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Volumn 39, Issue 4, 2011, Pages 945-953

Systemic inflammation and delirium: Important co-factors in the progression of dementia

Author keywords

Alzheimer's disease (AD); Animal model; Delirium; Dementia; Microglia; Microglial priming; Systemic inflammation

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; DOXYCYCLINE; GAMMA SECRETASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; RIFAMPICIN; SULINDAC; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 79960866841     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0390945     Document Type: Conference Paper
Times cited : (118)

References (75)
  • 1
    • 0025332027 scopus 로고
    • Anti-inflammatory drugs and Alzheimer disease
    • McGeer, P.L., McGeer, E., Rogers, J. and Sibley, J. (1990) Anti-inflammatory drugs and Alzheimer disease. Lancet 335, 1037 (Pubitemid 20148621)
    • (1990) Lancet , vol.335 , Issue.8696 , pp. 1037
    • McGeer, P.L.1    McGeer, E.2    Rogers, J.3    Sibley, J.4
  • 2
    • 0141453824 scopus 로고    scopus 로고
    • The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease
    • Aisen, P.S. (2002) The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease. Lancet Neurol. 1, 279-284
    • (2002) Lancet Neurol. , vol.1 , pp. 279-284
    • Aisen, P.S.1
  • 3
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's disease anti-inflammatory prevention trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • Martin, B.K., Szekely, C., Brandt, J., Piantadosi, S., Breitner, J.C., Craft, S., Evans, D., Green, R. and Mullan, M. (2008) Cognitive function over time in the Alzheimer's disease anti-inflammatory prevention trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch. Neurol. 65, 896-905
    • (2008) Arch. Neurol. , vol.65 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.5    Craft, S.6    Evans, D.7    Green, R.8    Mullan, M.9
  • 4
    • 77955047267 scopus 로고    scopus 로고
    • A summary risk score for the prediction of Alzheimer disease in elderly persons
    • Reitz, C., Tang, M.X., Schupf, N., Manly, J.J., Mayeux, R. and Luchsinger, J.A. (2010) A summary risk score for the prediction of Alzheimer disease in elderly persons. Arch. Neurol. 67, 835-841
    • (2010) Arch. Neurol. , vol.67 , pp. 835-841
    • Reitz, C.1    Tang, M.X.2    Schupf, N.3    Manly, J.J.4    Mayeux, R.5    Luchsinger, J.A.6
  • 6
    • 0004235298 scopus 로고
    • American Psychiatry Association (APA) 4th edn, American Psychiatry Association, Washington, DC
    • American Psychiatry Association (APA) (1994) Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th edn, American Psychiatry Association, Washington, DC
    • (1994) Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
  • 8
    • 49149119577 scopus 로고    scopus 로고
    • Unravelling the pathophysiology of delirium: A focus on the role of aberrant stress responses
    • MacLullich, A.M., Ferguson, K.J., Miller, T., de Rooij, S.E. and Cunningham, C. (2008) Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J. Psychosom. Res. 65, 229-238
    • (2008) J. Psychosom. Res. , vol.65 , pp. 229-238
    • MacLullich, A.M.1    Ferguson, K.J.2    Miller, T.3    De Rooij, S.E.4    Cunningham, C.5
  • 9
    • 0029917496 scopus 로고    scopus 로고
    • Precipitating factors for delirium in hospitalized elderly persons: Predictive model and interrelationship with baseline vulnerability
    • DOI 10.1001/jama.275.11.852
    • Inouye, S.K. and Charpentier, P.A. (1996) Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA, J. Am. Med. Assoc. 275, 852-857 (Pubitemid 26087222)
    • (1996) Journal of the American Medical Association , vol.275 , Issue.11 , pp. 852-857
    • Inouye, S.K.1    Charpentier, P.A.2
  • 10
    • 3543025110 scopus 로고    scopus 로고
    • The association between delirium and cognitive decline: A review of the empirical literature
    • Jackson, J.C., Gordon, S.M., Hart, R.P., Hopkins, R.O. and Ely, E.W. (2004) The association between delirium and cognitive decline: a review of the empirical literature. Neuropsychol. Rev. 14, 87-98
    • (2004) Neuropsychol. Rev. , vol.14 , pp. 87-98
    • Jackson, J.C.1    Gordon, S.M.2    Hart, R.P.3    Hopkins, R.O.4    Ely, E.W.5
  • 13
    • 77954964464 scopus 로고    scopus 로고
    • Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: A meta-analysis
    • Witlox, J., Eurelings, L.S., de Jonghe, J.F., Kalisvaart, K.J., Eikelenboom, P. and van Gool, W.A. (2010) Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. JAMA, J. Am. Med. Assoc. 304, 443-451
    • (2010) JAMA, J. Am. Med. Assoc. , vol.304 , pp. 443-451
    • Witlox, J.1    Eurelings, L.S.2    De Jonghe, J.F.3    Kalisvaart, K.J.4    Eikelenboom, P.5    Van Gool, W.A.6
  • 14
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • Dantzer, R., O'Connor, J.C., Freund, G.G., Johnson, R.W. and Kelley, K.W. (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 9, 46-56
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 15
    • 52949117520 scopus 로고    scopus 로고
    • Malaise in the water maze: Untangling the effects of LPS and IL-1β on learning and memory
    • Cunningham, C. and Sanderson, D.J. (2008) Malaise in the water maze: untangling the effects of LPS and IL-1β on learning and memory. Brain Behav. Immun. 22, 1117-1127
    • (2008) Brain Behav. Immun. , vol.22 , pp. 1117-1127
    • Cunningham, C.1    Sanderson, D.J.2
  • 16
    • 0032917425 scopus 로고    scopus 로고
    • Behavioral consequences of prion disease targeted to the hippocampus in a mouse model of scrapie
    • Betmouni, S., Deacon, R.M.J., Rawlins, J.N.P. and Perry, V.H. (1999) Behavioural consequences of prion disease targeted to the hippocampus in a mouse model of scrapie. Psychobiology 27, 63-71 (Pubitemid 29207307)
    • (1999) Psychobiology , vol.27 , Issue.1 , pp. 63-71
    • Betmouni, S.1    Deacon, R.M.J.2    Rawlins, J.N.P.3    Perry, V.H.4
  • 17
    • 0029784248 scopus 로고    scopus 로고
    • Evidence for an early inflammatory response in the central nervous system of mice with scrapie
    • DOI 10.1016/0306-4522(96)00212-6
    • Betmouni, S., Perry, V.H. and Gordon, J.L. (1996) Evidence for an early inflammatory response in the central nervous system of mice with scrapie. Neuroscience 74, 1-5 (Pubitemid 26291142)
    • (1996) Neuroscience , vol.74 , Issue.1 , pp. 1-5
    • Betmouni, S.1    Perry, V.H.2    Gordon, J.L.3
  • 19
    • 0037067048 scopus 로고    scopus 로고
    • Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease
    • DOI 10.1016/S0306-4522(02)00030-1, PII S0306452202000301
    • Combrinck, M.I., Perry, V.H. and Cunningham, C. (2002) Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease. Neuroscience 112, 7-11 (Pubitemid 34603493)
    • (2002) Neuroscience , vol.112 , Issue.1 , pp. 7-11
    • Combrinck, M.I.1    Perry, V.H.2    Cunningham, C.3
  • 21
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout, J.P., Chen, J., Abraham, J., Richwine, A.F., Berg, B.M., Kelley, K.W. and Johnson, R.W. (2005) Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J. 19, 1329-1331
    • (2005) FASEB J. , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6    Johnson, R.W.7
  • 22
    • 27144470284 scopus 로고    scopus 로고
    • Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    • DOI 10.1523/JNEUROSCI.2614-05.2005
    • Cunningham, C., Wilcockson, D.C., Campion, S., Lunnon, K. and Perry, V.H. (2005) Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 25, 9275-9284 (Pubitemid 41500836)
    • (2005) Journal of Neuroscience , vol.25 , Issue.40 , pp. 9275-9284
    • Cunningham, C.1    Wilcockson, D.C.2    Campion, S.3    Lunnon, K.4    Perry, V.H.5
  • 23
    • 77954218298 scopus 로고    scopus 로고
    • Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration
    • Field, R., Campion, S., Warren, C., Murray, C. and Cunningham, C. (2010) Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration. Brain Behav. Immun. 24, 996-1007
    • (2010) Brain Behav. Immun. , vol.24 , pp. 996-1007
    • Field, R.1    Campion, S.2    Warren, C.3    Murray, C.4    Cunningham, C.5
  • 24
    • 0036362861 scopus 로고    scopus 로고
    • Adverse effect of a Presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain
    • Lee, J., Chan, S.L. and Mattson, M.P. (2002) Adverse effect of a Presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromol. Med. 2, 29-45
    • (2002) Neuromol. Med. , vol.2 , pp. 29-45
    • Lee, J.1    Chan, S.L.2    Mattson, M.P.3
  • 25
    • 0042835437 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice
    • Sheng, J.G., Bora, S.H., Xu, G., Borchelt, D.R., Price, D.L. and Koliatsos, V.E. (2003) Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice. Neurobiol. Dis. 14, 133-145
    • (2003) Neurobiol. Dis. , vol.14 , pp. 133-145
    • Sheng, J.G.1    Bora, S.H.2    Xu, G.3    Borchelt, D.R.4    Price, D.L.5    Koliatsos, V.E.6
  • 26
    • 0035704245 scopus 로고    scopus 로고
    • Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Sly, L.M., Krzesicki, R.F., Brashler, J.R., Buhl, A.E., McKinley, D.D., Carter, D.B. and Chin, J.E. (2001) Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res. Bull. 56, 581-588
    • (2001) Brain Res. Bull. , vol.56 , pp. 581-588
    • Sly, L.M.1    Krzesicki, R.F.2    Brashler, J.R.3    Buhl, A.E.4    McKinley, D.D.5    Carter, D.B.6    Chin, J.E.7
  • 27
    • 46849088998 scopus 로고    scopus 로고
    • Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease
    • DOI 10.1093/brain/awn101
    • Godoy, M.C., Tarelli, R., Ferrari, C.C., Sarchi, M.I. and Pitossi, F.J. (2008) Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain 131, 1880-1894 (Pubitemid 351957456)
    • (2008) Brain , vol.131 , Issue.7 , pp. 1880-1894
    • Godoy, M.C.P.1    Tarelli, R.2    Ferrari, C.C.3    Sarchi, M.I.4    Pitossi, F.J.5
  • 29
    • 34247338117 scopus 로고    scopus 로고
    • Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms
    • DOI 10.1523/JNEUROSCI.5376-06.2007
    • McColl, B.W., Rothwell, N.J. and Allan, S.M. (2007) Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms. J. Neurosci. 27, 4403-4412 (Pubitemid 46640725)
    • (2007) Journal of Neuroscience , vol.27 , Issue.16 , pp. 4403-4412
    • McColl, B.W.1    Rothwell, N.J.2    Allan, S.M.3
  • 31
    • 40849095836 scopus 로고    scopus 로고
    • Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration
    • Palin, K., Cunningham, C., Forse, P., Perry, V.H. and Platt, N. (2008) Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration. Neurobiol. Dis. 30, 19-29
    • (2008) Neurobiol. Dis. , vol.30 , pp. 19-29
    • Palin, K.1    Cunningham, C.2    Forse, P.3    Perry, V.H.4    Platt, N.5
  • 32
    • 78650580820 scopus 로고    scopus 로고
    • Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline
    • Terrando, N., Monaco, C., Ma, D., Foxwell, B.M., Feldmann, M. and Maze, M. (2010) Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline. Proc. Natl. Acad. Sci. U.S.A. 107, 20518-20522
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 20518-20522
    • Terrando, N.1    Monaco, C.2    Ma, D.3    Foxwell, B.M.4    Feldmann, M.5    Maze, M.6
  • 34
    • 0037151285 scopus 로고    scopus 로고
    • Memory for context is impaired by a post context exposure injection of interleukin-1β into dorsal hippocampus
    • Barrientos, R.M., Higgins, E.A., Sprunger, D.B., Watkins, L.R., Rudy, J.W. and Maier, S.F. (2002) Memory for context is impaired by a post context exposure injection of interleukin-1β into dorsal hippocampus. Behav. Brain Res. 134, 291-298
    • (2002) Behav. Brain Res. , vol.134 , pp. 291-298
    • Barrientos, R.M.1    Higgins, E.A.2    Sprunger, D.B.3    Watkins, L.R.4    Rudy, J.W.5    Maier, S.F.6
  • 35
    • 77955262711 scopus 로고    scopus 로고
    • New insights into the pathophysiology of postoperative cognitive dysfunction
    • Krenk, L., Rasmussen, L.S. and Kehlet, H. (2010) New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiol. Scand. 54, 951-956
    • (2010) Acta Anaesthesiol. Scand. , vol.54 , pp. 951-956
    • Krenk, L.1    Rasmussen, L.S.2    Kehlet, H.3
  • 37
    • 53949083619 scopus 로고    scopus 로고
    • Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: Cautions and caveats
    • Maren, S. (2008) Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats. Eur. J. Neurosci. 28, 1661-1666
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 1661-1666
    • Maren, S.1
  • 38
    • 38449087454 scopus 로고    scopus 로고
    • Age increases vulnerability to bacterial endotoxin-induced behavioral decrements
    • Kohman, R.A., Tarr, A.J., Byler, S.L. and Boehm, G.W. (2007) Age increases vulnerability to bacterial endotoxin-induced behavioral decrements. Physiol. Behav. 91, 561-565
    • (2007) Physiol. Behav. , vol.91 , pp. 561-565
    • Kohman, R.A.1    Tarr, A.J.2    Byler, S.L.3    Boehm, G.W.4
  • 39
    • 77952237678 scopus 로고    scopus 로고
    • Persistent delirium in older hospital patients
    • Cole, M.G. (2010) Persistent delirium in older hospital patients. Curr. Opin. Psychiatry 23, 250-254
    • (2010) Curr. Opin. Psychiatry , vol.23 , pp. 250-254
    • Cole, M.G.1
  • 40
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • Chen, J., Buchanan, J.B., Sparkman, N.L., Godbout, J.P., Freund, G.G. and Johnson, R.W. (2008) Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav. Immun. 22, 301-311
    • (2008) Brain Behav. Immun. , vol.22 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 42
    • 77951957277 scopus 로고    scopus 로고
    • Systemic inflammation induces acute working memory deficits in the primed brain: Relevance for delirium
    • doi:10.1016/j.neurobiolaging.2010.04.002
    • Murray, C., Sanderson, D.J., Barkus, C., Deacon, R.M., Rawlins, J.N., Bannerman, D.M. and Cunningham, C. (2010) Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol. Aging, doi:10.1016/j.neurobiolaging.2010.04.002
    • (2010) Neurobiol. Aging
    • Murray, C.1    Sanderson, D.J.2    Barkus, C.3    Deacon, R.M.4    Rawlins, J.N.5    Bannerman, D.M.6    Cunningham, C.7
  • 44
    • 77953675879 scopus 로고    scopus 로고
    • Probing the biology of Alzheimer's disease in mice
    • Ashe, K.H. and Zahs, K.R. (2010) Probing the biology of Alzheimer's disease in mice. Neuron 66, 631-645
    • (2010) Neuron , vol.66 , pp. 631-645
    • Ashe, K.H.1    Zahs, K.R.2
  • 45
    • 53349129897 scopus 로고    scopus 로고
    • Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of β-amyloid generation
    • Lee, J.W., Lee, Y.K., Yuk, D.Y., Choi, D.Y., Ban, S.B., Oh, K.W. and Hong, J.T. (2008) Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of β-amyloid generation. J. Neuroinflammation 5, 37
    • (2008) J. Neuroinflammation , vol.5 , pp. 37
    • Lee, J.W.1    Lee, Y.K.2    Yuk, D.Y.3    Choi, D.Y.4    Ban, S.B.5    Oh, K.W.6    Hong, J.T.7
  • 47
    • 33947690200 scopus 로고    scopus 로고
    • Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model
    • Semmler, A., Frisch, C., Debeir, T., Ramanathan, M., Okulla, T., Klockgether, T. and Heneka, M.T. (2007) Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. Exp. Neurol. 204, 733-740
    • (2007) Exp. Neurol. , vol.204 , pp. 733-740
    • Semmler, A.1    Frisch, C.2    Debeir, T.3    Ramanathan, M.4    Okulla, T.5    Klockgether, T.6    Heneka, M.T.7
  • 52
    • 1242336763 scopus 로고    scopus 로고
    • Exacerbation of Motor Neuron Disease by Chronic Stimulation of Innate Immunity in a Mouse Model of Amyotrophic Lateral Sclerosis
    • DOI 10.1523/JNEUROSCI.4786-03.2004
    • Nguyen, M.D., D'Aigle, T., Gowing, G., Julien, J.P. and Rivest, S. (2004) Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. 24, 1340-1349 (Pubitemid 38222984)
    • (2004) Journal of Neuroscience , vol.24 , Issue.6 , pp. 1340-1349
    • Nguyen, M.D.1    D'Aigle, T.2    Gowing, G.3    Julien, J.-P.4    Rivest, S.5
  • 53
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • DOI 10.1523/JNEUROSCI.2868-05.2005
    • Kitazawa, M., Oddo, S., Yamasaki, T.R., Green, K.N. and LaFerla, F.M. (2005) Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 25, 8843-8853 (Pubitemid 41384452)
    • (2005) Journal of Neuroscience , vol.25 , Issue.39 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    LaFerla, F.M.5
  • 55
    • 0032404120 scopus 로고    scopus 로고
    • Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling
    • Balachandran, S., Kim, C.N., Yeh, W.C., Mak, T.W., Bhalla, K. and Barber, G.N. (1998) Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J. 17, 6888-6902 (Pubitemid 28550283)
    • (1998) EMBO Journal , vol.17 , Issue.23 , pp. 6888-6902
    • Balachandran, S.1    Kim, C.N.2    Yeh, W.-C.3    Mak, T.W.4    Bhalla, K.5    Barber, G.N.6
  • 56
    • 77249127919 scopus 로고    scopus 로고
    • eIF2α phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation
    • Jiang, Z., Belforte, J.E., Lu, Y., Yabe, Y., Pickel, J., Smith, C.B., Je, H.S., Lu, B. and Nakazawa, K. (2010) eIF2α phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation. J. Neurosci. 30, 2582-2594
    • (2010) J. Neurosci. , vol.30 , pp. 2582-2594
    • Jiang, Z.1    Belforte, J.E.2    Lu, Y.3    Yabe, Y.4    Pickel, J.5    Smith, C.B.6    Je, H.S.7    Lu, B.8    Nakazawa, K.9
  • 57
    • 0037344642 scopus 로고    scopus 로고
    • Long-term cognitive and functional decline in late onset Alzheimer's disease: Therapeutic implications
    • DOI 10.1093/ageing/32.2.200
    • Holmes, C. and Lovestone, S. (2003) Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications. Age Ageing 32, 200-204 (Pubitemid 36372428)
    • (2003) Age and Ageing , vol.32 , Issue.2 , pp. 200-204
    • Holmes, C.1    Lovestone, S.2
  • 58
    • 33846585119 scopus 로고    scopus 로고
    • Systemic infections and inflammation affect chronic neurodegeneration
    • Perry, V.H., Cunningham, C. and Holmes, C. (2007) Systemic infections and inflammation affect chronic neurodegeneration. Nat. Rev. Immunol. 7, 161-167
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 161-167
    • Perry, V.H.1    Cunningham, C.2    Holmes, C.3
  • 59
    • 71449097274 scopus 로고    scopus 로고
    • Role of infection in the pathogenesis of Alzheimer's disease: Implications for treatment
    • Holmes, C. and Cotterell, D. (2009) Role of infection in the pathogenesis of Alzheimer's disease: implications for treatment. CNS Drugs 23, 993-1002
    • (2009) CNS Drugs , vol.23 , pp. 993-1002
    • Holmes, C.1    Cotterell, D.2
  • 60
    • 23044447002 scopus 로고    scopus 로고
    • Association between dementia and infectious disease: Evidence from a case-control study
    • Dunn, N., Mullee, M., Perry, V.H. and Holmes, C. (2005) Association between dementia and infectious disease: evidence from a case-control study. Alzheimer Dis. Assoc. Disord. 19, 91-94
    • (2005) Alzheimer Dis. Assoc. Disord. , vol.19 , pp. 91-94
    • Dunn, N.1    Mullee, M.2    Perry, V.H.3    Holmes, C.4
  • 61
    • 0042919504 scopus 로고    scopus 로고
    • Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases
    • DOI 10.1161/01.STR.0000086754.32238.DA
    • Strandberg, T.E., Pitkala, K.H., Linnavuori, K.H. and Tilvis, R.S. (2003) Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases. Stroke 34, 2126-2131 (Pubitemid 37099824)
    • (2003) Stroke , vol.34 , Issue.9 , pp. 2126-2131
    • Strandberg, T.E.1    Pitkala, K.H.2    Linnavuori, K.H.3    Tilvis, R.S.4
  • 65
    • 0035680978 scopus 로고    scopus 로고
    • Past exposure to vaccines and subsequent risk of Alzheimer's disease
    • Verreault, R., Laurin, D., Lindsay, J. and De Serres, G. (2001) Past exposure to vaccines and subsequent risk of Alzheimer's disease. Can. Med. Assoc. J. 165, 1495-1498
    • (2001) Can. Med. Assoc. J. , vol.165 , pp. 1495-1498
    • Verreault, R.1    Laurin, D.2    Lindsay, J.3    De Serres, G.4
  • 69
    • 0037977890 scopus 로고    scopus 로고
    • The prognostic significance of subsyndromal delirium in elderly medical inpatients
    • Cole, M., McCusker, J., Dendukuri, N. and Han, L. (2003) The prognostic significance of subsyndromal delirium in elderly medical inpatients. J. Am. Geriatr. Soc. 51, 754-760
    • (2003) J. Am. Geriatr. Soc. , vol.51 , pp. 754-760
    • Cole, M.1    McCusker, J.2    Dendukuri, N.3    Han, L.4
  • 70
    • 33646884411 scopus 로고    scopus 로고
    • Significant cognitive dysfunction in non-delirious patients identified during and persisting following critical illness
    • DOI 10.1007/s00134-006-0112-y
    • Jones, C., Griffiths, R.D., Slater, T., Benjamin, K.S. and Wilson, S. (2006) Significant cognitive dysfunction in non-delirious patients identified during and persisting following critical illness. Intensive Care Med. 32, 923-926 (Pubitemid 43781378)
    • (2006) Intensive Care Medicine , vol.32 , Issue.6 , pp. 923-926
    • Jones, C.1    Griffiths, R.D.2    Slater, T.3    Benjamin, K.S.4    Wilson, S.5
  • 71
    • 79960866529 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines, sickness behavior and Alzheimer's disease
    • in the press
    • Holmes, C., Cunningham, C., Zotova, E., Culliford, D. and Perry, V.H. (2011) Pro-inflammatory cytokines, sickness behavior and Alzheimer's disease. Neurology, in the press
    • (2011) Neurology
    • Holmes, C.1    Cunningham, C.2    Zotova, E.3    Culliford, D.4    Perry, V.H.5
  • 72
    • 43149102747 scopus 로고    scopus 로고
    • Protective effects of NSAIDs on the development of Alzheimer disease
    • DOI 10.1212/01.wnl.0000311269.57716.63, PII 0000611420080506000006
    • Vlad, S.C., Miller, D.R., Kowall, N.W. and Felson, D.T. (2008) Protective effects of NSAIDs on the development of Alzheimer disease. Neurology 70, 1672-1677 (Pubitemid 351644133)
    • (2008) Neurology , vol.70 , Issue.19 PART 1 , pp. 1672-1677
    • Vlad, S.C.1    Miller, D.R.2    Kowall, N.W.3    Felson, D.T.4
  • 73
    • 77949754244 scopus 로고    scopus 로고
    • In follow-up analysis of clinical trial, NSAIDs seem to preserve cognitive function in patients with healthy brains
    • Laino, C. (2009) In follow-up analysis of clinical trial, NSAIDs seem to preserve cognitive function in patients with healthy brains. Neurol. Today 9, 21-22
    • (2009) Neurol. Today , vol.9 , pp. 21-22
    • Laino, C.1
  • 75
    • 0035915621 scopus 로고    scopus 로고
    • Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
    • Neuropathology Group. Medical Research Council Cognitive Function and Aging Study
    • Neuropathology Group. Medical Research Council Cognitive Function and Aging Study (2001) Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 357, 169-175
    • (2001) Lancet , vol.357 , pp. 169-175


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.