Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression

Radiation Oncology

Volumn 4, Issue , 2009, Pages

  Lara, Pedro C ^a,b   Lloret, Marta ^a,b   Clavo, Bernardino ^a,b   Apolinario, Rosa M ^b   Henríquez Hernández, Luis ^b,c   Bordón, Elisa ^b   Fontes, Fausto ^b   Rey, Agustín ^a,b  

^a HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^b Madrid Spain   (Spain)

^c UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

LUNG RESISTANCE PROTEIN; PROTEIN P53; RIBONUCLEOPROTEIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER CHEMOTHERAPY; CARCINOGENICITY; CHEMOSENSITIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; HYPOXIA; METASTASIS; RADIOSENSITIVITY; TISSUE OXYGENATION; UPREGULATION; UTERINE CERVIX CARCINOMA; BIOSYNTHESIS; CANCER STAGING; CELL HYPOXIA; DRUG RESISTANCE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; UTERINE CERVIX TUMOR;

ADULT; AGED; AGED, 80 AND OVER; CELL HYPOXIA; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; UTERINE CERVICAL NEOPLASMS; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 69049083600     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-4-29     Document Type: Article

References (33)

1. Huang LE Bindra RS Glazer PM Harris AL Hypoxia-induced genetic instability - a calculated mechanism underlying tumor progression J Mol Med 2007, 85:139-148 10.1007/s00109-006-0133-6 17180667
2. Lara PC Lloret M Clavo B Apolinario RM Bordon E Rey A Falcon O Alonso AR Belka C Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors Radiother Oncol 2008, 89:222-226 10.1016/j.radonc.2008.07.018 18706726
3. Wood RD DNA repair in eukaryotes Annu Rev Biochem 1996, 65:135-167 10.1146/annurev.bi.65.070196.001031 8811177
4. Bindra RS Crosby ME Glazer PM Regulation of DNA repair in hypoxic cancer cells Cancer Metastasis Rev 2007, 26:249-260 10.1007/s10555-007-9061-3 17415527
5. Tatum JL Kelloff GJ Gillies RJ Arbeit JM Brown JM Chao KS Chapman JD Eckelman WC Fyles AW Giaccia AJ Hill RP Koch CJ Krishna MC Krohn KA Lewis JS Mason RP Melillo G Padhani AR Powis G Rajendran JG Reba R Robinson SP Semenza GL Swartz HM Vaupel P Yang D Croft B Hoffman J Liu G Stone H Sullivan D Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy Int J Radiat Biol 2006, 82:699-757 10.1080/ 09553000601002324 17118889
6. Hockel M Schlenger K Aral B Mitze M Schaffer U Vaupel P Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res 1996, 56:4509-4515 8813149
7. Fyles AW Milosevic M Wong R Kavanagh MC Pintilie M Sun A Chapman W Levin W Manchul L Keane TJ Hill RP Oxygenation predicts radiation response and survival in patients with cervix cancer Radiother Oncol 1998, 48:149-156 10.1016/S0167-8140(98)00044-9 9783886
8. Sasabe E Zhou X Li D Oku N Yamamoto T Osaki T The involvement of hypoxia-inducible factor-1alpha in the susceptibility to gamma-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells Int J Cancer 2007, 120:268-277 10.1002/ijc.22294 17066447
9. Lelong-Rebel I Brisson C Fabre M Bergerat JP Rebel G Effect of pO2 on antitumor drug cytotoxicity on MDR and non-MDR variants selected from the LoVo metastatic colon carcinoma cell line Anticancer Res 2008, 28:55-68 18383825
10. Lloret M Lara PC Bordon E Fontes F Rey A Pinar B Falcon O Major vault protein may affect nonhomologous end-joining repair and apoptosis through Ku70/80 and bax downregulation in cervical carcinoma tumors Int J Radiat Oncol Biol Phys 2009, 73:976-979 19251084
11. Lloret M Lara PC Bordon E Rey A Falcon O Apolinario RM Clavo B Ruiz A MVP expression is related to IGF1-R in cervical carcinoma patients treated by radiochemotherapy Gynecol Oncol 2008, 110:304-307 10.1016/ j.ygyno.2008.04.034 18599112
12. Clavo B Perez JL Lopez L Suarez G Lloret M Morera J Macias D Martinez JC Santana M Hernandez MA Robaina F Gunderoth M Influence of haemoglobin concentration and peripheral muscle pO2 on tumour oxygenation in advanced head and neck tumours Radiother Oncol 2003, 66:71-74 10.1016/ S0167-8140(02)00391-2 12559523
13. Berger W Steiner E Grusch M Elbling L Micksche M Vaults and the major vault protein: Novel roles in signal pathway regulation and immunity Cell Mol Life Sci 2009, 66:43-61 10.1007/s00018-008-8364-z 18759128
14. Izquierdo MA Shoemaker RH Flens MJ Scheffer GL Wu L Prather TR Scheper RJ Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines Int J Cancer 1996, 65:230-237 10.1002/ (SICI)1097-0215(19960117)65:2<230::AID-IJC17>3.0.CO;2-H 8567122
15. Izquierdo MA Scheffer GL Flens MJ Shoemaker RH Rome LH Scheper RJ Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs Cytotechnology 1996, 19:191-197 10.1007/ BF00744212 8862006
16. Siva AC Raval-Fernandes S Stephen AG LaFemina MJ Scheper RJ Kickhoefer VA Rome LH Up-regulation of vaults may be necessary but not sufficient for multidrug resistance Int J Cancer 2001, 92:195-202 10.1002/ 1097-0215(200102)9999:9999<::AID-IJC1168>3.0.CO;2-7 11291045
17. Lange C Walther W Schwabe H Stein U Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter Biochem Biophys Res Commun 2000, 278:125-133 10.1006/bbrc.2000.3782 11071864
18. Stein U Walther W Laurencot CM Scheffer GL Scheper RJ Shoemaker RH Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP J Natl Cancer Inst 1997, 89:807-813 10.1093/jnci/89.11.807 9182980
19. Mossink MH van Zon A Scheper RJ Sonneveld P Wiemer EA Vaults: A ribonucleoprotein particle involved in drug resistance? Oncogene 2003, 22:7458-7467 10.1038/sj.onc.1206947 14576851
20. Suprenant KA Vault ribonucleoprotein particles: Sarcophagi, gondolas, or safety deposit boxes? Biochemistry 2002, 41:14447-14454 10.1021/ bi026747e 12463742
21. Steiner E Holzmann K Elbling L Micksche M Berger W Cellular functions of vaults and their involvement in multidrug resistance Curr Drug Targets 2006, 7:923-934 10.2174/138945006778019345 16918321
22. Izquierdo MA Scheffer GL Schroeijers AB de Jong MC Scheper RJ Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP Cytotechnology 1998, 27:137-148 10.1023/A:1008004502861 19002788
23. Silva P West CM Slevin N Valentine H Ryder WD Hampson L Bibi R Sloan P Thakker N Homer J Hampson I Tumor expression of major vault protein is an adverse prognostic factor for radiotherapy outcome in oropharyngeal carcinoma Int J Radiat Oncol Biol Phys 2007, 69:133-140 17459603
24. Beskow C Kanter L Holgersson A Nilsson B Frankendal B Avall-Lundqvist E Lewensohn R Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer Br J Cancer 2006, 94:1683-1689 16685270
25. Wilson CR Davidson SE Margison GP Jackson SP Hendry JH West CM Expression of Ku70 correlates with survival in carcinoma of the cervix Br J Cancer 2000, 83:1702-1706 10.1054/bjoc.2000.1510 11104569
26. Amsel AD Rathaus M Kronman N Cohen HY Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation Proc Natl Acad Sci USA 2008, 105:5117-5122 10.1073/pnas.0706700105 2278173 18362350
27. Wang Q Gao F May WS Zhang Y Flagg T Deng X Bcl2 negatively regulates DNA double-strand-break repair through a nonhomologous end-joining pathway Mol Cell 2008, 29:488-498 10.1016/j.molcel.2007.12.029 18313386
28. Cosse JP Michiels C Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression Anticancer Agents Med Chem 2008, 8:790-797 18855580
29. Shannon AM Bouchier-Hayes DJ Condron CM Toomey D Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies Cancer Treat Rev 2003, 29:297-307 10.1016/S0305-7372(03)00003-3 12927570
30. Adams JM Difazio LT Rolandelli RH Lujan JJ Hasko G Csoka B Selmeczy Z Nemeth ZH HIF-1: A key mediator in hypoxia Acta Physiol Hung 2009, 96:19-28 10.1556/APhysiol.96.2009.1.2 19264039
31. Semenza GL Expression of hypoxia-inducible factor 1: Mechanisms and consequences Biochem Pharmacol 2000, 59:47-53 10.1016/ S0006-2952(99)00292-0 10605934
32. Zhong H De Marzo AM Laughner E Lim M Hilton DA Zagzag D Buechler P Isaacs WB Semenza GL Simons JW Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases Cancer Res 1999, 59:5830-5835 10582706
33. Bergers G Javaherian K Lo KM Folkman J Hanahan D Effects of angiogenesis inhibitors on multistage carcinogenesis in mice Science 1999, 284:808-812 10.1126/science.284.5415.808 10221914