Effect of melatonin on temporal changes of reactive oxygen species and glutathione after MPP+ treatment in human astrocytoma U373MG cells

Journal of Pineal Research

Volumn 36, Issue 2, 2004, Pages 117-125

  Chuang, Jih Ing ^a   Chen, Tsung Hung ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Astrocyte; Melatonin; MPP+; Oxidative stress

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BUTHIONINE SULFOXIMINE; GLUTATHIONE; HYDROGEN PEROXIDE; MALEIC ACID DIETHYL ESTER; MELATONIN; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTOMA; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFECT; DRUG EXPOSURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NERVE DEGENERATION; OXIDATIVE STRESS; PINEAL BODY;

1-METHYL-4-PHENYLPYRIDINIUM; ASTROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; MELATONIN; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 1342280378     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-079X.2003.00107.x     Document Type: Article

References (64)

1. VILA M, JACKSON LEWIS V, GUEGAN C et al. The role of glial cells in Parkinson's disease. Curr Opin Neurol 2001; 14:483-489.
2. CHEN ST, CHUANG JI. The antioxidant melatonin prevents kainate-induced neuronal degenerating death in the rat striaturn. Exp Brain Res 1999; 124:241-247.
3. +. J Neural Transm 1989; 76:1-12.
4. DI MONTE DA, WU EY, IRWIN I, DELANNEY LE, LANGSTON JW. Production and disposition of 1-methyl-4-phrnylpyridinium in primary cultures of mouse astrocytes. Glia 1992; 5:48-55.
5. HEIKKILA RE, MANZINO L, CABBAT FS, DUVOISIN RC. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phrnyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 1984; 311:467-469.
6. CHANG FW, WANG SD, LU KT, LEE EHY. Differential interactive effects of gliotoxin and MPTP in the substantia nigra and the locus coeruleus in BALB/c mice. Brain Res Bull 1993; 31:253-266.
7. DIMONTE DA, WU EY, DELANNEY LE, IRWIN I, LANGSTON JW. Toxicity of 1-methyl-4-phrnyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes. J Pharmacol Exp Ther 1992; 261:44-49.
8. JAVITCH JA, D'AMATO RJ, STRITTMATTER SM, SNYDER SH. Parkinsonism- inducing neurotoxin, N-methyl-4-phrnyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 1985; 82:2173-2177.
9. UHL GR. Hypothesis: the role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease. Ann Neurol 1998; 43:555-560.
10. RAMSAY RR, SINGER TP. Energy-dependent uptake of N-methyl-4- phenylpyridium, the neurotoxic metabolite of 1-methyl-4-phrnyl-1,2,3,6- tetrahydropyridine, by mitochondria. J Biol Chem 1986; 261:7585-7587.
11. CASSARINO DS, PARKS JK, PARKER WD, Jr, BENNETT JP, Jr. The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochem Biophys Acta 1999; 1453:49-62.
12. NAKAMURA K, BINDOKAS VP, MARKS JD et al. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol 2000; 58:271-278.
13. + in vivo. Eur J Pharmacol 1993; 243:241-247.
14. SOFIC E, LANGE KW, JELLINGER K, REIDERER P. Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. Neurosci Lett 1992; 142:128-139.
15. GRIFFITH OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Rad Biol Med 1999; 27:922-935.
16. WÜLLNER U, SEYFRIED J, GROSCURTH P et al. Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function. Brain Res 1999; 826:53-62.
17. DABBENI-SALA F, FLOREANI M, FRANCESCHINI D, SKAPER SD, GIUSTI P. Kainic acid inducese selective mitochondrial oxidative phosphorylation enzyme dysfunction in cerebellar granule neurons: protective effects of melatonin and GSH ethyl ester. FASEB J 2001; Doi:10.1096/fj.00-0427fje.
18. JIN BK, SHIN DY, JEONG MY et al. Melatonin protects nigral dopaminergic neurons from N-methyl-4-phenylpyridine (MPP+) neurotoxicity in rats. Neurosci Lett 1998; 245:61-64.
19. MAYO JC, SAINZ RM, URIA H, ANTOLIN I, ESTEBAN MM, RODRIGUEZ C. Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: implications for Parkinson's disease. J Pineal Res 1998; 24:179-192.
20. CHEUNG RTF. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J Pineal Res 2003; 34:153-160.
21. BARLOW-WALDEN LR, REITER RJ, ABE M et al. Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int 1995; 26:497-502.
22. KOTLER M, RODRIGUEZ C, SAINZ RM, ANTOLIN I, MENENDEZ-PELAEZ A. Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J Pineal Res 1998; 24:83-89.
23. +-induced neurodegeneration and glutathione impairment in the nigrostriatal dopaminergic pathway. J Pineal Res 2002; 32:262-269.
24. TAN DX, CHEN LD, POEGGELER B, MANCHESTER LD, REITER RJ. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1993; 1:57-60.
25. ALLEGRA M, REITER RJ, TAN DX, GENTILE C, TESORIERE L, LIVREA MA. The chemistry of melatonin's interaction with reactive species. J Pineal Res 2003; 34:1-10.
26. MAKAR TK, NEDERGAARD M, PREUSS A, GELBARK AS, PERUMAL AS, COOPER AJ. Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J Neurochem 1994; 62:45-53.
27. LAAKKO T, KING L, FRAKER P. Versatility of merocyanine 540 for the flow cytometric detection of apoptosis in human and murine cells. J Immunol Methods 2002; 261:129-139.
28. ANDERSON ME. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 1985; 113:548-555.
29. ROTHE G, VALET G. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin. J Leukoc Biol 1990; 47:440-448.
30. FREY T. Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems. Cytometry 1997; 28:253-263.
31. GÓMEZ C, REIRIZ J, PIQUÉ M, GIL J, FERRER I, AMBROSIO S. Low concentrations of 1-methyl-4-phenylpyridinium ion induce caspase-mediated apoptosis in human SH-SY5Y neuroblastoma cells. J Neurosci Res 2001; 63:421-428.
32. HIRRLINGER J, SCHULZ JB, DRINGEN R. Effects of dopamine on the glutathione metabolism of cultured astroglial cells: implications for Parkinson's disease. J Neurochem 2002; 82:458-467.
33. GARCIA JC, REMIRES D, LEIVA A, GONZALEZ R. Depletion of brain glutathione potentiates the effect of 6-hydroxydopamine in a rat model of Parkinson's disease. J Mol Neurosci 2000; 14:147-153.
34. DRINGEN R. Metabolism and functions of glutathione in brain. Prog Neurobiol 2000; 62:649-671.
35. BLUM D, TORCH S, LAMBENG N et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 2001; 65:135-172.
36. +, oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem 2001; 76:1010-1021.
37. MYHRE O, ANDERSON JM, AARNES H, FONNUM F. Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminal, and lucigenin as indicators of reactive species formation. Biochem Pharmacol 2003; 65:1575-1582.
38. RICE ME, RUSSO-MENNA I. Differential compartmentalization of brain ascorbate and glutathione between neurons and glia. Neuroscience 1998; 82:1213-1223.
39. NAKAMURA K, WANG W, KANH UJ. The role of glutathione in dopaminergic neuronal survival. J Neurochem 1997; 69:1850-1858.
40. TOFFA S, KUNIKOWSKA GM, ZENG BY, JENNER P, MARSDEN CD. Glutathione depletion in rat brain does not cause nigrostriatal pathway degeneration. J Neural Transm 1997; 104:67-75.
41. SEYFRIED J, SOLDNER F, SCHULZ JB, KLOCKGETHER T, KOVAR KA, WULLNER U. Different effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells. Neurosci Lett 1999; 264:1-4.
42. CHUANG JI, CHANG TY, LIU HS. Glutathione depletion-induced apoptosis of Ha-ras-transformed NIH3T3 cells can be prevented by melatonin. Oncogene 2003; 22:1349-1357.
43. MIRKOVIC N, VOEHRINGER DW, STORY MD, MCCONKEY DJ, MCDONNELL TJ, MEYN RE. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols. Oncogene 1997; 15:1461-1470.
44. OISHI T, HASEGAWA E, MURAI Y. Sulfhydryl drugs reduce neurotoxicity of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse. J Neural Transm 1993; 6:45-52.
45. + produces progressive neuronal degeneration which is mediated by oxidative stress. Exp Neurol 1997; 144:193-198.
46. ABSI E, AYALA A, MACHADO A, PARRADO J. Protective effect of melatonin against the 1-Methyl-4-phenyl-pyridinium-induced inhibition of complex I of the mitochondrial respiratory chain. J Pineal Res 2000; 29:40-47.
47. ACUÑA-CASTROVIEJO D, MARTÍN M, MACÍAS M et al. Melatonin, mitochondria, and cellular bioenergetics. J Pineal Res 2001; 30:65-74.
48. PEI Z, CHEUNG RTF. Melatonin protects SHSY5Y neuronal cells but not cultured astrocytes from ischemia due to oxygen and glucose deprivation. J Pineal Res 2003; 34:194-201.
49. CHOI W, LEE E, CHUNG C et al. Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic cells: protective role of Bcl-2. J Neurochem 2001; 77:1531-1541.
50. LOTHARIUS J, DUGAN LL, O'MALLEY KL. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci 1999; 19:1284-1293.
51. VISWANATH V, WU Y, BOONPLUEANG R et al. Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phrnyl-1,2,3,6- tetrahydropyridine-induced Parkinson's disease. J Neurosci 2001; 21:9519-9528.
52. OHGOH M, SHIMIZU H, OGURA H, NISHIZAWA Y. Astroglial trophic support and neuronal cell death: influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured rat cortical neurons. J Neurochem 2000; 75:925-933.
53. HARTMANN A, TROADEC J, HUNOT S et al. Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis. J Neurosci 2001; 21:2247-2255.
54. GLASSFORD A, LEE JE, XU L, GIFFARD RG. Caspase inhibitors reduce the apoptotic but not necrotic component of kainite injury in primary murine cortical neuronal cultures. Neurol Res 2002; 24:796-800.
55. VERCAMMEN D, BEYAERT R, DENECKER G et al. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 1998; 187:1477-1485.
56. LI M, BEG AA. Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells. J Virol 2000; 76: 7470-7477.
57. MAYO JC, SAINZ RM, ANTOLIN I, RODRIGUEZ C. Ultrastructural confirmation of neuronal protection by melatonin against the neurotoxin 6-hydroxydopamine cell damage. Brain Res 1999; 818:221-227.
58. HARMS C, LAUTENSCHLAGER M, BERGK A et al. Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures. FASEB J 2000; 14:1814-1824.
59. KUNDUZOVA OR, ESCOURROU G, SEGUELAS M et al. Prevention of apoptotic and necrotic cell death, caspase-3 activation, and renal dysfunction by melatonin after ischemia/reperfusion. FASEB J 2003; 17:872-874.
60. TANG, YP, MA YL, CHAO CC, CHEN KY, LEE EH. Enhanced glial cell line-derived neruotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments. J Neurosci Res 1998; 53:593-604.
61. ANTOLIN I, RODRIGUEZ C, SAINZ RM et al. Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes. FASEB J 1996; 10:882-890.
62. SHIMOKE K, CHIBA H. Nerve growth factor prevents 1-methyl-4-phrnyl-1,2,3, 6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. J Neurosci Res 2001; 63:402-409.
63. SUGAWARA T, NOSHITA N, LEWEN A et al. Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci 2002; 22:209-217.
64. SHIH AY, JOHNSON DA, WONG G et al. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci 2003; 23:3394-3406.