메뉴 건너뛰기




Volumn 13, Issue 8, 2012, Pages 9545-9571

Implication of tumor microenvironment in chemoresistance: Tumor-associated stromal cells protect tumor cells from cell death

Author keywords

Apoptosis; Cancer; Chemoresistance; Microenvironment

Indexed keywords

ANGIOGENESIS INHIBITOR; CISPLATIN; DOXORUBICIN; MICRORNA; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2 INHIBITOR;

EID: 84865036227     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13089545     Document Type: Review
Times cited : (235)

References (132)
  • 1
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: A major contributor to minimal residual disease
    • Meads, M.B.; Gatenby, R.A.; Dalton, W.S. Environment-mediated drug resistance: A major contributor to minimal residual disease. Nat. Rev. Cancer 2009, 9, 665-674.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 8
    • 79958191830 scopus 로고    scopus 로고
    • Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
    • Rohwer, N.; Cramer, T. Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist.Updat. 2011, 3, 191-201.
    • (2011) Drug Resist.Updat , vol.3 , pp. 191-201
    • Rohwer, N.1    Cramer, T.2
  • 10
    • 79959868249 scopus 로고    scopus 로고
    • Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells
    • Teng, I.W.; Hou, P.C.; Lee, K.D.; Chu, P.Y.; Yeh, K.T.; Jin, V.X.; Tseng, M.J.; Tsai, S.J.; Chang, Y.S.; Wu, C.S., et al. Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer Res. 2011, 13, 4653-4663.
    • (2011) Cancer Res , vol.13 , pp. 4653-4663
    • Teng, I.W.1    Hou, P.C.2    Lee, K.D.3    Chu, P.Y.4    Yeh, K.T.5    Jin, V.X.6    Tseng, M.J.7    Tsai, S.J.8    Chang, Y.S.9    Wu, C.S.10
  • 11
    • 84860697028 scopus 로고    scopus 로고
    • The tumor microenvironment is a dominant force in multidrug resistance
    • Correia, A.L.; Bissell, M.J. The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist.Updat. 2012, 15, 39-49.
    • (2012) Drug Resist.Updat , vol.15 , pp. 39-49
    • Correia, A.L.1    Bissell, M.J.2
  • 13
    • 33846558132 scopus 로고    scopus 로고
    • L1-CAM in a membrane- bound or soluble form augments protection from apoptosis in ovarian carcinoma cells
    • Stoeck, A.; Gast, D.; Sanderson, M.P.; Issa, Y.; Gutwein, P.; Altevogt, P. L1-CAM in a membrane- bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Gynecol.Oncol. 2007, 2, 461-469.
    • (2007) Gynecol.Oncol , vol.2 , pp. 461-469
    • Stoeck, A.1    Gast, D.2    Sanderson, M.P.3    Issa, Y.4    Gutwein, P.5    Altevogt, P.6
  • 15
    • 79959610127 scopus 로고    scopus 로고
    • Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB
    • Eberle, K.E.; Sansing, H.A.; Szaniszlo, P.; Resto, V.A.; Berrier, A.L. Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB. PLoS One 2011, 6, e21496.
    • (2011) PLoS One , vol.6
    • Eberle, K.E.1    Sansing, H.A.2    Szaniszlo, P.3    Resto, V.A.4    Berrier, A.L.5
  • 17
    • 0028951043 scopus 로고
    • Dormancy of micro metastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren, L.; O'Reilly, M.S.; Folkman, J. Dormancy of micro metastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat. Med. 1995, 2, 149-153.
    • (1995) Nat. Med , vol.2 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 18
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet, P.; Jain, R.K. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011, 7347, 298-307.
    • (2011) Nature , vol.7347 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 19
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara, N.; Gerber, H.P.; Le Couter, J. The biology of VEGF and its receptors. Nat. Med. 2003, 6, 669-676.
    • (2003) Nat. Med , vol.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Le-Couter, J.3
  • 20
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin, D.J.; Ellis, L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 2005, 5, 1011-1027.
    • (2005) J. Clin. Oncol , vol.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 21
    • 76249106934 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 in human cancer: Concise review and rationale for development of IMC- 18F1 (Human antibody targeting vascular endothelial growth factor receptor-1)
    • Schwartz, J.D.; Rowinsky, E.K.; Youssoufian, H.; Pytowski, B.; Wu, Y. Vascular endothelial growth factor receptor-1 in human cancer: Concise review and rationale for development of IMC- 18F1 (Human antibody targeting vascular endothelial growth factor receptor-1). Cancer 2010, 4, S1027-S1032.
    • (2010) Cancer , vol.4
    • Schwartz, J.D.1    Rowinsky, E.K.2    Youssoufian, H.3    Pytowski, B.4    Wu, Y.5
  • 23
    • 0036006171 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF), a survival factor for tumour cells: Implications for anti-angiogenic therapy
    • Harmey, J.H.; Bouchier-Hayes, D. Vascular endothelial growth factor (VEGF), a survival factor for tumour cells: Implications for anti-angiogenic therapy. Bioessays 2002, 3, 280-283.
    • (2002) Bioessays , vol.3 , pp. 280-283
    • Harmey, J.H.1    Bouchier-Hayes, D.2
  • 24
    • 33749004555 scopus 로고    scopus 로고
    • Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: Implications for tumor growth, metastasis, and chemoresistance
    • Zhang, L.; Hannay, J.A.; Liu, J.; Das, P.; Zhan, M.; Nguyen, T.; Hicklin, D.J.; Yu, D.; Pollock, R.E.; Lev, D. Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: Implications for tumor growth, metastasis, and chemoresistance. Cancer Res. 2006, 17, 8770-8778.
    • (2006) Cancer Res , vol.17 , pp. 8770-8778
    • Zhang, L.1    Hannay, J.A.2    Liu, J.3    Das, P.4    Zhan, M.5    Nguyen, T.6    Hicklin, D.J.7    Yu, D.8    Pollock, R.E.9    Lev, D.10
  • 25
    • 80051676156 scopus 로고    scopus 로고
    • Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy
    • Yang, F.; Tang, X.; Riquelme, E.; Behrens, C.; Nilsson, M.B.; Giri, U.; Varella-Garcia, M.; Byers, L.A.; Lin, H.Y.; Wang, J., et al. Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy. Cancer Res. 2011, 16, 5512-5521.
    • (2011) Cancer Res , vol.16 , pp. 5512-5521
    • Yang, F.1    Tang, X.2    Riquelme, E.3    Behrens, C.4    Nilsson, M.B.5    Giri, U.6    Varella-Garcia, M.7    Byers, L.A.8    Lin, H.Y.9    Wang, J.10
  • 27
    • 33745087154 scopus 로고    scopus 로고
    • Survivin, a cancer target with an emerging role in normal adult tissues
    • Fukuda, S.; Pelus, L.M. Survivin, a cancer target with an emerging role in normal adult tissues. Mol. Cancer Ther. 2006, 5, 1087-1098.
    • (2006) Mol. Cancer Ther , vol.5 , pp. 1087-1098
    • Fukuda, S.1    Pelus, L.M.2
  • 28
    • 0032963472 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression
    • Nor, J.E.; Christensen, J.; Mooney, D.J.; Polverini, P.J. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am. J. Pathol. 1999, 2, 375-384.
    • (1999) Am. J. Pathol , vol.2 , pp. 375-384
    • Nor, J.E.1    Christensen, J.2    Mooney, D.J.3    Polverini, P.J.4
  • 29
    • 79952534370 scopus 로고    scopus 로고
    • Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells
    • Samuel, S.; Fan, F.; Dang, L.H.; Xia, L.; Gaur, P.; Ellis, L.M. Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells. Oncogene 2011, 10, 1205-1212.
    • (2011) Oncogene , vol.10 , pp. 1205-1212
    • Samuel, S.1    Fan, F.2    Dang, L.H.3    Xia, L.4    Gaur, P.5    Ellis, L.M.6
  • 30
    • 0036530301 scopus 로고    scopus 로고
    • VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
    • Dias, S.; Shmelkov, S.V.; Lam, G.; Rafii, S. VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood 2002, 7, 2532-2540.
    • (2002) Blood , vol.7 , pp. 2532-2540
    • Dias, S.1    Shmelkov, S.V.2    Lam, G.3    Rafii, S.4
  • 31
    • 0033522927 scopus 로고    scopus 로고
    • Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
    • Fujio, Y.; Walsh, K. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J. Biol. Chem. 1999, 23, 16349-16354.
    • (1999) J. Biol. Chem , vol.23 , pp. 16349-16354
    • Fujio, Y.1    Walsh, K.2
  • 32
    • 15044359505 scopus 로고    scopus 로고
    • VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli
    • Wang, L.; Chen, L.; Benincosa, J.; Fortney, J.; Gibson, L.F. VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli. Leukemia 2005, 3, 344-353.
    • (2005) Leukemia , vol.3 , pp. 344-353
    • Wang, L.1    Chen, L.2    Benincosa, J.3    Fortney, J.4    Gibson, L.F.5
  • 33
    • 0034929216 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells
    • Pidgeon, G.P.; Barr, M.P.; Harmey, J.H.; Foley, D.A.; Bouchier-Hayes, D.J. Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells. Br. J. Cancer 2001, 2, 273-278.
    • (2001) Br. J. Cancer , vol.2 , pp. 273-278
    • Pidgeon, G.P.1    Barr, M.P.2    Harmey, J.H.3    Foley, D.A.4    Bouchier-Hayes, D.J.5
  • 34
    • 17144383220 scopus 로고    scopus 로고
    • VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: Implication for apoptosis resistance
    • Lee, Y.K.; Shanafelt, T.D.; Bone, N.D.; Strege, A.K.; Jelinek, D.F.; Kay, N.E. VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: Implication for apoptosis resistance. Leukemia 2005, 4, 513-523.
    • (2005) Leukemia , vol.4 , pp. 513-523
    • Lee, Y.K.1    Shanafelt, T.D.2    Bone, N.D.3    Strege, A.K.4    Jelinek, D.F.5    Kay, N.E.6
  • 35
    • 0242405617 scopus 로고    scopus 로고
    • Endothelial-pericyte interactions in angiogenesis
    • Gerhardt, H.; Betsholtz, C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res. 2003, 1, 15-23.
    • (2003) Cell Tissue Res , vol.1 , pp. 15-23
    • Gerhardt, H.1    Betsholtz, C.2
  • 36
    • 80052667572 scopus 로고    scopus 로고
    • Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
    • Franco, M.; Roswall, P.; Cortez, E.; Hanahan, D.; Pietras, K. Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression. Blood 2011, 10, 2906-2917.
    • (2011) Blood , vol.10 , pp. 2906-2917
    • Franco, M.1    Roswall, P.2    Cortez, E.3    Hanahan, D.4    Pietras, K.5
  • 38
    • 70449360912 scopus 로고    scopus 로고
    • Chemo resistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells
    • doi:10.1186/1476-4598-8-80
    • Michaelis, M.; Klassert, D.; Barth, S.; Suhan, T.; Breitling, R.; Mayer, B.; Hinsch, N.; Doerr, H.W.; Cinatl, J.; Cinatl, J., Jr. Chemo resistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells. Mol. Cancer 2009, doi:10.1186/1476-4598-8-80.
    • (2009) Mol. Cancer
    • Michaelis, M.T.1    Breitling, R.2    Mayer, B.3    Hinsch, N.4    Doerr, H.W.5    Cinatl, J.6    Cinatl Jr., J.7
  • 39
    • 0034120314 scopus 로고    scopus 로고
    • Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line
    • Biroccio, A.; Candiloro, A.; Mottolese, M.; Sapora, O.; Albini, A.; Zupi, G.; del Bufalo, D. Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line. FASEB J. 2000, 5, 652-660.
    • (2000) FASEB J , vol.5 , pp. 652-660
    • Biroccio, A.1    Candiloro, A.2    Mottolese, M.3    Sapora, O.4    Albini, A.5    Zupi, G.6    del Bufalo, D.7
  • 40
    • 33846817095 scopus 로고    scopus 로고
    • Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts
    • Anai, S.; Goodison, S.; Shiverick, K.; Hirao, Y.; Brown, B.D.; Rosser, C.J. Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts. Mol. Cancer Ther. 2007, 1, 101-111.
    • (2007) Mol. Cancer Ther , vol.1 , pp. 101-111
    • Anai, S.1    Goodison, S.2    Shiverick, K.3    Hirao, Y.4    Brown, B.D.5    Rosser, C.J.6
  • 41
    • 14944359615 scopus 로고    scopus 로고
    • Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant
    • Tu, S.P.; Cui, J.T.; Liston, P.; Huajiang, X.; Xu, R.; Lin, M.C.; Zhu, Y.B.; Zou, B.; Ng, S.S.; Jiang, S.H., et al. Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant. Gastroenterology 2005, 2, 361-375.
    • (2005) Gastroenterology , vol.2 , pp. 361-375
    • Tu, S.P.1    Cui, J.T.2    Liston, P.3    Huajiang, X.4    Xu, R.5    Lin, M.C.6    Zhu, Y.B.7    Zou, B.8    Ng, S.S.9    Jiang, S.H.10
  • 43
    • 0030696785 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms
    • Karsan, A.; Yee, E.; Poirier, G.G.; Zhou, P.; Craig, R.; Harlan, J.M. Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms. Am. J. Pathol. 1997, 6, 1775-1784.
    • (1997) Am. J. Pathol , vol.6 , pp. 1775-1784
    • Karsan, A.1    Yee, E.2    Poirier, G.G.3    Zhou, P.4    Craig, R.5    Harlan, J.M.6
  • 46
    • 0036072017 scopus 로고    scopus 로고
    • Regulation of endothelial cell survival and apoptosis during angiogenesis
    • Chavakis, E.; Dimmeler, S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler. Thromb. Vasc. Biol 2002, 6, 887-893.
    • (2002) Arterioscler. Thromb. Vasc. Biol , vol.6 , pp. 887-893
    • Chavakis, E.1    Dimmeler, S.2
  • 49
    • 48749089520 scopus 로고    scopus 로고
    • Increased surviving expression confers chemoresistance to tumor-associated endothelial cells
    • Virrey, J.J.; Guan, S.; Li, W.; Schonthal, A.H.; Chen, T.C.; Hofman, F.M. Increased surviving expression confers chemoresistance to tumor-associated endothelial cells. Am. J. Pathol. 2008, 2, 575-585.
    • (2008) Am. J. Pathol , vol.2 , pp. 575-585
    • Virrey, J.J.1    Guan, S.2    Li, W.3    Schonthal, A.H.4    Chen, T.C.5    Hofman, F.M.6
  • 50
    • 34547790207 scopus 로고    scopus 로고
    • Chemotherapeutic stress selectively activates NF-kappa B- dependent AKT and VEGF expression in liver cancer-derived endothelial cells
    • Meng, F.; Henson, R.; Patel, T. Chemotherapeutic stress selectively activates NF-kappa B- dependent AKT and VEGF expression in liver cancer-derived endothelial cells. Am. J. Physiol. Cell Physiol. 2007, 2, C749-C760.
    • (2007) Am. J. Physiol. Cell Physiol , vol.2
    • Meng, F.1    Henson, R.2    Patel, T.3
  • 51
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim, K.J.; Li, B.; Winer, J.; Armanini, M.; Gillett, N.; Phillips, H.S.; Ferrara, N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993, 6423, 841-844.
    • (1993) Nature , vol.6423 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 53
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong, R.T.; Boucher, Y.; Kozin, S.V.; Winkler, F.; Hicklin, D.J.; Jain, R.K. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 2004, 11, 3731-3736.
    • (2004) Cancer Res , vol.11 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 54
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumors in mice
    • Oreilly, M.S.; Holmgren, L.; Chen, C.; Folkman, J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat. Med. 1996, 6, 689-692.
    • (1996) Nat. Med , vol.6 , pp. 689-692
    • Oreilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 55
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet, P.; Jain, R.K. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat. Rev. Drug Discov. 2011, 6, 417-427.
    • (2011) Nat. Rev. Drug Discov , vol.6 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 57
    • 77952809712 scopus 로고    scopus 로고
    • Effects of bevacizumab plus irinotecan on response and survival in patients with recurrent malignant glioma: A systematic review and survival-gain analysis
    • doi:10.1186/1471-2407-10-252
    • Xu, T.; Chen, J.; Lu, Y.; Wolff, J.E. Effects of bevacizumab plus irinotecan on response and survival in patients with recurrent malignant glioma: A systematic review and survival-gain analysis. BMC Cancer 2010, doi:10.1186/1471-2407-10-252.
    • (2010) BMC Cancer
    • Xu, T.1    Chen, J.2    Lu, Y.3    Wolff, J.E.4
  • 58
    • 2542520723 scopus 로고    scopus 로고
    • Two steps forward in the treatment of colorectal cancer
    • Mayer, R.J. Two steps forward in the treatment of colorectal cancer. N. Engl. J. Med. 2004, 23, 2406-2408.
    • (2004) N. Engl. J. Med , vol.23 , pp. 2406-2408
    • Mayer, R.J.1
  • 59
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antian giogenic therapy
    • Jain, R.K. Normalization of tumor vasculature: An emerging concept in antian giogenic therapy. Science 2005, 5706, 58-62.
    • (2005) Science , vol.5706 , pp. 58-62
    • Jain, R.K.1
  • 60
    • 79959944026 scopus 로고    scopus 로고
    • Antiangiogenic therapy, hypoxia, and metastasis: Risky liaisons, or not?
    • De Bock, K.; Mazzone, M.; Carmeliet, P. Antiangiogenic therapy, hypoxia, and metastasis: Risky liaisons, or not? Nat. Rev. Clin. Oncol. 2011, 7, 393-404.
    • (2011) Nat. Rev. Clin. Oncol , vol.7 , pp. 393-404
    • de Bock, K.1    Mazzone, M.2    Carmeliet, P.3
  • 62
    • 0038172576 scopus 로고    scopus 로고
    • Cancer: Out of air is not out of action
    • Bottaro, D.P.; Liotta, L.A. Cancer: Out of air is not out of action. Nature 2003, 6940, 593-595.
    • (2003) Nature , vol.6940 , pp. 593-595
    • Bottaro, D.P.1    Liotta, L.A.2
  • 63
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 10, 721-732.
    • (2003) Nat. Rev. Cancer , vol.10 , pp. 721-732
    • Semenza, G.L.1
  • 64
    • 0029103274 scopus 로고
    • Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer
    • Liu, Y.; Cox, S.R.; Morita, T.; Kourembanas, S. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ. Res. 1995, 3, 638-643.
    • (1995) Circ. Res , vol.3 , pp. 638-643
    • Liu, Y.1    Cox, S.R.2    Morita, T.3    Kourembanas, S.4
  • 66
    • 1642472018 scopus 로고    scopus 로고
    • Antiangiogenic therapy and tumor progression
    • Blagosklonny, M.V. Antiangiogenic therapy and tumor progression. Cancer Cell 2004, 1, 13-17.
    • (2004) Cancer Cell , vol.1 , pp. 13-17
    • Blagosklonny, M.V.1
  • 67
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos, J.M.; Lee, C.R.; Cruz-Munoz, W.; Bjarnason, G.A.; Christensen, J.G.; Kerbel, R.S. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009, 3, 232-239.
    • (2009) Cancer Cell , vol.3 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 69
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles, D.W.; Chan, A.; Dirix, L.Y.; Cortes, J.; Pivot, X.; Tomczak, P.; Delozier, T.; Sohn, J.H.; Provencher, L.; Puglisi, F., et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J. Clin. Oncol. 2010, 20, 3239-3247.
    • (2010) J. Clin. Oncol , vol.20 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3    Cortes, J.4    Pivot, X.5    Tomczak, P.6    Delozier, T.7    Sohn, J.H.8    Provencher, L.9    Puglisi, F.10
  • 70
    • 50149109090 scopus 로고    scopus 로고
    • Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib
    • Padera, T.P.; Kuo, A.H.; Hoshida, T.; Liao, S.; Lobo, J.; Kozak, K.R.; Fukumura, D.; Jain, R.K. Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Mol. Cancer Ther. 2008, 8, 2272-2279.
    • (2008) Mol. Cancer Ther , vol.8 , pp. 2272-2279
    • Padera, T.P.1    Kuo, A.H.2    Hoshida, T.3    Liao, S.4    Lobo, J.5    Kozak, K.R.6    Fukumura, D.7    Jain, R.K.8
  • 71
    • 0032450975 scopus 로고    scopus 로고
    • Interdependence between cytokines and cell adhesion molecules to induce interleukin-6 production by stromal cells in myeloma
    • Thomas, X.; Anglaret, B.; Magaud, J.P.; Epstein, J.; Archimbaud, E. Interdependence between cytokines and cell adhesion molecules to induce interleukin-6 production by stromal cells in myeloma. Leuk. Lymphoma 1998, 32, 107-119.
    • (1998) Leuk. Lymphoma , vol.32 , pp. 107-119
    • Thomas, X.1    Anglaret, B.2    Magaud, J.P.3    Epstein, J.4    Archimbaud, E.5
  • 72
    • 0034501628 scopus 로고    scopus 로고
    • The tumor microenvironment as a determinant of cancer cell survival: A possible mechanism for de novo drug resistance
    • Shain, K.H.; Landowski, T.H.; Dalton, W.S. The tumor microenvironment as a determinant of cancer cell survival: A possible mechanism for de novo drug resistance. Curr. Opin. Oncol. 2000, 6, 557-563.
    • (2000) Curr. Opin. Oncol , vol.6 , pp. 557-563
    • Shain, K.H.1    Landowski, T.H.2    Dalton, W.S.3
  • 73
    • 77951233373 scopus 로고    scopus 로고
    • Cancer associated fibroblasts (CAFs) in tumor microenvironment
    • Xing, F.; Saidou, J.; Watabe, K. Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci. 2010, 15, 166-179.
    • (2010) Front Biosci , vol.15 , pp. 166-179
    • Xing, F.1    Saidou, J.2    Watabe, K.3
  • 74
    • 84655169986 scopus 로고    scopus 로고
    • The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma
    • Sirica, A.E. The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma. Nat. Rev. Gastroenterol. Hepatol. 2012, 1, 44-54.
    • (2012) Nat. Rev. Gastroenterol. Hepatol , vol.1 , pp. 44-54
    • Sirica, A.E.1
  • 76
    • 67650451085 scopus 로고    scopus 로고
    • The multifaceted role of periostin in tumorigenesis
    • Ruan, K.; Bao, S.; Ouyang, G. The multifaceted role of periostin in tumorigenesis. Cell Mol. Life Sci. 2009, 14, 2219-2230.
    • (2009) Cell Mol. Life Sci , vol.14 , pp. 2219-2230
    • Ruan, K.1    Bao, S.2    Ouyang, G.3
  • 77
    • 0033579444 scopus 로고    scopus 로고
    • Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
    • Park, J.E.; Lenter, M.C.; Zimmermann, R.N.; Garin-Chesa, P.; Old, L.J.; Rettig, W.J. Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J. Biol. Chem. 1999, 51, 36505-36512.
    • (1999) J. Biol. Chem , vol.51 , pp. 36505-36512
    • Park, J.E.1    Lenter, M.C.2    Zimmermann, R.N.3    Garin-Chesa, P.4    Old, L.J.5    Rettig, W.J.6
  • 78
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure-an obstacle in cancer therapy
    • Heldin, C.H.; Rubin, K.; Pietras, K.; Ostman, A. High interstitial fluid pressure-an obstacle in cancer therapy. Nat. Rev. Cancer 2004, 10, 806-813.
    • (2004) Nat. Rev. Cancer , vol.10 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 79
    • 48149105146 scopus 로고    scopus 로고
    • Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
    • Serebriiskii, I.; Castello-Cros, R.; Lamb, A.; Golemis, E.A.; Cukierman, E. Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix. Biol. 2008, 6, 573-585.
    • (2008) Matrix. Biol , vol.6 , pp. 573-585
    • Serebriiskii, I.1    Castello-Cros, R.2    Lamb, A.3    Golemis, E.A.4    Cukierman, E.5
  • 81
    • 33644833474 scopus 로고    scopus 로고
    • Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: Phase II study results
    • Reardon, D.A.; Akabani, G.; Coleman, R.E.; Friedman, A.H.; Friedman, H.S.; Herndon, J.E.; McLendon, R.E.; Pegram, C.N.; Provenzale, J.M.; Quinn, J.A., et al. Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: Phase II study results. J. Clin. Oncol. 2006, 1, 115-122.
    • (2006) J. Clin. Oncol , vol.1 , pp. 115-122
    • Reardon, D.A.1    Akabani, G.2    Coleman, R.E.3    Friedman, A.H.4    Friedman, H.S.5    Herndon, J.E.6    McLendon, R.E.7    Pegram, C.N.8    Provenzale, J.M.9    Quinn, J.A.10
  • 82
    • 33745837774 scopus 로고    scopus 로고
    • Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
    • Loeffler, M.; Kruger, J.A.; Niethammer, A.G.; Reisfeld, R.A. Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. J. Clin. Invest. 2006, 7, 1955-1962.
    • (2006) J. Clin. Invest , vol.7 , pp. 1955-1962
    • Loeffler, M.1    Kruger, J.A.2    Niethammer, A.G.3    Reisfeld, R.A.4
  • 83
    • 34247472169 scopus 로고    scopus 로고
    • Towards in situ tissue repair: Human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2
    • Ringe, J.; Strassburg, S.; Neumann, K.; Endres, M.; Notter, M.; Burmester, G.R.; Kaps, C.; Sittinger, M. Towards in situ tissue repair: Human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2. J. Cell Biochem. 2007, 1, 135-146.
    • (2007) J. Cell Biochem , vol.1 , pp. 135-146
    • Ringe, J.1    Strassburg, S.2    Neumann, K.3    Endres, M.4    Notter, M.5    Burmester, G.R.6    Kaps, C.7    Sittinger, M.8
  • 87
    • 47249119717 scopus 로고    scopus 로고
    • TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells
    • Xu, Y.; Tabe, Y.; Jin, L.; Watt, J.; McQueen, T.; Ohsaka, A.; Andreeff, M.; Konopleva, M. TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells. Br. J. Haematol. 2008, 2, 192-201.
    • (2008) Br. J. Haematol , vol.2 , pp. 192-201
    • Xu, Y.1    Tabe, Y.2    Jin, L.3    Watt, J.4    McQueen, T.5    Ohsaka, A.6    Andreeff, M.7    Konopleva, M.8
  • 88
    • 80052062422 scopus 로고    scopus 로고
    • Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression
    • Hao, M.; Zhang, L.; An, G.; Meng, H.; Han, Y.; Xie, Z.; Xu, Y.; Li, C.; Yu, Z.; Chang, H.; Qiu, L. Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression. Leuk. Lymphoma 2011, 9, 1787-1794.
    • (2011) Leuk. Lymphoma , vol.9 , pp. 1787-1794
    • Hao, M.1    Zhang, L.2    An, G.3    Meng, H.4    Han, Y.5    Xie, Z.6    Xu, Y.7    Li, C.8    Yu, Z.9    Chang, H.10    Qiu, L.11
  • 89
    • 38349086394 scopus 로고    scopus 로고
    • CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
    • Jin, L.; Tabe, Y.; Konoplev, S.; Xu, Y.; Leysath, C.E.; Lu, H.; Kimura, S.; Ohsaka, A.; Rios, M.B.; Calvert, L., et al. CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol. Cancer Ther. 2008, 1, 48-58.
    • (2008) Mol. Cancer Ther , vol.1 , pp. 48-58
    • Jin, L.1    Tabe, Y.2    Konoplev, S.3    Xu, Y.4    Leysath, C.E.5    Lu, H.6    Kimura, S.7    Ohsaka, A.8    Rios, M.B.9    Calvert, L.10
  • 91
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 5, 646-674.
    • (2011) Cell , vol.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 92
    • 0036623140 scopus 로고    scopus 로고
    • Immune escape of tumors: Apoptosis resistance and tumor counterattack
    • Igney, F.H.; Krammer, P.H. Immune escape of tumors: Apoptosis resistance and tumor counterattack. J. Leukoc. Biol. 2002, 6, 907-920.
    • (2002) J. Leukoc. Biol , vol.6 , pp. 907-920
    • Igney, F.H.1    Krammer, P.H.2
  • 95
    • 42149099408 scopus 로고    scopus 로고
    • Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms
    • Biswas, S.K.; Sica, A.; Lewis, C.E. Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms. J. Immunol. 2008, 4, 2011-2017.
    • (2008) J. Immunol , vol.4 , pp. 2011-2017
    • Biswas, S.K.1    Sica, A.2    Lewis, C.E.3
  • 98
    • 45049085722 scopus 로고    scopus 로고
    • Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2
    • Angst, E.; Reber, H.A.; Hines, O.J.; Eibl, G. Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2. Surgery 2008, 1, 57-65.
    • (2008) Surgery , vol.1 , pp. 57-65
    • Angst, E.1    Reber, H.A.2    Hines, O.J.3    Eibl, G.4
  • 99
    • 64049092886 scopus 로고    scopus 로고
    • The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy
    • Halama, N.; Michel, S.; Kloor, M.; Zoernig, I.; Pommerencke, T.; von Knebel Doeberitz, M.; Schirmacher, P.; Weitz, J.; Grabe, N.; Jager, D. The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy. Cancer Immun. 2009, 9, 1.
    • (2009) Cancer Immun , vol.9 , pp. 1
    • Halama, N.1    Michel, S.2    Kloor, M.3    Zoernig, I.4    Pommerencke, T.5    von Knebel, D.M.6    Schirmacher, P.7    Weitz, J.8    Grabe, N.9    Jager, D.10
  • 100
    • 80052227854 scopus 로고    scopus 로고
    • Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy
    • Halama, N.; Michel, S.; Kloor, M.; Zoernig, I.; Benner, A.; Spille, A.; Pommerencke, T.; von Knebel, D.M.; Folprecht, G.; Luber, B., et al. Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy. Cancer Res. 2011, 17, 5670-5677.
    • (2011) Cancer Res , vol.17 , pp. 5670-5677
    • Halama, N.1    Michel, S.2    Kloor, M.3    Zoernig, I.4    Benner, A.5    Spille, A.6    Pommerencke, T.7    von Knebel, D.M.8    Folprecht, G.9    Luber, B.10
  • 104
    • 79960426821 scopus 로고    scopus 로고
    • Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors
    • Mattarollo, S.R.; Loi, S.; Duret, H.; Ma, Y.; Zitvogel, L.; Smyth, M.J. Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors. Cancer Res. 2011, 14, 4809-4820.
    • (2011) Cancer Res , vol.14 , pp. 4809-4820
    • Mattarollo, S.R.1    Loi, S.2    Duret, H.3    Ma, Y.4    Zitvogel, L.5    Smyth, M.J.6
  • 106
    • 84867583274 scopus 로고    scopus 로고
    • Tumorinfiltrating lymphocytes predict response to chemotherapy in patients with advance non-small cell lung cancer
    • doi:10.1007/s00262-012-1231-7
    • Liu, H.; Zhang, T.; Ye, J.; Li, H.; Huang, J.; Li, X.; Wu, B.; Huang, X.; Hou, J. Tumorinfiltrating lymphocytes predict response to chemotherapy in patients with advance non-small cell lung cancer. Cancer Immunol. Immunother. 2012, doi:10.1007/s00262-012-1231-7.
    • (2012) Cancer Immunol. Immunother
    • Liu, H.1    Zhang, T.2    Ye, J.3    Li, H.4    Huang, J.5    Li, X.6    Wu, B.7    Huang, X.8    Hou, J.9
  • 107
    • 62449250053 scopus 로고    scopus 로고
    • Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome
    • Gobert, M.; Treilleux, I.; Bendriss-Vermare, N.; Bachelot, T.; Goddard-Leon, S.; Arfi, V.; Biota, C.; Doffin, A.C.; Durand, I.; Olive, D., et al. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res. 2009, 5, 2000-2009.
    • (2009) Cancer Res , vol.5 , pp. 2000-2009
    • Gobert, M.1    Treilleux, I.2    Bendriss-Vermare, N.3    Bachelot, T.4    Goddard-Leon, S.5    Arfi, V.6    Biota, C.7    Doffin, A.C.8    Durand, I.9    Olive, D.10
  • 109
    • 79951815749 scopus 로고    scopus 로고
    • Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer
    • Tosolini, M.; Kirilovsky, A.; Mlecnik, B.; Fredriksen, T.; Mauger, S.; Bindea, G.; Berger, A.; Bruneval, P.; Fridman, W.H.; Pages, F., et al. Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. Cancer Res.2011, 4, 1263-1271.
    • (2011) Cancer Res , vol.4 , pp. 1263-1271
    • Tosolini, M.1    Kirilovsky, A.2    Mlecnik, B.3    Fredriksen, T.4    Mauger, S.5    Bindea, G.6    Berger, A.7    Bruneval, P.8    Fridman, W.H.9    Pages, F.10
  • 110
    • 67651160649 scopus 로고    scopus 로고
    • CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • Denardo, D.G.; Barreto, J.B.; Andreu, P.; Vasquez, L.; Tawfik, D.; Kolhatkar, N.; Coussens, L.M. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009, 2, 91-102.
    • (2009) Cancer Cell , vol.2 , pp. 91-102
    • Denardo, D.G.1    Barreto, J.B.2    Andreu, P.3    Vasquez, L.4    Tawfik, D.5    Kolhatkar, N.6    Coussens, L.M.7
  • 113
    • 77950196277 scopus 로고    scopus 로고
    • T(H)17 cells in tumour immunity and immunotherapy
    • Zou, W.; Restifo, N.P. T(H)17 cells in tumour immunity and immunotherapy. Nat. Rev. Immunol. 2010, 4, 248-256.
    • (2010) Nat. Rev. Immunol , vol.4 , pp. 248-256
    • Zou, W.1    Restifo, N.P.2
  • 114
    • 84858163275 scopus 로고    scopus 로고
    • Cytotoxic chemotherapy and CD4+ effector T cells: An emerging alliance for durable antitumor effects
    • doi:10.1155/2012/890178
    • Ding, Z.C.; Zhou, G. Cytotoxic chemotherapy and CD4+ effector T cells: An emerging alliance for durable antitumor effects. Clin. Dev. Immunol. 2012, doi:10.1155/2012/890178.
    • (2012) Clin. Dev. Immunol
    • Ding, Z.C.1    Zhou, G.2
  • 115
    • 79951811209 scopus 로고    scopus 로고
    • Tumor-intrinsic and-extrinsic roles of c-Kit: Mast cells as the primary off-target of tyrosine kinase inhibitors
    • Pittoni, P.; Piconese, S.; Tripodo, C.; Colombo, M.P. Tumor-intrinsic and-extrinsic roles of c-Kit: Mast cells as the primary off-target of tyrosine kinase inhibitors. Oncogene 2011, 7, 757-769.
    • (2011) Oncogene , vol.7 , pp. 757-769
    • Pittoni, P.1    Piconese, S.2    Tripodo, C.3    Colombo, M.P.4
  • 117
    • 84857201114 scopus 로고    scopus 로고
    • The dark side of mast cell-targeted therapy in prostate cancer
    • Pittoni, P.; Colombo, M.P. The dark side of mast cell-targeted therapy in prostate cancer. Cancer Res. 2012, 4, 831-835.
    • (2012) Cancer Res , vol.4 , pp. 831-835
    • Pittoni, P.1    Colombo, M.P.2
  • 118
    • 0142103807 scopus 로고    scopus 로고
    • Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization
    • Iyengar, P.; Combs, T.P.; Shah, S.J.; Gouon-Evans, V.; Pollard, J.W.; Albanese, C.; Flanagan, L.; Tenniswood, M.P.; Guha, C.; Lisanti, M.P., et al. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene 2003, 41, 6408-6423.
    • (2003) Oncogene , vol.41 , pp. 6408-6423
    • Iyengar, P.1    Combs, T.P.2    Shah, S.J.3    Gouon-Evans, V.4    Pollard, J.W.5    Albanese, C.6    Flanagan, L.7    Tenniswood, M.P.8    Guha, C.9    Lisanti, M.P.10
  • 121
    • 77954818666 scopus 로고    scopus 로고
    • MicroRNA and drug resistance
    • Ma, J.; Dong, C.; Ji, C. MicroRNA and drug resistance. Cancer Gene Ther. 2010, 8, 523-531.
    • (2010) Cancer Gene Ther , vol.8 , pp. 523-531
    • Ma, J.1    Dong, C.2    Ji, C.3
  • 123
    • 84859810024 scopus 로고    scopus 로고
    • Circulating MiR-125b as a marker predicting chemoresistance in breast cancer
    • Wang, H.; Tan, G.; Dong, L.; Cheng, L.; Li, K.; Wang, Z.; Luo, H. Circulating MiR-125b as a marker predicting chemoresistance in breast cancer. PLoS One 2012, 4, e34210.
    • (2012) PLoS One , vol.4
    • Wang, H.1    Tan, G.2    Dong, L.3    Cheng, L.4    Li, K.5    Wang, Z.6    Luo, H.7
  • 124
    • 83755205900 scopus 로고    scopus 로고
    • Plasma miR-221 as a predictive biomarker for chemoresistance in breast cancer patients who previously received neoadjuvant chemotherapy
    • Zhao, R.; Wu, J.; Jia, W.; Gong, C.; Yu, F.; Ren, Z.; Chen, K.; He, J.; Su, F. Plasma miR-221 as a predictive biomarker for chemoresistance in breast cancer patients who previously received neoadjuvant chemotherapy. Onkologie 2011, 12, 675-680.
    • (2011) Onkologie , vol.12 , pp. 675-680
    • Zhao, R.1    Wu, J.2    Jia, W.3    Gong, C.4    Yu, F.5    Ren, Z.6    Chen, K.7    He, J.8    Su, F.9
  • 125
    • 84860755726 scopus 로고    scopus 로고
    • The miRNA-17 approximately 92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation
    • Rao, E.; Jiang, C.; Ji, M.; Huang, X.; Iqbal, J.; Lenz, G.; Wright, G.; Staudt, L.M.; Zhao, Y.; McKeithan, T.W., et al. The miRNA-17 approximately 92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia 2012, 5, 1064-1072.
    • (2012) Leukemia , vol.5 , pp. 1064-1072
    • Rao, E.1    Jiang, C.2    Ji, M.3    Huang, X.4    Iqbal, J.5    Lenz, G.6    Wright, G.7    Staudt, L.M.8    Zhao, Y.9    McKeithan, T.W.10
  • 127
    • 77952944048 scopus 로고    scopus 로고
    • MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer
    • Kong, W.; He, L.; Coppola, M.; Guo, J.; Esposito, N.N.; Coppola, D.; Cheng, J.Q. MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J. Biol. Chem. 2010, 23, 17869-17879.
    • (2010) J. Biol. Chem , vol.23 , pp. 17869-17879
    • Kong, W.1    He, L.2    Coppola, M.3    Guo, J.4    Esposito, N.N.5    Coppola, D.6    Cheng, J.Q.7
  • 128
    • 84855781227 scopus 로고    scopus 로고
    • Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells
    • Bourguignon, L.Y.; Earle, C.; Wong, G.; Spevak, C.C.; Krueger, K. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene 2012, 2, 149-160.
    • (2012) Oncogene , vol.2 , pp. 149-160
    • Bourguignon, L.Y.1    Earle, C.2    Wong, G.3    Spevak, C.C.4    Krueger, K.5
  • 129
    • 78049442966 scopus 로고    scopus 로고
    • The cellular response to hypoxia: Tuning the system with micro RNAs
    • Loscalzo, J. The cellular response to hypoxia: Tuning the system with micro RNAs. J. Clin. Invest. 2010, 11, 3815-3817.
    • (2010) J. Clin. Invest , vol.11 , pp. 3815-3817
    • Loscalzo, J.1
  • 130
    • 33846941188 scopus 로고    scopus 로고
    • High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma
    • doi:10.1186/1476-4598-6-5
    • Hebert, C.; Norris, K.; Scheper, M.A.; Nikitakis, N.; Sauk, J.J. High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma. Mol. Cancer 2007, 6, doi:10.1186/1476-4598-6-5.
    • (2007) Mol. Cancer , pp. 6
    • Hebert, C.1    Norris, K.2    Scheper, M.A.3    Nikitakis, N.4    Sauk, J.J.5
  • 131
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan, D.; Coussens, L.M. Accessories to the crime: Functions of cells recruited to the tumor microenvironment. Cancer Cell 2012, 3, 309-322.
    • (2012) Cancer Cell , vol.3 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 132


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.