Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine in the mouse nigrostriatum

Journal of Pineal Research

Volumn 36, Issue 1, 2004, Pages 25-32

  Thomas, Bobby ^a   Mohanakumar, Kochupurackal P ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Endogenous antioxidant molecules and enzymes; Experimental Parkinson's disease; Fenton like reaction; Glutathione; MPP+ induced OH generation in mitochondria; Neuroprotective therapy; Superoxide dismutase

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; GLUTATHIONE; HYDROXYL RADICAL; MELATONIN; NEUROTOXIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CAUDATE NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DEGENERATIVE DISEASE; ENZYME ACTIVITY; FENTON REACTION; MITOCHONDRION; MOUSE; NEUROPROTECTION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PUTAMEN; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CELL-FREE SYSTEM; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; MELATONIN; MICE; MICE, INBRED BALB C; MITOCHONDRIA; OXIDATIVE STRESS; SUBSTANTIA NIGRA; SUPEROXIDE DISMUTASE;

EID: 1642440103     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-079X.2003.00096.x     Document Type: Article

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