Alzheimer β protein mediated oxidative damage of mitochondrial DNA: Prevention by melatonin

Journal of Pineal Research

Volumn 27, Issue 4, 1999, Pages 226-229

  Pappolla, Miguel A ^a,d   Chyan, Y J ^a   Poeggeler, B ^a   Bozner, P ^a   Ghiso, J ^b   LeDoux, S P ^c   Wilson, G L ^c  

^a UNIVERSITY OF SOUTH ALABAMA MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

^d UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer; Amyloid; DNA; Melatonin; Mitochondria; Oxidative stress

Indexed keywords

AMYLOID BETA PROTEIN; FREE RADICAL; MELATONIN; MITOCHONDRIAL DNA;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; DNA DAMAGE; HUMAN; HUMAN CELL; MITOCHONDRION; NEUROBLASTOMA CELL; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROPHYLAXIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANTIOXIDANTS; BASE SEQUENCE; CELL LINE; DNA DAMAGE; DNA PRIMERS; DNA, MITOCHONDRIAL; HUMANS; MELATONIN; OXIDATIVE STRESS;

EID: 0032698216     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-079X.1999.tb00619.x     Document Type: Article

References (25)

1. Behl, C., J.B. Davis, R. Lesley, D. Schubert (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77:817 827.
2. Bohr, V.A., D.S. Okumoto (1988) Analysis of pyrimidine dimer repair in defined genes. In: DNA Repair: A Laboratory Manual of Research Procedures, E.C. Friedberg, P.C. Hanawalt, eds, Vol. 3. Marcel Dekker, New York, pp. 347-366.
3. Bozner, P., V. Grishko, S.P. Ledoux, G.L. Wilson, Y-J. Chyan, M.A. Pappolla (1997) The amyloid β protein induces oxidative damage of mitochondrial DNA. J. Neuropathol. Exp. Neurol. 56:1356-1362.
4. Iversen, L.L., R.J. Mortishire-Smith, S.J. Pollack, M.S. Shearman (1995) The toxicity in vitro of β-amyloid protein. Biochem. J. 311:1-16.
5. Lorenzo, A., B.A. Yankner (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. USA 91:12243-12247.
6. Lyras, L., N.J. Cairns, A. Jenner, P. Jenner, B. Halliwell. (1997) An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J. Neurochem. 68:2061 2069.
7. Mecocci, P., U. MacGarvey, M.F. Beal. (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36:747-751.
8. Ozawa, T. (1997) Genetic and functional changes in mitochondria associated with aging. Physiol. Revs. 77:425-464.
9. Pappolla, M.A., R.A. Omar, K.S. Kim, N.K. Robakis (1992) Immunohistochemical evidence of oxidative stress in Alzheimer's disease. Am. J. Pathol. 140:621-628.
10. Pappolla, M.A., M. Sos, R.A. Omar, R.J. Bick, D.L.M. Hickson-Bick, R.J. Reiter, S. Efthimiopoulos, N.K. Robakis (1997) Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J. Neurosci. 17:1683-1690.
11. Pappolla, M.A., Y-J. Chyan, R.A. Omar, K. Hsiao, G. Perry, M.A. Smith, P. Bozner (1998a) Evidence of oxidative stress and in vivo neurotoxicity of beta amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo. Am. J. Pathol. 152:871 877.
12. Pappolla, M.A., P. Bozner, C. Soto, H. Shao, N. Robakis, M. Zagorski, B. Frangione, J. Ghiso (1998b) Inhibition of Alzheimer β-fibrillogenesis by melatonin. J. Biol. Chem. 273:7185-7189.
13. Pettepher, C.C., S.P. Ledoux, V.A. Bohr, G.L. Wilson (1991) Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptoxotocin. J. Biol. Chem. 266:3113-3117.
14. Pike, C.J., D. Burdick, A.J. Walencewicz, C.G. Glabe, C.W. Cotman (1993) Neurodegeneration induced by α-amyloid peptide in vitro: The role of peptide assembly state. J. Neurosci.
15. Poeggeler, B., R.J. Reiter, D-X. Tan, L.-D. Chen, L.C. Manchester (1993) Melatonin, hydroxyl radicals-mediated oxidative damage and aging. J. Pineal Res. 14:151 168.
16. Poeggeler, B., R.J. Reiter, R. Hardeland, D.-X. Tan, L.R. Barlow-Walden (1996) Melatonin and structurally-related, endogenous indoles act as potent electron donors and radical scavengers in vitro. Redox Report 2:179-184.
17. Reiter, R.J. (1998) Oxidative damage in the central nervous system: Protection by melatonin. Prog. Neurobiol. 56:359-384.
18. Smith, M.A., R.K. Kutty, P.L. Richey, S.D. Yan, D. Stern, G.J. Chader, B. Wiggert, R.B. Petersen, G. Perry (1994) Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am. J. Pathol. 145:42-47.
19. Smith, M.A., K. Hirai, K. Hsiao, M.A. Pappolla, P.L.R. Harris, S.L. Siedlak, M. Tabaton, G. Perry (1998) Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J. Neurochem. 70:2212-2215.
20. Soto, C., E.M. Castano, R.A. Kumar, R.C. Beavis, B. Frangione (1995a) Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure. Neurosci. Lett. 200:105-108.
21. Soto, C., E.M. Castano, B. Frangione, N.C. Inestrosa (1995b) The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation. J. Biol. Chem. 270:3063-3067.
22. Soto, C., B. Frangione (1995) Two conformational states of amyloid beta-peptide: Implications for the pathogenesis of Alzheimer's disease. Neurosci. Lett. 186:115-118.
23. Soto, C., E.M. Castano (1996) The conformation of Alzheimer's beta peptide determines the rate of amyloid formation and its resistance to proteolysis. Biochem. J. 314:701-707.
24. Yake, F.M., Y. Chen, B. Van Houten (1996) PCR-based assay for the detection and quantification of DNA damage and repair. In: Techonolgies for Detection of DNA Damage and Mutation, G.P. Pfeifer, ed. Plenum, New York, pp. 169-182.
25. Yake, F.M., B. Van Houten (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. USA 94:514-579.