Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 12, 2000, Pages 6739-6744

  Heiser, Volker ^a   Scherzinger, Eberhard ^a   Boeddrich, Annett ^a   Nordhoff, Eckhard ^a   Lurz, Rudi ^a   Schugardt, Nancy ^a   Lehrach, Hans ^a   Wanker, Erich E ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

Glutamine repeat; Inhibition

Indexed keywords

AMYLOID BETA PROTEIN; GOSSYPOL; HUNTINGTIN; MELATONIN; MONOCLONAL ANTIBODY; RIFAMPICIN; THIOFLAVINE;

ANIMAL CELL; ARTICLE; CELL NUCLEUS INCLUSION BODY; CELL STRAIN COS1; CONTROLLED STUDY; DEGENERATIVE DISEASE; FIBER; HUNTINGTON CHOREA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; BENZOATES; BIPHENYL COMPOUNDS; CONGO RED; COS CELLS; GOSSYPOL; HUMANS; HUNTINGTON DISEASE; MELATONIN; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; RIFAMPIN; THIAZOLES;

EID: 0034612220     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.110138997     Document Type: Article

References (28)

1. Harper, P. S. (1991) Huntington's Disease (Saunders, Philadelphia).
2. Vonsattel, J.-P., Meyers, R. H., Stevens, T. J., Ferrante, R. J., Bird, E. D. & Richardson, E. P. (1985) J. Neuropathol. Exp. Neurol. 44, 559-577.
3. Scherzinger, E., Lurz, R., Turmaine, M., Mangiarini, L., Hollenbach, B., Hasenbank, R., Bates, G. P., Davies, S. W., Lehrach, H. & Wanker, E. E. (1997) Cell 90, 549-558.
4. Davies, S. W., Trumaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L. & Bates, G. P. (1997) Cell 90, 537-548.
5. Warrick, J. M., Paulson, H. L., Gray-Board, G. L., Bui, Q. T., Fischbeck, K. H., Pittman, R. N. & Bonini, N. M. (1998) Cell 93, 939-949.
6. Lunkes, A. & Mandel, J. L. (1998) Hum. Mol. Genet. 7, 1355-1361.
7. DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P. & Aronin, N. (1997) Science 277, 1990-1993.
8. Ona, V. O., Li, M., Vonsattel, J. P., Andrews, L. J., Khan, S. Q., Chung, W. M., Frey, A. S., Menon, A. S., Li, X. J., Stieg, P. E., et al. (1999) Nature (London) 399, 263-267.
9. Perez, M. K., Paulson, H. L., Pendse, S. J., Saionz, S. J., Bonini, N. M. & Pittman, R. N. (1998) J. Cell Biol. 143, 1457-1470.
10. Cummings, C. J., Mancini, M. A., Antalffy, B., DeFranco, D. B., Orr, H. T. & Zoghbi, H. Y. (1998) Nat. Genet. 19, 148-154.
11. Sanchez, I., Xu, C.-J., Juo, P., Kakizuka, A., Blenis, J. & Yuan, J. (1999) Neuron 22, 623-633.
12. Maniatis, T., Fritsch, E. F. & Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
13. Sittler, A., Walter, S., Wedemeyer, N., Hasenbank, R., Scherzinger, E., Eickhoff, H., Bates, G. P., Lehrach, H. & Wanker, E. E. (1998) Mol. Cell 2, 427-436.
14. Wanker, E. E., Scherzinger, E., Heiser, V., Sittler, A., Eickhoff, H. & Lehrach, H. (1999) Methods Enzymol. 309, 375-386.
15. Scherzinger, E., Sittler, A., Schweiger, K., Heiser, V., Lurz, R., Hasenbank, R., Bates, G. P., Lehrach, H. & Wanker, E. E. (1999) Proc. Natl. Acad. Sci. USA 96, 4604-4609.
16. Trottier, Y., Lutz, Y., Stevanin, G., Imbert, G., Devys, D., Cancel, G., Saudou, F., Weber, C., David, G., Tora, L., et al. (1995) Nature (London) 378, 403-406.
17. Sittler, A., Devys, D., Weber, C. & Mandel, J. L. (1996) Hum. Mol. Gen. 5, 95-102.
18. Miroy, G. J., Lai, Z., Lashuel, H. A., Peterson, S. A., Strang, C. & Kelly, J. W. (1996) Proc. Natl. Acad. Sci. USA 93, 15051-15056.
19. Merry, D. E., Kobayashi, Y., Bailey, C. K., Taye, A. A. & Fischbeck, K. H. (1998) Hum. Mol. Genet. 7, 693-701.
20. Caughey, B. & Race, R. E. (1992) J. Neurochem. 59, 768-771.
21. Tomiyama, T., Shoji, A., Kataoka, K., Suwa, Y., Asano, S., Kaneko, H. & Endo, N. (1996) J. Biol. Chem. 271, 6839-6844.
22. Pappolla, M., Bozner, P., Soto, C., Shao, H., Robakis, N. K., Zagorski, M., Frangione, B. & Ghiso, J. (1998) J. Biol. Chem. 273, 7185-7188.
23. Medrano, F. J. & Andreu, J. M. (1986) Eur. J. Biochem. 158, 63-69.
24. Guntern, R., Bouras, C., Hof, P. R. & Vallet, P. G. (1992) Experientia 48, 8-10.
25. LeVine, H., III (1993) Protein Sci. 2, 404-410.
26. Hollenbach, B., Scherzinger, E., Schweiger, K., Lurz, R., Lehrach, H. & Wanker, E. E. (1999) Philos. Trans. R. Soc. London B 354, 991-994.
27. Klunk, W. E., Debnath, M. L., Karos, A. M. & Pettegrew, J. W. (1998) Life Sci. 63, 1807-1814.
28. Perutz, M. F., Johnson, T., Suzuki, M. & Finch, J. T. (1994) Proc. Natl. Acad. Sci. USA 91, 5355-5358.