Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats

European Journal of Pharmacology

Volumn 571, Issue 2-3, 2007, Pages 116-119

  Subramanian, Perumal ^a   Mirunalini, Shankaran ^a   Pandi Perumal, Seithikurippu R ^b   Trakht, Ilya ^b   Cardinali, D P ^c  

^a ANNAMALAI UNIVERSITY   (India)

^b College of Physicians and Surgeons of Columbia University ^*  (United States)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Antioxidants; Brain; Lipid peroxidation; Lipid profile; Liver; Melatonin

Indexed keywords

CATALASE; CHOLESTEROL; FATTY ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID; MELATONIN; PHOSPHOLIPID; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTILIPEMIC AGENTS; ANTIOXIDANTS; BRAIN; CATALASE; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FATTY ACIDS, NONESTERIFIED; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID METABOLISM; LIPID PEROXIDATION; LIVER; MALE; MELATONIN; OXIDATIVE STRESS; PHOSPHOLIPIDS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS; TRIGLYCERIDES;

EID: 34548600128     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.011     Document Type: Article

References (34)

1. Aoyama H., Mori N., and Mori W. Effects of melatonin on genetic hypercholesterolemia in rats. Atherosclerosis 69 (1988) 269-272
2. Chan T.Y., and Tang P.L. Effect of melatonin on the maintenance of cholesterol homeostasis in the rat. Endocr. Res. 21 (1995) 681-696
3. Damian E. The role of the pineal gland in the lipid metabolism. Endocrinologie 16 (1978) 179-189
4. Ellman G.L. Tissue sulphydryl groups. Arch. Biochem. Biophys. 82 (1959) 70-79
5. Emerit J., Edeas M., and Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed. Pharmacother. 58 (2004) 39-46
6. Esquifino A., Agrasal C., Velazquez E., Villanua M.A., and Cardinali D.P. Effect of melatonin on serum cholesterol and phospholipid levels, and on prolactin, thyroid-stimulating hormone and thyroid hormone levels, in hyperprolactinemic rats. Life Sci. 61 (1997) 1051-1058
7. Falhot K., Falhot W., and Lund B. An easy colorimetric method for routine determination of free fatty acids in plasma. Clin. Chim. Acta 19 (1973) 338-392
8. Folch J., and Stanely G.H.S. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226 (1957) 497-509
9. Foster C.S., and Dunn O. A simple method for the isolation and purification of total lipids from animal tissues. Clin. Chim. Acta 19 (1950) 338-340
10. Garcia J.J., Reiter R.J., Guerrero J.M., Escames G., Yu B.P., Oh C.S., and Munoz-Hoyos A. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett. 408 (1997) 297-300
11. Gupta Y.K., Gupta M., and Kohli K. Neuroprotective role of melatonin in oxidative stress vulnerable brain. Indian J. Physiol. Pharmacol. 47 (2003) 373-386
12. Hoyos M., Guerrero J.M., Perez-Cano R., Olivan J., Fabiani F., Garcia-Perganeda A., and Osuna C. Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats. J. Pineal Res. 28 (2000) 150-155
13. Kakkar P., Das B., and Viswanathan A. A modified spectrophotometric assay of superoxide dismutase. Ind. J. Biochem. Biophys. 21 (1984) 130-132
14. Longoni B., Salgo M.G., Pryor W.A., and Marchiafava P.L. Effects of melatonin on lipid peroxidation induced by oxygen radicals. Life Sci. 62 (1998) 853-859
15. Mazepa R.C., Cuevas M.J., Collado P.S., and Gonzalez-Gallego J. Melatonin increases muscle and liver glycogen content in nonexercised and exercised rats. Life Sci. 66 (2000) 153-160
16. Meki A.R., and Hussein A.A. Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney. Comp. Biochem. Physiol., C Toxicol. Pharmacol. 130 (2001) 305-313
17. Mori N., Aoyama H., Murase T., and Mori W. Anti-hypercholesterolemic effect of melatonin in rats. Acta Pathol. Jpn. 39 (1989) 613-618
18. Muller-Wieland D., Behnke B., Koopmann K., and Krone W. Melatonin inhibits LDL receptor activity and cholesterol synthesis in freshly isolated human mononuclear leukocytes. Biochem. Biophys. Res. Commun. 203 (1994) 416-421
19. Nichans W.G., and Samuelsson B. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur. J. Biochem. 6 (1968) 126-130
20. Pandi-Perumal S.R., Srinivasan V., Maestroni G.J.M., Cardinali D.P., Poeggeler B., and Hardeland R. Melatonin: nature's most versatile biological signal?. FEBS J. 273 (2006) 2813-2838
21. Park J.S., Wang M., Park S.J., and Lee S.H. Zinc finger of replication protein A, a non-DNA binding element, regulates its DNA binding activity through redox. J. Biol. Chem. 274 (1999) 29075-29080
22. Reiter R.J., Carneiro R.C., and Oh C.S. Melatonin in relation to cellular antioxidative defense mechanisms. Horm. Metab. Res. 29 (1997) 363-372
23. Reiter R.J., Tan D.X., Pilar T.M., Flores L.J., and Czarnocki Z. Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions. Acta Biochim. Pol. 54 (2007) 1-9
24. Rotruck J.T., Pope A.L., Gauther H.E., Swanson A.B., Hafeman D.G., and Hoekstna W.G. Selenium: biochemical roles as component of glutathione peroxidase. Science 179 (1973) 588-590
25. Sinha K.A. Colorimetric assay of catalase. Anal. Biochem. 47 (1972) 3889-3894
26. Subramanian P., Menon V.P., Arokian F.V., and Rajakrishnan V. Lithium modulates biochemical circadian rhythms in Wistar rats. Chronobiol. Int. 15 (1998) 29-38
27. Tan D.X., Manchester L.C., Terron M.P., Flores L.J., and Reiter R.J. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?. J. Pineal Res. 42 (2007) 28-42
28. Tricoire H., Moller M., Chemineau P., and Malpaux B. Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod. Reprod. Suppl. 61 (2003) 311-321
29. Tunez L., Munoz M.C., Feijoo-Lopez A.L., Valdvira E., Bujalance-Arenas L., and Montilla P. Effect of melatonin on hyperlipidemic nephropathy under constant light exposure. J. Physiol. Biochem. 58 (2002) 109-114
30. Urata Y., Honma S., Goto S., Todoroki S., Iida T., Cho S., Honma K., and Kondo T. Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells. Free Radic. Biol. Med. 27 (1999) 838-847
31. Vaughan M.K., Powanda M.C., Brainard G.C., Johnson L.Y., and Reiter R.J. Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters. Prog. Clin. Biol. Res. 92 (1982) 177-186
32. Vaughan M.K., Richardson B.A., Craft C.M., Powanda M.C., and Reiter R.J. Interaction of ageing, photoperiod and melatonin on plasma thyroid hormones and cholesterol levels in female Syrian hamsters (Mesocricetus auratus). Gerontology 28 (1982) 345-353
33. Zak B., Boyle A.J., and Zlaki A. A new method for the direct determination of serum cholesterol. Lab. Clin. Med. 45 (1953) 486-489
34. Zilversmit D.B., Mc Chandless E.L., and Davis A.K. Micro determination of plasma phospholipids by trichloroacetic acid precipitation. J. Lab. Clin. Med. 35 (1950) 155-158