A possible mechanism for altered immune response in the elderly

In Vivo

Volumn 24, Issue 4, 2010, Pages 471-487

  Mazzoccoli, Gianluigi ^a   De Cata, Angelo ^a   Carughi, Stefano ^a   Greco, Antonio ^a   Inglese, Michele ^a   Perfetto, Federico ^b   Tarquini, Roberto ^b  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Ageing; Lymphocyte populations; Neuroedocrine immune system

Indexed keywords

CD20 ANTIBODY; GROWTH HORMONE; HYDROCORTISONE; INTERLEUKIN 2; MELATONIN; PROTIRELIN; SOMATOMEDIN C; THYROTROPIN; THYROXINE;

AGED; ARTICLE; BLOOD SAMPLING; CD25+ T LYMPHOCYTE; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENDOCRINE GLAND; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; LYMPHOCYTE SUBPOPULATION; MALE; NORMAL HUMAN;

EID: 77955873724     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Van Coevorden A: Neuroendocrine rhythms and sleep in aging men. Am J Physiol 23: E651-E661, 1991.
2. Waldhauser F, Weiszenbacher G, Tatzer E, Gisingep B, Waldhauser M, Schemper M and Frisch H: Alterations in nocturnal serum melatonin levels in humans with growth and aging. J Clin Endocrinol Metab 66: 648-652, 1988. (Pubitemid 18076019)
3. Fauci AS and Dale DC: The effect of in vivo hydrocortisone on subpopulations of human lymphocytes. J Clin Invest 53: 240-246, 1974.
4. Fauci AS: Mechanism of corticosteroid function on lymphocyte subpopulations.I. Redistribution of circulating T and B lymphocytes to the bone marrow. Immunology 28: 669-680, 1975.
5. Charo IF and Ransohoff RM: The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354: 610-621, 2006.
6. Pownall R and Knapp MS: Immune responses have rhythms: Are they important? Immunol Today 10: 7-10, 1980.
7. Bradya RC, Treanorb JJ, Atmarc RL, Keitelc WA, Edelmand R, Chend WH, Winokure P, Belshef R, Grahamf IL, Noahg DL, Guoh K and Hillh H: Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults. Vaccine 27: 5091-5095, 2009.
8. Nelson W, Tong YL and Halberg F: Methods for cosinorrhy thmometry. Chronobiologia 6: 305-323, 1979.
9. st century: Optimizing protection of older adults. Vaccine 2: 5043-5053, 2009.
10. Glück R, Mischler R, Finkel B, Que JU, Cryz SJ Jr. and Scarpa B: Immunogenicity of new virosome influenza vaccine in elderly people. Lancet 344: 160-163, 1994.
11. Conne P, Gauthey L, Vernet P, Althaus B, Que JU, Finkel B, Glück R and Cryz SJ Jr.: Immunogenicity of trivalent subunit versus virosome-formulated influenza vaccines in geriatric patients. Vaccine 15: 1675-1679, 1997.
12. Mazzoccoli G, Correra M, Bianco G, De Cata A, Balzanelli M, Giuliani A and Tarquini R: Age-related changes of neuroendocrine-immune interactions in healthy humans. J Biol Reg Hom Agents 11: 143-147, 1997.
13. Calderon RA and Thomas DB: In vivo cyclic change in B-lymphocyte susceptibility to T-cell control. Nature 285: 662-664, 1980.
14. Ritchie AW, Oswald I, Miclem HS, Boyd JE, Elton RA, Jazwinska E and James K: Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies. B M J 286: 1773-1775, 1983. (Pubitemid 13096185)
15. Mazzoccoli G, Giuliani A, Carughi S, De Cata A, Puzzolante F, La Viola M, Urbano N, Perfetto F and Tarquini R: The hypothalamic-pituitary-thyroid axis and melatonin in humans: possible interactions in the control of body temperature. Neuroendocrinol Lett 25: 368-372, 2004.
16. Moore RY and Klein DC: Visual pathways and the central neural control of a circadian rhythm in pineal serotonin-N-acetyltransferase activity. Brain Res 71: 17-33, 1974.
17. Brzezinski A: Melatonin in humans. N Engl J Med 16: 186-195, 1997.
18. Rosenthal NE: Plasma melatonin as a measure of the human clock. J Clin Endocrinol Metab 73: 225-226, 1991.
19. Mazzoccoli G, Bianco G, Correra M, Carella AM, Balzanelli M, Giuliani A and Tarquini R: Circadian variation of lymphocyte subsets in healthy subjects. Rec Prog Med 89: 569-572, 1998.
20. Maestroni GJM, Conti A and Pierpaoli W: Melatonin antagonizes the immunosoppressive effect of acute stress via an opiatergic mechanism. Immunology 63: 465-469, 1988.
21. + cells to release opioid agonist(s) with immunoenhancing and anti-stress properties. J Neuroimmunol 28: 167-176, 1990.
22. Clark R: The somatogenic hormones and insulin-like growth factor-1: stimulators of lymphopoiesis and immune function. Endocrine Rev 18: 157-179, 1997.
23. Ginaldi L, De Martinis M, Modesti M, Loreto F and Quaglino D: Immunophenotypical changes of T lymphocytes in the elderly. Gerontology 46: 242-248, 2000.
24. Mazzoccoli M, Grilli M, Carughi S, Puzzolante F, De Cata A, La Viola M, Giuliani A, Urbano N, Tarquini R and Perfetto F: Immune system alterations in lung cancer patients. Int J Immunopathol Pharmacol 16: 167-174, 2003. (Pubitemid 36850857)
25. Mazzoccoli G, Balzanelli M, Giuliani A, De Cata A, La Viola M, Carella AM, Bianco G and Tarquini R: Lymphocyte subpopulations anomalies in lung cancer patients and relationship to the stage of disease. In Vivo 3: 205-209, 1999.
26. Born J, Lange T, Hansen K, Molle M and Fehm HL: Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol 158: 4454-4464, 1997. (Pubitemid 127483950)
27. Born J, Uthgenannt D, Dodt C, Nunninghoff D, Ringvolt E, Wagner T and Fehm HL: Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep. Mech Ageing Dev 84: 113-126, 1995.
28. - lymphocytes. Immunology 70: 351-356, 1990.
29. Sleasman JW, Morimoto C, Schlossman SF and Tedder TF: The role of functionally distinct helper T lymphocyte subpopulations in the induction of human B-cell differentiation. Eur J Immunol 20: 1357-1366, 1990.
30. Macintyre EA and Sigaux F: T-Cell receptor γδ: current state of knowledge and potential clinical applications in haematology. Br J Haematol 73: 2-5, 1989.
31. Bensussan A, Lagabrielle JF and Degos L: TcRγδ bearing lymphocyte clones with lymphokine activated killer activity against autologous leukemic cells. Blood 15: 135-139, 1989.
32. Klecha AJ, Genaro AM, Gorelik G, Barreiro Arco ML, Silberman DM, Schuman M, Garcia SI, Pirola C and Cremaschi GA: Integrative study of hypothalamus-pituitary-thyroid-immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway. J Endocrinol 189: 45-55, 2006.
33. Zhao ZY, Xie Y, Fu YR , Bogdan A and Touitou Y: Aging and the circadian rhythm of melatonin: a cross-sectional study of Chinese subjects 30-110 yr of age. Chronobiology Int 19: 1171-1182, 2002.
34. Schwartz RS: Diversity of the immune repertoire and immunoregulation. N Engl J Med 348: 1017-1026, 2003.
35. Létourneau S, Krieg C, Pantaleo G and Boyman O: IL-2- and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets. J All Clin Immunol 123: 758-762, 2009.
36. de Bernardi di Valserra M, Zanasi A, Ragusa S, Glück R and Herzog C: An open-label comparison of the immunogenicity and tolerability of intranasal and intramuscular formulations of virosomal influenza vaccine in healthy adults. Clin Ther 24: 100-111, 2002. (Pubitemid 34117527)
37. Saurwein-Teissla M, Stegera MM, Glückb R, Cryzb R and Grubeck-Loebensteina B: Influenza vaccination in a healthy geriatric population: preferential induction of antibodies specific for the H3N2 influenza strain despite equal T-cell responsiveness to all vaccine strains. Vaccine 16: 196-200, 1998.
38. de Bruijn IA, Nauta J, Gerez L and Palache AM: Virosomal influenza vaccine: a safe and effective influenza vaccine with high efficacy in elderly and subjects with low pre-vaccination antibody titers. Virus Res 103: 139-145, 2004.
39. de Bruijn IA, Nauta J, Cramer WCM, Gerez L and Palache AM: Clinical experience with inactivated, virosomal influenza vaccine. Vaccine 23: S39-S49, 2005.
40. Arnoua R, Icardib G, De Deckerc M, Ambrozaitisd A, Kazeke MP, Webere F and Van Dammef P: Intradermal influenza vaccine for older adults: A randomized controlled multicenter phase III study. Vaccine 27: 7304-7312, 2009.
41. Künzia V, Klapb JM, Seiberlingc MK, Herzoga C, Hartmanna K, Kürsteinera O, Kompierb R, Roberto G and Goudsmitb J: Immunogenicity and safety of low dose virosomal adjuvanted influenza vaccine administered intradermally compared to intramuscular full dose administration. Vaccine 27: 3561-3567, 2009.
42. Dimitrov S, Benedict C, Heutling D, Westermann J, Born J and Lange T: Cortisol and epinephrine control opposing circadian rhythms in T-cell subsets. Blood 113: 5134-5143, 2009.
43. Mazzoccoli G, Vendemiale G, La Viola M, De Cata A, Carughi S, Greco A, Balzanelli M and Tarquini R: Circadian variations of cortisol, melatonin and lymphocyte subpopulations in geriatric age. Int J Immunopathol Pharmacol 23: 251-258, 2010.
44. Nishimura Y, Maeda M, Kumagai N, Hayashi H, Miura Y and Otsuki T: Decrease in phosphorylation of ERK following decreased expression of NK cell-activating receptors in human NK cell line exposed to asbestos. Int J Immunopathol Pharmacol 22: 879-885, 2009.
45. Felaco P, Castellani ML, De Lutiis MA, Felaco M, Pandolci F, Salini V, De Amicis D, Vecchiet J, Tete S, Ciampoli C, Conti F, Cerulli G, Caraffa A, Antinolfi P, Cuccurullo C, Perrella A, Theoharides TC, Conti P, Toniato E, Kempuraj D and Shaik YB: IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents 23: 141-146, 2009.