MtDNA T8993G mutation-induced mitochondrial complex v inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca 2+, and lipid insults in NARP cybrids: A potential therapeutic target for melatonin

Journal of Pineal Research

Volumn 52, Issue 1, 2012, Pages 93-106

  Peng, Tsung I ^a,b   Hsiao, Chia Wei ^c   Reiter, Russel J ^d   Tanaka, Masashi ^e   Lai, Yiu Kay ^c   Jou, Mei Jie ^f  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^f CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

arachidonic acid; Ca 2+; cardiolipin; fission; melatonin; mitochondrial dynamics; mitochondrial movement; mtDNA T8993G; NARP; reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCIUM ION; CARDIOLIPIN; LIPID; MELATONIN; MITOCHONDRIAL COMPLEX V; MITOCHONDRIAL DNA; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL VIABILITY; CYBRID; DRUG TARGETING; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; GENE MUTATION; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IRRADIATION; LEIGH DISEASE; MEMBRANE PERMEABILITY; MOLECULAR DYNAMICS; NARP SYNDROME; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; SKIN FIBROBLAST;

ANALYSIS OF VARIANCE; ARACHIDONIC ACID; C-REACTIVE PROTEIN; CARDIOLIPINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; DNA, MITOCHONDRIAL; GENETIC ENGINEERING; GENETIC TECHNIQUES; HUMANS; MELATONIN; MITOCHONDRIA; MUTATION; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 83555174940     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2011.00923.x     Document Type: Article

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