Effects of melatonin in elderly patients with sleep disturbance: A pilot study

Current Therapeutic Research - Clinical and Experimental

Volumn 58, Issue 12, 1997, Pages 990-1000

  Fainstein, Isidoro ^a   Bonetto, Alberto J ^a   Brusco, Luis I ^a   Cardinali, Daniel P ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Aging; Dementia; Depression; Melatonin; Sleep disturbance

Indexed keywords

ALPRAZOLAM; AMITRIPTYLINE; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; BROMPERIDOL; CLOMIPRAMINE; CLONAZEPAM; FLUOXETINE; MELATONIN; PAROXETINE; PROMAZINE; SERTRALINE; THIORIDAZINE;

ADULT; AGED; AGITATION; ALERTNESS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DEGENERATIVE DISEASE; DEMENTIA; DEPRESSION; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; INSOMNIA; MALE; MULTIINFARCT DEMENTIA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SLEEP DISORDER; STATISTICAL ANALYSIS; SYMPTOM;

EID: 0031473076     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(97)80066-5     Document Type: Article

References (21)

1. Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: Mechanisms and interventions. Neurosci Biobehav Rev. 1995;19:553-571.
2. Mant A, Eyland EA. Sleep patterns and problems in elderly general practice attenders: An Australian survey. Community Health Stud. 1988;12:192-199.
3. Brock M. Chronobiology and aging. J Am Geriatr Soc. 1991;39:74-91.
4. Swaab DF, Van Someren EJW, Zhou J, et al. Biological rhythms in the human life cycle and their relationship to functional changes in the suprachiasmatic nucleus. Prog Brain Res. 1996;111:349-368.
5. Humbert W, Pévet P. Calcium content and pineal concretions of pineal glands of young and old rats. A scanning and x-ray microanalysis study. Cell Tissue Res. 1991;263:593-596.
6. Iguchi H, Kato KI, Ibasayhi H. Age-dependent reduction in serum melatonin concentration in healthy human subjects. J Clin Endocrinol Metab. 1982;55:27-29.
7. Skene DJ, Vivien-Roels B, Pévet P, et al. Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: Effect of age and Alzheimer disease. Brain Res. 1990;528:170-174.
8. Garfinkel D, Laudon M, Nof D, et al. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet. 1995;346:541-554.
9. Haimov I, Lavie P, Laudon M, et al. Melatonin replacement therapy of elderly insomniacs. Sleep. 1995;18:598-603.
10. Ferrari E, Magri F, Locatelli M, et al. Chrononeuroendocrine markers of the aging brain. Aging Clin Exp Res. 1996;8:320-327.
11. Copinschi G, Van Cauter E. Effects of aging on modulation of hormonal secretions by sleep and circadian rhythmicity. Horm Res. 1995;43:20-24.
12. Touitou Y. Effects of aging on endocrine and neuroendocrine rhythms in humans. Horm Res. 1995;43:12-19.
13. Drugs and insomnia. Consensus conference. JAMA. 1984;251:2410-2414.
14. American Psychiatry Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatry Association; 1994:551-560.
15. Buysee JD, Reynolds CF, Kupfer DJ, et al. Clinical diagnosis in 216 insomnia patients using the international classification of sleep disorders (ICSD), DSM-IV and ICD-10 categories: A report from the APA/NIHM DSM-IV field trial. Sleep. 1994;17:630-637.
16. Attenburrow MEJ, Cowen PJ, Sharpley AL. Low dose melatonin improves sleep in healthy middle-aged subjects. Psychopharmacology. 1996;126:179-181.
17. Vollrath L, Semm P, Gammel G. Sleep induction by intranasal administration of melatonin. Adv Biosci. 1981;29:327-329.
18. Waldhauser F, Saletu B, Trinchard Lugan I. Sleep laboratory investigations on hypnotic properties of melatonin. Psychopharmacology. 1990;100:222-226.
19. Kaplan HI, Sadock BJ, Grebb JA. Synopsis of Psychiatry, 7th ed. Baltimore: Williams & Wilkins; 1994:705-707.
20. Carskadon MA, Van den Hoed J, Dement WC. Insomnia and sleep disturbances in the aged: Sleep and daytime sleepiness in the elderly. J Geriatr Psychiatry. 1980;13:135-151.
21. Garfinkel D, Laudon M, Zisapel N. Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs. Arch Gerontol Geriatr. 1997;24: 223-231.