.2    Baeckstrom, D.3
  • 12
    • 0029041534 scopus 로고
    • Synergistic interaction of transforming growth factor alpha and c-Myc in mouse mammary and salivary gland tumorigenesis
    • Amundadottir L.T., Johnson M.D., Merlino G., Smith G.H., Dickson R.B. Synergistic interaction of transforming growth factor alpha and c-Myc in mouse mammary and salivary gland tumorigenesis. Cell Growth Differ. 1995, 6:737-748.
    • (1995) Cell Growth Differ. , vol.6 , pp. 737-748
    • Amundadottir, L.T.1    Johnson, M.D.2    Merlino, G.3    Smith, G.H.4    Dickson, R.B.5
  • 13
    • 17644367566 scopus 로고    scopus 로고
    • H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells
    • Shin I., Kim S., Song H., Kim H.R., Moon A. H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells. J. Biol. Chem. 2005, 280:14675-14683.
    • (2005) J. Biol. Chem. , vol.280 , pp. 14675-14683
    • Shin, I.1    Kim, S.2    Song, H.3    Kim, H.R.4    Moon, A.5
  • 14
    • 68849092038 scopus 로고    scopus 로고
    • Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression
    • Kim M.R., Choi H.S., Yang J.W., Park B.C., Kim J.A., Kang K.W. Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression. Mol. Cancer Ther. 2009, 8:2163-2171.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2163-2171
    • Kim, M.R.1    Choi, H.S.2    Yang, J.W.3    Park, B.C.4    Kim, J.A.5    Kang, K.W.6
  • 15
    • 0037453706 scopus 로고    scopus 로고
    • MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer
    • Fujita N., Jaye D.L., Kajita M., Geigerman C., Moreno C.S., Wade P.A. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 2003, 113:207-219.
    • (2003) Cell , vol.113 , pp. 207-219
    • Fujita, N.1    Jaye, D.L.2    Kajita, M.3    Geigerman, C.4    Moreno, C.S.5    Wade, P.A.6
  • 17
    • 33947528384 scopus 로고    scopus 로고
    • Snail silencing effectively suppresses tumour growth and invasiveness
    • Olmeda D., Jorda M., Peinado H., Fabra A., Cano A. Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene 2007, 26:1862-1874.
    • (2007) Oncogene , vol.26 , pp. 1862-1874
    • Olmeda, D.1    Jorda, M.2    Peinado, H.3    Fabra, A.4    Cano, A.5
  • 18
    • 33747625686 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of snail
    • Grotegut S., von Schweinitz D., Christofori G., Lehembre F. Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of snail. EMBO J. 2006, 25:3534-3545.
    • (2006) EMBO J. , vol.25 , pp. 3534-3545
    • Grotegut, S.1    von Schweinitz, D.2    Christofori, G.3    Lehembre, F.4
  • 19
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou B.P., Deng J., Xia W., Xu J., Li Y.M., Gunduz M., Hung M.C. Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 2004, 6:931-940.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.C.7
  • 20
    • 34250744600 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions
    • Doble B.W., Woodgett J.R. Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 2007, 185:73-84.
    • (2007) Cells Tissues Organs , vol.185 , pp. 73-84
    • Doble, B.W.1    Woodgett, J.R.2
  • 21
    • 0035884036 scopus 로고    scopus 로고
    • Association of c-Myc overexpression and hyperproliferation with arsenite-induced malignant transformation
    • Chen H., Liu J., Zhao C.Q., Diwan B.A., Merrick B.A., Waalkes M.P. Association of c-Myc overexpression and hyperproliferation with arsenite-induced malignant transformation. Toxicol. Appl. Pharmacol. 2001, 175:260-268.
    • (2001) Toxicol. Appl. Pharmacol. , vol.175 , pp. 260-268
    • Chen, H.1    Liu, J.2    Zhao, C.Q.3    Diwan, B.A.4    Merrick, B.A.5    Waalkes, M.P.6
  • 23
    • 12144266241 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription: implications for the epithelial-mesenchymal transition
    • Bachelder R.E., Yoon S.O., Franci C., de Herreros A.G., Mercurio A.M. Glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription: implications for the epithelial-mesenchymal transition. J. Cell Biol. 2005, 168:29-33.
    • (2005) J. Cell Biol. , vol.168 , pp. 29-33
    • Bachelder, R.E.1    Yoon, S.O.2    Franci, C.3    de Herreros, A.G.4    Mercurio, A.M.5
  • 24
    • 0036081578 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes
    • Schwabe R.F., Brenner D.A. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 283:G204-G211.
    • (2002) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.283
    • Schwabe, R.F.1    Brenner, D.A.2
  • 25
    • 0022439502 scopus 로고
    • Oncogenes in retroviruses and cells: biochemistry and molecular genetics
    • Bister K., Jansen H.W. Oncogenes in retroviruses and cells: biochemistry and molecular genetics. Adv. Cancer Res. 1986, 47:99-188.
    • (1986) Adv. Cancer Res. , vol.47 , pp. 99-188
    • Bister, K.1    Jansen, H.W.2
  • 27
    • 34248595991 scopus 로고    scopus 로고
    • Synergistic effect of cyclin D1 and c-Myc leads to more aggressive and invasive mammary tumors in severe combined immunodeficient mice
    • Wang Y., Thakur A., Sun Y., Wu J., Biliran H., Bollig A., Liao D.J. Synergistic effect of cyclin D1 and c-Myc leads to more aggressive and invasive mammary tumors in severe combined immunodeficient mice. Cancer Res. 2007, 67:3698-3707.
    • (2007) Cancer Res. , vol.67 , pp. 3698-3707
    • Wang, Y.1    Thakur, A.2    Sun, Y.3    Wu, J.4    Biliran, H.5    Bollig, A.6    Liao, D.J.7
  • 28
    • 33845981503 scopus 로고    scopus 로고
    • Novel c-MYC target genes mediate differential effects on cell proliferation and migration
    • Cappellen D., Schlange T., Bauer M., Maurer F., Hynes N.E. Novel c-MYC target genes mediate differential effects on cell proliferation and migration. EMBO Rep. 2007, 8:70-76.
    • (2007) EMBO Rep. , vol.8 , pp. 70-76
    • Cappellen, D.1    Schlange, T.2    Bauer, M.3    Maurer, F.4    Hynes, N.E.5
  • 30
    • 59649128301 scopus 로고    scopus 로고
    • A positive role for Myc in TGFbeta-induced snail transcription and epithelial-to-mesenchymal transition
    • Smith A.P., Verrecchia A., Fagà G., Doni M., Perna D., Martinato F., Guccione E., Amati B. A positive role for Myc in TGFbeta-induced snail transcription and epithelial-to-mesenchymal transition. Oncogene 2009, 28:422-430.
    • (2009) Oncogene , vol.28 , pp. 422-430
    • Smith, A.P.1    Verrecchia, A.2    Fagà, G.3    Doni, M.4    Perna, D.5    Martinato, F.6    Guccione, E.7    Amati, B.8
  • 31
    • 0033616602 scopus 로고    scopus 로고
    • Transient excess of MYC activity can elicit genomic instability and tumorigenesis
    • Felsher D.W., Bishop J.M. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc. Natl. Acad. Sci. USA 1999, 96:3940-3944.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3940-3944
    • Felsher, D.W.1    Bishop, J.M.2
  • 33
    • 34547425829 scopus 로고    scopus 로고
    • Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen
    • Bubman D., Guasparri I., Cesarman E. Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen. Oncogene 2007, 26:4979-4986.
    • (2007) Oncogene , vol.26 , pp. 4979-4986
    • Bubman, D.1    Guasparri, I.2    Cesarman, E.3
  • 35
    • 26444560222 scopus 로고    scopus 로고
    • Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways
    • Davies M., Robinson M., Smith E., Huntley S., Prime S., Paterson I. Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways. J. Cell. Biochem. 2005, 95:918-931.
    • (2005) J. Cell. Biochem. , vol.95 , pp. 918-931
    • Davies, M.1    Robinson, M.2    Smith, E.3    Huntley, S.4    Prime, S.5    Paterson, I.6
  • 37
    • 0037728809 scopus 로고    scopus 로고
    • The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    • Grille S.J., Bellacos A., Upso J., Klein-Szanto A.J., van Roy F., Lee-Kwon W., Donowitz M., Tsichlis P.N., Laru L. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res. 2003, 63:2172-2178.
    • (2003) Cancer Res. , vol.63 , pp. 2172-2178
    • Grille, S.J.1    Bellacos, A.2    Upso, J.3    Klein-Szanto, A.J.4    van Roy, F.5    Lee-Kwon, W.6    Donowitz, M.7    Tsichlis, P.N.8    Laru, L.9
  • 39
    • 0034059667 scopus 로고    scopus 로고
    • C-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells
    • Gregory M.A., Hann S.R. c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol. Cell. Biol. 2000, 20:2423-2435.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2423-2435
    • Gregory, M.A.1    Hann, S.R.2
  • 40
    • 0034306997 scopus 로고    scopus 로고
    • Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
    • Sears R., Nuckolls F., Haura E., Taya Y., Tamai K., Nevins J.R. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 2000, 14:2501-2514.
    • (2000) Genes Dev. , vol.14 , pp. 2501-2514
    • Sears, R.1    Nuckolls, F.2    Haura, E.3    Taya, Y.4    Tamai, K.5    Nevins, J.R.6
  • 41
    • 45149092780 scopus 로고    scopus 로고
    • NF-kappaB and epithelial to mesenchymal transition of cancer
    • Min C., Eddy S.F., Sherr D.H., Sonenshein G.E. NF-kappaB and epithelial to mesenchymal transition of cancer. J. Cell. Biochem. 2008, 104:733-744.
    • (2008) J. Cell. Biochem. , vol.104 , pp. 733-744
    • Min, C.1    Eddy, S.F.2    Sherr, D.H.3    Sonenshein, G.E.4
  • 42
    • 34147193818 scopus 로고    scopus 로고
    • Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail
    • Kim H.J., Litzenburger B.C., Cui X., Delgado D.A., Grabiner B.C., Lin X., Lewis M.T., Gottardis M.M., Wong T.W., Attar R.M., Carboni J.M., Lee A.V. Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail. Mol. Cell. Biol. 2007, 27:3165-3175.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3165-3175
    • Kim, H.J.1    Litzenburger, B.C.2    Cui, X.3    Delgado, D.A.4    Grabiner, B.C.5    Lin, X.6    Lewis, M.T.7    Gottardis, M.M.8    Wong, T.W.9    Attar, R.M.10    Carboni, J.M.11    Lee, A.V.12


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