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Volumn 23, Issue 3, 2013, Pages 267-300

Melatonin antioxidative defense: Therapeutical implications for aging and neurodegenerative processes

Author keywords

Aging; Alzheimer's disease; Amyotrophic lateral sclerosis; Free radicals; Huntington's disease; Melatonin; Mitochondria; Oxidative stress; Parkinson's disease; Stroke

Indexed keywords

ADENOSINE TRIPHOSPHATE; AGOMELATINE; CARBONIC ACID; CYTOCHROME C OXIDASE; FREE RADICAL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROXYL RADICAL; LY 156735; MELATONIN; MELATONIN DERIVATIVE; PLACEBO; RAMELTEON; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; TASIMELTEON; TIK 301; UNCLASSIFIED DRUG; VES 162;

EID: 84876283695     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-012-9337-4     Document Type: Review
Times cited : (261)

References (348)
  • 5
    • 0030878073 scopus 로고    scopus 로고
    • Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra
    • 1:CAS:528:DyaK2sXls1Chtbs%3D
    • Alam ZI, Jenner A, Daniel SE, Lees AJ, Cairns N, Marsden CD, Jenner P, Halliwell B (1997) Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 69:1196-1203
    • (1997) J Neurochem , vol.69 , pp. 1196-1203
    • Alam, Z.I.1    Jenner, A.2    Daniel, S.E.3    Lees, A.J.4    Cairns, N.5    Marsden, C.D.6    Jenner, P.7    Halliwell, B.8
  • 6
    • 67749124210 scopus 로고    scopus 로고
    • The role of melatonin in sleep disturbances in end-stage Huntington's disease
    • Alders J, Smits M, Kremer B, Naarding P (2009) The role of melatonin in sleep disturbances in end-stage Huntington's disease. J Neuropsychiatry Clin Neurosci 21:226-227
    • (2009) J Neuropsychiatry Clin Neurosci , vol.21 , pp. 226-227
    • Alders, J.1    Smits, M.2    Kremer, B.3    Naarding, P.4
  • 7
    • 80053467489 scopus 로고    scopus 로고
    • Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases
    • 1:CAS:528:DC%2BC3MXhtlahu7vI
    • Aliev G, Li Y, Palacios HH, Obrenovich ME (2011) Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases. Recent Pat Cardiovasc Drug Discov 6:222-241
    • (2011) Recent Pat Cardiovasc Drug Discov , vol.6 , pp. 222-241
    • Aliev, G.1    Li, Y.2    Palacios, H.H.3    Obrenovich, M.E.4
  • 8
    • 67650499599 scopus 로고    scopus 로고
    • Drug treatment of REM sleep behavior disorder: The use of drug therapies other than clonazepam
    • Anderson KN, Shneerson JM (2009) Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. J Clin Sleep Med 5:235-239
    • (2009) J Clin Sleep Med , vol.5 , pp. 235-239
    • Anderson, K.N.1    Shneerson, J.M.2
  • 9
    • 43049170505 scopus 로고    scopus 로고
    • REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer's disease
    • Anderson KN, Jamieson S, Graham AJ, Shneerson JM (2008) REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer's disease. Clin Neurol Neurosurg 110:492-495
    • (2008) Clin Neurol Neurosurg , vol.110 , pp. 492-495
    • Anderson, K.N.1    Jamieson, S.2    Graham, A.J.3    Shneerson, J.M.4
  • 10
    • 3142713361 scopus 로고    scopus 로고
    • Direct inhibition of the mitochondrial permeability transition pore: A possible mechanism responsible for anti-apoptotic effects of melatonin
    • 1:CAS:528:DC%2BD2cXjvVCls7s%3D
    • Andrabi SA, Sayeed I, Siemen D, Wolf G, Horn TF (2004) Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J 18:869-871
    • (2004) FASEB J , vol.18 , pp. 869-871
    • Andrabi, S.A.1    Sayeed, I.2    Siemen, D.3    Wolf, G.4    Horn, T.F.5
  • 11
  • 12
    • 0031303156 scopus 로고    scopus 로고
    • Efficacy of melatonin treatment in jet lag, shift work, and blindness
    • 1:CAS:528:DyaK1cXhsF2lurw%3D
    • Arendt J, Skene DJ, Middleton B, Lockley SW, Deacon S (1997) Efficacy of melatonin treatment in jet lag, shift work, and blindness. J Biol Rhythms 12:604-617
    • (1997) J Biol Rhythms , vol.12 , pp. 604-617
    • Arendt, J.1    Skene, D.J.2    Middleton, B.3    Lockley, S.W.4    Deacon, S.5
  • 13
    • 0041817939 scopus 로고    scopus 로고
    • Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia
    • Asayama K, Yamadera H, Ito T, Suzuki H, Kudo Y, Endo S (2003) Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch 70:334-341
    • (2003) J Nippon Med Sch , vol.70 , pp. 334-341
    • Asayama, K.1    Yamadera, H.2    Ito, T.3    Suzuki, H.4    Kudo, Y.5    Endo, S.6
  • 14
    • 67149134840 scopus 로고    scopus 로고
    • Impaired nocturnal melatonin in acute phase of ischaemic stroke: Cross-sectional matched case-control analysis
    • 1:CAS:528:DC%2BD1MXotFagsbk%3D
    • Atanassova PA, Terzieva DD, Dimitrov BD (2009) Impaired nocturnal melatonin in acute phase of ischaemic stroke: cross-sectional matched case-control analysis. J Neuroendocrinol 21:657-663
    • (2009) J Neuroendocrinol , vol.21 , pp. 657-663
    • Atanassova, P.A.1    Terzieva, D.D.2    Dimitrov, B.D.3
  • 17
    • 0025885392 scopus 로고
    • Photoperiodism and effects of indoleamines in a unicellular alga, Gonyaulax polyedra
    • 1:CAS:528:DyaK3MXlsFCku7o%3D
    • Balzer I, Hardeland R (1991) Photoperiodism and effects of indoleamines in a unicellular alga, Gonyaulax polyedra. Science 253:795-797
    • (1991) Science , vol.253 , pp. 795-797
    • Balzer, I.1    Hardeland, R.2
  • 19
    • 0033795036 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis of age-related macular degeneration
    • 1:STN:280:DC%2BD3cvovFCksw%3D%3D
    • Beatty S, Koh H, Phil M, Henson D, Boulton M (2000) The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 45:115-134
    • (2000) Surv Ophthalmol , vol.45 , pp. 115-134
    • Beatty, S.1    Koh, H.2    Phil, M.3    Henson, D.4    Boulton, M.5
  • 20
    • 0021915998 scopus 로고
    • Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome
    • 1:STN:280:DyaL2M3itFGqsg%3D%3D
    • Beck-Friis J, Kjellman BF, Aperia B, Unden F, von Rosen D, Ljunggren JG, Wetterberg L (1985) Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand 71:319-330
    • (1985) Acta Psychiatr Scand , vol.71 , pp. 319-330
    • Beck-Friis, J.1    Kjellman, B.F.2    Aperia, B.3    Unden, F.4    Von Rosen, D.5    Ljunggren, J.G.6    Wetterberg, L.7
  • 21
    • 79960980430 scopus 로고    scopus 로고
    • Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice
    • 1:CAS:528:DC%2BC3MXpt12rurc%3D
    • Bedrosian TA, Herring KL, Weil ZM, Nelson RJ (2011) Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice. Proc Natl Acad Sci USA 108:11686-11691
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11686-11691
    • Bedrosian, T.A.1    Herring, K.L.2    Weil, Z.M.3    Nelson, R.J.4
  • 22
    • 11044229199 scopus 로고    scopus 로고
    • Photocatalytic actions of the pesticide metabolite 2-hydroxyquinoxaline: Destruction of antioxidant vitamins and biogenic amines - Implications of organic redox cycling
    • 1:CAS:528:DC%2BD2MXnvV2ksA%3D%3D
    • Behrends A, Hardeland R, Ness H, Grube S, Poeggeler B, Haldar C (2004) Photocatalytic actions of the pesticide metabolite 2-hydroxyquinoxaline: destruction of antioxidant vitamins and biogenic amines - implications of organic redox cycling. Redox Rep 9:279-288
    • (2004) Redox Rep , vol.9 , pp. 279-288
    • Behrends, A.1    Hardeland, R.2    Ness, H.3    Grube, S.4    Poeggeler, B.5    Haldar, C.6
  • 23
    • 1342268351 scopus 로고    scopus 로고
    • Melatonin-induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late-phase activation of NF-kappaB and AP-1
    • 1:CAS:528:DC%2BD2cXlvFOktw%3D%3D
    • Beni SM, Kohen R, Reiter RJ, Tan DX, Shohami E (2004) Melatonin-induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late-phase activation of NF-kappaB and AP-1. FASEB J 18:149-151
    • (2004) FASEB J , vol.18 , pp. 149-151
    • Beni, S.M.1    Kohen, R.2    Reiter, R.J.3    Tan, D.X.4    Shohami, E.5
  • 25
    • 0038434113 scopus 로고    scopus 로고
    • Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells
    • Benítez-King G, Tunez I, Bellon A, Ortiz GG, Anton-Tay F (2003) Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells. Exp Neurol 182:151-159
    • (2003) Exp Neurol , vol.182 , pp. 151-159
    • Benítez-King, G.1    Tunez, I.2    Bellon, A.3    Ortiz, G.G.4    Anton-Tay, F.5
  • 26
    • 11444259754 scopus 로고    scopus 로고
    • The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia
    • Benítez-King G, Ramirez-Rodríguez G, Ortiz L, Meza I (2004) The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia. Curr Drug Targets CNS Neurol Disord 3:515-533
    • (2004) Curr Drug Targets CNS Neurol Disord , vol.3 , pp. 515-533
    • Benítez-King, G.1    Ramirez-Rodríguez, G.2    Ortiz, L.3    Meza, I.4
  • 28
    • 84857088346 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis and palliative care: Where we are, and the road ahead
    • Blackhall LJ (2012) Amyotrophic lateral sclerosis and palliative care: where we are, and the road ahead. Muscle Nerve 45:311-318
    • (2012) Muscle Nerve , vol.45 , pp. 311-318
    • Blackhall, L.J.1
  • 29
    • 80053197058 scopus 로고    scopus 로고
    • Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night
    • 1:CAS:528:DC%2BC3MXhtlWitL%2FL
    • Blask DE, Hill SM, Dauchy RT, Xiang S, Yuan L, Duplessis T, Mao L, Dauchy E, Sauer LA (2011) Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night. J Pineal Res 51:259-269
    • (2011) J Pineal Res , vol.51 , pp. 259-269
    • Blask, D.E.1    Hill, S.M.2    Dauchy, R.T.3    Xiang, S.4    Yuan, L.5    Duplessis, T.6    Mao, L.7    Dauchy, E.8    Sauer, L.A.9
  • 30
    • 0041562707 scopus 로고    scopus 로고
    • Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: Results in 14 patients
    • Boeve BF, Silber MH, Ferman TJ (2003) Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med 4:281-284
    • (2003) Sleep Med , vol.4 , pp. 281-284
    • Boeve, B.F.1    Silber, M.H.2    Ferman, T.J.3
  • 31
    • 70350075810 scopus 로고    scopus 로고
    • Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents
    • 1:CAS:528:DC%2BD1MXhtlOqtLjF
    • Borah A, Mohanakumar KP (2009) Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents. J Pineal Res 47:293-300
    • (2009) J Pineal Res , vol.47 , pp. 293-300
    • Borah, A.1    Mohanakumar, K.P.2
  • 32
    • 0345270390 scopus 로고    scopus 로고
    • Study of circadian melatonin secretion pattern at different stages of Parkinson's disease
    • 1:CAS:528:DC%2BD3sXisFSksLg%3D
    • Bordet R, Devos D, Brique S, Touitou Y, Guieu JD, Libersa C, Destee A (2003) Study of circadian melatonin secretion pattern at different stages of Parkinson's disease. Clin Neuropharmacol 26:65-72
    • (2003) Clin Neuropharmacol , vol.26 , pp. 65-72
    • Bordet, R.1    Devos, D.2    Brique, S.3    Touitou, Y.4    Guieu, J.D.5    Libersa, C.6    Destee, A.7
  • 35
    • 34249824314 scopus 로고    scopus 로고
    • Oxygen delivery to the tissues and mitochondrial respiration
    • 1:CAS:528:DC%2BD28Xht1WgsLbK
    • Boveris DL, Boveris A (2007) Oxygen delivery to the tissues and mitochondrial respiration. Front Biosci 12:1014-1023
    • (2007) Front Biosci , vol.12 , pp. 1014-1023
    • Boveris, D.L.1    Boveris, A.2
  • 37
    • 0018675192 scopus 로고
    • Melatonin in human cerebrospinal fluid in daytime; Its origin and variation with age
    • 1:CAS:528:DyaE1MXlslahtbk%3D
    • Brown GM, Young SN, Gauthier S, Tsui H, Grota LJ (1979) Melatonin in human cerebrospinal fluid in daytime; its origin and variation with age. Life Sci 25:929-936
    • (1979) Life Sci , vol.25 , pp. 929-936
    • Brown, G.M.1    Young, S.N.2    Gauthier, S.3    Tsui, H.4    Grota, L.J.5
  • 38
    • 79251571164 scopus 로고    scopus 로고
    • Melatonin and mental illness
    • S.R. Pandi-Perumal M. Kramer (eds) Cambridge University Press Cambridge
    • Brown GM, Cardinali DP, Pandi-Perumal SR (2010) Melatonin and mental illness. In: Pandi-Perumal SR, Kramer M (eds) Sleep and Mental Illness. Cambridge University Press, Cambridge, pp 119-129
    • (2010) Sleep and Mental Illness , pp. 119-129
    • Brown, G.M.1    Cardinali, D.P.2    Pandi-Perumal, S.R.3
  • 39
    • 0344492689 scopus 로고    scopus 로고
    • Monozygotic twins with Alzheimer's disease treated with melatonin: Case report
    • 1:CAS:528:DyaK1MXjvVOhsA%3D%3D
    • Brusco LI, Marquez M, Cardinali DP (1998) Monozygotic twins with Alzheimer's disease treated with melatonin: case report. J Pineal Res 25:260-263
    • (1998) J Pineal Res , vol.25 , pp. 260-263
    • Brusco, L.I.1    Marquez, M.2    Cardinali, D.P.3
  • 40
    • 0033994649 scopus 로고    scopus 로고
    • Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease
    • Brusco LI, Marquez M, Cardinali DP (2000) Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease. Neuroendocrinol Lett 21:39-42
    • (2000) Neuroendocrinol Lett , vol.21 , pp. 39-42
    • Brusco, L.I.1    Marquez, M.2    Cardinali, D.P.3
  • 41
    • 0036798932 scopus 로고    scopus 로고
    • Gastrointestinal melatonin: Localization, function, and clinical relevance
    • 1:CAS:528:DC%2BD38XmvFGhtLc%3D
    • Bubenik GA (2002) Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci 47:2336-2348
    • (2002) Dig Dis Sci , vol.47 , pp. 2336-2348
    • Bubenik, G.A.1
  • 42
    • 79954548208 scopus 로고    scopus 로고
    • Melatonin and aging: Prospects for human treatment
    • 1:CAS:528:DC%2BC3MXmtFagsrg%3D
    • Bubenik GA, Konturek SJ (2011) Melatonin and aging: prospects for human treatment. J Physiol Pharmacol 62:13-19
    • (2011) J Physiol Pharmacol , vol.62 , pp. 13-19
    • Bubenik, G.A.1    Konturek, S.J.2
  • 43
    • 77649245602 scopus 로고    scopus 로고
    • Oscillation development for neurotransmitter-related genes in the mouse striatum
    • 1:CAS:528:DC%2BC3cXhtFKqtw%3D%3D
    • Cai Y, Ding H, Li N, Chai Y, Zhang Y, Chan P (2010a) Oscillation development for neurotransmitter-related genes in the mouse striatum. NeuroReport 21:79-83
    • (2010) NeuroReport , vol.21 , pp. 79-83
    • Cai, Y.1    Ding, H.2    Li, N.3    Chai, Y.4    Zhang, Y.5    Chan, P.6
  • 44
    • 77949580716 scopus 로고    scopus 로고
    • Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's disease
    • 1:STN:280:DC%2BC3czitlKktw%3D%3D
    • Cai Y, Liu S, Sothern RB, Xu S, Chan P (2010b) Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's disease. Eur J Neurol 17:550-554
    • (2010) Eur J Neurol , vol.17 , pp. 550-554
    • Cai, Y.1    Liu, S.2    Sothern, R.B.3    Xu, S.4    Chan, P.5
  • 45
    • 0020535349 scopus 로고
    • Molecular mechanisms of neuroendocrine integration in the central nervous system: An approach through the study of the pineal gland and its innervating sympathetic pathway
    • 1:CAS:528:DyaL3sXks1Cnsr4%3D
    • Cardinali DP (1983) Molecular mechanisms of neuroendocrine integration in the central nervous system: an approach through the study of the pineal gland and its innervating sympathetic pathway. Psychoneuroendocrinology 8:3-30
    • (1983) Psychoneuroendocrinology , vol.8 , pp. 3-30
    • Cardinali, D.P.1
  • 46
    • 0016502371 scopus 로고
    • Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus
    • 1:CAS:528:DyaE28Xkslalt7c%3D
    • Cardinali DP, Freire F (1975) Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus. Mol Cell Endocrinol 2:317-330
    • (1975) Mol Cell Endocrinol , vol.2 , pp. 317-330
    • Cardinali, D.P.1    Freire, F.2
  • 47
    • 0000491884 scopus 로고    scopus 로고
    • Basic aspects of melatonin action
    • 1:STN:280:DC%2BD2cvgs1ymsw%3D%3D
    • Cardinali DP, Pévet P (1998) Basic aspects of melatonin action. Sleep Med Rev 2:175-190
    • (1998) Sleep Med Rev , vol.2 , pp. 175-190
    • Cardinali, D.P.1    Pévet, P.2
  • 48
    • 85017153512 scopus 로고    scopus 로고
    • Chronophysiology of melatonin: Therapeutical implications
    • 1:CAS:528:DC%2BC3cXhsF2ltrbM
    • Cardinali DP, Scacchi PA (2010) Chronophysiology of melatonin: therapeutical implications. Open Neuroendocrinol J 3:72-84
    • (2010) Open Neuroendocrinol J , vol.3 , pp. 72-84
    • Cardinali, D.P.1    Scacchi, P.A.2
  • 51
    • 78549284583 scopus 로고    scopus 로고
    • Clinical aspects of melatonin intervention in Alzheimer's disease progression
    • 1:CAS:528:DC%2BC3cXhtl2mtrvK
    • Cardinali DP, Furio AM, Brusco LI (2010) Clinical aspects of melatonin intervention in Alzheimer's disease progression. Curr Neuropharmacol 8:218-227
    • (2010) Curr Neuropharmacol , vol.8 , pp. 218-227
    • Cardinali, D.P.1    Furio, A.M.2    Brusco, L.I.3
  • 52
    • 79953743149 scopus 로고    scopus 로고
    • Melatonin and the metabolic syndrome: Physiopathologic and therapeutical implications
    • 1:CAS:528:DC%2BC3MXkt1KitLk%3D
    • Cardinali DP, Cano P, Jimenez-Ortega V, Esquifino AI (2011) Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications. Neuroendocrinology 93:133-142
    • (2011) Neuroendocrinology , vol.93 , pp. 133-142
    • Cardinali, D.P.1    Cano, P.2    Jimenez-Ortega, V.3    Esquifino, A.I.4
  • 53
  • 54
    • 0030929407 scopus 로고    scopus 로고
    • Melatonin protects against lipid peroxidation induced by delta-aminolevulinic acid in rat cerebellum, cortex and hippocampus
    • 1:CAS:528:DyaK2sXmvFCqurc%3D
    • Carneiro RC, Reiter RJ (1998) Melatonin protects against lipid peroxidation induced by delta-aminolevulinic acid in rat cerebellum, cortex and hippocampus. Neuroscience 82:293-299
    • (1998) Neuroscience , vol.82 , pp. 293-299
    • Carneiro, R.C.1    Reiter, R.J.2
  • 56
    • 0342275227 scopus 로고    scopus 로고
    • Melatonin levels in Parkinson's disease: Drug therapy versus electrical stimulation of the internal globus pallidus
    • 1:CAS:528:DyaK2sXmtVGhtr0%3D
    • Catala MD, Canete-Nicolas C, Iradi A, Tarazona PJ, Tormos JM, Pascual-Leóne A (1997) Melatonin levels in Parkinson's disease: drug therapy versus electrical stimulation of the internal globus pallidus. Exp Gerontol 32:553-558
    • (1997) Exp Gerontol , vol.32 , pp. 553-558
    • Catala, M.D.1    Canete-Nicolas, C.2    Iradi, A.3    Tarazona, P.J.4    Tormos, J.M.5    Pascual-Leóne, A.6
  • 57
    • 58049211820 scopus 로고    scopus 로고
    • Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: A double-blind, randomized, placebo-controlled study
    • 1:CAS:528:DC%2BD1cXhsFChtbzE
    • Caumo W, Levandovski R, Hidalgo MP (2009) Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. J Pain 10:100-108
    • (2009) J Pain , vol.10 , pp. 100-108
    • Caumo, W.1    Levandovski, R.2    Hidalgo, M.P.3
  • 58
    • 0027674712 scopus 로고
    • Melatonin and human puberty: Current perspectives
    • 1:CAS:528:DyaK2cXitlKhu7w%3D
    • Cavallo A (1993) Melatonin and human puberty: current perspectives. J Pineal Res 15:115-121
    • (1993) J Pineal Res , vol.15 , pp. 115-121
    • Cavallo, A.1
  • 60
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • 1:CAS:528:DyaE1MXltVGmtLc%3D
    • Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605
    • (1979) Physiol Rev , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 61
    • 79955930293 scopus 로고    scopus 로고
    • Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease
    • Chen CM (2011) Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease. Chang Gung Med J 34:135-152
    • (2011) Chang Gung Med J , vol.34 , pp. 135-152
    • Chen, C.M.1
  • 63
    • 0037378182 scopus 로고    scopus 로고
    • The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion
    • 1:CAS:528:DC%2BD3sXitlOgtbo%3D
    • Cheung RT (2003) The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J Pineal Res 34:153-160
    • (2003) J Pineal Res , vol.34 , pp. 153-160
    • Cheung, R.T.1
  • 64
    • 0031003546 scopus 로고    scopus 로고
    • Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats
    • 1:CAS:528:DyaK2sXislehtrw%3D
    • Cho S, Joh TH, Baik HH, Dibinis C, Volpe BT (1997) Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats. Brain Res 755:335-338
    • (1997) Brain Res , vol.755 , pp. 335-338
    • Cho, S.1    Joh, T.H.2    Baik, H.H.3    Dibinis, C.4    Volpe, B.T.5
  • 65
    • 77950642047 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in seizure-induced neuronal cell death
    • Chuang YC (2010) Mitochondrial dysfunction and oxidative stress in seizure-induced neuronal cell death. Acta Neurol Taiwan 19:3-15
    • (2010) Acta Neurol Taiwan , vol.19 , pp. 3-15
    • Chuang, Y.C.1
  • 66
    • 1342280378 scopus 로고    scopus 로고
    • + treatment in human astrocytoma U373MG cells
    • 1:CAS:528:DC%2BD2cXhs1Sru7k%3D
    • + treatment in human astrocytoma U373MG cells. J Pineal Res 36:117-125
    • (2004) J Pineal Res , vol.36 , pp. 117-125
    • Chuang, J.I.1    Chen, T.H.2
  • 67
    • 84877798798 scopus 로고    scopus 로고
    • Riluzole: What It Does to Spinal and Brainstem Neurons and How It Does It
    • Cifra A, Mazzone GL, Nistri A (2012) Riluzole: What It Does to Spinal and Brainstem Neurons and How It Does It. Neuroscientist. http://dx.doi.org/10. 1177/1073858412444932
    • (2012) Neuroscientist
    • Cifra, A.1    Mazzone, G.L.2    Nistri, A.3
  • 68
    • 11844277100 scopus 로고    scopus 로고
    • The basic physiology and pathophysiology of melatonin
    • Claustrat B, Brun J, Chazot G (2005) The basic physiology and pathophysiology of melatonin. Sleep Med Rev 9:11-24
    • (2005) Sleep Med Rev , vol.9 , pp. 11-24
    • Claustrat, B.1    Brun, J.2    Chazot, G.3
  • 69
    • 0033832475 scopus 로고    scopus 로고
    • Melatonin for treatment of sundowning in elderly persons with dementia - A preliminary study
    • 1:CAS:528:DC%2BD3cXmtlGktbg%3D
    • Cohen-Mansfield J, Garfinkel D, Lipson S (2000) Melatonin for treatment of sundowning in elderly persons with dementia - a preliminary study. Arch Gerontol Geriatr 31:65-76
    • (2000) Arch Gerontol Geriatr , vol.31 , pp. 65-76
    • Cohen-Mansfield, J.1    Garfinkel, D.2    Lipson, S.3
  • 71
    • 79960866841 scopus 로고    scopus 로고
    • Systemic inflammation and delirium: Important co-factors in the progression of dementia
    • 1:CAS:528:DC%2BC3MXpslKqsrw%3D
    • Cunningham C (2011) Systemic inflammation and delirium: important co-factors in the progression of dementia. Biochem Soc Trans 39:945-953
    • (2011) Biochem Soc Trans , vol.39 , pp. 945-953
    • Cunningham, C.1
  • 72
    • 0031226491 scopus 로고    scopus 로고
    • Protective effect of melatonin in carrageenan-induced models of local inflammation: Relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity
    • 1:CAS:528:DyaK2sXnt1Wnurc%3D
    • Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabo C (1997) Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. J Pineal Res 23:106-116
    • (1997) J Pineal Res , vol.23 , pp. 106-116
    • Cuzzocrea, S.1    Zingarelli, B.2    Gilad, E.3    Hake, P.4    Salzman, A.L.5    Szabo, C.6
  • 73
    • 0035170284 scopus 로고    scopus 로고
    • Melatonin protects against 6-OHDA-induced neurotoxicity in rats: A role for mitochondrial complex i activity
    • 1:CAS:528:DC%2BD3MXht1Snsb4%3D
    • Dabbeni-Sala F, Di Santo S, Franceschini D, Skaper SD, Giusti P (2001) Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity. FASEB J 15:164-170
    • (2001) FASEB J , vol.15 , pp. 164-170
    • Dabbeni-Sala, F.1    Di Santo, S.2    Franceschini, D.3    Skaper, S.D.4    Giusti, P.5
  • 74
    • 84855931783 scopus 로고    scopus 로고
    • Melatonin-dependent timing of seasonal reproduction by the pars tuberalis: Pivotal roles for long daylengths and thyroid hormones
    • 1:CAS:528:DC%2BC38XhvFKhtr8%3D
    • Dardente H (2012) Melatonin-dependent timing of seasonal reproduction by the pars tuberalis: pivotal roles for long daylengths and thyroid hormones. J Neuroendocrinol 24:249-266
    • (2012) J Neuroendocrinol , vol.24 , pp. 249-266
    • Dardente, H.1
  • 75
    • 75149124310 scopus 로고    scopus 로고
    • The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors
    • 1:CAS:528:DC%2BC3cXitFClsLw%3D
    • Das A, McDowell M, Pava MJ, Smith JA, Reiter RJ, Woodward JJ, Varma AK, Ray SK, Banik NL (2010) The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors. J Pineal Res 48:157-169
    • (2010) J Pineal Res , vol.48 , pp. 157-169
    • Das, A.1    McDowell, M.2    Pava, M.J.3    Smith, J.A.4    Reiter, R.J.5    Woodward, J.J.6    Varma, A.K.7    Ray, S.K.8    Banik, N.L.9
  • 76
    • 0030069491 scopus 로고    scopus 로고
    • Chronobiotics - Drugs that shift rhythms
    • 1:CAS:528:DyaK28Xht1emtL4%3D
    • Dawson D, Armstrong SM (1996) Chronobiotics - drugs that shift rhythms. Pharmacol Ther 69:15-36
    • (1996) Pharmacol Ther , vol.69 , pp. 15-36
    • Dawson, D.1    Armstrong, S.M.2
  • 77
    • 78649647585 scopus 로고    scopus 로고
    • Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review
    • de Jonghe A, Korevaar JC, van Munster BC, de Rooij SE (2010) Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. Int J Geriatr Psychiatry 25:1201-1208
    • (2010) Int J Geriatr Psychiatry , vol.25 , pp. 1201-1208
    • De Jonghe, A.1    Korevaar, J.C.2    Van Munster, B.C.3    De Rooij, S.E.4
  • 85
    • 0029104550 scopus 로고
    • Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry
    • 1:CAS:528:DyaK2MXksFSmsro%3D
    • Dubbels R, Reiter RJ, Klenke E, Goebel A, Schnakenberg E, Ehlers C, Schiwara HW, Schloot W (1995) Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry. J Pineal Res 18:28-31
    • (1995) J Pineal Res , vol.18 , pp. 28-31
    • Dubbels, R.1    Reiter, R.J.2    Klenke, E.3    Goebel, A.4    Schnakenberg, E.5    Ehlers, C.6    Schiwara, H.W.7    Schloot, W.8
  • 86
    • 77956289235 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors
    • 1:CAS:528:DC%2BC3cXhsVSltbbP
    • Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J (2010) International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacol Rev 62:343-380
    • (2010) Pharmacol Rev , vol.62 , pp. 343-380
    • Dubocovich, M.L.1    Delagrange, P.2    Krause, D.N.3    Sugden, D.4    Cardinali, D.P.5    Olcese, J.6
  • 87
    • 80255122786 scopus 로고    scopus 로고
    • Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: Shared targets for drug development
    • 1:CAS:528:DC%2BC3MXhtlGhtbbJ
    • Ehrnhoefer DE, Wong BK, Hayden MR (2011) Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development. Nat Rev Drug Discov 10:853-867
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 853-867
    • Ehrnhoefer, D.E.1    Wong, B.K.2    Hayden, M.R.3
  • 88
  • 89
    • 0029866124 scopus 로고    scopus 로고
    • Melatonin-dopamine interaction in the striatal projection area of sensorimotor cortex in the rat
    • 1:CAS:528:DyaK28XisVCmsLs%3D
    • Escames G, Acuña-Castroviejo CD, Vives F (1996) Melatonin-dopamine interaction in the striatal projection area of sensorimotor cortex in the rat. NeuroReport 7:597-600
    • (1996) NeuroReport , vol.7 , pp. 597-600
    • Escames, G.1    Acuña-Castroviejo, C.D.2    Vives, F.3
  • 90
    • 11244336652 scopus 로고    scopus 로고
    • Mechanisms of N-methyl-d-aspartate receptor inhibition by melatonin in the rat striatum
    • 1:CAS:528:DC%2BD2MXjtVSjsQ%3D%3D
    • Escames G, León J, Lopez LC, Acuña-Castroviejo D (2004) Mechanisms of N-methyl-d-aspartate receptor inhibition by melatonin in the rat striatum. J Neuroendocrinol 16:929-935
    • (2004) J Neuroendocrinol , vol.16 , pp. 929-935
    • Escames, G.1    León, J.2    Lopez, L.C.3    Acuña-Castroviejo, D.4
  • 91
    • 78549282095 scopus 로고    scopus 로고
    • Antiinflammatory activity of melatonin in central nervous system
    • 1:CAS:528:DC%2BC3cXhtl2mtrvL
    • Esposito E, Cuzzocrea S (2010) Antiinflammatory activity of melatonin in central nervous system. Curr Neuropharmacol 8:228-242
    • (2010) Curr Neuropharmacol , vol.8 , pp. 228-242
    • Esposito, E.1    Cuzzocrea, S.2
  • 92
    • 13944269248 scopus 로고    scopus 로고
    • Circadian organization of the immune response: A role for melatonin
    • 1:CAS:528:DC%2BD2cXptFKktLg%3D
    • Esquifino AI, Pandi-Perumal SR, Cardinali DP (2004) Circadian organization of the immune response: a role for melatonin. Clin Applied Immunol Rev 4:423-433
    • (2004) Clin Applied Immunol Rev , vol.4 , pp. 423-433
    • Esquifino, A.I.1    Pandi-Perumal, S.R.2    Cardinali, D.P.3
  • 93
    • 0026484388 scopus 로고
    • The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
    • 1:STN:280:DyaK3s7htFOjtQ%3D%3D
    • Fahn S, Cohen G (1992) The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann Neurol 32:804-812
    • (1992) Ann Neurol , vol.32 , pp. 804-812
    • Fahn, S.1    Cohen, G.2
  • 94
    • 0031473076 scopus 로고    scopus 로고
    • Effects of melatonin in elderly patients with sleep disturbance. A pilot study
    • 1:CAS:528:DyaK1cXltVGhtA%3D%3D
    • Fainstein I, Bonetto A, Brusco LI, Cardinali DP (1997) Effects of melatonin in elderly patients with sleep disturbance. A pilot study. Curr Ther Res 58:990-1000
    • (1997) Curr Ther Res , vol.58 , pp. 990-1000
    • Fainstein, I.1    Bonetto, A.2    Brusco, L.I.3    Cardinali, D.P.4
  • 95
    • 7444227078 scopus 로고    scopus 로고
    • Melatonin reduces amyloid beta-induced apoptosis in pheochromocytoma (PC12) cells
    • 1:CAS:528:DC%2BD2cXpsFCgsr8%3D
    • Feng Z, Zhang JT (2004) Melatonin reduces amyloid beta-induced apoptosis in pheochromocytoma (PC12) cells. J Pineal Res 37:257-266
    • (2004) J Pineal Res , vol.37 , pp. 257-266
    • Feng, Z.1    Zhang, J.T.2
  • 96
    • 28744450569 scopus 로고    scopus 로고
    • Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease
    • 1:CAS:528:DC%2BD2MXhtlSiu73M
    • Feng Z, Qin C, Chang Y, Zhang JT (2006) Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease. Free Radic Biol Med 40:101-109
    • (2006) Free Radic Biol Med , vol.40 , pp. 101-109
    • Feng, Z.1    Qin, C.2    Chang, Y.3    Zhang, J.T.4
  • 97
    • 0033670376 scopus 로고    scopus 로고
    • Variability of interactions between neuroendocrine and immunological functions in physiological aging and dementia of the Alzheimer's type
    • 1:CAS:528:DC%2BD3cXovFymtrs%3D
    • Ferrari E, Fioravanti M, Magri F, Solerte SB (2000) Variability of interactions between neuroendocrine and immunological functions in physiological aging and dementia of the Alzheimer's type. Ann N Y Acad Sci 917:582-596
    • (2000) Ann N y Acad Sci , vol.917 , pp. 582-596
    • Ferrari, E.1    Fioravanti, M.2    Magri, F.3    Solerte, S.B.4
  • 99
    • 0027239615 scopus 로고
    • Circadian secretion pattern of melatonin in de novo parkinsonian patients: Evidence for phase-shifting properties of l-dopa
    • 1:STN:280:DyaK3sznvVKltw%3D%3D
    • Fertl E, Auff E, Doppelbauer A, Waldhauser F (1993) Circadian secretion pattern of melatonin in de novo parkinsonian patients: evidence for phase-shifting properties of l-dopa. J Neural Transm Park Dis Dement Sect 5:227-234
    • (1993) J Neural Transm Park Dis Dement Sect , vol.5 , pp. 227-234
    • Fertl, E.1    Auff, E.2    Doppelbauer, A.3    Waldhauser, F.4
  • 100
    • 14944385354 scopus 로고    scopus 로고
    • Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors
    • 1:CAS:528:DC%2BD2MXis1ygs7o%3D
    • Floden AM, Li S, Combs CK (2005) Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci 25:2566-2575
    • (2005) J Neurosci , vol.25 , pp. 2566-2575
    • Floden, A.M.1    Li, S.2    Combs, C.K.3
  • 102
    • 80051667284 scopus 로고    scopus 로고
    • The role of free radical generation in increasing cerebrovascular permeability
    • 1:CAS:528:DC%2BC3MXhtVagtbnP
    • Fraser PA (2011) The role of free radical generation in increasing cerebrovascular permeability. Free Radic Biol Med 51:967-977
    • (2011) Free Radic Biol Med , vol.51 , pp. 967-977
    • Fraser, P.A.1
  • 103
    • 0036973151 scopus 로고    scopus 로고
    • Effect of melatonin on changes in locomotor activity rhythm of Syrian hamsters injected with beta amyloid peptide 25-35 in the suprachiasmatic nuclei
    • 1:CAS:528:DC%2BD3sXhsFeisA%3D%3D
    • Furio AM, Cutrera RA, Castillo TV, Perez LS, Riccio P, Caccuri RL, Brusco LL, Cardinali DP (2002) Effect of melatonin on changes in locomotor activity rhythm of Syrian hamsters injected with beta amyloid peptide 25-35 in the suprachiasmatic nuclei. Cell Mol Neurobiol 22:699-709
    • (2002) Cell Mol Neurobiol , vol.22 , pp. 699-709
    • Furio, A.M.1    Cutrera, R.A.2    Castillo, T.V.3    Perez, L.S.4    Riccio, P.5    Caccuri, R.L.6    Brusco, L.L.7    Cardinali, D.P.8
  • 104
    • 34848894332 scopus 로고    scopus 로고
    • Possible therapeutic value of melatonin in mild cognitive impairment: A retrospective study
    • 1:CAS:528:DC%2BD2sXht1Knu7rM
    • Furio AM, Brusco LI, Cardinali DP (2007) Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study. J Pineal Res 43:404-409
    • (2007) J Pineal Res , vol.43 , pp. 404-409
    • Furio, A.M.1    Brusco, L.I.2    Cardinali, D.P.3
  • 105
    • 77954521012 scopus 로고    scopus 로고
    • Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus
    • 1:CAS:528:DC%2BD1cXps1antr4%3D
    • Furio AM, Fontao R, Falco N, Ruiz JI, Caccuri RL, Cardinali DP (2008) Neuroprotective effect of melatonin on glucocorticoid toxicity in the rat hippocampus. Open Physiol J 1:23-27
    • (2008) Open Physiol J , vol.1 , pp. 23-27
    • Furio, A.M.1    Fontao, R.2    Falco, N.3    Ruiz, J.I.4    Caccuri, R.L.5    Cardinali, D.P.6
  • 106
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • 1:CAS:528:DC%2BC3MXpslKqsro%3D
    • Galano A, Tan DX, Reiter RJ (2011) Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 51:1-16
    • (2011) J Pineal Res , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 107
    • 77950631180 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder
    • 1:CAS:528:DC%2BC3cXltFSltb4%3D
    • Galecki P, Szemraj J, Bartosz G, Bienkiewicz M, Galecka E, Florkowski A, Lewinski A, Karbownik-Lewinska M (2010) Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. J Pineal Res 48:311-317
    • (2010) J Pineal Res , vol.48 , pp. 311-317
    • Galecki, P.1    Szemraj, J.2    Bartosz, G.3    Bienkiewicz, M.4    Galecka, E.5    Florkowski, A.6    Lewinski, A.7    Karbownik-Lewinska, M.8
  • 109
    • 70349876561 scopus 로고    scopus 로고
    • Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease
    • García T, Ribes D, Colomina MT, Cabre M, Domingo JL, Gomez M (2009) Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease. Toxicology 265:49-55
    • (2009) Toxicology , vol.265 , pp. 49-55
    • García, T.1    Ribes, D.2    Colomina, M.T.3    Cabre, M.4    Domingo, J.L.5    Gomez, M.6
  • 110
    • 75149149368 scopus 로고    scopus 로고
    • Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer's disease after chronic exposure to aluminum
    • García T, Esparza JL, Nogues MR, Romeu M, Domingo JL, Gomez M (2010) Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer's disease after chronic exposure to aluminum. Hippocampus 20:218-225
    • (2010) Hippocampus , vol.20 , pp. 218-225
    • García, T.1    Esparza, J.L.2    Nogues, M.R.3    Romeu, M.4    Domingo, J.L.5    Gomez, M.6
  • 112
    • 62649174879 scopus 로고    scopus 로고
    • Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: A randomized, double-blind, placebo-controlled study
    • 1:CAS:528:DC%2BD1MXktlKksLw%3D
    • Garzon C, Guerrero JM, Aramburu O, Guzman T (2009) Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. Aging Clin Exp Res 21:38-42
    • (2009) Aging Clin Exp Res , vol.21 , pp. 38-42
    • Garzon, C.1    Guerrero, J.M.2    Aramburu, O.3    Guzman, T.4
  • 114
    • 60849138397 scopus 로고    scopus 로고
    • Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease
    • Gehrman PR, Connor DJ, Martin JL, Shochat T, Corey-Bloom J, Ancoli-Israel S (2009) Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am J Geriatr Psychiatry 17:166-169
    • (2009) Am J Geriatr Psychiatry , vol.17 , pp. 166-169
    • Gehrman, P.R.1    Connor, D.J.2    Martin, J.L.3    Shochat, T.4    Corey-Bloom, J.5    Ancoli-Israel, S.6
  • 116
    • 79955633871 scopus 로고    scopus 로고
    • Glutathione as a signaling molecule: Another challenge to pathogens
    • 1:CAS:528:DC%2BC38XitlOit7Y%3D
    • Ghanta S, Chattopadhyay S (2011) Glutathione as a signaling molecule: another challenge to pathogens. Plant Signal Behav 6:783-788
    • (2011) Plant Signal Behav , vol.6 , pp. 783-788
    • Ghanta, S.1    Chattopadhyay, S.2
  • 117
    • 71849095133 scopus 로고    scopus 로고
    • Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases
    • 1:CAS:528:DC%2BD1MXhsFanurjI
    • Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF (2010) Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta 1802:122-134
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 122-134
    • Gibson, G.E.1    Starkov, A.2    Blass, J.P.3    Ratan, R.R.4    Beal, M.F.5
  • 119
    • 0030136147 scopus 로고    scopus 로고
    • In vitro and in vivo protection against kainate-induced excitotoxicity by melatonin
    • 1:CAS:528:DyaK28Xkt1OqsLo%3D
    • Giusti P, Franceschini D, Petrone M, Manev H, Floreani M (1996a) In vitro and in vivo protection against kainate-induced excitotoxicity by melatonin. J Pineal Res 20:226-231
    • (1996) J Pineal Res , vol.20 , pp. 226-231
    • Giusti, P.1    Franceschini, D.2    Petrone, M.3    Manev, H.4    Floreani, M.5
  • 120
    • 0029885085 scopus 로고    scopus 로고
    • Neuroprotection by melatonin from kainate-induced excitotoxicity in rats
    • 1:CAS:528:DyaK28XjslSrsb4%3D
    • Giusti P, Lipartiti M, Franceschini D, Schiavo N, Floreani M, Manev H (1996b) Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. FASEB J 10:891-896
    • (1996) FASEB J , vol.10 , pp. 891-896
    • Giusti, P.1    Lipartiti, M.2    Franceschini, D.3    Schiavo, N.4    Floreani, M.5    Manev, H.6
  • 121
    • 0029788185 scopus 로고    scopus 로고
    • Melatonin effects on behavior: Possible mediation by the central GABAergic system
    • 1:CAS:528:DyaK28XmtF2msr4%3D
    • Golombek DA, Pévet P, Cardinali DP (1996) Melatonin effects on behavior: possible mediation by the central GABAergic system. Neurosci Biobehav Rev 20:403-412
    • (1996) Neurosci Biobehav Rev , vol.20 , pp. 403-412
    • Golombek, D.A.1    Pévet, P.2    Cardinali, D.P.3
  • 123
    • 79959354999 scopus 로고    scopus 로고
    • Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    • 1:CAS:528:DC%2BC3MXhtVGktrrN
    • Green DR, Galluzzi L, Kroemer G (2011) Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 333:1109-1112
    • (2011) Science , vol.333 , pp. 1109-1112
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 126
    • 0036481625 scopus 로고    scopus 로고
    • Melatonin-immune system relationships
    • 1:CAS:528:DC%2BD38XhvVaqu7k%3D
    • Guerrero JM, Reiter RJ (2002) Melatonin-immune system relationships. Curr Top Med Chem 2:167-179
    • (2002) Curr Top Med Chem , vol.2 , pp. 167-179
    • Guerrero, J.M.1    Reiter, R.J.2
  • 127
    • 0031203676 scopus 로고    scopus 로고
    • Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones unguiculatus)
    • 1:CAS:528:DyaK2sXmt1Oqu7o%3D
    • Guerrero JM, Reiter RJ, Ortiz GG, Pablos MI, Sewerynek E, Chuang JI (1997) Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones unguiculatus). J Pineal Res 23:24-31
    • (1997) J Pineal Res , vol.23 , pp. 24-31
    • Guerrero, J.M.1    Reiter, R.J.2    Ortiz, G.G.3    Pablos, M.I.4    Sewerynek, E.5    Chuang, J.I.6
  • 129
    • 10644278744 scopus 로고    scopus 로고
    • Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: A randomized, double-blind, placebo-controlled trial
    • 1:CAS:528:DC%2BD2MXmtFOnuw%3D%3D
    • Gupta M, Gupta YK, Agarwal S, Aneja S, Kalaivani M, Kohli K (2004) Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsia 45:1636-1639
    • (2004) Epilepsia , vol.45 , pp. 1636-1639
    • Gupta, M.1    Gupta, Y.K.2    Agarwal, S.3    Aneja, S.4    Kalaivani, M.5    Kohli, K.6
  • 130
    • 79955076193 scopus 로고    scopus 로고
    • Antioxidant therapies for acute spinal cord injury
    • 1:CAS:528:DC%2BC3MXkvVGhs78%3D
    • Hall ED (2011) Antioxidant therapies for acute spinal cord injury. Neurotherapeutics 8:152-167
    • (2011) Neurotherapeutics , vol.8 , pp. 152-167
    • Hall, E.D.1
  • 131
    • 0037031043 scopus 로고    scopus 로고
    • Prevention of age related macular degeneration
    • Hall NF, Gale CR (2002) Prevention of age related macular degeneration. BMJ 325:1-2
    • (2002) BMJ , vol.325 , pp. 1-2
    • Hall, N.F.1    Gale, C.R.2
  • 132
    • 72949115293 scopus 로고    scopus 로고
    • Antioxidant therapies for traumatic brain injury
    • 1:CAS:528:DC%2BC3cXitFKmsro%3D
    • Hall ED, Vaishnav RA, Mustafa AG (2010) Antioxidant therapies for traumatic brain injury. Neurotherapeutics 7:51-61
    • (2010) Neurotherapeutics , vol.7 , pp. 51-61
    • Hall, E.D.1    Vaishnav, R.A.2    Mustafa, A.G.3
  • 133
    • 0035834571 scopus 로고    scopus 로고
    • An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: Glutathione S-transferase M1 and quinone oxidoreductase 1 and 2
    • 1:CAS:528:DC%2BD3MXnvFGit7s%3D
    • Harada S, Fujii C, Hayashi A, Ohkoshi N (2001) An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2. Biochem Biophys Res Commun 288:887-892
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 887-892
    • Harada, S.1    Fujii, C.2    Hayashi, A.3    Ohkoshi, N.4
  • 134
    • 27644552995 scopus 로고    scopus 로고
    • Antioxidative protection by melatonin: Multiplicity of mechanisms from radical detoxification to radical avoidance
    • 1:CAS:528:DC%2BD2MXhtFansLnM
    • Hardeland R (2005) Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 27:119-130
    • (2005) Endocrine , vol.27 , pp. 119-130
    • Hardeland, R.1
  • 135
    • 46449116418 scopus 로고    scopus 로고
    • Melatonin, hormone of darkness and more - Occurrence, control mechanisms, actions and bioactive metabolites
    • 1:CAS:528:DC%2BD1cXotVyktrc%3D
    • Hardeland R (2008) Melatonin, hormone of darkness and more - occurrence, control mechanisms, actions and bioactive metabolites. Cell Mol Life Sci 65:2001-2018
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2001-2018
    • Hardeland, R.1
  • 136
    • 67649236122 scopus 로고    scopus 로고
    • Melatonin: Signaling mechanisms of a pleiotropic agent
    • 1:CAS:528:DC%2BD1MXnsVSls78%3D
    • Hardeland R (2009a) Melatonin: signaling mechanisms of a pleiotropic agent. BioFactors 35:183-192
    • (2009) BioFactors , vol.35 , pp. 183-192
    • Hardeland, R.1
  • 137
    • 73849109199 scopus 로고    scopus 로고
    • Neuroprotection by radical avoidance: Search for suitable agents
    • 1:CAS:528:DC%2BD1MXhsFKru7rP
    • Hardeland R (2009b) Neuroprotection by radical avoidance: search for suitable agents. Molecules 14:5054-5102
    • (2009) Molecules , vol.14 , pp. 5054-5102
    • Hardeland, R.1
  • 138
    • 77952378059 scopus 로고    scopus 로고
    • Investigational melatonin receptor agonists
    • 1:CAS:528:DC%2BC3cXlvFOisLs%3D
    • Hardeland R (2010a) Investigational melatonin receptor agonists. Expert Opin Investig Drugs 19:747-764
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 747-764
    • Hardeland, R.1
  • 139
    • 78549259166 scopus 로고    scopus 로고
    • Melatonin metabolism in the central nervous system
    • 1:CAS:528:DC%2BC3cXhtl2mtrvO
    • Hardeland R (2010b) Melatonin metabolism in the central nervous system. Curr Neuropharmacol 8:168-181
    • (2010) Curr Neuropharmacol , vol.8 , pp. 168-181
    • Hardeland, R.1
  • 140
    • 26844450246 scopus 로고    scopus 로고
    • Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug
    • Hardeland R, Pandi-Perumal SR (2005) Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug. Nutr Metab (Lond) 2:22
    • (2005) Nutr Metab (Lond) , vol.2 , pp. 22
    • Hardeland, R.1    Pandi-Perumal, S.R.2
  • 141
    • 37349001980 scopus 로고    scopus 로고
    • Actions of melatonin, its structural and functional analogs in the central nervous system and the significance of metabolism
    • Hardeland R, Poeggeler B (2007) Actions of melatonin, its structural and functional analogs in the central nervous system and the significance of metabolism. Cent Nerv Syst Agents Med Chem 7:303
    • (2007) Cent Nerv Syst Agents Med Chem , vol.7 , pp. 303
    • Hardeland, R.1    Poeggeler, B.2
  • 142
    • 68249127400 scopus 로고    scopus 로고
    • Melatonin beyond its classical functions
    • 1:CAS:528:DC%2BD1cXps1ansbc%3D
    • Hardeland R, Poeggeler B (2008) Melatonin beyond its classical functions. Open Physiol J 1:1-23
    • (2008) Open Physiol J , vol.1 , pp. 1-23
    • Hardeland, R.1    Poeggeler, B.2
  • 143
    • 0029268538 scopus 로고
    • On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals
    • 1:CAS:528:DyaK2MXls1yisLY%3D
    • Hardeland R, Balzer I, Poeggeler B, Fuhrberg B, Uria H, Behrmann G, Wolf R, Meyer TJ, Reiter RJ (1995) On the primary functions of melatonin in evolution: mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals. J Pineal Res 18:104-111
    • (1995) J Pineal Res , vol.18 , pp. 104-111
    • Hardeland, R.1    Balzer, I.2    Poeggeler, B.3    Fuhrberg, B.4    Uria, H.5    Behrmann, G.6    Wolf, R.7    Meyer, T.J.8    Reiter, R.J.9
  • 146
    • 78549290673 scopus 로고    scopus 로고
    • Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease
    • 1:CAS:528:DC%2BC3cXhtl2mtrvJ
    • He H, Dong W, Huang F (2010) Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease. Curr Neuropharmacol 8:211-217
    • (2010) Curr Neuropharmacol , vol.8 , pp. 211-217
    • He, H.1    Dong, W.2    Huang, F.3
  • 147
    • 0034612220 scopus 로고    scopus 로고
    • Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy
    • 1:CAS:528:DC%2BD3cXktFaitLY%3D
    • Heiser V, Scherzinger E, Boeddrich A, Nordhoff E, Lurz R, Schugardt N, Lehrach H, Wanker EE (2000) Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. Proc Natl Acad Sci USA 97:6739-6744
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6739-6744
    • Heiser, V.1    Scherzinger, E.2    Boeddrich, A.3    Nordhoff, E.4    Lurz, R.5    Schugardt, N.6    Lehrach, H.7    Wanker, E.E.8
  • 148
    • 62449216579 scopus 로고    scopus 로고
    • Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker
    • 1:CAS:528:DC%2BD1MXislaiu7c%3D
    • Hu K, Van Someren EJ, Shea SA, Scheer FA (2009) Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: involvement of the circadian pacemaker. Proc Natl Acad Sci USA 106:2490-2494
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2490-2494
    • Hu, K.1    Van Someren, E.J.2    Shea, S.A.3    Scheer, F.A.4
  • 149
    • 0027313442 scopus 로고
    • The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates
    • 1:CAS:528:DyaK3sXmsVWnt78%3D
    • Huether G (1993) The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia 49:665-670
    • (1993) Experientia , vol.49 , pp. 665-670
    • Huether, G.1
  • 150
    • 0028362803 scopus 로고
    • Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin
    • 1:STN:280:DyaK2c3nvF2ktw%3D%3D
    • Huether G (1994) Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin. Ann N Y Acad Sci 719:146-158
    • (1994) Ann N y Acad Sci , vol.719 , pp. 146-158
    • Huether, G.1
  • 151
    • 0026668767 scopus 로고
    • Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract
    • 1:CAS:528:DyaK38XlsVeqtbg%3D
    • Huether G, Poeggeler B, Reimer A, George A (1992) Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sci 51:945-953
    • (1992) Life Sci , vol.51 , pp. 945-953
    • Huether, G.1    Poeggeler, B.2    Reimer, A.3    George, A.4
  • 152
    • 0020383281 scopus 로고
    • Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis
    • 1:STN:280:DyaL387kt12huw%3D%3D
    • Iguchi H, Kato KI, Ibayashi H (1982) Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis. J Clin Endocrinol Metab 54:1025-1027
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 1025-1027
    • Iguchi, H.1    Kato, K.I.2    Ibayashi, H.3
  • 153
    • 0031661066 scopus 로고    scopus 로고
    • Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment
    • 1:CAS:528:DyaK1cXmtlCrs7s%3D
    • Jean-Louis G, von Gizycki H, Zizi F (1998a) Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 25:177-183
    • (1998) J Pineal Res , vol.25 , pp. 177-183
    • Jean-Louis, G.1    Von Gizycki, H.2    Zizi, F.3
  • 154
    • 0032133318 scopus 로고    scopus 로고
    • Effects of melatonin in two individuals with Alzheimer's disease
    • 1:STN:280:DyaK1cvjtlektQ%3D%3D
    • Jean-Louis G, Zizi F, von Gizycki H, Taub H (1998b) Effects of melatonin in two individuals with Alzheimer's disease. Percept Mot Skills 87:331-339
    • (1998) Percept Mot Skills , vol.87 , pp. 331-339
    • Jean-Louis, G.1    Zizi, F.2    Von Gizycki, H.3    Taub, H.4
  • 155
    • 1342280375 scopus 로고    scopus 로고
    • Melatonin receptor agonist 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via K(+) current inhibition
    • 1:CAS:528:DC%2BD2cXhs1Sru7g%3D
    • Jiao S, Wu MM, Hu CL, Zhang ZH, Mei YA (2004) Melatonin receptor agonist 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via K(+) current inhibition. J Pineal Res 36:109-116
    • (2004) J Pineal Res , vol.36 , pp. 109-116
    • Jiao, S.1    Wu, M.M.2    Hu, C.L.3    Zhang, Z.H.4    Mei, Y.A.5
  • 157
    • 84856705904 scopus 로고    scopus 로고
    • Cadmium-induced disruption in 24-h expression of clock and redox enzyme genes in rat medial basal hypothalamus. Prevention by melatonin
    • Jiménez-Ortega V, Cano P, Scacchi PA, Cardinali DP, Esquifino AI (2011) Cadmium-induced disruption in 24-h expression of clock and redox enzyme genes in rat medial basal hypothalamus. Prevention by melatonin. Front Neurol 2:13
    • (2011) Front Neurol , vol.2 , pp. 13
    • Jiménez-Ortega, V.1    Cano, P.2    Scacchi, P.A.3    Cardinali, D.P.4    Esquifino, A.I.5
  • 160
    • 79954420629 scopus 로고    scopus 로고
    • 2+ stress in astrocyte
    • 1:CAS:528:DC%2BC3MXlvFSgu78%3D
    • 2+ stress in astrocyte. J Pineal Res 50:427-435
    • (2011) J Pineal Res , vol.50 , pp. 427-435
    • Jou, M.J.1
  • 161
    • 80054024011 scopus 로고    scopus 로고
    • Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders
    • 1:CAS:528:DC%2BC3MXhtlKjtLjE
    • Jucker M, Walker LC (2011) Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 70:532-540
    • (2011) Ann Neurol , vol.70 , pp. 532-540
    • Jucker, M.1    Walker, L.C.2
  • 162
    • 77953966854 scopus 로고    scopus 로고
    • Posttreatment with uridine and melatonin following traumatic brain injury reduces edema in various brain regions in rats
    • 1:CAS:528:DC%2BC3cXhtV2it7jP
    • Kabadi SV, Maher TJ (2010) Posttreatment with uridine and melatonin following traumatic brain injury reduces edema in various brain regions in rats. Ann N Y Acad Sci 1199:105-113
    • (2010) Ann N y Acad Sci , vol.1199 , pp. 105-113
    • Kabadi, S.V.1    Maher, T.J.2
  • 163
    • 0036265095 scopus 로고    scopus 로고
    • Melatonin and aging
    • 1:CAS:528:DC%2BD38Xkt1Snurk%3D
    • Karasek M, Reiter RJ (2002) Melatonin and aging. Neuroendocrinol Lett 23(Suppl 1):14-16
    • (2002) Neuroendocrinol Lett , vol.23 , Issue.SUPPL. 1 , pp. 14-16
    • Karasek, M.1    Reiter, R.J.2
  • 164
    • 33750546285 scopus 로고    scopus 로고
    • Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum
    • 1:STN:280:DC%2BD28rosFWruw%3D%3D
    • Kaur C, Sivakumar V, Zhang Y, Ling EA (2006) Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum. Glia 54:826-839
    • (2006) Glia , vol.54 , pp. 826-839
    • Kaur, C.1    Sivakumar, V.2    Zhang, Y.3    Ling, E.A.4
  • 165
    • 33846879581 scopus 로고    scopus 로고
    • Expression of transferrin receptors in the pineal gland of postnatal and adult rats and its alteration in hypoxia and melatonin treatment
    • 1:STN:280:DC%2BD28jivVequw%3D%3D
    • Kaur C, Sivakumar V, Ling EA (2007) Expression of transferrin receptors in the pineal gland of postnatal and adult rats and its alteration in hypoxia and melatonin treatment. Glia 55:263-273
    • (2007) Glia , vol.55 , pp. 263-273
    • Kaur, C.1    Sivakumar, V.2    Ling, E.A.3
  • 166
    • 77749336553 scopus 로고    scopus 로고
    • Melatonin protects periventricular white matter from damage due to hypoxia
    • 1:CAS:528:DC%2BC3cXktFKqtbw%3D
    • Kaur C, Sivakumar V, Ling EA (2010) Melatonin protects periventricular white matter from damage due to hypoxia. J Pineal Res 48:185-193
    • (2010) J Pineal Res , vol.48 , pp. 185-193
    • Kaur, C.1    Sivakumar, V.2    Ling, E.A.3
  • 167
    • 79952042665 scopus 로고    scopus 로고
    • Hypoxia-induced cellular and vascular changes in the nucleus tractus solitarius and ventrolateral medulla
    • 1:CAS:528:DC%2BC3MXit1eit70%3D
    • Kaur C, Viswanathan S, Ling EA (2011) Hypoxia-induced cellular and vascular changes in the nucleus tractus solitarius and ventrolateral medulla. J Neuropathol Exp Neurol 70:201-217
    • (2011) J Neuropathol Exp Neurol , vol.70 , pp. 201-217
    • Kaur, C.1    Viswanathan, S.2    Ling, E.A.3
  • 168
    • 80052827401 scopus 로고    scopus 로고
    • Inflammation in the early stages of neurodegenerative pathology
    • 1:CAS:528:DC%2BC3MXhtFyms73K
    • Khandelwal PJ, Herman AM, Moussa CE (2011) Inflammation in the early stages of neurodegenerative pathology. J Neuroimmunol 238:1-11
    • (2011) J Neuroimmunol , vol.238 , pp. 1-11
    • Khandelwal, P.J.1    Herman, A.M.2    Moussa, C.E.3
  • 169
    • 18244431484 scopus 로고    scopus 로고
    • The effect of melatonin on antioxidant enzymes in human diabetic skin fibroblasts
    • 1:CAS:528:DC%2BD3sXmsVWltL8%3D
    • Kilanczyk E, Bryszewska M (2003) The effect of melatonin on antioxidant enzymes in human diabetic skin fibroblasts. Cell Mol Biol Lett 8:333-336
    • (2003) Cell Mol Biol Lett , vol.8 , pp. 333-336
    • Kilanczyk, E.1    Bryszewska, M.2
  • 170
    • 0033509001 scopus 로고    scopus 로고
    • Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia
    • 1:CAS:528:DC%2BD3cXksVCqtro%3D
    • Kilic E, Ozdemir YG, Bolay H, Kelestimur H, Dalkara T (1999) Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J Cereb Blood Flow Metab 19:511-516
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 511-516
    • Kilic, E.1    Ozdemir, Y.G.2    Bolay, H.3    Kelestimur, H.4    Dalkara, T.5
  • 171
    • 84856244012 scopus 로고    scopus 로고
    • Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral ischemia
    • Kilic U, Yilmaz B, Ugur M, Yuksel A, Reiter RJ, Hermann DM, Kilic E (2011) Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral ischemia. J Pineal Res 52:228-235
    • (2011) J Pineal Res , vol.52 , pp. 228-235
    • Kilic, U.1    Yilmaz, B.2    Ugur, M.3    Yuksel, A.4    Reiter, R.J.5    Hermann, D.M.6    Kilic, E.7
  • 172
    • 14944367845 scopus 로고    scopus 로고
    • Microglia as a potential bridge between the amyloid {beta}-peptide and tau
    • 1:CAS:528:DC%2BD2MXivFymsLg%3D
    • Kitazawa M, Yamasaki TR, Laferla FM (2004) Microglia as a potential bridge between the amyloid {beta}-peptide and tau. Ann N Y Acad Sci 1035:85-103
    • (2004) Ann N y Acad Sci , vol.1035 , pp. 85-103
    • Kitazawa, M.1    Yamasaki, T.R.2    Laferla, F.M.3
  • 173
    • 33947510169 scopus 로고    scopus 로고
    • Arylalkylamine N-acetyltransferase: "the Timezyme
    • 1:CAS:528:DC%2BD2sXhsFKhtbg%3D
    • Klein DC (2007) Arylalkylamine N-acetyltransferase: "the Timezyme". J Biol Chem 282:4233-4237
    • (2007) J Biol Chem , vol.282 , pp. 4233-4237
    • Klein, D.C.1
  • 174
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • 1:CAS:528:DyaK2sXhtlKjtro%3D
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 175
    • 80054810410 scopus 로고    scopus 로고
    • Melatonin prevents down-regulation of astrocytic phosphoprotein PEA-15 in ischemic brain injury
    • 1:CAS:528:DC%2BC3MXhtl2ns7vF
    • Koh PO (2011) Melatonin prevents down-regulation of astrocytic phosphoprotein PEA-15 in ischemic brain injury. J Pineal Res 51:381-386
    • (2011) J Pineal Res , vol.51 , pp. 381-386
    • Koh, P.O.1
  • 176
    • 83555166114 scopus 로고    scopus 로고
    • Melatonin attenuates decrease of protein phosphatase 2A subunit B in ischemic brain injury
    • 1:CAS:528:DC%2BC3MXhs12nsLnN
    • Koh PO (2012) Melatonin attenuates decrease of protein phosphatase 2A subunit B in ischemic brain injury. J Pineal Res 52:57-61
    • (2012) J Pineal Res , vol.52 , pp. 57-61
    • Koh, P.O.1
  • 177
    • 0030048497 scopus 로고    scopus 로고
    • Management of motor fluctuations in Parkinson's disease
    • Koller WC (1996) Management of motor fluctuations in Parkinson's disease. Eur Neurol 36(Suppl 1):43-48
    • (1996) Eur Neurol , vol.36 , Issue.SUPPL. 1 , pp. 43-48
    • Koller, W.C.1
  • 178
    • 0030830445 scopus 로고    scopus 로고
    • Melatonin effects in a patient with severe REM sleep behavior disorder: Case report and theoretical considerations
    • 1:STN:280:DyaK1c%2FlslyjsA%3D%3D
    • Kunz D, Bes F (1997) Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. Neuropsychobiology 36:211-214
    • (1997) Neuropsychobiology , vol.36 , pp. 211-214
    • Kunz, D.1    Bes, F.2
  • 179
    • 0033430105 scopus 로고    scopus 로고
    • Melatonin as a therapy in REM sleep behavior disorder patients: An open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation
    • 1:STN:280:DyaK1M3ns1agtw%3D%3D
    • Kunz D, Bes F (1999) Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov Disord 14:507-511
    • (1999) Mov Disord , vol.14 , pp. 507-511
    • Kunz, D.1    Bes, F.2
  • 182
    • 73249130089 scopus 로고    scopus 로고
    • The low affinity binding of melatonin to calmodulin: Use of computational methods to explain its physiological relevance
    • D. Cardinali S.R. Pandi-Perumal (eds) Nova Science New York
    • Landau M, Zisapel N (2007) The low affinity binding of melatonin to calmodulin: use of computational methods to explain its physiological relevance. In: Cardinali DP, Pandi-Perumal SR (eds) Melatonin - From Molecules to Therapy. Nova Science, New York, pp 69-79
    • (2007) Melatonin - From Molecules to Therapy , pp. 69-79
    • Landau, M.1    Zisapel, N.2
  • 184
    • 1642521879 scopus 로고    scopus 로고
    • Delayed treatment with melatonin enhances electrophysiological recovery following transient focal cerebral ischemia in rats
    • 1:CAS:528:DC%2BD2cXotFKksw%3D%3D
    • Lee EJ, Wu TS, Lee MY, Chen TY, Tsai YY, Chuang JI, Chang GL (2004) Delayed treatment with melatonin enhances electrophysiological recovery following transient focal cerebral ischemia in rats. J Pineal Res 36:33-42
    • (2004) J Pineal Res , vol.36 , pp. 33-42
    • Lee, E.J.1    Wu, T.S.2    Lee, M.Y.3    Chen, T.Y.4    Tsai, Y.Y.5    Chuang, J.I.6    Chang, G.L.7
  • 185
    • 6944221714 scopus 로고    scopus 로고
    • RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line
    • León-Blanco MM, Guerrero JM, Reiter RJ, Pozo D (2004) RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line. Cancer Lett 216:73-80
    • (2004) Cancer Lett , vol.216 , pp. 73-80
    • León-Blanco, M.M.1    Guerrero, J.M.2    Reiter, R.J.3    Pozo, D.4
  • 186
    • 33746290412 scopus 로고    scopus 로고
    • The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization
    • 1:CAS:528:DC%2BD28XmvFajtbw%3D
    • Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (2006) The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J 25:3012-3023
    • (2006) EMBO J , vol.25 , pp. 3012-3023
    • Levoye, A.1    Dam, J.2    Ayoub, M.A.3    Guillaume, J.L.4    Couturier, C.5    Delagrange, P.6    Jockers, R.7
  • 187
    • 0021268447 scopus 로고
    • Assessment and treatment of chronobiologic disorders using plasma melatonin levels and bright light exposure: The clock-gate model and the phase response curve
    • 1:STN:280:DyaL2c3pvVylsQ%3D%3D
    • Lewy AJ, Sack RA, Singer CL (1984) Assessment and treatment of chronobiologic disorders using plasma melatonin levels and bright light exposure: the clock-gate model and the phase response curve. Psychopharmacol Bull 20:561-565
    • (1984) Psychopharmacol Bull , vol.20 , pp. 561-565
    • Lewy, A.J.1    Sack, R.A.2    Singer, C.L.3
  • 188
    • 0029804987 scopus 로고    scopus 로고
    • Melatonin prevents oxidative stress-induced cell death in hippocampal cells
    • Lezoualc'h F, Skutella T, Widmann M, Behl C (1996) Melatonin prevents oxidative stress-induced cell death in hippocampal cells. NeuroReport 7:2071-2077
    • (1996) NeuroReport , vol.7 , pp. 2071-2077
    • Lezoualc'H, F.1    Skutella, T.2    Widmann, M.3    Behl, C.4
  • 189
    • 14644414141 scopus 로고    scopus 로고
    • Effect of melatonin on calyculin A-induced tau hyperphosphorylation
    • 1:CAS:528:DC%2BD2MXhvVClu7w%3D
    • Li XC, Wang ZF, Zhang JX, Wang Q, Wang JZ (2005) Effect of melatonin on calyculin A-induced tau hyperphosphorylation. Eur J Pharmacol 510:25-30
    • (2005) Eur J Pharmacol , vol.510 , pp. 25-30
    • Li, X.C.1    Wang, Z.F.2    Zhang, J.X.3    Wang, Q.4    Wang, J.Z.5
  • 190
    • 78650904174 scopus 로고    scopus 로고
    • Bright light treatment in elderly patients with nonseasonal major depressive disorder: A randomized placebo-controlled trial
    • Lieverse R, Van Someren EJ, Nielen MM, Uitdehaag BM, Smit JH, Hoogendijk WJ (2011) Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial. Arch Gen Psychiatry 68:61-70
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 61-70
    • Lieverse, R.1    Van Someren, E.J.2    Nielen, M.M.3    Uitdehaag, B.M.4    Smit, J.H.5    Hoogendijk, W.J.6
  • 191
    • 69949156813 scopus 로고    scopus 로고
    • Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
    • 1:CAS:528:DC%2BD1MXhtVSks77I
    • Lin HW, Lee EJ (2009) Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages. Neuropsychiatr Dis Treat 5:157-162
    • (2009) Neuropsychiatr Dis Treat , vol.5 , pp. 157-162
    • Lin, H.W.1    Lee, E.J.2
  • 192
    • 60349129257 scopus 로고    scopus 로고
    • Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin
    • 1:CAS:528:DC%2BD1MXhvVCku7s%3D
    • Ling ZQ, Tian Q, Wang L, Fu ZQ, Wang XC, Wang Q, Wang JZ (2009) Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin. J Alzheimers Dis 16:287-300
    • (2009) J Alzheimers Dis , vol.16 , pp. 287-300
    • Ling, Z.Q.1    Tian, Q.2    Wang, L.3    Fu, Z.Q.4    Wang, X.C.5    Wang, Q.6    Wang, J.Z.7
  • 193
    • 22044444433 scopus 로고    scopus 로고
    • N-acetyltransferase is not the rate-limiting enzyme of melatonin synthesis at night
    • 1:CAS:528:DC%2BD2MXmsVegsbk%3D
    • Liu T, Borjigin J (2005) N-acetyltransferase is not the rate-limiting enzyme of melatonin synthesis at night. J Pineal Res 39:91-96
    • (2005) J Pineal Res , vol.39 , pp. 91-96
    • Liu, T.1    Borjigin, J.2
  • 194
    • 0032901972 scopus 로고    scopus 로고
    • Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-ε 4/4 genotype
    • 1:CAS:528:DyaK1MXmslWqsA%3D%3D
    • Liu RY, Zhou JN, Van Heerikhuize J, Hofman MA, Swaab DF (1999) Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-ε 4/4 genotype. J Clin Endocrinol Metab 84:323-327
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 323-327
    • Liu, R.Y.1    Zhou, J.N.2    Van Heerikhuize, J.3    Hofman, M.A.4    Swaab, D.F.5
  • 195
    • 1542313858 scopus 로고    scopus 로고
    • Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
    • 1:CAS:528:DC%2BD2cXisFWks7s%3D
    • Louzada PR, Paula Lima AC, Mendonca-Silva DL, Noel F, De Mello FG, Ferreira ST (2004) Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders. FASEB J 18:511-518
    • (2004) FASEB J , vol.18 , pp. 511-518
    • Louzada, P.R.1    Paula Lima, A.C.2    Mendonca-Silva, D.L.3    Noel, F.4    De Mello, F.G.5    Ferreira, S.T.6
  • 196
    • 0034918570 scopus 로고    scopus 로고
    • Actigraphic sleep-wake patterns and urinary 6-sulfatoxymelatonin excretion in patients with Alzheimer's disease
    • 1:CAS:528:DC%2BD3MXlvVKhsb0%3D
    • Luboshitzky R, Shen-Orr Z, Tzischichinsky O, Maldonado M, Herer P, Lavie P (2001) Actigraphic sleep-wake patterns and urinary 6-sulfatoxymelatonin excretion in patients with Alzheimer's disease. Chronobiol Int 18:513-524
    • (2001) Chronobiol Int , vol.18 , pp. 513-524
    • Luboshitzky, R.1    Shen-Orr, Z.2    Tzischichinsky, O.3    Maldonado, M.4    Herer, P.5    Lavie, P.6
  • 198
    • 12344325585 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke
    • 1:CAS:528:DC%2BD2MXpsFersA%3D%3D
    • Macleod MR, O'Collins T, Horky LL, Howells DW, Donnan GA (2005) Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. J Pineal Res 38:35-41
    • (2005) J Pineal Res , vol.38 , pp. 35-41
    • Macleod, M.R.1    O'Collins, T.2    Horky, L.L.3    Howells, D.W.4    Donnan, G.A.5
  • 199
    • 1942435946 scopus 로고    scopus 로고
    • Qualitative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians
    • 1:CAS:528:DC%2BD2cXjs1GlsLw%3D
    • Magri F, Sarra S, Cinchetti W, Guazzoni V, Fioravanti M, Cravello L, Ferrari E (2004) Qualitative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians. J Pineal Res 36:256-261
    • (2004) J Pineal Res , vol.36 , pp. 256-261
    • Magri, F.1    Sarra, S.2    Cinchetti, W.3    Guazzoni, V.4    Fioravanti, M.5    Cravello, L.6    Ferrari, E.7
  • 200
    • 77956977811 scopus 로고    scopus 로고
    • Future directions for immune modulation in neurodegenerative disorders: Focus on Parkinson's disease
    • 1:CAS:528:DC%2BC3cXpvVSrsLk%3D
    • Maguire-Zeiss KA, Federoff HJ (2010) Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. J Neural Transm 117:1019-1025
    • (2010) J Neural Transm , vol.117 , pp. 1019-1025
    • Maguire-Zeiss, K.A.1    Federoff, H.J.2
  • 201
    • 34250673430 scopus 로고    scopus 로고
    • Actigraphy in agitated patients with dementia: Monitoring treatment outcomes
    • 1:STN:280:DC%2BD1MvosF2nsA%3D%3D
    • Mahlberg R, Walther S (2007) Actigraphy in agitated patients with dementia: monitoring treatment outcomes. Z Gerontol Geriatr 40:178-184
    • (2007) Z Gerontol Geriatr , vol.40 , pp. 178-184
    • Mahlberg, R.1    Walther, S.2
  • 202
    • 3242740203 scopus 로고    scopus 로고
    • Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: An open-label pilot study using actigraphy
    • Mahlberg R, Kunz D, Sutej I, Kuhl KP, Hellweg R (2004) Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy. J Clin Psychopharmacol 24:456-459
    • (2004) J Clin Psychopharmacol , vol.24 , pp. 456-459
    • Mahlberg, R.1    Kunz, D.2    Sutej, I.3    Kuhl, K.P.4    Hellweg, R.5
  • 203
    • 67349172119 scopus 로고    scopus 로고
    • Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients
    • Mahlberg R, Kienast T, Hadel S, Heidenreich JO, Schmitz S, Kunz D (2009) Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients. Sleep Med 10:439-445
    • (2009) Sleep Med , vol.10 , pp. 439-445
    • Mahlberg, R.1    Kienast, T.2    Hadel, S.3    Heidenreich, J.O.4    Schmitz, S.5    Kunz, D.6
  • 204
    • 10544255343 scopus 로고    scopus 로고
    • Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats
    • 1:CAS:528:DyaK28XntFWku70%3D
    • Manev H, Uz T, Kharlamov A, Joo JY (1996) Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats. FASEB J 10:1546-1551
    • (1996) FASEB J , vol.10 , pp. 1546-1551
    • Manev, H.1    Uz, T.2    Kharlamov, A.3    Joo, J.Y.4
  • 205
    • 34247235199 scopus 로고    scopus 로고
    • The mammalian pineal gland: Known facts, unknown facets
    • 1:CAS:528:DC%2BD2sXkslCns7Y%3D
    • Maronde E, Stehle JH (2007) The mammalian pineal gland: known facts, unknown facets. Trends Endocrinol Metab 18:142-149
    • (2007) Trends Endocrinol Metab , vol.18 , pp. 142-149
    • Maronde, E.1    Stehle, J.H.2
  • 206
    • 0006295841 scopus 로고    scopus 로고
    • Melatonin-induced increased activity of the respiratory chain complexes i and IV can prevent mitochondrial damage induced by ruthenium red in vivo
    • 1:CAS:528:DC%2BD3cXjt1Cgsro%3D
    • Martin M, Macias M, Escames G, Reiter RJ, Agapito MT, Ortiz GG, Acuña-Castroviejo D (2000) Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo. J Pineal Res 28:242-248
    • (2000) J Pineal Res , vol.28 , pp. 242-248
    • Martin, M.1    Macias, M.2    Escames, G.3    Reiter, R.J.4    Agapito, M.T.5    Ortiz, G.G.6    Acuña-Castroviejo, D.7
  • 207
    • 0036172464 scopus 로고    scopus 로고
    • Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria
    • 1:CAS:528:DC%2BD38XhtlCqt7g%3D
    • Martin M, Macias M, León J, Escames G, Khaldy H, Acuña-Castroviejo D (2002) Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria. Int J Biochem Cell Biol 34:348-357
    • (2002) Int J Biochem Cell Biol , vol.34 , pp. 348-357
    • Martin, M.1    Macias, M.2    León, J.3    Escames, G.4    Khaldy, H.5    Acuña-Castroviejo, D.6
  • 208
    • 37549044656 scopus 로고    scopus 로고
    • Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats
    • 1:CAS:528:DC%2BD2sXhsVOgsbbJ
    • Mathes AM, Kubulus D, Weiler J, Bentley A, Waibel L, Wolf B, Bauer I, Rensing H (2008) Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats. Crit Care Med 36:24-29
    • (2008) Crit Care Med , vol.36 , pp. 24-29
    • Mathes, A.M.1    Kubulus, D.2    Weiler, J.3    Bentley, A.4    Waibel, L.5    Wolf, B.6    Bauer, I.7    Rensing, H.8
  • 210
    • 0031981649 scopus 로고    scopus 로고
    • Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: Implications for Parkinson's disease
    • 1:CAS:528:DyaK1cXhvFSisr0%3D
    • Mayo JC, Sainz RM, Uria H, Antolin I, Esteban MM, Rodríguez C (1998) Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: implications for Parkinson's disease. J Pineal Res 24:179-192
    • (1998) J Pineal Res , vol.24 , pp. 179-192
    • Mayo, J.C.1    Sainz, R.M.2    Uria, H.3    Antolin, I.4    Esteban, M.M.5    Rodríguez, C.6
  • 213
    • 34249072817 scopus 로고    scopus 로고
    • Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease: A randomized, double blind, placebo-controlled study
    • 1:CAS:528:DC%2BD2sXlvF2isrw%3D
    • Medeiros CA, Carvalhedo de Bruin PF, Lopes LA, Magalhaes MC, de Lourdes SM, Sales dBV (2007) Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease: a randomized, double blind, placebo-controlled study. J Neurol 254:459-464
    • (2007) J Neurol , vol.254 , pp. 459-464
    • Medeiros, C.A.1    Carvalhedo De Bruin, P.F.2    Lopes, L.A.3    Magalhaes, M.C.4    De Lourdes, S.M.5    Sales, D.6
  • 215
    • 0030000079 scopus 로고    scopus 로고
    • Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain
    • 1:CAS:528:DyaK28XjsVOksLg%3D
    • Melchiorri D, Reiter RJ, Chen LD, Sewerynek E, Nistico G (1996) Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain. Eur J Pharmacol 305:239-242
    • (1996) Eur J Pharmacol , vol.305 , pp. 239-242
    • Melchiorri, D.1    Reiter, R.J.2    Chen, L.D.3    Sewerynek, E.4    Nistico, G.5
  • 217
    • 0027725205 scopus 로고
    • Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization
    • Menéndez-Pelaez A, Reiter RJ (1993) Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J Pineal Res 15:59-69
    • (1993) J Pineal Res , vol.15 , pp. 59-69
    • Menéndez-Pelaez, A.1    Reiter, R.J.2
  • 218
  • 219
    • 0041932292 scopus 로고    scopus 로고
    • The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways
    • 1:CAS:528:DC%2BD3sXmvVehtrg%3D
    • Millan MJ, Gobert A, Lejeune F, Dekeyne A, Newman-Tancredi A, Pasteau V, Rivet JM, Cussac D (2003) The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306:954-964
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 954-964
    • Millan, M.J.1    Gobert, A.2    Lejeune, F.3    Dekeyne, A.4    Newman-Tancredi, A.5    Pasteau, V.6    Rivet, J.M.7    Cussac, D.8
  • 220
    • 0033558327 scopus 로고    scopus 로고
    • Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking
    • 1:STN:280:DyaK1M7ntFWjtg%3D%3D
    • Mishima K, Tozawa T, Satoh K, Matsumoto Y, Hishikawa Y, Okawa M (1999) Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking. Biol Psychiatry 45:417-421
    • (1999) Biol Psychiatry , vol.45 , pp. 417-421
    • Mishima, K.1    Tozawa, T.2    Satoh, K.3    Matsumoto, Y.4    Hishikawa, Y.5    Okawa, M.6
  • 221
    • 0034129506 scopus 로고    scopus 로고
    • Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons
    • 1:CAS:528:DC%2BD3cXkt1antLc%3D
    • Mishima K, Okawa M, Hozumi S, Hishikawa Y (2000) Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons. Chronobiol Int 17:419-432
    • (2000) Chronobiol Int , vol.17 , pp. 419-432
    • Mishima, K.1    Okawa, M.2    Hozumi, S.3    Hishikawa, Y.4
  • 222
    • 0035142213 scopus 로고    scopus 로고
    • Diminished melatonin secretion in the elderly caused by insufficient environmental illumination
    • 1:CAS:528:DC%2BD3MXhtVGnsrk%3D
    • Mishima K, Okawa M, Shimizu T, Hishikawa Y (2001) Diminished melatonin secretion in the elderly caused by insufficient environmental illumination. J Clin Endocrinol Metab 86:129-134
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 129-134
    • Mishima, K.1    Okawa, M.2    Shimizu, T.3    Hishikawa, Y.4
  • 223
    • 60349099515 scopus 로고    scopus 로고
    • Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: A novel therapeutic drug for sleep disorders
    • 1:CAS:528:DC%2BD1MXjvFOnsbw%3D
    • Miyamoto M (2009) Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders. CNS Neurosci Ther 15:32-51
    • (2009) CNS Neurosci Ther , vol.15 , pp. 32-51
    • Miyamoto, M.1
  • 224
    • 0035991394 scopus 로고    scopus 로고
    • The anatomy and innervation of the mammalian pineal gland
    • 1:CAS:528:DC%2BD38XkvVansLw%3D
    • Moller M, Baeres FM (2002) The anatomy and innervation of the mammalian pineal gland. Cell Tissue Res 309:139-150
    • (2002) Cell Tissue Res , vol.309 , pp. 139-150
    • Moller, M.1    Baeres, F.M.2
  • 225
    • 0033755796 scopus 로고    scopus 로고
    • A critical assessment of the melatonin effect on sleep in humans
    • 1:CAS:528:DC%2BD3cXnvVyitL0%3D
    • Monti JM, Cardinali DP (2000) A critical assessment of the melatonin effect on sleep in humans. Biol Signals Recept 9:328-339
    • (2000) Biol Signals Recept , vol.9 , pp. 328-339
    • Monti, J.M.1    Cardinali, D.P.2
  • 226
    • 0033020470 scopus 로고    scopus 로고
    • Polysomnographic study of the effect of melatonin on sleep in elderly patients with chronic primary insomnia
    • 1:CAS:528:DyaK1MXhs1Omtrk%3D
    • Monti JM, Alvarino F, Cardinali DP, Savio I, Pintos A (1999) Polysomnographic study of the effect of melatonin on sleep in elderly patients with chronic primary insomnia. Arch Gerontol Geriatr 28:85-98
    • (1999) Arch Gerontol Geriatr , vol.28 , pp. 85-98
    • Monti, J.M.1    Alvarino, F.2    Cardinali, D.P.3    Savio, I.4    Pintos, A.5
  • 227
    • 67650108488 scopus 로고    scopus 로고
    • The modulatory effect of substance P on rat pineal norepinephrine release and melatonin secretion
    • 1:CAS:528:DC%2BD1MXosVehu70%3D
    • Mukda S, Moller M, Ebadi M, Govitrapong P (2009) The modulatory effect of substance P on rat pineal norepinephrine release and melatonin secretion. Neurosci Lett 461:258-261
    • (2009) Neurosci Lett , vol.461 , pp. 258-261
    • Mukda, S.1    Moller, M.2    Ebadi, M.3    Govitrapong, P.4
  • 228
    • 4043067948 scopus 로고    scopus 로고
    • A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl 6 chloromelatonin
    • 1:CAS:528:DC%2BD2cXmsVGgt74%3D
    • Mulchahey JJ, Goldwater DR, Zemlan FP (2004) A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl 6 chloromelatonin. Life Sci 75:1843-1856
    • (2004) Life Sci , vol.75 , pp. 1843-1856
    • Mulchahey, J.J.1    Goldwater, D.R.2    Zemlan, F.P.3
  • 229
    • 78651106773 scopus 로고    scopus 로고
    • Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury
    • 1:CAS:528:DC%2BC3MXhvV2rt7Y%3D
    • Nag S, Kapadia A, Stewart DJ (2011) Review: molecular pathogenesis of blood-brain barrier breakdown in acute brain injury. Neuropathol Appl Neurobiol 37:3-23
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 3-23
    • Nag, S.1    Kapadia, A.2    Stewart, D.J.3
  • 232
    • 0033564472 scopus 로고    scopus 로고
    • Daily rhythm of serum melatonin levels and effect of light exposure in patients with dementia of the Alzheimer's type
    • 1:STN:280:DyaK1MzgsVCitw%3D%3D
    • Ohashi Y, Okamoto N, Uchida K, Iyo M, Mori N, Morita Y (1999) Daily rhythm of serum melatonin levels and effect of light exposure in patients with dementia of the Alzheimer's type. Biol Psychiatry 45:1646-1652
    • (1999) Biol Psychiatry , vol.45 , pp. 1646-1652
    • Ohashi, Y.1    Okamoto, N.2    Uchida, K.3    Iyo, M.4    Mori, N.5    Morita, Y.6
  • 233
    • 0036786233 scopus 로고    scopus 로고
    • Hepatic mitochondrial dysfunction in senescence-accelerated mice: Correction by long-term, orally administered physiological levels of melatonin
    • 1:CAS:528:DC%2BD38XntlGisbs%3D
    • Okatani Y, Wakatsuki A, Reiter RJ, Miyahara Y (2002) Hepatic mitochondrial dysfunction in senescence-accelerated mice: correction by long-term, orally administered physiological levels of melatonin. J Pineal Res 33:127-133
    • (2002) J Pineal Res , vol.33 , pp. 127-133
    • Okatani, Y.1    Wakatsuki, A.2    Reiter, R.J.3    Miyahara, Y.4
  • 234
    • 0025242960 scopus 로고
    • Oxidation reactions in Parkinson's disease
    • Olanow CW (1990) Oxidation reactions in Parkinson's disease. Neurology 40(Suppl):32-37
    • (1990) Neurology , vol.40 , Issue.SUPPL. , pp. 32-37
    • Olanow, C.W.1
  • 235
    • 0026704066 scopus 로고
    • An introduction to the free radical hypothesis in Parkinson's disease
    • 1:CAS:528:DyaK3sXnvVSnsQ%3D%3D
    • Olanow CW (1992) An introduction to the free radical hypothesis in Parkinson's disease. Ann Neurol 32(Suppl):S2-S9
    • (1992) Ann Neurol , vol.32 , Issue.SUPPL.
    • Olanow, C.W.1
  • 236
    • 0034719057 scopus 로고    scopus 로고
    • The role of deep brain stimulation as a surgical treatment for Parkinson's disease
    • 1:STN:280:DC%2BD3M%2FpvVKqtw%3D%3D
    • Olanow CW, Brin MF, Obeso JA (2000) The role of deep brain stimulation as a surgical treatment for Parkinson's disease. Neurology 55:S60-S66
    • (2000) Neurology , vol.55
    • Olanow, C.W.1    Brin, M.F.2    Obeso, J.A.3
  • 237
    • 67649905028 scopus 로고    scopus 로고
    • Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease
    • 1:CAS:528:DC%2BD1MXovVKnsrk%3D
    • Olcese JM, Cao C, Mori T, Mamcarz MB, Maxwell A, Runfeldt MJ, Wang L, Zhang C, Lin X, Zhang G, Arendash GW (2009) Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J Pineal Res 47:82-96
    • (2009) J Pineal Res , vol.47 , pp. 82-96
    • Olcese, J.M.1    Cao, C.2    Mori, T.3    Mamcarz, M.B.4    Maxwell, A.5    Runfeldt, M.J.6    Wang, L.7    Zhang, C.8    Lin, X.9    Zhang, G.10    Arendash, G.W.11
  • 238
    • 77953302472 scopus 로고    scopus 로고
    • Nature and cause of mitochondrial dysfunction in Huntington's disease: Focusing on huntingtin and the striatum
    • 1:CAS:528:DC%2BC3cXotl2ru7Y%3D
    • Oliveira JM (2010) Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum. J Neurochem 114:1-12
    • (2010) J Neurochem , vol.114 , pp. 1-12
    • Oliveira, J.M.1
  • 239
    • 14344265259 scopus 로고    scopus 로고
    • Inhibition of 5-aminolevulinic acid-induced DNA damage by melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, quercetin or resveratrol
    • 1:CAS:528:DC%2BD2MXhvFKnu7w%3D
    • Onuki J, Almeida EA, Medeiros MH, Di Mascio P (2005) Inhibition of 5-aminolevulinic acid-induced DNA damage by melatonin, N1-acetyl-N2-formyl-5- methoxykynuramine, quercetin or resveratrol. J Pineal Res 38:107-115
    • (2005) J Pineal Res , vol.38 , pp. 107-115
    • Onuki, J.1    Almeida, E.A.2    Medeiros, M.H.3    Di Mascio, P.4
  • 241
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • 1:CAS:528:DC%2BD2sXitVagsr8%3D
    • Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87:315-424
    • (2007) Physiol Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 246
    • 0032698216 scopus 로고    scopus 로고
    • Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: Prevention by melatonin
    • 1:CAS:528:DyaK1MXntVemtrc%3D
    • Pappolla MA, Chyan YJ, Poeggeler B, Bozner P, Ghiso J, LeDoux SP, Wilson GL (1999) Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin. J Pineal Res 27:226-229
    • (1999) J Pineal Res , vol.27 , pp. 226-229
    • Pappolla, M.A.1    Chyan, Y.J.2    Poeggeler, B.3    Bozner, P.4    Ghiso, J.5    Ledoux, S.P.6    Wilson, G.L.7
  • 247
    • 0033968704 scopus 로고    scopus 로고
    • An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: Implications for Alzheimer's disease
    • 1:CAS:528:DC%2BD3cXisFeqtLg%3D
    • Pappolla MA, Chyan YJ, Poeggeler B, Frangione B, Wilson G, Ghiso J, Reiter RJ (2000) An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease. J Neural Transm 107:203-231
    • (2000) J Neural Transm , vol.107 , pp. 203-231
    • Pappolla, M.A.1    Chyan, Y.J.2    Poeggeler, B.3    Frangione, B.4    Wilson, G.5    Ghiso, J.6    Reiter, R.J.7
  • 249
    • 3042730070 scopus 로고    scopus 로고
    • Cognitive effects of exogenous melatonin administration in elderly persons: A pilot study
    • Peck JS, LeGoff DB, Ahmed I, Goebert D (2004) Cognitive effects of exogenous melatonin administration in elderly persons: a pilot study. Am J Geriatr Psychiatry 12:432-436
    • (2004) Am J Geriatr Psychiatry , vol.12 , pp. 432-436
    • Peck, J.S.1    Legoff, D.B.2    Ahmed, I.3    Goebert, D.4
  • 250
    • 4344600602 scopus 로고    scopus 로고
    • Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model
    • Pei Z, Cheung RT (2004) Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model. J Pineal Res 37:85-91
    • (2004) J Pineal Res , vol.37 , pp. 85-91
    • Pei, Z.1    Cheung, R.T.2
  • 252
    • 0036118882 scopus 로고    scopus 로고
    • Formation of aberrant phosphotau fibrillar polymers in neural cultured cells
    • 1:CAS:528:DC%2BD38Xit1Cns7c%3D
    • Perez M, Hernandez F, Gomez-Ramos A, Smith M, Perry G, Avila J (2002) Formation of aberrant phosphotau fibrillar polymers in neural cultured cells. Eur J Biochem 269:1484-1489
    • (2002) Eur J Biochem , vol.269 , pp. 1484-1489
    • Perez, M.1    Hernandez, F.2    Gomez-Ramos, A.3    Smith, M.4    Perry, G.5    Avila, J.6
  • 254
    • 33748364115 scopus 로고    scopus 로고
    • In vivo protective effect of melatonin on cadmium-induced changes in redox balance and gene expression in rat hypothalamus and anterior pituitary
    • 1:CAS:528:DC%2BD28XhtVCltb3L
    • Poliandri AH, Esquifino AI, Cano P, Jimenez V, Lafuente A, Cardinali DP, Duvilanski BH (2006) In vivo protective effect of melatonin on cadmium-induced changes in redox balance and gene expression in rat hypothalamus and anterior pituitary. J Pineal Res 41:238-246
    • (2006) J Pineal Res , vol.41 , pp. 238-246
    • Poliandri, A.H.1    Esquifino, A.I.2    Cano, P.3    Jimenez, V.4    Lafuente, A.5    Cardinali, D.P.6    Duvilanski, B.H.7
  • 255
    • 0031201899 scopus 로고    scopus 로고
    • Melatonin's antioxidant protection against delta-aminolevulinic acid-induced oxidative damage in rat cerebellum
    • 1:CAS:528:DyaK2sXmt1Oqu7g%3D
    • Princ FG, Juknat AA, Maxit AG, Cardalda C, Batlle A (1997) Melatonin's antioxidant protection against delta-aminolevulinic acid-induced oxidative damage in rat cerebellum. J Pineal Res 23:40-46
    • (1997) J Pineal Res , vol.23 , pp. 40-46
    • Princ, F.G.1    Juknat, A.A.2    Maxit, A.G.3    Cardalda, C.4    Batlle, A.5
  • 256
    • 14944341045 scopus 로고    scopus 로고
    • Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: Implications for clinical trials
    • 1:CAS:528:DC%2BD2MXitleqtrg%3D
    • Quinn J, Kulhanek D, Nowlin J, Jones R, Pratico D, Rokach J, Stackman R (2005) Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials. Brain Res 1037:209-213
    • (2005) Brain Res , vol.1037 , pp. 209-213
    • Quinn, J.1    Kulhanek, D.2    Nowlin, J.3    Jones, R.4    Pratico, D.5    Rokach, J.6    Stackman, R.7
  • 257
    • 78049451374 scopus 로고    scopus 로고
    • Melatonin: A pleiotropic molecule regulating inflammation
    • 1:CAS:528:DC%2BC3cXhtlKrsrfL
    • Radogna F, Diederich M, Ghibelli L (2010) Melatonin: a pleiotropic molecule regulating inflammation. Biochem Pharmacol 80:1844-1852
    • (2010) Biochem Pharmacol , vol.80 , pp. 1844-1852
    • Radogna, F.1    Diederich, M.2    Ghibelli, L.3
  • 258
    • 59249087280 scopus 로고    scopus 로고
    • Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: Two randomised controlled multicentre trials
    • 1:CAS:528:DC%2BD1MXhsFKguro%3D
    • Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G, Klerman EB (2009) Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials. Lancet 373:482-491
    • (2009) Lancet , vol.373 , pp. 482-491
    • Rajaratnam, S.M.1    Polymeropoulos, M.H.2    Fisher, D.M.3    Roth, T.4    Scott, C.5    Birznieks, G.6    Klerman, E.B.7
  • 259
    • 0018995028 scopus 로고
    • The pineal and its hormones in the control of reproduction in mammals
    • 1:CAS:528:DyaL3MXltFahu74%3D
    • Reiter RJ (1980) The pineal and its hormones in the control of reproduction in mammals. Endocr Rev 1:109-131
    • (1980) Endocr Rev , vol.1 , pp. 109-131
    • Reiter, R.J.1
  • 260
    • 0031845040 scopus 로고    scopus 로고
    • Oxidative damage in the central nervous system: Protection by melatonin
    • 1:CAS:528:DyaK1cXmtFKhtbc%3D
    • Reiter RJ (1998) Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 56:359-384
    • (1998) Prog Neurobiol , vol.56 , pp. 359-384
    • Reiter, R.J.1
  • 261
    • 0037253191 scopus 로고    scopus 로고
    • What constitutes a physiological concentration of melatonin?
    • 1:CAS:528:DC%2BD3sXntVGmsQ%3D%3D
    • Reiter RJ, Tan DX (2003) What constitutes a physiological concentration of melatonin? J Pineal Res 34:79-80
    • (2003) J Pineal Res , vol.34 , pp. 79-80
    • Reiter, R.J.1    Tan, D.X.2
  • 262
    • 78549240952 scopus 로고    scopus 로고
    • Neurotoxins: Free radical mechanisms and melatonin protection
    • 1:CAS:528:DC%2BC3cXhtl2mtrvI
    • Reiter RJ, Manchester LC, Tan DX (2010) Neurotoxins: free radical mechanisms and melatonin protection. Curr Neuropharmacol 8:194-210
    • (2010) Curr Neuropharmacol , vol.8 , pp. 194-210
    • Reiter, R.J.1    Manchester, L.C.2    Tan, D.X.3
  • 264
    • 20644435796 scopus 로고    scopus 로고
    • HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the Siberian hamster
    • 1:CAS:528:DC%2BD3cXjvFahtL8%3D
    • Ribelayga C, Pévet P, Simonneaux V (2000) HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the Siberian hamster. Am J Physiol Regul Integr Comp Physiol 278:R1339-R1345
    • (2000) Am J Physiol Regul Integr Comp Physiol , vol.278
    • Ribelayga, C.1    Pévet, P.2    Simonneaux, V.3
  • 265
    • 44949175084 scopus 로고    scopus 로고
    • Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: A randomized controlled trial
    • 1:CAS:528:DC%2BD1cXntFeis7o%3D
    • Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, van Someren EJ (2008) Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA 299:2642-2655
    • (2008) JAMA , vol.299 , pp. 2642-2655
    • Riemersma-Van Der Lek, R.F.1    Swaab, D.F.2    Twisk, J.3    Hol, E.M.4    Hoogendijk, W.J.5    Van Someren, E.J.6
  • 266
    • 77955785577 scopus 로고    scopus 로고
    • Major life events and risk of Parkinson's disease
    • Rod NH, Hansen J, Schernhammer E, Ritz B (2010) Major life events and risk of Parkinson's disease. Mov Disord 25:1639-1645
    • (2010) Mov Disord , vol.25 , pp. 1639-1645
    • Rod, N.H.1    Hansen, J.2    Schernhammer, E.3    Ritz, B.4
  • 268
    • 0043091912 scopus 로고    scopus 로고
    • Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: A comparative, in vivo study versus vitamin C and e
    • 1:CAS:528:DC%2BD3sXmsFygt70%3D
    • Rosales-Corral S, Tan DX, Reiter RJ, Valdivia-Velazquez M, Martinez-Barboza G, Acosta-Martinez JP, Ortiz GG (2003) Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: a comparative, in vivo study versus vitamin C and E. J Pineal Res 35:80-84
    • (2003) J Pineal Res , vol.35 , pp. 80-84
    • Rosales-Corral, S.1    Tan, D.X.2    Reiter, R.J.3    Valdivia-Velazquez, M.4    Martinez-Barboza, G.5    Acosta-Martinez, J.P.6    Ortiz, G.G.7
  • 269
  • 273
    • 0042869981 scopus 로고    scopus 로고
    • Melatonin and cell death: Differential actions on apoptosis in normal and cancer cells
    • 1:CAS:528:DC%2BD3sXms1Witr0%3D
    • Sainz RM, Mayo JC, Rodríguez C, Tan DX, Lopez-Burillo S, Reiter RJ (2003) Melatonin and cell death: differential actions on apoptosis in normal and cancer cells. Cell Mol Life Sci 60:1407-1426
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1407-1426
    • Sainz, R.M.1    Mayo, J.C.2    Rodríguez, C.3    Tan, D.X.4    Lopez-Burillo, S.5    Reiter, R.J.6
  • 274
    • 33847675291 scopus 로고    scopus 로고
    • Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model
    • 1:CAS:528:DC%2BD2sXltFCntbc%3D
    • Saravanan KS, Sindhu KM, Mohanakumar KP (2007) Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model. J Pineal Res 42:247-253
    • (2007) J Pineal Res , vol.42 , pp. 247-253
    • Saravanan, K.S.1    Sindhu, K.M.2    Mohanakumar, K.P.3
  • 276
    • 0842332600 scopus 로고    scopus 로고
    • Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
    • 1:CAS:528:DC%2BD2cXlvFeitw%3D%3D
    • Scheer FA, Van Montfrans GA, Van Someren EJ, Mairuhu G, Buijs RM (2004) Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension 43:192-197
    • (2004) Hypertension , vol.43 , pp. 192-197
    • Scheer, F.A.1    Van Montfrans, G.A.2    Van Someren, E.J.3    Mairuhu, G.4    Buijs, R.M.5
  • 277
    • 0042622198 scopus 로고    scopus 로고
    • AII amacrine cells express the MT1 melatonin receptor in human and macaque retina
    • 1:CAS:528:DC%2BD3sXlvFGgtrc%3D
    • Scher J, Wankiewicz E, Brown GM, Fujieda H (2003) AII amacrine cells express the MT1 melatonin receptor in human and macaque retina. Exp Eye Res 77:375-382
    • (2003) Exp Eye Res , vol.77 , pp. 375-382
    • Scher, J.1    Wankiewicz, E.2    Brown, G.M.3    Fujieda, H.4
  • 278
    • 33645500581 scopus 로고    scopus 로고
    • Circulating melatonin levels: Possible link between Parkinson's disease and cancer risk?
    • Schernhammer E, Chen H, Ritz B (2006) Circulating melatonin levels: possible link between Parkinson's disease and cancer risk? Cancer Causes Control 17:577-582
    • (2006) Cancer Causes Control , vol.17 , pp. 577-582
    • Schernhammer, E.1    Chen, H.2    Ritz, B.3
  • 279
    • 0036882297 scopus 로고    scopus 로고
    • Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia
    • Serfaty M, Kennell-Webb S, Warner J, Blizard R, Raven P (2002) Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry 17:1120-1127
    • (2002) Int J Geriatr Psychiatry , vol.17 , pp. 1120-1127
    • Serfaty, M.1    Kennell-Webb, S.2    Warner, J.3    Blizard, R.4    Raven, P.5
  • 280
    • 0030804999 scopus 로고    scopus 로고
    • Melatonin protects bovine cerebral endothelial cells from hyperoxia-induced DNA damage and death
    • 1:CAS:528:DyaK2sXkvFamu7Y%3D
    • Shaikh AY, Xu J, Wu Y, He L, Hsu CY (1997) Melatonin protects bovine cerebral endothelial cells from hyperoxia-induced DNA damage and death. Neurosci Lett 229:193-197
    • (1997) Neurosci Lett , vol.229 , pp. 193-197
    • Shaikh, A.Y.1    Xu, J.2    Wu, Y.3    He, L.4    Hsu, C.Y.5
  • 281
    • 84871813720 scopus 로고    scopus 로고
    • Radio-protective effects of melatonin against irradiation-induced oxidative damage in rat peripheral blood
    • Shirazi A, Mihandoost E, Mohseni M, Ghazi-Khansari M, Rabie MS (2011) Radio-protective effects of melatonin against irradiation-induced oxidative damage in rat peripheral blood. Phys Med. http://dx.doi.org/10.1016/j.ejmp.2011. 11.007
    • (2011) Phys Med
    • Shirazi, A.1    Mihandoost, E.2    Mohseni, M.3    Ghazi-Khansari, M.4    Rabie, M.S.5
  • 282
    • 0035187347 scopus 로고    scopus 로고
    • Lack of changes in serum prolactin, FSH, TSH, and estradiol after melatonin treatment in doses that improve sleep and reduce benzodiazepine consumption in sleep-disturbed, middle-aged, and elderly patients
    • 1:CAS:528:DC%2BD3MXktVyhsQ%3D%3D
    • Siegrist C, Benedetti C, Orlando A, Beltran JM, Tuchscherr L, Noseda CM, Brusco LI, Cardinali DP (2001) Lack of changes in serum prolactin, FSH, TSH, and estradiol after melatonin treatment in doses that improve sleep and reduce benzodiazepine consumption in sleep-disturbed, middle-aged, and elderly patients. J Pineal Res 30:34-42
    • (2001) J Pineal Res , vol.30 , pp. 34-42
    • Siegrist, C.1    Benedetti, C.2    Orlando, A.3    Beltran, J.M.4    Tuchscherr, L.5    Noseda, C.M.6    Brusco, L.I.7    Cardinali, D.P.8
  • 283
    • 4644244154 scopus 로고    scopus 로고
    • Oxidation of melatonin and its catabolites, N1-acetyl-N2-formyl-5- methoxykynuramine and N1-acetyl-5-methoxykynuramine, by activated leukocytes
    • 1:CAS:528:DC%2BD2cXotFaru7k%3D
    • Silva SO, Rodrigues MR, Carvalho SR, Catalani LH, Campa A, Ximenes VF (2004) Oxidation of melatonin and its catabolites, N1-acetyl-N2-formyl-5- methoxykynuramine and N1-acetyl-5-methoxykynuramine, by activated leukocytes. J Pineal Res 37:171-175
    • (2004) J Pineal Res , vol.37 , pp. 171-175
    • Silva, S.O.1    Rodrigues, M.R.2    Carvalho, S.R.3    Catalani, L.H.4    Campa, A.5    Ximenes, V.F.6
  • 284
    • 0038621817 scopus 로고    scopus 로고
    • Generation of the melatonin endocrine message in mammals: A review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters
    • 1:CAS:528:DC%2BD3sXltVSgtbc%3D
    • Simonneaux V, Ribelayga C (2003) Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 55:325-395
    • (2003) Pharmacol Rev , vol.55 , pp. 325-395
    • Simonneaux, V.1    Ribelayga, C.2
  • 286
    • 79951634450 scopus 로고    scopus 로고
    • Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse
    • 1:CAS:528:DC%2BC3MXivF2ksr0%3D
    • Singhal NK, Srivastava G, Patel DK, Jain SK, Singh MP (2011) Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. J Pineal Res 50:97-109
    • (2011) J Pineal Res , vol.50 , pp. 97-109
    • Singhal, N.K.1    Srivastava, G.2    Patel, D.K.3    Jain, S.K.4    Singh, M.P.5
  • 287
    • 0037244324 scopus 로고    scopus 로고
    • Melatonin rhythmicity: Effect of age and Alzheimer's disease
    • 1:CAS:528:DC%2BD3sXkvFWmtw%3D%3D
    • Skene DJ, Swaab DF (2003) Melatonin rhythmicity: effect of age and Alzheimer's disease. Exp Gerontol 38:199-206
    • (2003) Exp Gerontol , vol.38 , pp. 199-206
    • Skene, D.J.1    Swaab, D.F.2
  • 288
    • 0025063656 scopus 로고
    • Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: Effect of age and Alzheimer's disease
    • 1:CAS:528:DyaK3cXmt1yrtrg%3D
    • Skene DJ, Vivien-Roels B, Sparks DL, Hunsaker JC, Pévet P, Ravid D, Swaab DF (1990) Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease. Brain Res 528:170-174
    • (1990) Brain Res , vol.528 , pp. 170-174
    • Skene, D.J.1    Vivien-Roels, B.2    Sparks, D.L.3    Hunsaker, J.C.4    Pévet, P.5    Ravid, D.6    Swaab, D.F.7
  • 289
    • 0033399823 scopus 로고    scopus 로고
    • Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate
    • 1:CAS:528:DC%2BD3cXmvFyhsQ%3D%3D
    • Southgate G, Daya S (1999) Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate. Metab Brain Dis 14:165-171
    • (1999) Metab Brain Dis , vol.14 , pp. 165-171
    • Southgate, G.1    Daya, S.2
  • 290
    • 82355191864 scopus 로고    scopus 로고
    • Melatonin receptor agonists: New options for insomnia and depression treatment
    • 1:CAS:528:DC%2BC38XnsVGhsg%3D%3D
    • Spadoni G, Bedini A, Rivara S, Mor M (2011) Melatonin receptor agonists: new options for insomnia and depression treatment. CNS Neurosci Ther 17:733-741
    • (2011) CNS Neurosci Ther , vol.17 , pp. 733-741
    • Spadoni, G.1    Bedini, A.2    Rivara, S.3    Mor, M.4
  • 291
    • 77953936624 scopus 로고    scopus 로고
    • A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease
    • 1:CAS:528:DC%2BC3cXlt1SjsLs%3D
    • Spuch C, Antequera D, Isabel Fernandez-Bachiller M, Isabel Rodríguez-Franco M, Carro E (2010) A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease. Neurotox Res 17:421-431
    • (2010) Neurotox Res , vol.17 , pp. 421-431
    • Spuch, C.1    Antequera, D.2    Isabel Fernandez-Bachiller, M.3    Isabel Rodríguez-Franco, M.4    Carro, E.5
  • 292
    • 78649321488 scopus 로고    scopus 로고
    • Jet lag, circadian rhythm sleep disturbances, and depression: The role of melatonin and its analogs
    • 1:CAS:528:DC%2BC3MXlvVGi
    • Srinivasan V, Singh J, Pandi-Perumal SR, Brown GM, Spence DW, Cardinali DP (2010) Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Adv Ther 27:796-813
    • (2010) Adv Ther , vol.27 , pp. 796-813
    • Srinivasan, V.1    Singh, J.2    Pandi-Perumal, S.R.3    Brown, G.M.4    Spence, D.W.5    Cardinali, D.P.6
  • 294
    • 77955714612 scopus 로고    scopus 로고
    • Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1
    • 1:CAS:528:DC%2BC3cXptlWmu7o%3D
    • Sterniczuk R, Dyck RH, Laferla FM, Antle MC (2010) Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes. Brain Res 1348:139-148
    • (2010) Circadian Changes. Brain Res , vol.1348 , pp. 139-148
    • Sterniczuk, R.1    Dyck, R.H.2    Laferla, F.M.3    Antle, M.C.4
  • 297
    • 34548600128 scopus 로고    scopus 로고
    • Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats
    • 1:CAS:528:DC%2BD2sXhtVCitr3O
    • Subramanian P, Mirunalini S, Pandi-Perumal SR, Trakht I, Cardinali DP (2007) Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats. Eur J Pharmacol 571:116-119
    • (2007) Eur J Pharmacol , vol.571 , pp. 116-119
    • Subramanian, P.1    Mirunalini, S.2    Pandi-Perumal, S.R.3    Trakht, I.4    Cardinali, D.P.5
  • 298
    • 0022347706 scopus 로고
    • The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia
    • Swabb DF, Fliers E, Partiman TS (1985) The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res 342:37-44
    • (1985) Brain Res , vol.342 , pp. 37-44
    • Swabb, D.F.1    Fliers, E.2    Partiman, T.S.3
  • 299
    • 80053892506 scopus 로고    scopus 로고
    • Brain aging, Alzheimer's disease, and mitochondria
    • 1:CAS:528:DC%2BC3MXhtl2htbbM
    • Swerdlow RH (2011) Brain aging, Alzheimer's disease, and mitochondria. Biochim Biophys Acta 1812:1630-1639
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 1630-1639
    • Swerdlow, R.H.1
  • 301
    • 79952540106 scopus 로고    scopus 로고
    • Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: The impact of circulating estrogen on its hormetic dose-response
    • 1:CAS:528:DC%2BC3MXjs1Gltrc%3D
    • Tai SH, Hung YC, Lee EJ, Lee AC, Chen TY, Shen CC, Chen HY, Lee MY, Huang SY, Wu TS (2011) Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: the impact of circulating estrogen on its hormetic dose-response. J Pineal Res 50:292-303
    • (2011) J Pineal Res , vol.50 , pp. 292-303
    • Tai, S.H.1    Hung, Y.C.2    Lee, E.J.3    Lee, A.C.4    Chen, T.Y.5    Shen, C.C.6    Chen, H.Y.7    Lee, M.Y.8    Huang, S.Y.9    Wu, T.S.10
  • 304
    • 0006128323 scopus 로고    scopus 로고
    • High physiological levels of melatonin in the bile of mammals
    • 1:CAS:528:DyaK1MXnt1yntL8%3D
    • Tan D, Manchester LC, Reiter RJ, Qi W, Hanes MA, Farley NJ (1999) High physiological levels of melatonin in the bile of mammals. Life Sci 65:2523-2529
    • (1999) Life Sci , vol.65 , pp. 2523-2529
    • Tan, D.1    Manchester, L.C.2    Reiter, R.J.3    Qi, W.4    Hanes, M.A.5    Farley, N.J.6
  • 306
    • 78549295540 scopus 로고    scopus 로고
    • Significance of high levels of endogenous melatonin in mammalian cerebrospinal fluid and in the central nervous system
    • 1:CAS:528:DC%2BC3cXhtl2mtrvN
    • Tan DX, Manchester LC, Sanchez-Barcelo E, Mediavilla MD, Reiter RJ (2010) Significance of high levels of endogenous melatonin in mammalian cerebrospinal fluid and in the central nervous system. Curr Neuropharmacol 8:162-167
    • (2010) Curr Neuropharmacol , vol.8 , pp. 162-167
    • Tan, D.X.1    Manchester, L.C.2    Sanchez-Barcelo, E.3    Mediavilla, M.D.4    Reiter, R.J.5
  • 307
    • 35348966882 scopus 로고    scopus 로고
    • Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention
    • 1:CAS:528:DC%2BD2sXht1anurvI
    • Tansey MG, McCoy MK, Frank-Cannon TC (2007) Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol 208:1-25
    • (2007) Exp Neurol , vol.208 , pp. 1-25
    • Tansey, M.G.1    McCoy, M.K.2    Frank-Cannon, T.C.3
  • 308
    • 74049134972 scopus 로고    scopus 로고
    • Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model
    • 1:CAS:528:DC%2BD1MXhsFensb3K
    • Tapias V, Cannon JR, Greenamyre JT (2010) Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J Neurosci Res 88:420-427
    • (2010) J Neurosci Res , vol.88 , pp. 420-427
    • Tapias, V.1    Cannon, J.R.2    Greenamyre, J.T.3
  • 310
    • 1642440103 scopus 로고    scopus 로고
    • Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the mouse nigrostriatum
    • 1:CAS:528:DC%2BD2cXotFKksg%3D%3D
    • Thomas B, Mohanakumar KP (2004) Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the mouse nigrostriatum. J Pineal Res 36:25-32
    • (2004) J Pineal Res , vol.36 , pp. 25-32
    • Thomas, B.1    Mohanakumar, K.P.2
  • 311
    • 0043028209 scopus 로고    scopus 로고
    • Reproducibility over 5 years of measurements of 6-sulphatoxymelatonin in urine samples from postmenopausal women
    • 1:CAS:528:DC%2BD3sXmt1els70%3D
    • Travis RC, Allen NE, Peeters PH, van Noord PA, Key TJ (2003) Reproducibility over 5 years of measurements of 6-sulphatoxymelatonin in urine samples from postmenopausal women. Cancer Epidemiol Biomarkers Prev 12:806-808
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 806-808
    • Travis, R.C.1    Allen, N.E.2    Peeters, P.H.3    Van Noord, P.A.4    Key, T.J.5
  • 312
    • 0036142587 scopus 로고    scopus 로고
    • Melatonin enters the cerebrospinal fluid through the pineal recess
    • 1:CAS:528:DC%2BD38XjtVOrsA%3D%3D
    • Tricoire H, Locatelli A, Chemineau P, Malpaux B (2002) Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 143:84-90
    • (2002) Endocrinology , vol.143 , pp. 84-90
    • Tricoire, H.1    Locatelli, A.2    Chemineau, P.3    Malpaux, B.4
  • 313
    • 80051671405 scopus 로고    scopus 로고
    • Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats
    • 1:CAS:528:DC%2BC3MXhtVOlurjJ
    • Tsai MC, Chen WJ, Tsai MS, Ching CH, Chuang JI (2011) Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats. J Pineal Res 51:233-245
    • (2011) J Pineal Res , vol.51 , pp. 233-245
    • Tsai, M.C.1    Chen, W.J.2    Tsai, M.S.3    Ching, C.H.4    Chuang, J.I.5
  • 314
    • 7644237780 scopus 로고    scopus 로고
    • Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease
    • 1:CAS:528:DC%2BD2cXpsFCgsr4%3D
    • Tunez I, Montilla P, Del Carmen MM, Feijoo M, Salcedo M (2004) Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. J Pineal Res 37:252-256
    • (2004) J Pineal Res , vol.37 , pp. 252-256
    • Tunez, I.1    Montilla, P.2    Del Carmen, M.M.3    Feijoo, M.4    Salcedo, M.5
  • 315
    • 7044263197 scopus 로고    scopus 로고
    • Melatonin, sleep, and circadian rhythms: Rationale for development of specific melatonin agonists
    • Turek FW, Gillette MU (2004) Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Sleep Med 5:523-532
    • (2004) Sleep Med , vol.5 , pp. 523-532
    • Turek, F.W.1    Gillette, M.U.2
  • 316
    • 0029881535 scopus 로고    scopus 로고
    • Daily rhythm of serum melatonin in patients with dementia of the degenerate type
    • 1:CAS:528:DyaK28XivFKqurw%3D
    • Uchida K, Okamoto N, Ohara K, Morita Y (1996) Daily rhythm of serum melatonin in patients with dementia of the degenerate type. Brain Res 717:154-159
    • (1996) Brain Res , vol.717 , pp. 154-159
    • Uchida, K.1    Okamoto, N.2    Ohara, K.3    Morita, Y.4
  • 317
    • 0032878234 scopus 로고    scopus 로고
    • Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells
    • 1:CAS:528:DyaK1MXmt1eks7Y%3D
    • Urata Y, Honma S, Goto S, Todoroki S, Iida T, Cho S, Honma K, Kondo T (1999) Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells. Free Radic Biol Med 27:838-847
    • (1999) Free Radic Biol Med , vol.27 , pp. 838-847
    • Urata, Y.1    Honma, S.2    Goto, S.3    Todoroki, S.4    Iida, T.5    Cho, S.6    Honma, K.7    Kondo, T.8
  • 318
    • 84862748058 scopus 로고    scopus 로고
    • Age-related changes in neuroendocrine rhythmic function in the rhesus macaque
    • (Dordr)
    • Urbanski HF, Sorwell KG (2011) Age-related changes in neuroendocrine rhythmic function in the rhesus macaque. Age (Dordr). http://dx.doi.org/10.1007/ s11357-011-9352-z
    • (2011) Age
    • Urbanski, H.F.1    Sorwell, K.G.2
  • 319
    • 0033647048 scopus 로고    scopus 로고
    • Circadian and sleep disturbances in the elderly
    • van Someren EJ (2000) Circadian and sleep disturbances in the elderly. Exp Gerontol 35:1229-1237
    • (2000) Exp Gerontol , vol.35 , pp. 1229-1237
    • Van Someren, E.J.1
  • 323
    • 0031732993 scopus 로고    scopus 로고
    • Role of nitric oxide in traumatic brain injury in the rat
    • 1:CAS:528:DyaK1cXnsVWqsLs%3D
    • Wada K, Chatzipanteli K, Busto R, Dietrich WD (1998) Role of nitric oxide in traumatic brain injury in the rat. J Neurosurg 89:807-818
    • (1998) J Neurosurg , vol.89 , pp. 807-818
    • Wada, K.1    Chatzipanteli, K.2    Busto, R.3    Dietrich, W.D.4
  • 324
    • 35649020265 scopus 로고    scopus 로고
    • Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: Quality of sleep and next-day alertness outcomes
    • 1:CAS:528:DC%2BD2sXhtlektLrP
    • Wade AG, Ford I, Crawford G, McMahon AD, Nir T, Laudon M, Zisapel N (2007) Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin 23:2597-2605
    • (2007) Curr Med Res Opin , vol.23 , pp. 2597-2605
    • Wade, A.G.1    Ford, I.2    Crawford, G.3    McMahon, A.D.4    Nir, T.5    Laudon, M.6    Zisapel, N.7
  • 325
    • 0022484725 scopus 로고
    • Changes in melatonin secretion with age and pubescence
    • 1:CAS:528:DyaL2sXivVSktg%3D%3D
    • Waldhauser F, Steger H (1986) Changes in melatonin secretion with age and pubescence. J Neural Transm Suppl 21:183-197
    • (1986) J Neural Transm Suppl , vol.21 , pp. 183-197
    • Waldhauser, F.1    Steger, H.2
  • 327
    • 70449339417 scopus 로고    scopus 로고
    • The antiapoptotic activity of melatonin in neurodegenerative diseases
    • 1:CAS:528:DC%2BD1MXhsFOqt7%2FJ
    • Wang X (2009) The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci Ther 15:345-357
    • (2009) CNS Neurosci Ther , vol.15 , pp. 345-357
    • Wang, X.1
  • 330
    • 0028920392 scopus 로고
    • Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand
    • 1:CAS:528:DyaK2MXksVaks7s%3D
    • Wiesenberg I, Missbach M, Kahlen JP, Schrader M, Carlberg C (1995) Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res 23:327-333
    • (1995) Nucleic Acids Res , vol.23 , pp. 327-333
    • Wiesenberg, I.1    Missbach, M.2    Kahlen, J.P.3    Schrader, M.4    Carlberg, C.5
  • 331
    • 57349165757 scopus 로고    scopus 로고
    • Parkinson's disease as a neuroendocrine disorder of circadian function: Dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process
    • 1:CAS:528:DC%2BD1MXmsVWkug%3D%3D
    • Willis GL (2008) Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process. Rev Neurosci 19:245-316
    • (2008) Rev Neurosci , vol.19 , pp. 245-316
    • Willis, G.L.1
  • 332
    • 0032973751 scopus 로고    scopus 로고
    • A therapeutic role for melatonin antagonism in experimental models of Parkinson's disease
    • 1:CAS:528:DyaK1MXktlGju7k%3D
    • Willis GL, Armstrong SM (1999) A therapeutic role for melatonin antagonism in experimental models of Parkinson's disease. Physiol Behav 66:785-795
    • (1999) Physiol Behav , vol.66 , pp. 785-795
    • Willis, G.L.1    Armstrong, S.M.2
  • 333
    • 9644275747 scopus 로고    scopus 로고
    • Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: A new mechanism involving antagonism of the melatonin receptor
    • 1:CAS:528:DC%2BD2cXhtVCltbrF
    • Willis GL, Robertson AD (2004) Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: a new mechanism involving antagonism of the melatonin receptor. Pharmacol Biochem Behav 79:413-429
    • (2004) Pharmacol Biochem Behav , vol.79 , pp. 413-429
    • Willis, G.L.1    Robertson, A.D.2
  • 334
    • 34347385604 scopus 로고    scopus 로고
    • Primary and secondary features of Parkinson's disease improve with strategic exposure to bright light: A case series study
    • Willis GL, Turner EJ (2007) Primary and secondary features of Parkinson's disease improve with strategic exposure to bright light: a case series study. Chronobiol Int 24:521-537
    • (2007) Chronobiol Int , vol.24 , pp. 521-537
    • Willis, G.L.1    Turner, E.J.2
  • 336
    • 34547547735 scopus 로고    scopus 로고
    • Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease
    • Wu YH, Swaab DF (2007) Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. Sleep Med 8:623-636
    • (2007) Sleep Med , vol.8 , pp. 623-636
    • Wu, Y.H.1    Swaab, D.F.2
  • 339
    • 33845427595 scopus 로고    scopus 로고
    • Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin-releasing hormone
    • 1:CAS:528:DC%2BD2sXktlGlsQ%3D%3D
    • Wu YH, Zhou JN, Balesar R, Unmehopa U, Bao A, Jockers R, Van Heerikhuize J, Swaab DF (2006b) Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: colocalization of MT1 with vasopressin, oxytocin, and corticotropin-releasing hormone. J Comp Neurol 499:897-910
    • (2006) J Comp Neurol , vol.499 , pp. 897-910
    • Wu, Y.H.1    Zhou, J.N.2    Balesar, R.3    Unmehopa, U.4    Bao, A.5    Jockers, R.6    Van Heerikhuize, J.7    Swaab, D.F.8
  • 340
    • 34249291586 scopus 로고    scopus 로고
    • Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease
    • 1:CAS:528:DC%2BD2sXmtVahs7Y%3D
    • Wu YH, Zhou JN, Van Heerikhuize J, Jockers R, Swaab DF (2007) Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease. Neurobiol Aging 28:1239-1247
    • (2007) Neurobiol Aging , vol.28 , pp. 1239-1247
    • Wu, Y.H.1    Zhou, J.N.2    Van Heerikhuize, J.3    Jockers, R.4    Swaab, D.F.5
  • 341
    • 0028895201 scopus 로고
    • Improvement of sleep quality by melatonin
    • 1:STN:280:DyaK28%2Fot1Sisw%3D%3D
    • Wurtman RJ, Zhdanova I (1995) Improvement of sleep quality by melatonin. Lancet 346:1491
    • (1995) Lancet , vol.346 , pp. 1491
    • Wurtman, R.J.1    Zhdanova, I.2
  • 342
    • 80052015761 scopus 로고    scopus 로고
    • Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A
    • 1:CAS:528:DC%2BC3MXht1GkurzN
    • Yang X, Yang Y, Fu Z, Li Y, Feng J, Luo J, Zhang Q, Wang Q, Tian Q (2011) Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol 25:1118-1125
    • (2011) J Psychopharmacol , vol.25 , pp. 1118-1125
    • Yang, X.1    Yang, Y.2    Fu, Z.3    Li, Y.4    Feng, J.5    Luo, J.6    Zhang, Q.7    Wang, Q.8    Tian, Q.9
  • 343
    • 0026131467 scopus 로고
    • 125I]Iodomelatonin-binding sites in the pigeon brain: Binding characteristics, regional distribution and diurnal variation
    • 1:CAS:528:DyaK3MXhs1Whs70%3D
    • 125I]Iodomelatonin-binding sites in the pigeon brain: binding characteristics, regional distribution and diurnal variation. J Endocrinol 128:475-482
    • (1991) J Endocrinol , vol.128 , pp. 475-482
    • Yuan, H.1    Pang, S.F.2
  • 345
    • 0033825627 scopus 로고    scopus 로고
    • Oxidative stress and genetics in the pathogenesis of Parkinson's disease
    • 1:CAS:528:DC%2BD3cXmtVGntbk%3D
    • Zhang Y, Dawson VL, Dawson TM (2000) Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis 7:240-250
    • (2000) Neurobiol Dis , vol.7 , pp. 240-250
    • Zhang, Y.1    Dawson, V.L.2    Dawson, T.M.3
  • 346
    • 63249118896 scopus 로고    scopus 로고
    • Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism
    • 1:CAS:528:DC%2BD1MXktFamtL4%3D
    • Zhang Q, Ding H, Li W, Fan Z, Sun A, Luo J, Ke ZJ (2009) Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism. Brain Res 1264:111-118
    • (2009) Brain Res , vol.1264 , pp. 111-118
    • Zhang, Q.1    Ding, H.2    Li, W.3    Fan, Z.4    Sun, A.5    Luo, J.6    Ke, Z.J.7
  • 347
    • 79959820044 scopus 로고    scopus 로고
    • Sleep-wake disturbances in common neurodegenerative diseases: A closer look at selected aspects of the neural circuitry
    • Zhong G, Naismith SL, Rogers NL, Lewis SJ (2011) Sleep-wake disturbances in common neurodegenerative diseases: a closer look at selected aspects of the neural circuitry. J Neurol Sci 307:9-14
    • (2011) J Neurol Sci , vol.307 , pp. 9-14
    • Zhong, G.1    Naismith, S.L.2    Rogers, N.L.3    Lewis, S.J.4
  • 348
    • 0042090064 scopus 로고    scopus 로고
    • Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels
    • 1:CAS:528:DC%2BD3sXmsFygtL4%3D
    • Zhou JN, Liu RY, Kamphorst W, Hofman MA, Swaab DF (2003) Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res 35:125-130
    • (2003) J Pineal Res , vol.35 , pp. 125-130
    • Zhou, J.N.1    Liu, R.Y.2    Kamphorst, W.3    Hofman, M.A.4    Swaab, D.F.5


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