A critical assessment of the melatonin effect on sleep in humans

Biological Signals and Receptors

Volumn 9, Issue 6, 2000, Pages 328-339

  Monti, J M ^a   Cardinali, D P ^a  

^a Dept of Pharmacol and Therapeutics ^*  (Uruguay)

Author keywords

Alzheimer disease; Circadian physiology; Melatonin; Melatonin receptors; Pineal gland; Sleep disorders

Indexed keywords

MELATONIN;

ARTICLE; CIRCADIAN RHYTHM; COMPARTMENT MODEL; FATIGUE; HORMONE RELEASE; HUMAN; INSOMNIA; LATENT PERIOD; LIGHT DARK CYCLE; PHOTOPERIODICITY; SLEEP; SOMNOLENCE; SUPRACHIASMATIC NUCLEUS;

ADULT; AGE FACTORS; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; DEMENTIA; HUMANS; MELATONIN; MIDDLE AGED; PHOTOPERIOD; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS;

MAMMALIA;

EID: 0033755796     PISSN: 14224933     EISSN: None     Source Type: Journal    
DOI: 10.1159/000014656     Document Type: Article

References (54)

1. Basic aspects of melatonin action
2. Complex effects of melatonin: Evidence for photoperiodic responses in humans?
3. Neural regulation of circadian rhythms
4. Entrainment of the circadian clock
5. Physiology of the circadian system in animals and humans
6. The human body circadian: How the biologic clock influences sleep and emotion
7. Phase shifting the human circadian clock using melatonin
8. Melatonin site and mechanism of action: Single or multiple?
9. Introduction to mammalian pineal innervation
10. Binding of melatonin to human and rat plasma proteins
11. Bioavailability of oral melatonin in humans
12. Measurement of 6-hydroxymelatonin in human urine and its diurnal variations
13. Cyclic 3-hydroxymelatonin: A melatonin metabolite generated as a result of hydroxyl radical scavenging
14. Melatonin and the seasonal control of reproduction
15. Effects of different doses and durations of melatonin infusions on plasma melatonin concentrations in pinealectomized Syrian hamsters: Consequences at the level of sexual activity
16. Polymorphism and signalling of melatonin receptors
17. Chronobiotics - Drugs that shift rhythms
18. Melatonin. A mammalian pineal hormone
19. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
20. Melatonin receptors
21. Characterization of high-affinity melatonin binding sites in purified cell nuclei of rat liver
22. Thiazolidine diones, specific ligands of the nuclear receptor retionid Z receptor/retionid acid receptor-related orphan receptor alpha with potent antiarthritic activity
23. Melatonin binding sites in brain: Single or multiple?
24. Regional concentrations of melatonin in the rat brain in the light and dark period
25. Hypothyroidism and rehabilitation of day and night mela-tonin levels in pineal, hypothalamus and serum of male rats
26. High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus
27. Melatonin: Effects on brain function
28. On the effects of mela-tonin on sleep and behavior in man
29. Sleep induction by intranasal administration of melatonin
30. Effects of melatonin on human mood and performance
31. The effect of melatonin on normal sleep
32. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans
33. Sleep-inducing effects of low doses of melatonin ingested in the evening
34. Sleep laboratory investigations on hypnotic properties of melatonin
35. Effects of exogenous melatonin on memory, sleepiness, and performance after a 4-hr nap
36. Melatonin improves evening napping
37. Melatonin effect on daytime sleep in men: Suppression of EEG low frequency activity and enhancement of spindle frequency activity
38. Day-time melatonin administration: Effects on core temperature and sleep onset latency
39. Daytime melatonin and temazepam in young adult humans: Equivalent effects on sleep latency and body temperature
40. Effects of low doses of melatonin on late afternoon napping and mood
41. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance
42. Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG
43. Melatonin: Role in gating nocturnal rise in sleep propensity
44. Melatonin administration in insomnia
45. The role of melatonin and circadian phase in age-related sleep maintenance insomnia: Assessment in a clinical trial of melatonin replacement
46. Polysomnographic study of the effect of melatonin on sleep in elderly patients with chronic primary insomnia
47. Improvement of sleep quality in elderly people by controlled-release melatonin
48. Potential of melatonin replacement therapy in older patients with sleep disorders
49. The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: A preliminary study
50. Improvement of sleep quality by melatonin
51. Melatonin and insomnia
52. Effects of melatonin in elderly patients with sleep disturbance. A pilot study
53. Effect of melatonin in selected populations of sleep-disturbed patients
54. Monozygotic twins with Alzheimer's disease treated with melatonin: Case report