-
1
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732. (Pubitemid 37328811)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
2
-
-
0035751937
-
Assessing TP53 status in human tumours to evaluate clinical outcome
-
Soussi T, Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer 2001; 1: 233-240. (Pubitemid 33741898)
-
(2001)
Nature Reviews Cancer
, vol.1
, Issue.3
, pp. 233-240
-
-
Soussi, T.1
Beroud, C.2
-
3
-
-
42449114966
-
Transcriptional control of human p53-regulated genes
-
DOI 10.1038/nrm2395, PII NRM2395
-
Riley T, Sontag E, Chen P, Levine A. Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 2008; 9: 402-412. (Pubitemid 351574202)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.5
, pp. 402-412
-
-
Riley, T.1
Sontag, E.2
Chen, P.3
Levine, A.4
-
4
-
-
65949083750
-
Cytoplasmic functions of the tumour suppressor p53
-
Green DR, Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature 2009; 458: 1127-1130.
-
(2009)
Nature
, vol.458
, pp. 1127-1130
-
-
Green, D.R.1
Kroemer, G.2
-
5
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
DOI 10.1038/387296a0
-
Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387: 296-299. (Pubitemid 27220766)
-
(1997)
Nature
, vol.387
, Issue.6630
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
6
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
DOI 10.1038/387299a0
-
Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997; 387: 299-303. (Pubitemid 27220767)
-
(1997)
Nature
, vol.387
, Issue.6630
, pp. 299-303
-
-
Kubbutat, M.H.G.1
Jones, S.N.2
Vousden, K.H.3
-
9
-
-
0028110809
-
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
-
Graeber TG, Peterson JF, Tsai M, Monica K, Fornace Jr AJ, Giaccia AJ. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol 1994; 14: 6264-6277.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 6264-6277
-
-
Graeber, T.G.1
Peterson, J.F.2
Tsai, M.3
Monica, K.4
Fornace Jr., A.J.5
Giaccia, A.J.6
-
10
-
-
0032578028
-
Hypoxia-induced apoptosis: Effect of hypoxic severity and role of p53 in neuronal cell death
-
DOI 10.1016/S0006-8993(98)00286-8, PII S0006899398002868
-
Banasiak KJ, Haddad GG. Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death. Brain Res 1998; 797: 295-304. (Pubitemid 28332742)
-
(1998)
Brain Research
, vol.797
, Issue.2
, pp. 295-304
-
-
Banasiak, K.J.1
Haddad, G.G.2
-
11
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
-
An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV, Neckers LM. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 1998; 392: 405-408.
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
Maltepe, E.4
Blagosklonny, M.V.5
Neckers, L.M.6
-
12
-
-
0032581277
-
Role of HIF-1α in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis
-
DOI 10.1038/28867
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394: 485-490. (Pubitemid 28373960)
-
(1998)
Nature
, vol.394
, Issue.6692
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herber, J.-M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshet, E.16
-
13
-
-
0032535077
-
Up-regulation of hypoxia-inducible factor-1α is not sufficient for hypoxic/anoxic p53 induction
-
Wenger RH, Camenisch G, Desbaillets I, Chilov D, Gassmann M. Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction. Cancer Res 1998; 58: 5678-5680. (Pubitemid 29006404)
-
(1998)
Cancer Research
, vol.58
, Issue.24
, pp. 5678-5680
-
-
Wenger, R.H.1
Camenisch, G.2
Desbaillets, I.3
Chilov, D.4
Gassmann, M.5
-
14
-
-
3042779529
-
P53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment
-
DOI 10.1038/sj.onc.1207657
-
Pan Y, Oprysko PR, Asham AM, Koch CJ, Simon MC. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 2004; 23: 4975-4983. (Pubitemid 38938730)
-
(2004)
Oncogene
, vol.23
, Issue.29
, pp. 4975-4983
-
-
Pan, Y.1
Oprysko, P.R.2
Asham, A.M.3
Koch, C.J.4
Simon, M.C.5
-
15
-
-
0036179376
-
Hypoxia links ATR and p53 through replication arrest
-
DOI 10.1128/MCB.22.6.1834-1843.2002
-
Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol 2002; 22: 1834-1843. (Pubitemid 34174999)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.6
, pp. 1834-1843
-
-
Hammond, E.M.1
Denko, N.C.2
Dorie, M.J.3
Abraham, R.T.4
Giaccia, A.J.5
-
16
-
-
0038529602
-
Direct interactions between HIF-1α and Mdm2 modulate p53 function
-
DOI 10.1074/jbc.C200694200
-
Chen D, Li M, Luo J, Gu W. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 2003; 278: 13595-13598. (Pubitemid 36799889)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.16
, pp. 13595-13598
-
-
Chen, D.1
Li, M.2
Luo, J.3
Gu, W.4
-
17
-
-
0033572417
-
Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
-
Alarcon R, Koumenis C, Geyer RK, Maki CG, Giaccia AJ. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. Cancer Res 1999; 59: 6046-6051. (Pubitemid 30035618)
-
(1999)
Cancer Research
, vol.59
, Issue.24
, pp. 6046-6051
-
-
Alarcon, R.1
Koumenis, C.2
Geyer, R.K.3
Maki, C.G.4
Giaccia, A.J.5
-
18
-
-
0035140981
-
Regulation of p53 by Hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
-
DOI 10.1128/MCB.21.4.1297-1310.2001
-
Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M et al. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol 2001; 21: 1297-1310. (Pubitemid 32114977)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.4
, pp. 1297-1310
-
-
Koumenis, C.1
Alarcon, R.2
Hammond, E.3
Sutphin, P.4
Hoffman, W.5
Murphy, M.6
Derr, J.7
Taya, Y.8
Lowe, S.W.9
Kastan, M.10
Giaccia, A.11
-
19
-
-
0037151032
-
P38 mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons
-
DOI 10.1074/jbc.M200042200
-
Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. J Biol Chem 2002; 277: 22909-22914. (Pubitemid 34967274)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.25
, pp. 22909-22914
-
-
Zhu, Y.1
Mao, X.O.2
Sun, Y.3
Xia, Z.4
Greenberg, D.A.5
-
20
-
-
34249050483
-
Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: Its role in post-translational modification of p53 and MDM2
-
Lee SJ, Lim CJ, Min JK, Lee JK, Kim YM, Lee JY et al. Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2. Cell Death Differ 2007; 14: 1106-1116.
-
(2007)
Cell Death Differ
, vol.14
, pp. 1106-1116
-
-
Lee, S.J.1
Lim, C.J.2
Min, J.K.3
Lee, J.K.4
Kim, Y.M.5
Lee, J.Y.6
-
21
-
-
0038146962
-
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
-
DOI 10.1074/jbc.M212360200
-
Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003; 278: 12207-12213. (Pubitemid 36800201)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.14
, pp. 12207-12213
-
-
Hammond, E.M.1
Dorie, M.J.2
Giaccia, A.J.3
-
22
-
-
0034632669
-
Redox regulation of p53 during hypoxia
-
Chandel NS, Vander Heiden MG, Thompson CB, Schumacker PT. Redox regulation of p53 during hypoxia. Oncogene 2000; 19: 3840-3848. (Pubitemid 30658974)
-
(2000)
Oncogene
, vol.19
, Issue.34
, pp. 3840-3848
-
-
Chandel, N.S.1
Vander Heiden, M.G.2
Thompson, C.B.3
Schumacker, P.T.4
-
23
-
-
77953809546
-
Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury
-
Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T et al. Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury. Circ Res 2010; 106: 1692-1702.
-
(2010)
Circ Res
, vol.106
, pp. 1692-1702
-
-
Naito, A.T.1
Okada, S.2
Minamino, T.3
Iwanaga, K.4
Liu, M.L.5
Sumida, T.6
-
24
-
-
0141864381
-
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells
-
DOI 10.1128/MCB.23.20.7083-7095.2003
-
Galban S, Martindale JL, Mazan-Mamczarz K, Lopez de Silanes I, Fan J, Wang W et al. Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol 2003; 23: 7083-7095. (Pubitemid 37210992)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.20
, pp. 7083-7095
-
-
Galban, S.1
Martindale, J.L.2
Mazan-Mamczarz, K.3
Lopez De Silanes, I.4
Fan, J.5
Wang, W.6
Decker, J.7
Gorospe, M.8
-
25
-
-
4344669774
-
Bimodal effect of hypoxia in cancer: Role of hypoxia inducible factor in apoptosis
-
Wang Y, Pakunlu RI, Tsao W, Pozharov V, Minko T. Bimodal effect of hypoxia in cancer: role of hypoxia inducible factor in apoptosis. Mol Pharm 2004; 1: 156-165.
-
(2004)
Mol Pharm
, vol.1
, pp. 156-165
-
-
Wang, Y.1
Pakunlu, R.I.2
Tsao, W.3
Pozharov, V.4
Minko, T.5
-
26
-
-
0037452759
-
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
-
DOI 10.1073/pnas.2627984100
-
Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003; 100: 1931-1936. (Pubitemid 36254551)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.4
, pp. 1931-1936
-
-
Yu, J.1
Wang, Z.2
Kinzler, K.W.3
Vogelstein, B.4
Zhang, L.5
-
27
-
-
0035896558
-
Hypoxia inhibits G1/S transition through regulation of p27 expression
-
Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 2001; 276: 7919-7926.
-
(2001)
J Biol Chem
, vol.276
, pp. 7919-7926
-
-
Gardner, L.B.1
Li, Q.2
Park, M.S.3
Flanagan, W.M.4
Semenza, G.L.5
Dang, C.V.6
-
28
-
-
34047105144
-
Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance
-
DOI 10.1038/sj.onc.1210008, PII 1210008
-
Kilic M, Kasperczyk H, Fulda S, Debatin KM. Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance. Oncogene 2007; 26: 2027-2038. (Pubitemid 46514744)
-
(2007)
Oncogene
, vol.26
, Issue.14
, pp. 2027-2038
-
-
Kilic, M.1
Kasperczyk, H.2
Fulda, S.3
Debatin, K.-M.4
-
29
-
-
33749164424
-
Functional analysis of p53 binding under differential stresses
-
DOI 10.1128/MCB.00322-06
-
Krieg AJ, Hammond EM, Giaccia AJ. Functional analysis of p53 binding under differential stresses. Mol Cell Biol 2006; 26: 7030-7045. (Pubitemid 44477683)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.19
, pp. 7030-7045
-
-
Krieg, A.J.1
Hammond, E.M.2
Giaccia, A.J.3
-
30
-
-
0033515883
-
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
-
DOI 10.1126/science.284.5411.156
-
Soengas MS, Alarcon RM, Yoshida H, Giaccia AJ, Hakem R, Mak TW et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 1999; 284: 156-159. (Pubitemid 29282071)
-
(1999)
Science
, vol.284
, Issue.5411
, pp. 156-159
-
-
Soengas, M.S.1
Alarcon, R.M.2
Yoshida, H.3
Giaccia, A.J.4
Hakem, R.5
Mak, T.W.6
Lowe, S.W.7
-
31
-
-
33646229339
-
Genomewide analysis of p53 under hypoxic conditions
-
Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA et al. Genomewide analysis of p53 under hypoxic conditions. Mol Cell Biol 2006; 26: 3492-3504.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 3492-3504
-
-
Hammond, E.M.1
Mandell, D.J.2
Salim, A.3
Krieg, A.J.4
Johnson, T.M.5
Shirazi, H.A.6
-
32
-
-
19944371176
-
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
-
DOI 10.1016/j.ccr.2004.10.012, PII S153561080400306X
-
Fei P, Wang W, Kim SH, Wang S, Burns TF, Sax JK et al. Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell 2004; 6: 597-609. (Pubitemid 40017703)
-
(2004)
Cancer Cell
, vol.6
, Issue.6
, pp. 597-609
-
-
Fei, P.1
Wang, W.2
Kim, S.-H.3
Wang, S.4
Burns, T.F.5
Sax, J.K.6
Buzzai, M.7
Dicker, D.T.8
McKenna, W.G.9
Bernhard, E.J.10
El-Deiry, W.S.11
-
33
-
-
33847077136
-
Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis
-
Liu T, Laurell C, Selivanova G, Lundeberg J, Nilsson P, Wiman KG. Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. Cell Death Differ 2007; 14: 411-421.
-
(2007)
Cell Death Differ
, vol.14
, pp. 411-421
-
-
Liu, T.1
Laurell, C.2
Selivanova, G.3
Lundeberg, J.4
Nilsson, P.5
Wiman, K.G.6
-
34
-
-
2642574174
-
P300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1)
-
DOI 10.1042/BJ20031299
-
Schmid T, Zhou J, Kohl R, Brune B. p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1). Biochem J 2004; 380 (Part 1): 289-295. (Pubitemid 38725754)
-
(2004)
Biochemical Journal
, vol.380
, Issue.1
, pp. 289-295
-
-
Schmid, T.1
Zhou, J.2
Kohl, R.3
Brune, B.4
-
35
-
-
0037117479
-
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
-
DOI 10.1073/pnas.082117899
-
Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G et al. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci USA 2002; 99: 5367-5372. (Pubitemid 34411554)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.8
, pp. 5367-5372
-
-
Freedman, S.J.1
Sun, Z.-Y.J.2
Poy, F.3
Kung, A.L.4
Livingston, D.M.5
Wagner, G.6
Eck, M.J.7
-
36
-
-
53549085960
-
CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
-
Filippi S, Latini P, Frontini M, Palitti F, Egly JM, Proietti-De-Santis L. CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response. Embo J 2008; 27: 2545-2556.
-
(2008)
Embo J
, vol.27
, pp. 2545-2556
-
-
Filippi, S.1
Latini, P.2
Frontini, M.3
Palitti, F.4
Egly, J.M.5
Proietti-De-Santis, L.6
-
37
-
-
53249088036
-
PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia
-
Xenaki G, Ontikatze T, Rajendran R, Stratford IJ, Dive C, Krstic-Demonacos M et al. PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene 2008; 27: 5785-5796.
-
(2008)
Oncogene
, vol.27
, pp. 5785-5796
-
-
Xenaki, G.1
Ontikatze, T.2
Rajendran, R.3
Stratford, I.J.4
Dive, C.5
Krstic-Demonacos, M.6
-
38
-
-
34447516987
-
In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1α function regardless of the presence of DNA damage
-
DOI 10.1074/jbc.M702203200
-
Rempe DA, Lelli KM, Vangeison G, Johnson RS, Federoff HJ. In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. J Biol Chem 2007; 282: 16187-16201. (Pubitemid 47100340)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.22
, pp. 16187-16201
-
-
Rempe, D.A.1
Lelli, K.M.2
Vangeison, G.3
Johnson, R.S.4
Federoff, H.J.5
-
39
-
-
0030922763
-
P53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes
-
Long X, Boluyt MO, Hipolito ML, Lundberg MS, Zheng JS, O'Neill L et al. p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes. J Clin Invest 1997; 99: 2635-2643. (Pubitemid 27259810)
-
(1997)
Journal of Clinical Investigation
, vol.99
, Issue.11
, pp. 2635-2643
-
-
Long, X.1
Boluyt, M.O.2
De Lourdes Hipolito, M.3
Lundberg, M.S.4
Zheng, J.-S.5
O'Neill, L.6
Cirielli, C.7
Lakatta, E.G.8
Crow, M.T.9
-
40
-
-
0034632052
-
P53 Checkpoint-defective cells are sensitive to X rays, but not hypoxia
-
DOI 10.1006/excr.2000.4928
-
Denko NC, Green SL, Edwards D, Giaccia AJ. p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. Exp Cell Res 2000; 258: 82-91. (Pubitemid 30461110)
-
(2000)
Experimental Cell Research
, vol.258
, Issue.1
, pp. 82-91
-
-
Denko, N.C.1
Green, S.L.2
Edwards, D.3
Giaccia, A.J.4
-
41
-
-
0035910385
-
Hypoxia death stimulus induces translocation of p53 protein to mitochondria - Detection by immunofluorescence on whole cells
-
DOI 10.1016/S0014-5793(00)02368-1, PII S0014579300023681
-
Sansome C, Zaika A, Marchenko ND, Moll UM. Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett 2001; 488: 110-115. (Pubitemid 32103581)
-
(2001)
FEBS Letters
, vol.488
, Issue.3
, pp. 110-115
-
-
Sansome, C.1
Zaika, A.2
Marchenko, N.D.3
Moll, U.M.4
-
42
-
-
34248682977
-
Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia
-
DOI 10.1042/BST0341283
-
Endo H, Saito A, Chan PH. Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia. Biochem Soc Trans 2006; 34 (Part 6): 1283-1286. (Pubitemid 46769038)
-
(2006)
Biochemical Society Transactions
, vol.34
, Issue.6
, pp. 1283-1286
-
-
Endo, H.1
Saito, A.2
Chan, P.H.3
-
43
-
-
70149106164
-
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
-
Bertout JA, Majmundar AJ, Gordan JD, Lam JC, Ditsworth D, Keith B et al. HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci USA 2009; 106: 14391-14396.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 14391-14396
-
-
Bertout, J.A.1
Majmundar, A.J.2
Gordan, J.D.3
Lam, J.C.4
Ditsworth, D.5
Keith, B.6
-
44
-
-
71549151624
-
Suppression of hypoxiainducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells
-
Roberts AM, Watson IR, Evans AJ, Foster DA, Irwin MS, Ohh M. Suppression of hypoxiainducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells. Cancer Res 2009; 69: 9056-9064.
-
(2009)
Cancer Res
, vol.69
, pp. 9056-9064
-
-
Roberts, A.M.1
Watson, I.R.2
Evans, A.J.3
Foster, D.A.4
Irwin, M.S.5
Ohh, M.6
-
45
-
-
0032588585
-
HIF-1α and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia
-
DOI 10.1006/exnr.1999.7160
-
Halterman MW, Federoff HJ. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol 1999; 159: 65-72. (Pubitemid 29444903)
-
(1999)
Experimental Neurology
, vol.159
, Issue.1
, pp. 65-72
-
-
Halterman, M.W.1
Federoff, H.J.2
-
46
-
-
36849046868
-
Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines
-
Cosse JP, Sermeus A, Vannuvel K, Ninane N, Raes M, Michiels C et al. Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines. Mol Cancer 2007; 6: 61.
-
(2007)
Mol Cancer
, vol.6
, pp. 61
-
-
Cosse, J.P.1
Sermeus, A.2
Vannuvel, K.3
Ninane, N.4
Raes, M.5
Michiels, C.6
-
47
-
-
78349256998
-
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
-
Chen B, Longtine MS, Sadovsky Y, Nelson DM. Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. Am J Physiol Cell Physiol 2010; 299: C968-C976.
-
(2010)
Am J Physiol Cell Physiol
, vol.299
-
-
Chen, B.1
Longtine, M.S.2
Sadovsky, Y.3
Nelson, D.M.4
-
48
-
-
2942733275
-
DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1α in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX
-
DOI 10.1128/MCB.24.13.5757-5766.2004
-
Kaluzova M, Kaluz S, Lerman MI, Stanbridge EJ. DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. Mol Cell Biol 2004; 24: 5757-5766. (Pubitemid 38787961)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.13
, pp. 5757-5766
-
-
Kaluzova, M.1
Kaluz, S.2
Lerman, M.I.3
Stanbridge, E.J.4
-
49
-
-
76249122584
-
Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability
-
Pires IM, Bencokova Z, Milani M, Folkes LK, Li JL, Stratford MR et al. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Res 2010; 70: 925-935.
-
(2010)
Cancer Res
, vol.70
, pp. 925-935
-
-
Pires, I.M.1
Bencokova, Z.2
Milani, M.3
Folkes, L.K.4
Li, J.L.5
Stratford, M.R.6
-
50
-
-
4143076004
-
Treatment with siRNA and antisense oligonucleotides targeted to HIF-1α induced apoptosis in human tongue squamous cell carcinomas
-
DOI 10.1002/ijc.20334
-
Zhang Q, Zhang ZF, Rao JY, Sato JD, Brown J, Messadi DV et al. Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas. Int J Cancer 2004; 111: 849-857. (Pubitemid 39096233)
-
(2004)
International Journal of Cancer
, vol.111
, Issue.6
, pp. 849-857
-
-
Zhang, Q.1
Zhang, Z.-F.2
Rao, J.Y.3
Sato, J.D.4
Brown, J.5
Messadi, D.V.6
Le, A.D.7
-
51
-
-
10744228261
-
C-Myc Sensitization to Oxygen Deprivation-induced Cell Death Is Dependent on Bax/Bak, but Is Independent of p53 and Hypoxia-inducible Factor-1
-
DOI 10.1074/jbc.M312241200
-
Brunelle JK, Santore MT, Budinger GR, Tang Y, Barrett TA, Zong WX et al. c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1. J Biol Chem 2004; 279: 4305-4312. (Pubitemid 38199018)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.6
, pp. 4305-4312
-
-
Brunelle, J.K.1
Santore, M.T.2
Budinger, G.R.S.3
Tang, Y.4
Barrett, T.A.5
Zong, W.-X.6
Kandel, E.7
Keith, B.8
Simon, M.C.9
Thompson, C.B.10
Hay, N.11
Chandel, N.S.12
-
52
-
-
71549121951
-
Chemoradiation interactions under reduced oxygen conditions: Cellular characteristics of an in vitro model
-
Wouters A, Pauwels B, Lambrechts HA, Pattyn GG, Ides J, Baay M et al. Chemoradiation interactions under reduced oxygen conditions: Cellular characteristics of an in vitro model. Cancer Lett 2009; 286: 180-188.
-
(2009)
Cancer Lett
, vol.286
, pp. 180-188
-
-
Wouters, A.1
Pauwels, B.2
Lambrechts, H.A.3
Pattyn, G.G.4
Ides, J.5
Baay, M.6
-
53
-
-
0031149430
-
Hypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level
-
DOI 10.1006/excr.1997.3497
-
Amellem O, Stokke T, Sandvik JA, Smedshammer L, Pettersen EO. Hypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level. Exp Cell Res 1997; 232: 361-370. (Pubitemid 27194050)
-
(1997)
Experimental Cell Research
, vol.232
, Issue.2
, pp. 361-370
-
-
Amellem, O.1
Stokke, T.2
Sandvik, J.A.3
Smedshammer, L.4
Pettersen, E.O.5
-
54
-
-
70149113948
-
Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide
-
Cosse JP, Ronvaux M, Ninane N, Raes MJ, Michiels C. Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide. Neoplasia 2009; 11: 976-986.
-
(2009)
Neoplasia
, vol.11
, pp. 976-986
-
-
Cosse, J.P.1
Ronvaux, M.2
Ninane, N.3
Raes, M.J.4
Michiels, C.5
-
55
-
-
77953184918
-
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
-
Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature 2010; 465: 577-583.
-
(2010)
Nature
, vol.465
, pp. 577-583
-
-
Sendoel, A.1
Kohler, I.2
Fellmann, C.3
Lowe, S.W.4
Hengartner, M.O.5
-
56
-
-
33947120556
-
Hypoxia-induced cell death of HepG2 cells involves a necrotic cell death mediated by calpain
-
Kim MJ, Oh SJ, Park SH, Kang HJ, Won MH, Kang TC et al. Hypoxia-induced cell death of HepG2 cells involves a necrotic cell death mediated by calpain. Apoptosis 2007; 12: 707-718.
-
(2007)
Apoptosis
, vol.12
, pp. 707-718
-
-
Kim, M.J.1
Oh, S.J.2
Park, S.H.3
Kang, H.J.4
Won, M.H.5
Kang, T.C.6
-
57
-
-
32544458522
-
Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors
-
DOI 10.1038/sj.onc.1209128, PII 1209128
-
Koshikawa N, Maejima C, Miyazaki K, Nakagawara A, Takenaga K. Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors. Oncogene 2006; 25: 917-928. (Pubitemid 43237710)
-
(2006)
Oncogene
, vol.25
, Issue.6
, pp. 917-928
-
-
Koshikawa, N.1
Maejima, C.2
Miyazaki, K.3
Nakagawara, A.4
Takenaga, K.5
-
58
-
-
3042616216
-
Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis
-
DOI 10.1158/0008-5472.CAN-03-3038
-
Zhang L, Hill RP. Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis. Cancer Res 2004; 64: 4180-4189. (Pubitemid 38802421)
-
(2004)
Cancer Research
, vol.64
, Issue.12
, pp. 4180-4189
-
-
Zhang, L.1
Hill, R.P.2
-
59
-
-
69949108875
-
Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha
-
Nardinocchi L, Puca R, Sacchi A, Rechavi G, Givol D, D'Orazi G. Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha. PLoS One 2009; 4: e6819.
-
(2009)
PLoS One
, vol.4
-
-
Nardinocchi, L.1
Puca, R.2
Sacchi, A.3
Rechavi, G.4
Givol, D.5
D'orazi, G.6
-
60
-
-
33748767112
-
Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level
-
DOI 10.1242/jcs.03069
-
Hubert A, Paris S, Piret JP, Ninane N, Raes M, Michiels C. Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level. J Cell Sci 2006; 119 (Part 16): 3351-3362. (Pubitemid 44405220)
-
(2006)
Journal of Cell Science
, vol.119
, Issue.16
, pp. 3351-3362
-
-
Hubert, A.1
Paris, S.2
Piret, J.-P.3
Ninane, N.4
Raes, M.5
Michiels, C.6
-
61
-
-
4744348300
-
Hypoxia-induced nucleophosmin protects cell death through inhibition of p53
-
DOI 10.1074/jbc.C400297200
-
Li J, Zhang X, Sejas DP, Bagby GC, Pang Q. Hypoxia-induced nucleophosmin protects cell death through inhibition of p53. J Biol Chem 2004; 279: 41275-41279. (Pubitemid 39313565)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.40
, pp. 41275-41279
-
-
Li, J.1
Zhang, X.2
Sejas, D.P.3
Bagby, G.C.4
Pang, Q.5
-
62
-
-
77957786826
-
Hypoxiainducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB
-
Rohwer N, Dame C, Haugstetter A, Wiedenmann B, Detjen K, Schmitt CA et al. Hypoxiainducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB. PLoS ONE 2010; 5: e12038.
-
(2010)
PLoS ONE
, vol.5
-
-
Rohwer, N.1
Dame, C.2
Haugstetter, A.3
Wiedenmann, B.4
Detjen, K.5
Schmitt, C.A.6
-
63
-
-
77955470408
-
Regulation of p53 activity by HIPK2: Molecular mechanisms and therapeutical implications in human cancer cells
-
Puca R, Nardinocchi L, Givol D, D'Orazi G. Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells. Oncogene 2010; 29: 4378-4387.
-
(2010)
Oncogene
, vol.29
, pp. 4378-4387
-
-
Puca, R.1
Nardinocchi, L.2
Givol, D.3
D'orazi, G.4
-
64
-
-
0035798156
-
Transcriptional repression of the human p53 gene by cobalt chloride mimicking hypoxia
-
DOI 10.1016/S0014-5793(01)02989-1, PII S0014579301029891
-
Lee SG, Lee H, Rho HM. Transcriptional repression of the human p53 gene by cobalt chloride mimicking hypoxia. FEBS Lett 2001; 507: 259-263. (Pubitemid 33030246)
-
(2001)
FEBS Letters
, vol.507
, Issue.3
, pp. 259-263
-
-
Lee, S.G.1
Lee, H.2
Rho, H.M.3
-
65
-
-
57349198307
-
P53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemiareperfusion injury
-
Sutton TA, Wilkinson J, Mang HE, Knipe NL, Plotkin Z, Hosein M et al. p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemiareperfusion injury. Am J Physiol Renal Physiol 2008; 295: F1666-F1677.
-
(2008)
Am J Physiol Renal Physiol
, vol.295
-
-
Sutton, T.A.1
Wilkinson, J.2
Mang, H.E.3
Knipe, N.L.4
Plotkin, Z.5
Hosein, M.6
-
66
-
-
65949087224
-
PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia
-
Singaravelu K, Devalaraja-Narashimha K, Lastovica B, Padanilam BJ. PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia. Am J Physiol Renal Physiol 2009; 296: F847-F858.
-
(2009)
Am J Physiol Renal Physiol
, vol.296
-
-
Singaravelu, K.1
Devalaraja-Narashimha, K.2
Lastovica, B.3
Padanilam, B.J.4
-
67
-
-
23644453277
-
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
-
DOI 10.1016/j.ccr.2005.06.016, PII S1535610805002254
-
Moeller BJ, Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY et al. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 2005; 8: 99-110. (Pubitemid 41132739)
-
(2005)
Cancer Cell
, vol.8
, Issue.2
, pp. 99-110
-
-
Moeller, B.J.1
Dreher, M.R.2
Rabbani, Z.N.3
Schroeder, T.4
Cao, Y.5
Li, C.Y.6
Dewhirst, M.W.7
-
68
-
-
42649106141
-
Hypoxia induces protection against etoposide-induced apoptosis: Molecular profiling of changes in gene expression and transcription factor activity
-
Sermeus A, Cosse JP, Crespin M, Mainfroid V, de Longueville F, Ninane N et al. Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity. Mol Cancer 2008; 7: 27.
-
(2008)
Mol Cancer
, vol.7
, pp. 27
-
-
Sermeus, A.1
Cosse, J.P.2
Crespin, M.3
Mainfroid, V.4
De Longueville, F.5
Ninane, N.6
-
69
-
-
0038795317
-
Hypoxia attenuates the p53 response to cellular damage
-
DOI 10.1038/sj.onc.1206434
-
Achison M, Hupp TR. Hypoxia attenuates the p53 response to cellular damage. Oncogene 2003; 22: 3431-3440. (Pubitemid 36713741)
-
(2003)
Oncogene
, vol.22
, Issue.22
, pp. 3431-3440
-
-
Achison, M.1
Hupp, T.R.2
-
70
-
-
33745868751
-
Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: Involvement of mitochondrial inhibition and p53 suppression
-
DOI 10.1681/ASN.2005121371
-
Wang J, Biju MP, Wang MH, Haase VH, Dong Z. Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression. J Am Soc Nephrol 2006; 17: 1875-1885. (Pubitemid 44036172)
-
(2006)
Journal of the American Society of Nephrology
, vol.17
, Issue.7
, pp. 1875-1885
-
-
Wang, J.1
Biju, M.P.2
Wang, M.-H.3
Haase, V.H.4
Dong, Z.5
-
71
-
-
33749016506
-
Overexpression of hypoxia-inducible factor 1 α and p53 is a marker for an unfavorable prognosis in gastric cancer
-
DOI 10.1158/1078-0432.CCR-05-2382
-
Sumiyoshi Y, Kakeji Y, Egashira A, Mizokami K, Orita H, Maehara Y. Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer. Clin Cancer Res 2006; 12: 5112-5117. (Pubitemid 44453338)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.17
, pp. 5112-5117
-
-
Sumiyoshi, Y.1
Kakeji, Y.2
Egashira, A.3
Mizokami, K.4
Orita, H.5
Maehara, Y.6
-
72
-
-
0030864485
-
Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions
-
Kim CY, Tsai MH, Osmanian C, Graeber TG, Lee JE, Giffard RG et al. Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res 1997; 57: 4200-4204. (Pubitemid 27413423)
-
(1997)
Cancer Research
, vol.57
, Issue.19
, pp. 4200-4204
-
-
Kim, C.Y.1
Tsai, M.H.2
Osmanian, C.3
Graeber, T.G.4
Lee, J.E.5
Giffard, R.G.6
DiPaolo, J.A.7
Peehl, D.M.8
Giaccia, A.J.9
-
73
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
DOI 10.1038/379088a0
-
Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW et al. Hypoxiamediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996; 379: 88-91. (Pubitemid 26008141)
-
(1996)
Nature
, vol.379
, Issue.6560
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
Housman, D.E.4
Koch, C.J.5
Lowe, S.W.6
Giaccia, A.J.7
-
74
-
-
0033992478
-
P53 and human cancer: The first ten thousand mutations
-
Hainaut P, Hollstein M. p53 and human cancer: the first ten thousand mutations. Adv Cancer Res 2000; 77: 81-137. (Pubitemid 29439303)
-
(2000)
Advances in Cancer Research
, vol.77
, pp. 81-137
-
-
Hainaut, P.1
Hollstein, M.2
-
75
-
-
33947358207
-
Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia
-
DOI 10.1016/j.canlet.2006.08.017, PII S0304383506005271
-
Kamat CD, Green DE, Warnke L, Thorpe JE, Ceriello A, Ihnat MA. Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia. Cancer Lett 2007; 249: 209-219. (Pubitemid 46452929)
-
(2007)
Cancer Letters
, vol.249
, Issue.2
, pp. 209-219
-
-
Kamat, C.D.1
Green, D.E.2
Warnke, L.3
Thorpe, J.E.4
Ceriello, A.5
Ihnat, M.A.6
-
76
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia- inducible factor 1α
-
Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 2000; 14: 34-44. (Pubitemid 30051577)
-
(2000)
Genes and Development
, vol.14
, Issue.1
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
77
-
-
73649094752
-
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2
-
Choy MK, Movassagh M, Bennett MR, Foo RS. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. J Cell Physiol 2010; 222: 635-639.
-
(2010)
J Cell Physiol
, vol.222
, pp. 635-639
-
-
Choy, M.K.1
Movassagh, M.2
Bennett, M.R.3
Foo, R.S.4
-
78
-
-
21644470214
-
Mdm2 and HIF-1α interaction in tumor cells during hypoxia
-
DOI 10.1002/jcp.20406
-
Nieminen AL, Qanungo S, Schneider EA, Jiang BH, Agani FH. Mdm2 and HIF-1alpha interaction in tumor cells during hypoxia. J Cell Physiol 2005; 204: 364-369. (Pubitemid 40934627)
-
(2005)
Journal of Cellular Physiology
, vol.204
, Issue.2
, pp. 364-369
-
-
Nieminen, A.-L.1
Qanungo, S.2
Schneider, E.A.3
Jiang, B.-H.4
Agani, F.H.5
-
79
-
-
33846703114
-
Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1α and Hdm2
-
DOI 10.1158/0008-5472.CAN-06-2710
-
LaRusch GA, Jackson MW, Dunbar JD, Warren RS, Donner DB, Mayo LD. Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2. Cancer Res 2007; 67: 450-454. (Pubitemid 46192180)
-
(2007)
Cancer Research
, vol.67
, Issue.2
, pp. 450-454
-
-
LaRusch, G.A.1
Jackson, M.W.2
Dunbar, J.D.3
Warren, R.S.4
Donner, D.B.5
Mayo, L.D.6
-
80
-
-
48249137727
-
Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner
-
Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T et al. Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. PLoS One 2008; 3: e2215.
-
(2008)
PLoS One
, vol.3
-
-
Oda, S.1
Oda, T.2
Nishi, K.3
Takabuchi, S.4
Wakamatsu, T.5
Tanaka, T.6
-
81
-
-
79955772507
-
P53 gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice
-
Mizuno S, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Voelkel NF et al. p53 gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice. Am J Physiol Lung Cell Mol Physiol 2011; 300: L753-L761.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.300
-
-
Mizuno, S.1
Bogaard, H.J.2
Kraskauskas, D.3
Alhussaini, A.4
Gomez-Arroyo, J.5
Voelkel, N.F.6
-
82
-
-
33947520124
-
P53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
-
DOI 10.1038/nature05602, PII NATURE05602
-
Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y et al. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 2007; 446: 444-448. (Pubitemid 46474597)
-
(2007)
Nature
, vol.446
, Issue.7134
, pp. 444-448
-
-
Sano, M.1
Minamino, T.2
Toko, H.3
Miyauchi, H.4
Orimo, M.5
Qin, Y.6
Akazawa, H.7
Tateno, K.8
Kayama, Y.9
Harada, M.10
Shimizu, I.11
Asahara, T.12
Hamada, H.13
Tomita, S.14
Molkentin, J.D.15
Zou, Y.16
Komuro, I.17
-
83
-
-
0034667433
-
Hyperinducibility of hypoxiaresponsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer
-
Salnikow K, Costa M, Figg WD, Blagosklonny MV. Hyperinducibility of hypoxiaresponsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer. Cancer Res 2000; 60: 5630-5634.
-
(2000)
Cancer Res
, vol.60
, pp. 5630-5634
-
-
Salnikow, K.1
Costa, M.2
Figg, W.D.3
Blagosklonny, M.V.4
-
84
-
-
77950905821
-
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
-
Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT et al. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci USA 2010; 107: 6334-6339.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 6334-6339
-
-
Yamakuchi, M.1
Lotterman, C.D.2
Bao, C.3
Hruban, R.H.4
Karim, B.5
Mendell, J.T.6
-
85
-
-
84859524245
-
P53 inhibits vascular endothelial growth factor expression in solid tumor
-
e-pub ahead of print 15 January 2011
-
Yoshioka Y, Shimizu S, Ito T, Taniguchi M, Nomura M, Nishida T et al. p53 inhibits vascular endothelial growth factor expression in solid tumor. J Surg Res 2011; e-pub ahead of print 15 January 2011.
-
(2011)
J Surg Res
-
-
Yoshioka, Y.1
Shimizu, S.2
Ito, T.3
Taniguchi, M.4
Nomura, M.5
Nishida, T.6
-
86
-
-
64649086259
-
Smallmolecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia
-
Yang J, Ahmed A, Poon E, Perusinghe N, de Haven Brandon A, Box G et al. Smallmolecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol 2009; 29: 2243-2253.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2243-2253
-
-
Yang, J.1
Ahmed, A.2
Poon, E.3
Perusinghe, N.4
De Haven Brandon, A.5
Box, G.6
-
87
-
-
0032524285
-
P53 inhibits hypoxia-inducible factor-stimulated transcription
-
DOI 10.1074/jbc.273.20.11995
-
Blagosklonny MV, An WG, Romanova LY, Trepel J, Fojo T, Neckers L. p53 inhibits hypoxia-inducible factor-stimulated transcription. J Biol Chem 1998; 273: 11995-11998. (Pubitemid 28240554)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.20
, pp. 11995-11998
-
-
Blagosklonny, M.V.1
An, W.G.2
Romanova, L.Y.3
Trepel, J.4
Fojo, T.5
Neckers, L.6
-
88
-
-
33746071114
-
P300 and p53 levels determine activation of HIF-1 downstream targets in invasive breast cancer
-
DOI 10.1016/j.humpath.2006.03.015, PII S0046817706001936
-
Vleugel MM, Shvarts D, van der Wall E, van Diest PJ. p300 and p53 levels determine activation of HIF-1 downstream targets in invasive breast cancer. Hum Pathol 2006; 37: 1085-1092. (Pubitemid 44080822)
-
(2006)
Human Pathology
, vol.37
, Issue.8
, pp. 1085-1092
-
-
Vleugel, M.M.1
Shvarts, D.2
Van Der Wall, E.3
Van Diest, P.J.4
-
89
-
-
4544224808
-
Influences of the p53 status on hypoxia-induced gene expression
-
DOI 10.1269/jrr.45.333
-
Liu J, Shibata T, Qu R, Ogura M, Hiraoka M. Influences of the p53 status on hypoxiainduced gene expression. J Radiat Res (Tokyo) 2004; 45: 333-339. (Pubitemid 39237137)
-
(2004)
Journal of Radiation Research
, vol.45
, Issue.2
, pp. 333-339
-
-
Liu, J.1
Shibata, T.2
Qu, R.3
Ogura, M.4
Hiraoka, M.5
-
90
-
-
0035855668
-
Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia
-
DOI 10.1038/sj.onc.1204742
-
Suzuki H, Tomida A, Tsuruo T. Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 2001; 20: 5779-5788. (Pubitemid 32937947)
-
(2001)
Oncogene
, vol.20
, Issue.41
, pp. 5779-5788
-
-
Suzuki, H.1
Tomida, A.2
Tsuruo, T.3
-
91
-
-
0036678830
-
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53
-
Hansson LO, Friedler A, Freund S, Rudiger S, Fersht AR. Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci USA 2002; 99: 10305-10309.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10305-10309
-
-
Hansson, L.O.1
Friedler, A.2
Freund, S.3
Rudiger, S.4
Fersht, A.R.5
-
92
-
-
11344292626
-
Binding of natively unfolded HIF-1α ODD domain to p53
-
DOI 10.1016/j.molcel.2004.11.019, PII S1097276504007105
-
Sanchez-Puig N, Veprintsev DB, Fersht AR. Binding of natively unfolded HIF-1alpha ODD domain to p53. Mol Cell 2005; 17: 11-21. (Pubitemid 40075361)
-
(2005)
Molecular Cell
, vol.17
, Issue.1
, pp. 11-21
-
-
Sanchez-Puig, N.1
Veprintsev, D.B.2
Fersht, A.R.3
-
93
-
-
22744447648
-
HIF-1alpha and p53: The ODD couple?
-
Fels DR, Koumenis C. HIF-1alpha and p53: the ODD couple? Trends Biochem Sci 2005; 30: 426-429.
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 426-429
-
-
Fels, D.R.1
Koumenis, C.2
-
94
-
-
0032185124
-
P300/MDM2 complexes participate in MDM2-mediated p53 degradation
-
Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX et al. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell 1998; 2: 405-415. (Pubitemid 128381293)
-
(1998)
Molecular Cell
, vol.2
, Issue.4
, pp. 405-415
-
-
Grossman, S.R.1
Perez, M.2
Kung, A.L.3
Joseph, M.4
Mansur, C.5
Xiao, Z.-X.6
Kumar, S.7
Howley, P.M.8
Livingston, D.M.9
-
95
-
-
33646869916
-
Interactions between HIF-1 and Jab1: Balancing apoptosis and adaptation - Outline of a working hypothesis
-
DOI 10.1007/0-387-26206-7-28
-
Larsen M, Hog A, Lund EL, Kristjansen PE. Interactions between HIF-1 and Jab1: balancing apoptosis and adaptation. Outline of a working hypothesis. Adv Exp Med Biol 2005; 566: 203-211. (Pubitemid 43779504)
-
(2005)
Advances in Experimental Medicine and Biology
, vol.566
, pp. 203-211
-
-
Larsen, M.1
Hog, A.2
Lund, E.L.3
Kristjansen, P.E.G.4
-
96
-
-
0037016769
-
Jab1 interacts directly with HIF-1α and regulates its stability
-
DOI 10.1074/jbc.C100442200
-
Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK et al. Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem 2002; 277: 9-12. (Pubitemid 34952021)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.1
, pp. 9-12
-
-
Bae, M.-K.1
Ahn, M.-Y.2
Jeong, J.-W.3
Bae, M.-H.4
Lee, Y.M.5
Bae, S.-K.6
Park, J.-W.7
Kim, K.-R.8
Kim, K.-W.9
-
97
-
-
0035794541
-
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system
-
DOI 10.1093/emboj/20.7.1630
-
Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C et al. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. Embo J 2001; 20: 1630-1639. (Pubitemid 32299400)
-
(2001)
EMBO Journal
, vol.20
, Issue.7
, pp. 1630-1639
-
-
Bech-Otschir, D.1
Kraft, R.2
Huang, X.3
Henklein, P.4
Kapelari, B.5
Pollmann, C.6
Dubiel, W.7
-
98
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
DOI 10.1038/20459
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399: 271-275. (Pubitemid 29246458)
-
(1999)
Nature
, vol.399
, Issue.6733
, pp. 271-275
-
-
Maxwell, P.H.1
Wlesener, M.S.2
Chang, G.-W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
99
-
-
26444579935
-
Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression
-
DOI 10.1002/jcb.20489
-
Karhausen J, Kong T, Narravula S, Colgan SP. Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression. J Cell Biochem 2005; 95: 1264-1275. (Pubitemid 41420132)
-
(2005)
Journal of Cellular Biochemistry
, vol.95
, Issue.6
, pp. 1264-1275
-
-
Karhausen, J.1
Kong, T.2
Narravula, S.3
Colgan, S.P.4
-
100
-
-
0027244853
-
The p53-mdm-2 autoregulatory feedback loop
-
Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev 1993; 7: 1126-1132. (Pubitemid 23207405)
-
(1993)
Genes and Development
, vol.7
, Issue.7
, pp. 1126-1132
-
-
Wu, X.1
Bayle, J.H.2
Olson, D.3
Levine, A.J.4
-
101
-
-
33749663052
-
The positive regulation of p53 by the tumor suppressor VHL
-
Roe JS, Youn HD. The positive regulation of p53 by the tumor suppressor VHL. Cell Cycle 2006; 5: 2054-2056.
-
(2006)
Cell Cycle
, vol.5
, pp. 2054-2056
-
-
Roe, J.S.1
Youn, H.D.2
-
102
-
-
33646140913
-
P53 stabilization and transactivation by a von Hippel-Lindau protein
-
Roe JS, Kim H, Lee SM, Kim ST, Cho EJ, Youn HD. p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol Cell 2006; 22: 395-405.
-
(2006)
Mol Cell
, vol.22
, pp. 395-405
-
-
Roe, J.S.1
Kim, H.2
Lee, S.M.3
Kim, S.T.4
Cho, E.J.5
Youn, H.D.6
-
103
-
-
0036674617
-
Live or let die: The cell's response to p53
-
DOI 10.1038/nrc864
-
Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002; 2: 594-604. (Pubitemid 37328926)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.8
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
104
-
-
44049092395
-
The dark side of a tumor suppressor: Anti-apoptotic p53
-
DOI 10.1038/cdd.2008.33, PII CDD200833
-
Janicke RU, Sohn D, Schulze-Osthoff K. The dark side of a tumor suppressor: antiapoptotic p53. Cell Death Differ 2008; 15: 959-976. (Pubitemid 351712601)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.6
, pp. 959-976
-
-
Janicke, R.U.1
Sohn, D.2
Schulze-Osthoff, K.3
-
106
-
-
4944246547
-
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
-
DOI 10.1136/jcp.2003.015032
-
Greijer AE, van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004; 57: 1009-1014. (Pubitemid 39331346)
-
(2004)
Journal of Clinical Pathology
, vol.57
, Issue.10
, pp. 1009-1014
-
-
Greijer, A.E.1
Van Der Wall, E.2
-
107
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
DOI 10.1038/nature04871, PII NATURE04871
-
Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006; 441: 437-443. (Pubitemid 44050138)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
108
-
-
58149136865
-
Roles of p53, MYC and HIF-1 in regulating glycolysis - The seventh hallmark of cancer
-
Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. Cell Mol Life Sci 2008; 65: 3981-3999.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 3981-3999
-
-
Yeung, S.J.1
Pan, J.2
Lee, M.H.3
-
109
-
-
34347227058
-
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
-
DOI 10.1042/BJ20070389
-
Semenza GL. Oxygen-dependent regulation of mitochondrial respiration by hypoxiainducible factor 1. Biochem J 2007; 405: 1-9. (Pubitemid 46999919)
-
(2007)
Biochemical Journal
, vol.405
, Issue.1
, pp. 1-9
-
-
Semenza, G.L.1
-
111
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
DOI 10.1126/science.1126863
-
Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O et al. p53 regulates mitochondrial respiration. Science 2006; 312: 1650-1653. (Pubitemid 43902663)
-
(2006)
Science
, vol.312
, Issue.5780
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.-G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
112
-
-
0037716990
-
Mitochondrial impairment in p53-deficient human cancer cells
-
DOI 10.1093/mutage/18.3.287
-
Zhou S, Kachhap S, Singh KK. Mitochondrial impairment in p53-deficient human cancer cells. Mutagenesis 2003; 18: 287-292. (Pubitemid 36592423)
-
(2003)
Mutagenesis
, vol.18
, Issue.3
, pp. 287-292
-
-
Zhou, S.1
Kachhap, S.2
Singh, K.K.3
-
113
-
-
77952212178
-
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
-
Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci USA 2010; 107: 7455-7460.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7455-7460
-
-
Hu, W.1
Zhang, C.2
Wu, R.3
Sun, Y.4
Levine, A.5
Feng, Z.6
-
114
-
-
33745918951
-
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
-
DOI 10.1016/j.cell.2006.05.036, PII S0092867406007628
-
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006; 126: 107-120. (Pubitemid 44040989)
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.C.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
115
-
-
1942506067
-
The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression
-
DOI 10.1158/0008-5472.CAN-03-0846
-
Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E. The tumor suppressor p53 downregulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 2004; 64: 2627-2633. (Pubitemid 38523921)
-
(2004)
Cancer Research
, vol.64
, Issue.7
, pp. 2627-2633
-
-
Schwartzenberg-Bar-Yoseph, F.1
Armoni, M.2
Karnieli, E.3
-
116
-
-
33845741242
-
The cellular basis for diverse responses to oxygen
-
DOI 10.1016/j.freeradbiomed.2006.10.048, PII S0891584906006940
-
Chandel NS, Budinger GR. The cellular basis for diverse responses to oxygen. Free Radic Biol Med 2007; 42: 165-174. (Pubitemid 44970533)
-
(2007)
Free Radical Biology and Medicine
, vol.42
, Issue.2
, pp. 165-174
-
-
Chandel, N.S.1
Budinger, G.R.S.2
-
117
-
-
79960027346
-
Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular ROS production
-
E-pub Ahead of Print 14 January 2011
-
Ladelfa MF, Toledo MF, Laiseca JE, Monte M. Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular ROS production. Antioxid Redox Signal 2011; e-pub ahead of print 14 January 2011.
-
(2011)
Antioxid Redox Signal
-
-
Ladelfa, M.F.1
Toledo, M.F.2
Laiseca, J.E.3
Monte, M.4
-
118
-
-
34548842816
-
Inhibition of tumor angiogenesis by p53: A new role for the guardian of the genome
-
DOI 10.1007/s00109-007-0221-2
-
Teodoro JG, Evans SK, Green MR. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome. J Mol Med 2007; 85: 1175-1186. (Pubitemid 47622219)
-
(2007)
Journal of Molecular Medicine
, vol.85
, Issue.11
, pp. 1175-1186
-
-
Teodoro, J.G.1
Evans, S.K.2
Green, M.R.3
-
119
-
-
0035884402
-
Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma
-
Pal S, Datta K, Mukhopadhyay D. Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma. Cancer Res 2001; 61: 6952-6957. (Pubitemid 32896524)
-
(2001)
Cancer Research
, vol.61
, Issue.18
, pp. 6952-6957
-
-
Pal, S.1
Datta, K.2
Mukhopadhyay, D.3
-
120
-
-
0034235047
-
Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression
-
Zhang L, Yu D, Hu M, Xiong S, Lang A, Ellis LM et al. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res 2000; 60: 3655-3661. (Pubitemid 30482190)
-
(2000)
Cancer Research
, vol.60
, Issue.13
, pp. 3655-3661
-
-
Zhang, L.1
Yu, D.2
Hu, M.3
Xiong, S.4
Lang, A.5
Ellis, L.M.6
Pollock, R.E.7
|