Molecular Changes Underlying Reduced Pineal Melatonin Levels in Alzheimer Disease: Alterations in Preclinical and Clinical Stages

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 12, 2003, Pages 5898-5906

  Wu, Ying Hui ^a,b   Feenstra, Matthijs G P ^b   Zhou, Jiang Ning ^a   Liu, Rong Yu ^a   Toranõ, Javier Sastre ^c   Van Kan, Hendrikus J M ^c   Fischer, David F ^b   Ravid, Rivka ^b   Swaab, Dick F ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BETA 1 ADRENERGIC RECEPTOR; BRAIN MONOAMINE; MELATONIN; MESSENGER RNA; SEROTONIN;

ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID LEVEL; CIRCADIAN RHYTHM; COGNITION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NEUROPATHOLOGY; NORADRENERGIC SYSTEM; NUCLEOTIDE SEQUENCE; PINEAL BODY; PRIORITY JOURNAL; SLEEP WAKING CYCLE;

AGED; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; CIRCADIAN RHYTHM; DOPAMINE; HUMANS; HYDROXYINDOLEACETIC ACID; MELATONIN; MONOAMINE OXIDASE; NOREPINEPHRINE; PINEAL GLAND; RECEPTORS, ADRENERGIC, BETA-1; RNA, MESSENGER; SEROTONIN;

EID: 0346732361     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030833     Document Type: Article

References (61)

1. Lebert F, Pasquier F, Petit H 1996 [Behavior assessment in Alzheimer type dementia using the disruptive behavior questionnaire]. Presse Med 25:665-667
2. Pollak CP, Perlick D 1991 Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol 4:204-210
3. Skene DJ, Vivien-Roels B, Sparks DL, Hunsaker JC, Pevet P, Ravid D, Swaab DF 1990 Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease. Brain Res 528:170-174
4. Liu RY, Zhou JN, van Heerikhuize J, Hofman MA, Swaab DF 1999 Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-σ4/4 genotype. J Clin Endocrinol Metab 84:323-327
5. Mishima K, Tozawa T, Satoh K, Matsumoto Y, Hishikawa Y, Okawa M 1999 Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking. Biol Psychiatry 45:417-421
6. Cassone VM, Chesworth MJ, Armstrong SM 1986 Entrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei. Physiol Behav 36:1111-1121
7. Vanecek J, Watanabe K 1999 Mechanisms of melatonin action in the pituitary and SCN. Adv Exp Med Biol 460:191-198
8. Reiter RJ, Tan DX, Osuna C, Gitto E 2000 Actions of melatonin in the reduction of oxidative stress. A review. J Biomed Sci 7:444-458
9. Reiter RJ, Tan DX, Manchester LC, El-Sawi MR 2002 Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging. Ann NY Acad Sci 959:238-250
10. Pappolla MA, Chyan YJ, Poeggeler B, Frangione B, Wilson G, Ghiso J, Reiter RJ 2000 An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease. J Neural Transm 107:203-231
11. Matsubara E, Bryant-Thomas T, Pacheco Quinto J, Henry TL, Poeggeler B, Herbert D, Cruz-Sanchez F, Chyan YJ, Smith MA, Perry G, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson GL, Ghiso J, Williams C, Refolo LM, Pappolla MA 2003 Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. J Neurochem 85:1101-1108.
12. Zhou JN, Liu RY, Kamphorst W, Hofman MA, Swaab DF 2003 Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res 35:125-130
13. Neuwelt EA, Lewy AJ 1983 Disappearance of plasma melatonin after removal of a neoplastic pineal gland. N Engl J Med 308:1132-1135
14. Cardinali DP 1981 Melatonin. A mammalian pineal hormone. Endocr Rev 2:327-346
15. Reiter RJ 1991 Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 12:151-180
16. Brzezinski A 1997 Melatonin in humans. N Engl J Med 336:186-195
17. Borjigin J, Li X, Snyder SH 1999 The pineal gland and melatonin: molecular and pharmacologic regulation. Annu Rev Pharmacol Toxicol 39:53-65
18. Swaab DF, Fliers E, Partiman TS 1985 The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res 342:37-44
19. Liu RY, Zhou JN, Hoogendijk WJ, van Heerikhuize J, Kamphorst W, Unmehopa UA, Hofman MA, Swaab DF 2000 Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression. J Neuropathol Exp Neurol 59:314-322
20. Jengeleski CA, Powers RE, O'Connor DT, Price DL 1989 Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease. Brain Res 481:378-382
21. Van de Nes JA, Kamphorst W, Ravid R, Swaab DF 1998 Comparison of β-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: amorphic plaques and cytoskeletal changes occur independently. Acta Neuropathol (Berl) 96:129-138
22. Braak H, Braak E 1991 Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239-259
23. Braak H, Braak E 1996 Evolution of the neuropathology of Alzheimer's disease. Acta Neurol Scand Suppl 165:3-12
24. Rub U, Del Tredici K, Del Turco D, Braak H 2002 The intralaminar nuclei assigned to the medial pain system and other components of this system are early and progressively affected by the Alzheimer's disease-related cytoskeletal pathology. J Chem Neuroanat 23:279-290
25. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM 1984 Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944
26. Mayeda A, Mannon S, Hofstetter J, Adkins M, Baker R, Hu K, Nurnberger Jr J 1998 Effects of indirect light and propranolol on melatonin levels in normal human subjects. Psychiatry Res 81:9-17
27. Murphy DL, Tamarkin L, Sunderland T, Garrick NA, Cohen RM 1986 Human plasma melatonin is elevated during treatment with the monoamine oxidase inhibitors clorgyline and tranylcypromine but not deprenyl. Psychiatry Res 17:119-127
28. King TS, Richardson BA, Reiter RJ 1982 Regulation of rat pineal melatonin synthesis: effect of monoamine oxidase inhibition. Mol Cell Endocrinol 25: 327-338
29. Ravid R, Van Zwieten EJ, Swaab DF 1992 Brain banking and the human hypothalamus - factors to match for, pitfalls and potentials. Prog Brain Res 93:83-95
30. Lerchl A, Partsch CJ 1994 Reliable analysis of individual human melatonin profiles by complex cosinor analysis. J Pineal Res 16:85-90
31. Hofman MA, Skene DJ, Swaab DF 1995 Effect of photoperiod on the diurnal melatonin and 5-methoxytryptophol rhythms in the human pineal gland. Brain Res 671:254-260
32. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
33. Stanley M, Brown GM 1988 Melatonin levels are reduced in the pineal glands of suicide victims. Psychopharmacol Bull 24:484-488
34. Maywood ES, Hastings MH, Max M, Ampleford E, Menaker M, Loudon AS 1993 Circadian and daily rhythms of melatonin in the blood and pineal gland of free-running and entrained Syrian hamsters. J Endocrinol 136:65-73
35. Feenstra MG, Botterblom MH, van Uum JF 1998 Local activation of metabotropic glutamate receptors inhibits the handling-induced increased release of dopamine in the nucleus accumbensbut not that of dopamine or noradrenaline in the prefrontal cortex: comparison with inhibition of ionotropic receptors. J Neurochem 70:1104-1113
36. Ihalainen JA, Riekkinen Jr P, Feenstra MG 1999 Comparison of dopamine and noradrenaline release in mouse prefrontal cortex, striatum and hippocampus using microdialysis. Neurosci Lett 277:71-74
37. Sambrook J, Russell DW 2001 Molecular cloning: a laboratory manual. 3rd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
38. Vatsis KP, Weber WW 1993 Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus. Arch Biochem Biophys 301:71-76
39. Coon SL, Mazuruk K, Bernard M, Roseboom PH, Klein DC, Rodriguez IR 1996 The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics 34:76-84
40. Debiec-Rychter M, Land SJ, King CM 1999 Histological localization of acetyltransferases in human tissue. Cancer Lett 143:99-102
41. Fowler J, Logan J, Volkow N, Wang G, MacGregor R, Ding Y 2002 Monoamine oxidase: radiotracer development and human studies. Methods 27:263
42. Warrington JA, Nair A, Mahadevappa M, Tsyganskaya M 2000 Comparison of human adult and fetal expression and identification of 535 housekeeping/ maintenance genes. Physiol Genomics 2:143-147
43. Tanna NK, Kohn MI, Horwich DN, Jolles PR, Zimmerman RA, Alves WM, Alavi A 1991 Analysis of brain and cerebrospinal fluid volumes with MR imaging: impact on PET data correction for atrophy. Part II. Aging and Alzheimer dementia. Radiology 178:123-130
44. Ferrari E, Arcaini A, Gornati R, Pelanconi L, Cravello L, Fioravanti M, Solerte SB, Magri F 2000 Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia. Exp Gerontol 35:1239-1250
45. Coon SL, Del Olmo E, Young 3rd WS, Klein DC 2002 Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). J Clin Endocrinol Metab 87:4699-4706
46. Klein DC, Coon SL, Roseboom PH, Weller JL, Bernard M, Gastel JA, Zatz M, Iuvone PM, Rodriguez IR, Begay V, Falcon J, Cahill GM, Cassone VM, Baler R 1997 The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Prog Horm Res 52:307-357; discussion 357-358
47. Gastel JA, Roseboom PH, Rinaldi PA, Weller JL, Klein DC 1998 Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Science 279:1358-1360
48. Sparks DL, Woeltz VM, Markesbery WR 1991 Alterations in brain monoamine oxidase activity in aging, Alzheimer's disease, and Pick's disease. Arch Neurol 48:718-721
49. Sherif F, Gottfries CG, Alafuzoff I, Oreland L 1992 Brain γ-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease. J Neural Transm Park Dis Dement Sect 4:227-240
50. Emilsson L, Saetre P, Balciuniene J, Castensson A, Cairns N, Jazin EE 2002 Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimer's disease patients. Neurosci Lett 326:56-60
51. Takehashi M, Tanaka S, Masliah E, Ueda K 2002 Association of monoamine oxidase A gene polymorphism with Alzheimer's disease and Lewy body variant. Neurosci Lett 327:79-82
52. Hoogendijk WJ, Feenstra MG, Botterblom MH, Gilhuis J, Sommer IE, Kamphorst W, Eikelenboom P, Swaab DF 1999 Increased activity of surviving locus ceruleus neurons in Alzheimer's disease. Ann Neurol 45:82-91
53. Nazarali AJ, Reynolds GP 1992 Monoamine neurotransmitters and their metabolites in brain regions in Alzheimer's disease: a postmortem study. Cell Mol Neurobiol 12:581-587
54. Boschi G, Scherman D, Rips R 1989 Predominant cytosolic distribution of serotonin in rat pineal gland in contrast to biogenic monoamine localization in midbrain and adrenal gland. J Pineal Res 7:23-29
55. Oxenkrug GF, Balon R, Jain AK, McIntyre IM 1988 Melatonin plasma response to MAO inhibitor: influence on human pineal activity? Acta Psychiatr Scand 77:160-162
56. Oxenkrug GF, McIntyre IM, Requintina PJ, Duffy JD 1991 The response of the pineal melatonin biosynthesis to the selective MAO-A inhibitor, clorgyline, in young and middle-aged rats. Prog Neuropsychopharmacol Biol Psychiatry 15:895-902
57. Pfeffer M, Kuhn R, Krug L, Korf HW, Stehle JH 1998 Rhythmic variation in â1-adrenergic receptor mRNA levels in the rat pineal gland: circadian and developmental regulation. Eur J Neurosci 10:2896-2904
58. Moller M, Phansuwan-Pujito P, Morgan KC, Badiu C 1997 Localization and diurnal expression of mRNA encoding the β1-adrenoceptor in the rat pineal gland: an in situ hybridization study. Cell Tissue Res 288:279-284
59. Hofman MA, Swaab DF 1994 Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging. Brain Res 651:134-142
60. Hynd MR, Lewohl JM, Scott HL, Dodd PR 2003 Biochemical and molecular studies using human autopsy brain tissue. J Neurochem 85:543-562
61. Van Someren EJ, Kessler A, Mirmiran M, Swaab DF 1997 Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biol Psychiatry 41:955-963