In vitro and in vivo protection against kainate-induced excitotoxicity by melatonin

Journal of Pineal Research

Volumn 20, Issue 4, 1996, Pages 226-231

  Giusti, Pietro ^a   Franceschini, Davide ^a   Petrone, Marcella ^a   Manev, Hari ^b   Floreani, Maura ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Kainate; Lipid peroxidation; M latonin; Mortality; Rats; ROS

Indexed keywords

ASCORBIC ACID; FERRIC ION; FERRIC SULFATE; KAINIC ACID; MELATONIN; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; BRAIN; BRAIN DISEASE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; LIPID PEROXIDATION; MALE; METABOLISM; MORTALITY; OXIDATIVE STRESS; PATHOLOGY; RAT; SYNAPTOSOME; WISTAR RAT;

ANIMALS; ASCORBIC ACID; BRAIN; BRAIN DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRIC COMPOUNDS; KAINIC ACID; LIPID PEROXIDATION; MALE; MELATONIN; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SYNAPTOSOMES;

EID: 0030136147     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-079X.1996.tb00263.x     Document Type: Article

References (28)

1. BEN-ARI, Y., E. TREMBLAY, O.P. OTTERSEN, R. NAQUET (1979) Evidence suggesting secondary epileptogenic lesions after kainic acid: Pretreatment with diazepam reduces distant but not local damage. Brain Res. 165:362-365.
2. BONDY, S.C., D.K. LEE (1993) Oxidative stress induced by glutamate receptor agonists. Brain Res. 610:229-233.
3. BUEGE, J.A., S.D. AUST (1978) Microsomal lipid peroxidation. Methods Enzymol. 52:302-351.
4. CAGNOLI, C.M., C. ATABAY, A. KHARLAMOV, H. MANEV (1995) Melatonin protects neurons from singlet oxygen-induced apoptosis. J. Pineal Res. 18:222-226.
5. DANIELS, W.M.V., R.J. REITER, D. MELCHIORRI, E. SEWERYNEK, M.I. PABLOS, G.G. ORTIZ (1995) Melatonin counteracts lipid peroxidation induced by carbon tetrachloride but does not restore glucose-6-phosphatase activity. J. Pineal Res. 19:1-6.
6. GIUSTI, P., M. GUSELLA, M. LIPARTITI, D. MILANI, W. ZHU, S. VICINI, H. MANEV (1995) Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity. Exp. Neurol. 131:39-46.
7. KÖHLER, C. (1984) Neuronal degeneration after intracerebral injection of excitotoxins. A histological analysis of kainic acid, ibotenic acid and quinolinic acid lesions in rat. In: Excitotoxins. K. Fuke, P. Robert, R. Schwartz, eds. Plenum Press: New York, pp. 99-111.
8. LEBEL, C.P., S.C. BONDY (1990) Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes. Neurochem. Int. 17:435-440.
9. LIPARTITI, M., D. FRANCESCHINI, R. ZANONI, M. GUSELLA, P. GIUSTI, C.M. CAGNOLI, A. KHARLAMOV, H. MANEV (1996) Neuroprotective effects of melatonin. In: Recent Advances In Tryptophan Researches. G. Allegri Filippini, C. Costa, A. Bertazzo, eds. Plenum Press: New York, in press.
10. LOWRY, O.H., N.J. ROSEBROUGH, A.L. FARR, R.J. RANDALL (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
11. MALLO, C., R. ZAIDAN, G. GALY, E. VERMEULEN, J. BRUN, G. CHAZOT, B. CLAUSTRAT (1989) Pharmakokinetics of melatonin in man after intravenous infusion and bolus injection. Eur. J. Clin. Pharmacol. 38:297-301.
12. MELCHIORRI, D., R.J. REITER, E. SEWERYNEK, L.D. CHEN, G. NISTICÒ (1995) Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. FASEB J. 9:1205-1210.
13. 3H]kainic acid binding sites in rat CNS as determined by autoradiography. Brain Res. 252:91-100.
14. NAKANISHI, S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603.
15. PELLEGRINI-GIAMPIETRO, D.E., E.G. CHERICI, M. ALESIANI, V. CARLA, F. MORONI (1990) Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J. Neurosci. 10:1035-1042.
16. PIERI, C., M. MARRA, F. MORONI, R. RECCHIONI, F. MARCHESELLI (1994) Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci. 55:PL271-PL276.
17. PHILIPS, J.W. (1994) A "radical" view of cerebral injury. Prog. Neurobiol. 42:441-447.
18. POEGGELER, B., S. SAARELA, R.J. REITER, D.-X. TAN, L.-D. CHEN, L.C. MANCHESTER, L.R. BARLOW-WALDEN (1994) Melatonin - A highly potent endogenous radical scavenger and electron donor: New aspect of the oxidation, chemistry of this indole accessed in vitro. Ann. New York Acad. Sci. 738:419-420.
19. PUTTFARCHEN, P.S., R.L. GETZ, J.T. COYLE (1993) Kainic acid-induced lipid peroxidation. protection with butylated hydroxytoluene U7851F in primary cultures of cerebellar granule cells. Brain Res. 624:223-232.
20. REITER, R.J. (1995) Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J. 9:26-34.
21. REITER, R.J., B. POEGGELER, D.X. TAN, L.D. CHEN, L.C. MANCHESTER, J.M. GUERRERO (1993) Antioxidant capacity of melatonin: A novel action not requiring receptor. Neuroendocrinol. Lett. 15:103-116
22. REITER, R.J., D. MELCHIORRI, E. SEWERYNEK, B. POEGGELER, L.R. BARLOW-WALDEN, S.H. CHANG, G.G. ORTIZ, D. ACUA-CASTROVIEJO (1995) A review of the evidence supporting melatonin's role as an antioxidant. J. Pineal Res. 18:1-11.
23. REYNOLDS, I.J., T.G. HASTINGS (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15, 3318-3327
24. SCAIANO, J. C. (1995) Exploratory laser flash photolysis study of free radical reactions and magnetic field effects in melatonin chemistry. J. Pineal Res. 19:189-195.
25. 2-induced lipid peroxidation in homogenates of different rat brain regions. J. Pineal Res. 19:51-56.
26. SPERK, G. (1994) Kainic acid seizures in the rat. Prog. Neurobiol. 42:1-32.
27. TAN, D.X., L.D. CHEN, B. POEGGELER, L.C. MANCHESTER, R.J. REITER (1993) Melatonin:a potent endogenous hydroxyl radical scavenger. Endocrine J. 1:57-60.
28. WHITTAKER, V.P., L.A. BARKER (1972) Methods in Neurochemistry, Vol. 2. R. Fried, ed. Marcel Dekker, Inc.: New York, pp. 1-52.