Melatonin as a therapy in REM sleep behavior disorder patients: An open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation

Movement Disorders

Volumn 14, Issue 3, 1999, Pages 507-511

  Kunz, Dieter ^a   Bes, Frederik ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b NONE

Author keywords

Circadian rhythms; Melatonin; Parasomnia; Polysomnography; REM sleep

Indexed keywords

MELATONIN;

ADULT; AGED; ARTICLE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; HUMAN; MALE; MUSCLE ATONIA; PATHOPHYSIOLOGY; POLYSOMNOGRAPHY; PRIORITY JOURNAL; REM SLEEP; SLEEP DISORDER; SLEEP PATTERN; SUPRACHIASMATIC NUCLEUS;

ADULT; AGED; CIRCADIAN RHYTHM; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; MELATONIN; MIDDLE AGED; PILOT PROJECTS; POLYSOMNOGRAPHY; SLEEP DISORDERS; SLEEP, REM;

EID: 0033430105     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8257(199905)14:3<507::AID-MDS1021>3.0.CO;2-8     Document Type: Article

References (51)

1. Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW. Chronic behavioral disorders of human sleep: a new category of parasomnia. Sleep 1986;9:293-308.
2. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder. Neurology 1996;46:388-393.
3. Plazzi G, Corsini R, Provini F, et al. REM sleep behavior disorders in multiple system atrophy. Neurology 1997;48:1094-1097.
4. Tachibana N. REM sleep behavior disorders and neurological diseases. Presented at the Japanese-German International Symposium 'Sleep-Wake Disorders'; October 9, 1996; Erfurt, Germany.
5. Schenck CH, Mahowald MW. Lewy body variant of Alzheimer's disease (AD) identified by postmortem ubiquitin staining in a previously reported case of AD associated with REM sleep behavior disorder. Biol Psychiatry 1997;42:527-528.
6. Uchiyama M, Isse K, Tanaka K, et al. Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology 1995;45:709-712.
7. Besset A. Effects of antidepressants on human sleep. Adv Biosci 1978;21:141-148.
8. Schenck CH, Mahowald MW, Suck WK, O'Connor KA, Hurwitz TD. Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetin treatment of depression and obsessive-compulsive disorder. Sleep 1992;15:226-235.
9. Comella CL, Tanner CM, Ristanovic RK. Polysomnographic sleep measures in Parkinson's disease patients with treatment-induced hallucinations. Ann Neurol 1993;34:710-714.
10. Scharf B, Moskovitz C, Lupton MD, Klawans HL. Dream phenomena induced by chronic levodopa therapy. J Neural Transm 1978;43:143-151.
11. Betts TA, Alford C. Beta-blockers and sleep: a controlled trial. Eur J Clin Pharmacol 1985;28:65-68.
12. Trajanovic NN, Shapiro CM, Sandor P. REM sleep behavior disorder in patients with Tourette's syndrome. Sleep Research 1997; 26:524.
13. Olson EJ, Silber MH, Boeve BF. REM sleep behavior disorder: demographic, clinical and laboratory findings in 88 cases. Sleep Research 1997;26:451.
14. Schenck CH, Mahowald MW. Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults. JAMA 1996;100:333-337.
15. American Psychiatric Association. Benzodiazepine Dependency, Toxicity, and Abuse: A Task Force Report of the American Psychiatric Association. Washington, DC: American Psychiatric Association, 1990.
16. Kunz D, Bes F. Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. Neuropsychobiology 1997;36:211-214.
17. Diagnostic Classification Steering Committee. International Classification of Sleep Disorders: Diagnostic and Coding Manual. Rochester, MN: American Sleep Disorders Association, 1990.
18. McIntyre I, Burrows GD, Norman TR. Suppression of plasma melatonin by a single dose of the benzodiazepine alprazolam in humans. Biol Psychiatry 1988;24:105-108.
19. Skene DJ, Bojkowski CJ, Arendt J. Comparison of the effects of acute fluvoxamine and desipramine administration on melatonin and cortisol production in humans. Br J Clin Pharmacol 1994;37: 181-186.
20. Cowen PJ, Bevan JS, Gosden B, Elliott SA. Treatment with b-adrenoreceptor blockers reduces plasma melatonin concentration. Br J Clin Pharmacol 1985;19:258-260.
21. Murphy P, Badia P, Myers BL, Boecker MR. Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans. Physiol Behav 1991;55:1063-1066.
22. Pfluger DH, Minder CE. Effects of exposure to 16.7 Hz magnetic fields on urinary 6-hydroxymelatonin sulfate excretion of Swiss railway workers. J Pineal Res 1996;21:91-100.
23. Rechtschaffen A, Kales AA. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Bethesda, MD: National Institute of Neurological Diseases and Blindness, 1968.
24. Lapierre O, Montplaisir J. Polysomnographic features of REM sleep behavior disorder: development of a scoring method. Neurology 1992;42:1371-1374.
25. Williams RL, Karacan I, Moore C. Sleep Disorders: Diagnosis and Treatment, 2nd ed. New York, NY: John Wiley, 1988:1-5.
26. Wurtman RJ, Zhdanova IV. Improvement of sleep quality by melatonin. Lancet 1995;346:1491.
27. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995;57:552-558.
28. Cagnacci A, Kräuchi K, Wirz-Justice A, Volpe A. Homeostatic versus circadian effects of melatonin on core body temperature in humans. J Biol Rhythm 1997;12:509-517.
29. Lavie P. Melatonin: role in gating nocturnal rise in sleep propensity. J Biol Rhythm 1997;12:657-665.
30. Dijk DJ, Cajochen C. Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. J Biol Rhythm 1997;12:627-635.
31. Nave R, Herer P, Haimov I, Shlitner A, Lavie P. Hypnotic and hypothermie effects of melatonin on daytime sleep in humans: lack of antagonism by flumazenil. Neurosci Lett 1996;214:123-126.
32. Jenner P, Chadwick D, Reynolds EH, Marsden CD. Altered 5HT metabolism with clonazepam, diazepam and diphenylhydantoin. J Pharm Pharmacol 1975;27:707-710.
33. Weaver DR, Stehle JH, Stopa EG, Reppert SM. Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin. J Clin Endocrinol Metab 1993;76:295-301.
34. Arendt J, Deacon S, English J, Hampton S, Morgan L. Melatonin and adjustment to phase shift. J Sleep Res 1995;4(suppl 2):74-79.
35. Arendt J, Aldhous M, Marks V. Alleviation of jet lag by melatonin: preliminary results of controlled double-blind trial. BMJ 1986;292: 1170.
36. Dahlitz M, Alvarez B, Vignau J, English J, Arendt J, Parkes JD. Delayed sleep phase syndrome response to melatonin. Lancet 1991;337:1121-1124.
37. Sack RL, Lewy AJ, Blood ML, Keith LD, Nakagawa H. Circadian rhythm abnormalities in totally blind people: incidence and clinical significance. J Clin Endocrinol Metab 1992;75:127-134.
38. Lewy AJ, Ahmed S, Jackson JML, Sack RL. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol Int 1992;9:380-392.
39. Dawson D, Armstrong SM. Chronobiotics - drugs that shift rhythms. Pharmacol Ther 1996;69:15-36.
40. Czeisler CA. Commentary: evidence for melatonin as a circadian phase-shifting agent. J Biol Rhythm 1997;12:618-623.
41. Gwinner E, Benzinger J. Synchronization of a circadian rhythm in pinealectomized European starlings by daily injections of melatonin. J Comp Physiol 1978;127:209-213.
42. Tzischinsky O, Lavie P. Melatonin possesses time dependent effects. Sleep 1994;17:638-645.
43. Wirz-Justice A. Circadian rhythms in mammalian neurotransmitter receptors. Prog Neurobiol 1987;29:219-259.
44. Borbèly AA. A two-process model of sleep regulation. Human Neurobiology 1982;1:195-204.
45. Daan S, Beersma DGM, Borbèly AA. Timing of human sleep: recovery process gated by a circadian pacemaker. Am J Physiol 1984;246:R161-R178.
46. Edgar DM, Dement WC, Fuller CA. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci 1993;13:1065-1079.
47. Wurts SW, Seidel WF, Dement WC, Edgar DM. Effects of suprachiasmatic nucleus lesions on REM sleep continuity. Sleep Research 1997;26:758.
48. Armstrong SM, Redman JR. Melatonin: a chronobiotic with anti-aging properties. Med Hypotheses 1991;34:300-309.
49. Cajochen C, Kräuchi K, Möri D, Graw P, Wirz-Justice A. Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis. Am J Physiol 1997; 272:R1189-R1196.
50. van-Den-Heuvel CJ, Reid KJ, Dawson D. Effect of atenolol on nocturnal sleep and temperature in young men: reversal by pharmacological doses of melatonin. Physiol Behav 1997;61:795-802.
51. Zhdanova I, Taylor JA, Leclair OU, Wurtman RJ. Effects of melatonin on blood pressure in people over 50 years old. Sleep 1998; 21(suppl):213.