메뉴 건너뛰기




Volumn 101, Issue 10, 2009, Pages 1769-1781

Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer

Author keywords

Breast cancer; EMT; Hypoxia; Snail; Tamoxifen

Indexed keywords

MARKER; OXYGEN; TAMOXIFEN; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

EID: 70449527638     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605369     Document Type: Article
Times cited : (148)

References (42)
  • 1
    • 23844528776 scopus 로고    scopus 로고
    • The Snail genes as inducers of cell movement and survival: Implications in development and cancer
    • Barrallo-Gimeno A, Nieto MA (2005) The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132: 3151-3161
    • (2005) Development , vol.132 , pp. 3151-3161
    • Barrallo-Gimeno, A.1    Nieto, M.A.2
  • 3
    • 85047698213 scopus 로고    scopus 로고
    • Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    • Blanco MJ, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, Palacios J, Nieto MA (2002) Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 21: 3241-3246
    • (2002) Oncogene , vol.21 , pp. 3241-3246
    • Blanco, M.J.1    Moreno-Bueno, G.2    Sarrio, D.3    Locascio, A.4    Cano, A.5    Palacios, J.6    Nieto, M.A.7
  • 4
    • 33751277287 scopus 로고    scopus 로고
    • CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance
    • Brennan DJ, Jirstrom K, Kronblad A, Millikan RC, Landberg G, Duffy MJ, Ryden L, Gallagher WM, O'Brien SL (2006) CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin Cancer Res 12: 6421-6431
    • (2006) Clin Cancer Res , vol.12 , pp. 6421-6431
    • Brennan, D.J.1    Jirstrom, K.2    Kronblad, A.3    Millikan, R.C.4    Landberg, G.5    Duffy, M.J.6    Ryden, L.7    Gallagher, W.M.8    O'Brien, S.L.9
  • 6
    • 34247528557 scopus 로고    scopus 로고
    • Hypoxia and metastasis in breast cancer
    • Chaudary N, Hill RP (2006) Hypoxia and metastasis in breast cancer. Breast Dis 26: 55-64
    • (2006) Breast Dis , vol.26 , pp. 55-64
    • Chaudary, N.1    Hill, R.P.2
  • 7
    • 0035963314 scopus 로고    scopus 로고
    • Mechanisms of inactivation of E-cadherin in breast carcinoma: Modification of the two-hit hypothesis of tumor suppressor gene
    • Cheng CW, Wu PE, Yu JC, Huang CS, Yue CT, Wu CW, Shen CY (2001) Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 20: 3814-3823
    • (2001) Oncogene , vol.20 , pp. 3814-3823
    • Cheng, C.W.1    Wu, P.E.2    Yu, J.C.3    Huang, C.S.4    Yue, C.T.5    Wu, C.W.6    Shen, C.Y.7
  • 8
    • 33749024777 scopus 로고    scopus 로고
    • Reassessing epithelial to mesench-ymal transition as a prerequisite for carcinoma invasion and metastasis
    • Christiansen JJ, Rajasekaran AK (2006) Reassessing epithelial to mesench-ymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 66: 8319-8326
    • (2006) Cancer Res , vol.66 , pp. 8319-8326
    • Christiansen, J.J.1    Rajasekaran, A.K.2
  • 9
    • 36849002930 scopus 로고    scopus 로고
    • The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha
    • Dhasarathy A, Kajita M, Wade PA (2007) The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol 21: 2907-2918
    • (2007) Mol Endocrinol , vol.21 , pp. 2907-2918
    • Dhasarathy, A.1    Kajita, M.2    Wade, P.A.3
  • 10
    • 0141526076 scopus 로고    scopus 로고
    • Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer
    • Fearon ER (2003) Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer. Cancer Cell 3: 307-310
    • (2003) Cancer Cell , vol.3 , pp. 307-310
    • Fearon, E.R.1
  • 11
    • 56849118244 scopus 로고    scopus 로고
    • Epithelial injury induces an innate repair mechanism linked to cellular senescence and fibrosis involving insulinlike growth factor binding protein-5
    • Flint D, Allan G, Beattie J (2008) Epithelial injury induces an innate repair mechanism linked to cellular senescence and fibrosis involving insulinlike growth factor binding protein-5. J Endocrinol 199(2): 155-164
    • (2008) J Endocrinol , vol.199 , Issue.2 , pp. 155-164
    • Flint, D.1    Allan, G.2    Beattie, J.3
  • 12
    • 0037086277 scopus 로고    scopus 로고
    • The SLUG zinc-finger protein represses E-cadherin in breast cancer
    • Hajra KM, Chen DY, Fearon ER (2002) The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 62: 1613-1618
    • (2002) Cancer Res , vol.62 , pp. 1613-1618
    • Hajra, K.M.1    Chen, D.Y.2    Fearon, E.R.3
  • 13
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulatory factor in tumour growth
    • Harris AL (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 14
    • 0029812950 scopus 로고    scopus 로고
    • Expression of beta-catenin in normal breast tissue and breast carcinoma: A comparative study with epithelial cadherin and alpha-catenin
    • Hashizume R, Koizumi H, Ihara A, Ohta T, Uchikoshi T (1996) Expression of beta-catenin in normal breast tissue and breast carcinoma: a comparative study with epithelial cadherin and alpha-catenin. Histo-pathology 29: 139-146
    • (1996) Histo-pathology , vol.29 , pp. 139-146
    • Hashizume, R.1    Koizumi, H.2    Ihara, A.3    Ohta, T.4    Uchikoshi, T.5
  • 16
    • 0141760411 scopus 로고    scopus 로고
    • Hypoxia attenuates the expression of E-cadherin via upregulation of SNAIL in ovarian carcinoma cells
    • Imai T, Horiuchi A, Wang C, Oka K, Ohira S, Nikaido T, Konishi I (2003) Hypoxia attenuates the expression of E-cadherin via upregulation of SNAIL in ovarian carcinoma cells. Am J Pathol 163: 1437-1447
    • (2003) Am J Pathol , vol.163 , pp. 1437-1447
    • Imai, T.1    Horiuchi, A.2    Wang, C.3    Oka, K.4    Ohira, S.5    Nikaido, T.6    Konishi, I.7
  • 18
    • 0347504931 scopus 로고    scopus 로고
    • Expression of P-cadherin, but not E-cadherin or N-cadherin, relates to pathological and functional differentiation of breast carcinomas
    • Kovacs A, Dhillon J, Walker RA (2003) Expression of P-cadherin, but not E-cadherin or N-cadherin, relates to pathological and functional differentiation of breast carcinomas. Mol Pathol 56: 318-322
    • (2003) Mol Pathol , vol.56 , pp. 318-322
    • Kovacs, A.1    Dhillon, J.2    Walker, R.A.3
  • 19
    • 33646423829 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha is a prognostic marker in premeno-pausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response
    • Kronblad A, Jirstrom K, Ryden L, Nordenskjold B, Landberg G (2006) Hypoxia inducible factor-1alpha is a prognostic marker in premeno-pausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response. Int J Cancer 118: 2609-2616
    • (2006) Int J Cancer , vol.118 , pp. 2609-2616
    • Kronblad, A.1    Jirstrom, K.2    Ryden, L.3    Nordenskjold, B.4    Landberg, G.5
  • 20
    • 0037453727 scopus 로고    scopus 로고
    • Another tie that binds the MTA family to breast cancer
    • Kumar R (2003) Another tie that binds the MTA family to breast cancer. Cell 113: 142-143
    • (2003) Cell , vol.113 , pp. 142-143
    • Kumar, R.1
  • 21
    • 15544362735 scopus 로고    scopus 로고
    • Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level
    • Kurrey NK, K A, Bapat SA (2005) Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level. Gynecol Oncol 97: 155-165
    • (2005) Gynecol Oncol , vol.97 , pp. 155-165
    • Kurrey, N.K.1    Bapat, S.A.2
  • 22
    • 34547610957 scopus 로고    scopus 로고
    • UPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells
    • Lester RD, Jo M, Montel V, Takimoto S, Gonias SL (2007) uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol 178: 425-436
    • (2007) J Cell Biol , vol.178 , pp. 425-436
    • Lester, R.D.1    Jo, M.2    Montel, V.3    Takimoto, S.4    Gonias, S.L.5
  • 23
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta LA, Kohn EC (2001) The microenvironment of the tumour-host interface. Nature 411: 375-379
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 24
    • 54549108997 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis
    • Lou Y, Preobrazhenska O, auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S (2008) Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis. Dev Dyn 237: 2755-2768
    • (2008) Dev Dyn , vol.237 , pp. 2755-2768
    • Lou, Y.1
  • 25
    • 0037336565 scopus 로고    scopus 로고
    • Signalling to and from tight junctions
    • Matter K, Balda MS (2003) Signalling to and from tight junctions. Nat Rev Mol Cell Biol 4: 225-236
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 225-236
    • Matter, K.1    Balda, M.S.2
  • 26
    • 0027522546 scopus 로고
    • E-cadherin expression in primary and metastatic gastric cancer: Down-regulation correlates with cellular dedifferentiation and glandular disintegration
    • Mayer B, Johnson JP, Leitl F, Jauch KW, Heiss MM, Schildberg FW, Birchmeier W, Funke I (1993) E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 53: 1690-1695
    • (1993) Cancer Res , vol.53 , pp. 1690-1695
    • Mayer, B.1    Johnson, J.P.2    Leitl, F.3    Jauch, K.W.4    Heiss, M.M.5    Schildberg, F.W.6    Birchmeier, W.7    Funke, I.8
  • 29
    • 33947528384 scopus 로고    scopus 로고
    • Snail silencing effectively suppresses tumour growth and invasiveness
    • Olmeda D, Jorda M, Peinado H, Fabra A, Cano A (2007) Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene 26: 1862-1874
    • (2007) Oncogene , vol.26 , pp. 1862-1874
    • Olmeda, D.1    Jorda, M.2    Peinado, H.3    Fabra, A.4    Cano, A.5
  • 30
    • 50649124650 scopus 로고    scopus 로고
    • Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha
    • Park SH, Cheung LW, Wong AS, Leung PC (2008) Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha. Mol Endocrinol 22: 2085-2098
    • (2008) Mol Endocrinol , vol.22 , pp. 2085-2098
    • Park, S.H.1    Cheung, L.W.2    Wong, A.S.3    Leung, P.C.4
  • 32
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7: 415-428
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 34
    • 0142166332 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics, Trends Mol Med 8: S62-S67 Semenza GL (2003) Targeting HIF-1 for cancer therapy
    • Semenza GL (2002) HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8: S62-S67 Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732
    • (2002) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 35
    • 0033650162 scopus 로고    scopus 로고
    • The lymph node as a bridgehead in the metastatic dissemination of tumors
    • Sleeman JP (2000) The lymph node as a bridgehead in the metastatic dissemination of tumors. Recent Results Cancer Res 157: 55-81
    • (2000) Recent Results Cancer Res , vol.157 , pp. 55-81
    • Sleeman, J.P.1
  • 36
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery JP (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15: 740-746
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 37
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 38
    • 0036021479 scopus 로고    scopus 로고
    • Hypoxia in breast cancer: Pathogenesis, characterization and biological/therapeutic implications
    • Vaupel P, Briest S, Hockel M (2002) Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications. Wien Med Wochenschr 152: 334-342
    • (2002) Wien Med Wochenschr , vol.152 , pp. 334-342
    • Vaupel, P.1    Briest, S.2    Hockel, M.3
  • 39
    • 47749131186 scopus 로고    scopus 로고
    • TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development
    • Yang MH, Wu KJ (2008) TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle 7: 2090-2096
    • (2008) Cell Cycle , vol.7 , pp. 2090-2096
    • Yang, M.H.1    Wu, K.J.2
  • 40
    • 16844377441 scopus 로고    scopus 로고
    • 0s subcellular localization and functions
    • Yang Z, Rayala S, Nguyen D, Vadlamudi RK, Chen S, Kumar R (2005) Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail0s subcellular localization and functions. Cancer Res 65: 3179-3184
    • (2005) Cancer Res , vol.65 , pp. 3179-3184
    • Yang, Z.1    Rayala, S.2    Nguyen, D.3    Vadlamudi, R.K.4    Chen, S.5    Kumar, R.6
  • 41
    • 33646586374 scopus 로고    scopus 로고
    • Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: A multigenic study on cancer susceptibility
    • Yu JC, Hsu HM, Chen ST, Hsu GC, Huang CS, Hou MF, Fu YP, Cheng TC, Wu PE, Shen CY (2006) Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. J Biomed Sci 13: 419-432
    • (2006) J Biomed Sci , vol.13 , pp. 419-432
    • Yu, J.C.1    Hsu, H.M.2    Chen, S.T.3    Hsu, G.C.4    Huang, C.S.5    Hou, M.F.6    Fu, Y.P.7    Cheng, T.C.8    Wu, P.E.9    Shen, C.Y.10
  • 42
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6: 931-940
    • (2004) Nat Cell Biol , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.