Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells

Carcinogenesis

Volumn 29, Issue 12, 2008, Pages 2267-2278

  Cannito, Stefania ^a   Novo, Erica ^a   Compagnone, Alessandra ^a   di Bonzo, Lorenzo Valfrè ^a   Busletta, Chiara ^a   Zamara, Elena ^a   Paternostro, Claudia ^a   Povero, Davide ^a   Bandino, Andrea ^a   Bozzo, Francesca ^a   Cravanzola, Carlo ^a   Bravoco, Vittoria ^a   Colombatto, Sebastiano ^a   Parola, Maurizio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VASCULOTROPIN; WNT PROTEIN;

ARTICLE; AUTOCRINE EFFECT; CANCER CELL; CANCER INVASION; CELL MIGRATION; CELL STRAIN HEPG2; CELL STRAIN HT29; CELL STRAIN MCF 7; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GENE SWITCHING; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; MITOCHONDRION; MOLECULAR BIOLOGY; OXIDATION REDUCTION REACTION; PARACRINE SIGNALING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BETA CATENIN; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIUM; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MESODERM; NEOPLASM INVASIVENESS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 57349164238     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn216     Document Type: Article

References (50)

1. Vaupel,P. et al. (2007) Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev., 26, 225-239.
2. Harrison,L. et al. (2004) Hypoxia and anemia; factors in decreased sensitivity to radiation therapy and chemotherapy? Oncologist, 9, 31-40.
3. Brown,J.M. (1999) The hypoxic cell: A target for selective cancer therapy - eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res., 59, 5863-5870.
4. Graeber,T.G. et al. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature, 379, 88-91.
5. Harris,A.L. (2002) Hypoxia - a key regulator factor for tumour growth. Nat. Rev. Cancer, 2, 38-47.
6. Semenza,G.L. (2000) Hypoxia, clonal selection, and the role of HIF-1 in tumour progression. Crit. Rev. Biochem. Mol. Biol., 35, 71-103.
7. Tatum,J.L. et al. (2006) Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int. J. Radiat. Biol., 82, 699-757.
8. Höckel,M. et al. (1999) Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res., 59, 4525-4528.
9. Höckel,M. et al. (2001) Tumour hypoxia: Definitions and current clinical, biological, and molecular aspects. J. Natl Cancer Inst., 93, 266-276.
10. Le,Q.T. et al. (2004) Hypoxic gene expression and metastasis. Cancer Metastasis Rev., 23, 293-310.
11. Semenza,G.L. (2002) HIF-1 and tumour progression: Pathophysiology and therapeutics. Trends Mol. Med., 8, S62-S67.
12. Semenza,G.L. (2001) Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology. Trends Mol. Med., 7, 345-350.
13. Semenza,G.L. (2004) Hydroxylation of HIF-1: Oxygen sensing at the molecular level. Physiology (Bethesda), 19, 176-182.
14. Sharp,F.R. et al. (2004) HIF-1 and oxygen sensing in the brain. Nat. Rev. Neurosci., 5, 437-448.
15. Zhong,H. et al. (1999) Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. Cancer Res., 59, 5830-5835.
16. Talks,K.L. et al. (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157, 411-421.
17. Semenza,G.L. (2003) Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer, 3, 721-732.
18. Carmeliet,P. et al. (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature, 394, 485-490.
19. Thiery,J.P. (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol., 15, 740-746.
20. Bates,R.C. et al. (2005) The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol. Ther., 4 365-370.
21. Larue,L. et al. (2005) Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene, 24, 7443-7454.
22. Huber,M.A. et al. (2005) Molecular requirements for epithelial-mesenchymal transition during tumour progression. Curr. Opin. Cell Biol., 17, 548-558.
23. Lee,J.M. et al. (2006) The epithelial-mesenchymal transition: New insights in signalling, development, and disease. J. Cell Biol., 172, 973-981.
24. Thiery,J.P. et al. (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol., 7, 131-142.
25. Moustakas,A. et al. (2007) Signaling networks guiding epithelial-mesenchymal transition during embryogenesis and cancer progression. Cancer Sci., 98, 1512-1520.
26. Zhou,B.P. et al. (2004) Dual regulation of SNAIL by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol., 6, 931-940.
27. Barallo-Gimeno,A. et al. (2005) The Snail genes as inducers of cell movement and survival: Implications in development and cancer. Development, 132, 3151-3161.
28. Prindull,G. (2005) Hypothesis: Cell plasticity, linking embryonal stem cells to adult stem cell reservoirs and metastatic cancer cells? Exp. Hematol., 33, 738-746.
29. Aleffi,S. et al. (2005) Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology, 42, 1339-1348.
30. Novo,E. et al. (2007) Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells. Am. J. Pathol., 170, 1942-1953.
31. Willert,K. et al. (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature, 22, 448-452.
32. Parola,M. et al. (1998) HNE interacts directly with JNK isoforms in human hepatic stellate cells. J. Clin. Invest., 102, 1942-1950.
33. Robino,G. et al. (2000) Interaction between 4-hydroxy-2,3 alkenals and the platelet-derived growth factor-beta receptor. Reduced tyrosine phosphorylation and downstream signalling in hepatic stellate cells. J. Biol. Chem., 275, 40561-40567.
34. Zamara,E. et al. (2004) 4-Hydroxynonenal as a selective profibrogenic stimulus for activated human hepatic stellate cells. J. Hepatol., 40, 60-68.
35. Novo,E. et al. (2006) Overexpression of Bcl-2 by activated human hepatic stellate cells: Resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans. Gut, 55, 1174-1182.
36. Romanelli,R.G. et al. (2006) Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells. Am. J. Physiol. Gastrointest. Liver Physiol., 290, G120-G128.
37. Rezvani,H.R. et al. (2007) Hypoxia inducible factor 1α, a key factor in the keratinocyte response to UVB exposure. J. Biol. Chem. 282, 16413-16422.
38. Novo,E. et al. (2006) Dose dependent and divergent effects of superoxide anion on cell death, proliferation and migration of human hepatic stellate cells. Gut, 55, 90-97.
39. Autelli,R. et al. (2005) Intracellular free iron and acidic pathways mediate TNF-induced death of rat hepatoma cells. Apoptosis 10, 777-786.
40. Tarin,D. et al. (2005) The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res., 65, 5996-6000.
41. Imai,T. et al. (2003) Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am. J. Pathol., 163, 1437-1447.
42. Lester,R.D. et al. (2007) uPAR induces epithelial mesenchymal transition in hypoxic breast cancer cells. J. Cell Biol., 178 425-436.
43. Lester,R.D. et al. (2005) Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. J. Biol. Chem., 280, 39273-39277.
44. Yang,A.D. et al. (2006) Vascular endothelial growth factor receptor 1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res., 66, 46-51.
45. Kietzmann,T. et al. (2005) Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression. Semin. Cell Dev. Biol., 16, 474-486.
46. Guzy,R.D. et al. (2005) Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab., 1, 401-408.
47. Dröge, W. (2002) Free radicals in the physiological control of cell function. Physiol. Rev., 82, 47-95.
48. Wu,W.-S. (2006) The signalling mechanisms of ROS in tumour progression. Cancer Metastasis Rev., 25, 695-705.
49. Funato,Y. et al. (2006) The thioredoxin-related redox regulating protein nucleoredoxin inhibits Wnt-β-catenin signalling through dishevelled. Nat. Cell Biol., 8, 501-508.
50. Korswagen,H.C. (2006) Regulation of the Wnt/β-catenin pathways by redox signalling. Dev. Cell, 10, 687-688.