Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review

International Journal of Geriatric Psychiatry

Volumn 25, Issue 12, 2010, Pages 1201-1208

  De Jonghe, A ^a   Korevaar, J C ^a   Van Munster, B C ^a   De Rooij, S E ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

circadian rhythm disturbance; delirium; dementia; melatonin; systematic review

Indexed keywords

MELATONIN;

AGITATION; CIRCADIAN RHYTHM SLEEP DISORDER; CLINICAL TRIAL; DELIRIUM; DEMENTIA; DRUG EFFICACY; DRUG TOLERABILITY; HUMAN; RATING SCALE; REVIEW; SLEEP; SYSTEMATIC REVIEW;

AGED; AGED, 80 AND OVER; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CIRCADIAN RHYTHM; DELIRIUM; DEMENTIA; FEMALE; HUMANS; MALE; MELATONIN; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMOTOR AGITATION; SLEEP; SLEEP DISORDERS, CIRCADIAN RHYTHM;

EID: 78649647585     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2454     Document Type: Review

References (53)

1. Asayama K, Yamadera H, Ito T, Suzuki H, Kudo Y, Endo S,. 2003. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch 70 (4): 334-341.
2. Bachman D, Rabins P,. 2006. Sundowning and other temporally associated agitation states in dementia patients. Annu Rev Med 57: 499-511.
3. Bliwise DL,. 1993. Development of an agitated behavior rating scale for discrete temporal observations. Lee, K.A. J Nurs Meas 1: 115-124. Ref Type: Generic.
4. Brusco LI, Marquez M, Cardinali DP,. 1998. Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease. Neuro Endocrinol Lett 19 (3): 111-115.
5. Brzezinski A,. 1997. Melatonin in humans. N Engl J Med 336 (3): 186-195.
6. Cardinali DP, Brusco LI, Liberczuk C, Furio AM,. 2002. The use of melatonin in Alzheimer's disease. Neuro Endocrinol Lett 23 (Suppl 1): 20-23.
7. Caumo W, Torres F, Moreira NL Jr, et al., 2007. The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesth Analg 105 (5): 1263-1271 table.
8. Cohen-Mansfield J, Billig N,. 1986. Agitated behaviors in the elderly. I. A conceptual review. J Am Geriatr Soc 34 (10): 711-721.
9. Cohen-Mansfield J, Marx MS, Rosenthal AS,. 1989. A description of agitation in a nursing home. J Gerontol 44 (3): M77-M84.
10. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J,. 1994. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 44 (12): 2308-2314.
11. Dawson D, Encel N,. 1993. Melatonin and sleep in humans. J Pineal Res 15 (1): 1-12.
12. Dowling GA, Burr RL, Van Someren EJ, et al., 2008. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr Soc 56 (2): 239-246.
13. Ely EW, Inouye SK, Bernard GR, et al., 2001. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286 (21): 2703-2710.
14. Evans LK,. 1987. Sundown syndrome in institutionalized elderly. J Am Geriatr Soc 35 (2): 101-108.
15. Fong TG, Jones RN, Shi P, et al., 2009. Delirium accelerates cognitive decline in Alzheimer disease. Neurology 72 (18): 1570-1575.
16. Francis J, Kapoor WN,. 1992. Prognosis after hospital discharge of older medical patients with delirium. J Am Geriatr Soc 40 (6): 601-606.
17. Francis J, Martin D, Kapoor WN,. 1990. A prospective study of delirium in hospitalized elderly. JAMA 263 (8): 1097-1101.
18. Gallagher-Thompson D, Brooks JO III, Bliwise D, Leader J, Yesavage JA,. 1992. The relations among caregiver stress, sundowning symptoms, and cognitive decline in Alzheimer's disease. J Am Geriatr Soc 40 (8): 807-810.
19. Gehrman PR, Connor DJ, Martin JL, Shochat T, Corey-Bloom J, Ncoli-Israel S,. 2009. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am J Geriatr Psychiatry 17 (2): 166-169.
20. Haffmans PM, Sival RC, Lucius SA, Cats Q, van GL,. 2001. Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study. Int J Geriatr Psychiatry 16 (1): 106-110.
21. Haimov I, Lavie P, Laudon M, Herer P, Vigder C, Zisapel N,. 1995. Melatonin replacement therapy of elderly insomniacs. Sleep 18 (7): 598-603.
22. Hanania M, Kitain E,. 2002. Melatonin for treatment and prevention of postoperative delirium. Anesth Analg 94 (2): 338-339 table.
23. Hess CW,. 1997. Sleep disorders and dementia. Praxis (Bern. 1994.) 86 (35): 1343-1349.
24. Huskisson EC,. Measurement of pain. Lancet 2 (7889): 1127-1131 9-11- 1974. Ref Type: Generic.
25. Lebert F, Pasquier F, Petit H,. 1996. Sundowning syndrome in demented patients without neuroleptic therapy. Arch Gerontol Geriatr 22 (1): 49-54.
26. Lewis MC, Barnett SR,. 2004. Postoperative delirium: the tryptophan dyregulation model. Med Hypotheses 63 (3): 402-406.
27. Maestroni GJ,. 1993. The immunoneuroendocrine role of melatonin. J Pineal Res 14 (1): 1-10.
28. Magri F, Sarra S, Cinchetti W, et al., 2004. Qualitative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians. J Pineal Res 36 (4): 256-261.
29. Mahlberg R, Kunz D, Sutej I, Kuhl KP, Hellweg R,. 2004. Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy. J Clin Psychopharmacol 24 (4): 456-459.
30. Mishima K, Okawa M, Hozumi S, Hishikawa Y,. 2000. Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons. Chronobiol Int 17 (3): 419-432.
31. Ohashi Y, Okamoto N, Uchida K, Iyo M, Mori N, Morita Y,. 1997. Differential pattern of the circadian rhythm of serum melatonin in young and elderly healthy subjects. Biol Signals 6 (4-6): 301-306.
32. Okawa M, Mishima K, Hishikawa Y, Hozumi S, Hori H, Takahashi K,. 1991. Circadian rhythm disorders in sleep-waking and body temperature in elderly patients with dementia and their treatment. Sleep 14 (6): 478-485.
33. Olofsson K, Alling C, Lundberg D, Malmros C,. 2004. Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients. Acta Anaesthesiol Scand 48 (6): 679-684.
34. Reiter RJ, Tan DX, Pappolla MA,. 2004. Melatonin relieves the neural oxidative burden that contributes to dementias. Ann N Y Acad Sci 1035: 179-196.
35. Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, Van Someren EJ,. 2008. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA 299 (22): 2642-2655.
36. Robinson TN, Raeburn CD, Angles EM, Moss M,. 2008. Low tryptophan levels are associated with postoperative delirium in the elderly. Am J Surg 196 (5): 670-674.
37. Rockwood K, Cosway S, Carver D, Jarrett P, Stadnyk K, Fisk J,. 1999. The risk of dementia and death after delirium. Age Ageing 28 (6): 551-556.
38. Rosen WG, Mohs RC, Davis KL,. 1984. A new rating scale for Alzheimer's disease. Am J Psychiatry 141 (11): 1356-1364.
39. Sack RL, Lewy AJ, Erb DL, Vollmer WM, Singer CM,. 1986. Human melatonin production decreases with age. J Pineal Res 3 (4): 379-388.
40. Serfaty M, Kennell-Webb S, Warner J, Blizard R, Raven P,. 2002. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry 17 (12): 1120-1127.
41. Shigeta H, Yasui A, Nimura Y, et al., 2001. Postoperative delirium and melatonin levels in elderly patients. Am J Surg 182 (5): 449-454.
42. Shochat T, Haimov I, Lavie P,. 1998. Melatonin-the key to the gate of sleep. Ann Med 30 (1): 109-114.
43. Singer C, Tractenberg RE, Kaye J, et al., 2003. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep 26 (7): 893-901. (Pubitemid 39610638)
44. Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP,. 2008. Therapeutic actions of melatonin in cancer: possible mechanisms. Integr Cancer Ther 7 (3): 189-203.
45. Stopa EG, Volicer L, Kuo-Leblanc V, et al., 1999. Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia. J Neuropathol Exp Neurol 58 (1): 29-39.
46. Uchida K, Aoki T, Ishizuka B,. 1999. Postoperative delirium and plasma melatonin. Med Hypotheses 53 (2): 103-106.
47. van der Mast RC, van den Broek WW, Fekkes D, Pepplinkhuizen L, Habbema JD,. 2000. Is delirium after cardiac surgery related to plasma amino acids and physical condition? J Neuropsychiatry Clin Neurosci 12 (1): 57-63.
48. Van Someren EJ, Hagebeuk EE, Lijzenga C, et al., 1996. Circadian rest-activity rhythm disturbances in Alzheimer's disease. Biol Psychiatry 40 (4): 259-270.
49. Volicer L, Harper DG, Manning BC, Goldstein R, Satlin A,. 2001. Sundowning and circadian rhythms in Alzheimer's disease. Am J Psychiatry 158 (5): 704-711.
50. Wewers ME, Lowe NK,. 1990. A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health 13 (4): 227-236.
51. Wick JY, Zanni GR,. 2005. Sundowning: disruptive behavior with many causes. Consult Pharm 20 (11): 947-961.
52. Wu YH, Swaab DF,. 2005. The human pineal gland and melatonin in aging and Alzheimer's disease. J Pineal Res 38 (3): 145-152.
53. Wu YH, Swaab DF,. 2007. Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. Sleep Med 8 (6): 623-636.