Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons

Chronobiology International

Volumn 17, Issue 3, 2000, Pages 419-432

  Mishima, K ^a   Okawa, M ^b   Hozumi, S ^b   Hishikawa, Y ^b  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MELATONIN;

AGED; AGING; AUTONOMIC NERVOUS SYSTEM; CASE REPORT; CHRONOBIOLOGY; CIRCADIAN RHYTHM; DEMENTIA; FEMALE; HUMAN; INSOMNIA; LIGHT EXPOSURE; NEUROENDOCRINE SYSTEM; REVIEW; SLEEP DEPRIVATION; SLEEP WAKING CYCLE; SUPRACHIASMATIC NUCLEUS;

AGED; CIRCADIAN RHYTHM; DEMENTIA; HUMANS; INSTITUTIONALIZATION; MELATONIN; NEUROSECRETORY SYSTEMS; PHOTOTHERAPY; SLEEP DISORDERS;

MAMMALIA;

EID: 0034129506     PISSN: 07420528     EISSN: None     Source Type: Journal    
DOI: 10.1081/CBI-100101055     Document Type: Review

References (85)

1. Aharon-Peretz J, Masiah A, Pillar T et al. 1991. Sleep-wake cycles in multi-infarct dementia and dementia of the Alzheimer type. Neurology. 41:1616-19.
2. Ancoli-Israel S, Clopton P, Klauber MR et al. 1997. Use of wrist activity for monitoring sleep/wake in demented nursing-home patients. Sleep. 20(1):24-27.
3. Ancoli-Israel S, Klauber MR, Jones DW et al. 1997. Variations in circadian rhythms of activity, sleep, and light exposure related to dementia in nursing-home patients. Sleep. 20:18-23.
4. Bliwise DL. 1993. Sleep in normal aging and dementia. Sleep. 16:40-81.
5. Brusco LI, Fainstein I, Marquez M et al. 1999. Effect of melatonin in selected populations of sleep-disturbed patients. Biol Signals Recept. 8:126-31.
6. Brusco LI, Marquez M, Cardinali DP. 1998. Monozygotic twins with Alzheimer's disease treated with melatonin: case report. J Pineal Res. 25:260-63.
7. Cagnacci A, Elliott JA, Yen SS. 1992. Melatonin: a major regulator of the circadian rhythm of core temperature in humans. J Clin Endocrinol Metab. 75:447-52.
8. Cagnacci A, Soldani R, Romagnolo C et al. 1994. Melatonin-induced decrease of body temperature in women: a threshold event. Neuroendocrinology. 60:549-52.
9. Campbell SS, Gillin JC, Kripke DF et al. 1989. Gender differences in the circadian temperature rhythms of healthy elderly subjects: relationships to sleep quality. Sleep. 12:529-36.
10. Campbell SS, Kripke DF, Gillin JC et al. 1988. Exposure to light in healthy elderly subjects and Alzheimer's patients. Physiol Behav. 42:141-44.
11. Campbell SS, Terman M, Lewy AJ et al. 1995. Light treatment for sleep disorders: consensus report. V. Age-related disturbances. J Biol Rhythms. 10:151-54.
12. Carrier J, Monk TH, Reynolds CF et al. 1999. Are age differences in sleep due to phase differences in the output of the circadian timing system? Chronobiol Int. 16:79-91.
13. Cohen RA, Albers HE. 1991. Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: a case study. Neurology. 41:726-29.
14. Czeisler CA, Duffy JF, Shanahan TL et al. 1999. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science. 284:2177-81.
15. Czeisler CA, Kronauer RE, Allan JS et al. 1989. Bright light induction of strong (type 0) resetting of the human circadian pacemaker. Science. 244:1328-33.
16. Czeisler CA, Weitzman ED, Moore EM et al. 1980. Human sleep: its duration and organization depend on its circadian phase. Science. 210:1264-67.
17. Davis FC, Viswanathan N. 1998. Stability of circadian timing with age in Syrian hamsters. Am J Physiol. 275:R960-68.
18. Deuschle M, Gotthardt U, Schweiger U et al. 1997. With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens. Life Sci. 61:2239-46.
19. Dollins AB, Zhdanova IV, Wurtman RJ et al. 1994. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA. 91:1824-28.
20. Dori D, Casale G, Solerte SB et al. 1994. Chrono-neuroendocrinological aspects of physiological aging and senile dementia. Chronobiologia. 21:121-26.
21. Duffy JF, Dijk DJ, Hall EF et al. 1999. Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people. J Investig Med. 47:141-50.
22. Garfinkel D, Laudon M, Nof D et al. 1995. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet. 346:541-44.
23. Gottlieb GL. 1990. Sleep disorders and their management. Special considerations in the elderly. Am J Med. 88:29S-33S.
24. Haimov I, Laudon M, Zisapel N et al. 1994. Sleep disorders and melatonin rhythms in elderly people. BMJ. 309:167.
25. Haimov I, Lavie P, Laudon M et al. 1995. Melatonin replacement therapy of elderly insomniacs. Sleep. 18:598-603.
26. Hartmann A, Veldhuis JD, Deuschle M et al. 1997. Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation. Neurobiol Aging. 18: 285-89.
27. Hashimoto S, Kohsaka M, Nakamura K et al. 1997. Midday exposure to bright light changes the circadian organization of plasma melatonin rhythm in humans. Neurosci Lett. 221:89-92.
28. Heuser U, Gotthardt U, Schweiger U et al. 1994. Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender. Neurobiol Aging. 15:227-31.
29. Hoogendijk WJ, Van Someren EJW, Mirmiran M et al. 1996. Circadian rhythm-related behavioral disturbances and structural hypothalamic changes in Alzheimer's disease. Int Psychogeriatr. 3:245-52.
30. Hurd MW, Ralph MR. 1998. The significance of circadian organization for longevity in the golden hamster. J Biol Rhythms. 13:430-36.
31. Jean Louis G, Zizi F, Von Gizycki H et al. 1998. Effects of melatonin in two individuals with Alzheimer's disease. Percept Mot Skills. 87:331-39.
32. Klarsfeld A, Rouyer F. 1998. Effects of circadian mutations and LD periodicity on the life span of Drosophila melanogaster. J Biol Rhythms. 13:471-78.
33. Lewy AJ, Ahmed S, Jackson JM et al. 1992. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol Int. 9:380-92.
34. Lieberman HR, Waldhauser F, Garfield G et al. 1984. Effects of melatonin on human mood and performance. Brain Res. 323:201-7.
35. Liu RY, Zhou JN, Van Heerikhuize J et al. 1999. Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype. J Clin Endocrinol Metab. 84:323-27.
36. Lovell BB, Ancoli IS, Gevirtz R. 1995. Effect of bright light treatment on agitated behavior in institutionalized elderly subjects. Psychiatry Res. 57:7-12.
37. McArthur AJ, Gillette MU, Prosser RA. 1991. Melatonin directly resets the rat suprachiasrnatic circadian clock in vitro. Brain Res. 565:158-61.
38. Minors DS, Waterhouse JM, Wirz-Justice A. 1991. A human phase-response curve to light. Neurosci Lett. 133:36-40.
39. Mirmiran M, Swaab DF, Kok JH et al. 1992. Circadian rhythms and the suprachiasmatic nucleus in perinatal development, aging and Alzheimer's disease. Prog Brain Res. 93:151-62.
40. Mishima K, Hishikawa Y. 1997. Chronotherapy for circadian rhythm disorders in elderly patients with dementia. In: Hayaishi O, Inoue S, editors. Sleep and sleep disorders: from molecule to behavior. Kyoto: Academic, pp. 177-91.
41. Mishima K, Hishikawa Y, Okawa M. 1998. Randomized, dim-light controlled, cross-over test of morning bright-light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer's type. Chronobiol Int. 15:647-54.
42. Mishima K, Okawa M, Hishikawa Y et al. 1994. Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia. Acta Psychiatr Scand. 89: 1-7.
43. Mishima K, Okawa M, Satoh K et al. 1995. Bright light as a regulator of biological rhythms in elderly patients with dementia. Sleep Res. 24A:530.
44. Mishima K, Okawa M, Satoh K et al. 1997. Different manifestations of circadian rhythms in senile dementia of Alzheimer's type and multi-infarct dementia. Neurobiol Aging. 18:105-9.
45. Mishima K, Satoh K, Shimizu T et al. 1997. Hypnotic and hypothermic action of daytime-administered melatonin. Psychopharmacology Berl. 133:168-71.
46. Mishima K, Tozawa T, Satoh K et al. 1999. Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking. Biol Psychiatry. 45:417-21.
47. Monk TH, Buysse DJ, Reynolds CF et al. 1995. Circadian temperature rhythms of older people. Exp Gerontol. 30:455-74.
48. Nadal M, Wikstrom L, Ruthstrom L. 1994. Secretory pattern of vasopressin in plasma and cerebrospinal fluid of patients with dementia and of two control groups. Eur J Endocrinol. 130:346-49.
49. Niijima A, Nagai K, Nagai N et al. 1993. Effects of light stimulation on the activity of the autonomic nerves in anesthetized rats. Physiol Behav. 54:555-61.
50. Okawa M, Mishima K, Hishikawa Y et al. 1991. Circadian rhythm disorders in sleep-waking and body temperature in elderly patients with dementia and their treatment. Sleep. 14:478-85.
51. Okawa M, Uchiyama M, Shirakawa S et al. 1993. Favourable effects of combined treatment with vitamin B12 and bright light for sleep-wake rhythm disorders. In: Kumar M, Mallick HN, Nayar U, editors. Sleep-wakefulness. New Delhi: Wiley Eastern Limited, pp. 71-77.
52. Okumoto Y, Koyama E, Matsubara H et al. 1998. Sleep improvement by light in a demented aged individual. Psychiatry Clin Neurosci. 52:194-96.
53. Pat HR, Klauber MR, Shochat T et al. 1998. Hourly profiles of sleep and wakefulness in severely versus mild-moderately demented nursing home patients. Aging Milano. 10:308-15.
54. Penev PD, Kolker DE, Zee PC et al. 1998. Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease. Am J Physiol. 275:H2334-37.
55. Pollak CP, Stokes PE. 1997. Circadian rest-activity rhythms in demented and nondemented older community residents and their caregivers. J Am Geriatr Soc. 45: 446-52.
56. Porter NM, Landfield PW. 1998. Stress hormones and brain aging: adding injury to insult? [news; comment]. Nat Neurosci. 1:3-4.
57. Prinz PN, Christie C, Smallwood R et al. 1984. Circadian temperature variation in healthy aged and in Alzheimer's disease. J Gerontol. 39:30-35.
58. Prinz PN, Moe KE, Vitiello MV et al. 1992. Entrained body temperature rhythms are similar in mild Alzheimer's disease, geriatric onset depression, and normal aging. J Geriatr Psychiatry Neurol. 5:65-71.
59. Prinz PN, Peskind ER, Vitaliano PP et al. 1982. Changes in the sleep and waking EEGs of nondemented and demented elderly subjects. J Am Geriatr Soc. 30:86-93.
60. Reynolds CF, Kupfer DJ, Taska LS et al. 1985. EEG sleep in elderly depressed, demented, and healthy subjects. Biol Psychiatry. 20:431-42.
61. Saito Y, Shimizu T, Takahashi Y et al. 1996. Effect of bright light exposure on muscle sympathetic nerve activity in human. Neurosci Lett. 219:135-37.
62. Sapolsky RM. 1996. Why stress is bad for your brain. Science. 273:749-50.
63. Satlin A, Teicher MH, Lieberman HR et al. 1991. Circadian locomotor activity rhythms in Alzheimer's disease. Neuropsychopharmacology. 5:115-26.
64. Satlin A, Volicer L, Ross V et al. 1992. Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer's disease. Am J Psychiatry. 149:1028-32.
65. Satlin A, Volicer L, Stopa EG et al. 1995. Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease. Neurobiol Aging. 16:765-71.
66. Seeman TE, Robbins RJ. 1994. Aging and hypothalamic-pituitary-adrenal response to challenge in humans. Endocr Rev. 15:233-60.
67. Skene DJ, Vivien RB, Sparks DL et al. 1990. Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease. Brain Res. 528:170-74.
68. Stopa EG, Volicer L, Kuo LV et al. 1999. Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia. J Neuropathol Exp Neurol. 58:29-39.
69. Swaab DF, Fliers E, Partiman TS 1985. The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res. 342:37-44.
70. Tohgi H, Abe T, Takahashi S et al. 1992. Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia. Neurosci Lett. 141:9-12.
71. Touitou Y, Fevre M, Bogdan A et al. 1984. Patterns of plasma melatonin with ageing and mental condition: stability of nyctohemeral rhythms and differences in seasonal variations. Acta Endocrinol Copenh. 106:145-51.
72. Touitou Y, Reinberg A, Bogdan A et al. 1986. Age-related changes in both circadian and seasonal rhythms of rectal temperature with special reference to senile dementia of Alzheimer type. Gerontology. 32:110-18.
73. Tozawa T, Mishima K, Satoh K et al. 1998. Melatonin replacement therapy for rest-activity rhythm disorders in patients with senile dementia of Alzheimer's type. Neurobiol Aging. 19:S182.
74. Uchida K, Okamoto N, Ohara K et al. 1996. Daily rhythm of serum melatonin in patients with dementia of the degenerate type. Brain Res. 717:154-59.
75. Van Someren EJW, Hagebeuk EE, Lijzenga C et al. 1996. Circadian rest-activity rhythm disturbances in Alzheimer's disease. Biol Psychiatry. 40:259-70.
76. Van Someren EJW, Kessler A, Mirmiran M et al. 1997. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biol Psychiatry. 41:955-63.
77. Van Someren EJW, Swaab DF, Colenda CC et al. 1999. Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods. Chronobiol Int. 16:505-18.
78. Vitiello MV, Bliwise DL, Prinz PN. 1992. Sleep in Alzheimer's disease and the sundown syndrome. Neurology. 42:83-93.
79. Vitiello MV, Poceta JS, Prinz PN. 1991. Sleep in Alzheimer's disease and other dementing disorders. Can J Psychol. 45:221-39.
80. Waldhauser F, Saletu B, Trinchard LI. 1990. Sleep laboratory investigations on hypnotic properties of melatonin. Psychopharmacology Berl. 100:222-26.
81. Weitzman ED, Moline ML, Czeisler CA et al. 1982. Chronobiology of aging: temperature, sleep-wake rhythms and entrainment. Neurobiol Aging. 3:299-309.
82. Wever RA. 1979. The circadian system of man. Results of experiments under temporal isolation. Berlin: Springer-Verlag.
83. Witting W, Kwa IH, Eikelenboom P et al. 1990. Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease. Biol Psychiatry. 27:563-72.
84. Zhdanova IV, Wurtman RJ, Lynch HJ et al. 1995. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther. 57:552-58.
85. Zulley J, Wever R, Aschoff J. 1981. The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature. Pflugers Arch. 391:314-18.