메뉴 건너뛰기




Volumn 51, Issue 5, 2011, Pages 967-977

The role of free radical generation in increasing cerebrovascular permeability

Author keywords

Arachidonic acid; Blood brain barrier; Bradykinin; Free radicals; NADPH oxidase; Penumbra; Phospholipase A 2

Indexed keywords

ARACHIDONIC ACID; BRADYKININ; CYTOCHROME P450; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FREE RADICAL; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; LIPOXYGENASE; LYSOPHOSPHATIDIC ACID; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; RECEPTOR FOR ADVANCED GLYCATION END PRODUCT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

EID: 80051667284     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.06.003     Document Type: Review
Times cited : (128)

References (143)
  • 1
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • DOI 10.1124/pr.57.2.4
    • B.T. Hawkins, and T.P. Davis The blood-brain barrier/neurovascular unit in health and disease Pharmacol. Rev. 57 2005 173 185 (Pubitemid 41043883)
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 2
    • 0036319341 scopus 로고    scopus 로고
    • Aquaporin water channels and endothelial cell function
    • DOI 10.1046/j.1469-7580.2002.00058.x
    • A.S. Verkman Aquaporin water channels and endothelial cell function J. Anat. 200 2002 617 627 (Pubitemid 34823053)
    • (2002) Journal of Anatomy , vol.200 , Issue.6 , pp. 617-627
    • Verkman, A.S.1
  • 3
    • 77953687856 scopus 로고    scopus 로고
    • Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier
    • D.S. Miller Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier Trends Pharmacol. Sci. 31 2010 246 254
    • (2010) Trends Pharmacol. Sci. , vol.31 , pp. 246-254
    • Miller, D.S.1
  • 4
    • 48249092633 scopus 로고    scopus 로고
    • All vertebrates started out with a glial blood-brain barrier 4-500 million years ago
    • M. Bundgaard, and N.J. Abbott All vertebrates started out with a glial blood-brain barrier 4-500 million years ago Glia 56 2008 699 708
    • (2008) Glia , vol.56 , pp. 699-708
    • Bundgaard, M.1    Abbott, N.J.2
  • 5
    • 0025259756 scopus 로고
    • Measurement of filtration coefficient in single cerebral microvessels of the frog
    • P.A. Fraser, A.D. Dallas, and S. Davies Measurement of filtration coefficient in single cerebral microvessels of the frog J. Physiol. 423 1990 343 361 (Pubitemid 20137762)
    • (1990) Journal of Physiology , vol.423 , pp. 343-361
    • Fraser, P.A.1    Dallas, A.D.2
  • 6
    • 0013934801 scopus 로고
    • Filtration and reflection coefficients of the rabbit blood-brain barrier
    • J.D. Fenstermacher, and J.A. Johnson Filtration and reflection coefficients of the rabbit blood-brain barrier Am. J. Physiol. 211 1966 341 346
    • (1966) Am. J. Physiol. , vol.211 , pp. 341-346
    • Fenstermacher, J.D.1    Johnson, J.A.2
  • 7
    • 0017354247 scopus 로고
    • Filtration and diffusion of water across the blood-brain barrier in man
    • O.B. Paulson, M.M. Hertz, T.G. Bolwig, and N.A. Lassen Filtration and diffusion of water across the blood-brain barrier in man Microvasc. Res. 13 1977 113 124
    • (1977) Microvasc. Res. , vol.13 , pp. 113-124
    • Paulson, O.B.1    Hertz, M.M.2    Bolwig, T.G.3    Lassen, N.A.4
  • 9
    • 0021195723 scopus 로고
    • Water flow across the walls of single muscle capillaries in the frog, Rana pipiens
    • F.E. Curry, and J. Froekjaer-Jensen Water flow across the walls of single muscle capillaries in the frog Rana pipiens J. Physiol. 350 1984 293 307 (Pubitemid 14057434)
    • (1984) Journal of Physiology , vol.350 , pp. 293-307
    • Curry, F.E.1    Frokjaer-Jensen, J.2
  • 11
    • 0001521079 scopus 로고
    • Free radicals in biological materials
    • B. Commoner, J. Townsend, and G.E. Pake Free radicals in biological materials Nature 174 1954 689 691
    • (1954) Nature , vol.174 , pp. 689-691
    • Commoner, B.1    Townsend, J.2    Pake, G.E.3
  • 12
    • 0014678527 scopus 로고
    • Electron spin resonance signals in injured nerve
    • B. Commoner, J.C. Woolum, and E. Larsson Electron spin resonance signals in injured nerve Science 165 1969 703 704
    • (1969) Science , vol.165 , pp. 703-704
    • Commoner, B.1    Woolum, J.C.2    Larsson, E.3
  • 14
    • 0017852672 scopus 로고
    • Free radicals in cerebral ischemia
    • E.S. Flamm, H.B. Demopoulos, M.L. Seligman, R.G. Poser, and J. Ransohoff Free radicals in cerebral ischemia Stroke 9 1978 445 447 (Pubitemid 8389070)
    • (1978) Stroke , vol.9 , Issue.5 , pp. 445-447
    • Flamm, E.S.1    Demopoulos, H.B.2    Seligman, M.L.3
  • 15
    • 19544376509 scopus 로고    scopus 로고
    • Free radicals as triggers of brain edema formation after stroke
    • J.H. Heo, S.W. Han, and S.K. Lee Free radicals as triggers of brain edema formation after stroke Free Radic. Biol. Med. 39 2005 51 70
    • (2005) Free Radic. Biol. Med. , vol.39 , pp. 51-70
    • Heo, J.H.1    Han, S.W.2    Lee, S.K.3
  • 16
    • 0021363366 scopus 로고
    • Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals
    • P.H. Chan, J.W. Schmidley, R.A. Fishman, and S.M. Longar Brain injury edema and vascular permeability changes induced by oxygen-derived free radicals Neurology 34 1984 315 320 (Pubitemid 14173207)
    • (1984) Neurology , vol.34 , Issue.3 , pp. 315-320
    • Chan, P.H.1    Schmidley, J.W.2    Fishman, R.A.3    Longar, S.M.4
  • 17
    • 0026782517 scopus 로고
    • Pathophysiology and treatment of focal cerebral ischemia. Part II. Mechanisms of damage and treatment
    • B.K. Siesjö Pathophysiology and treatment of focal cerebral ischemia. Part II. Mechanisms of damage and treatment J. Neurosurg. 77 1992 337 354
    • (1992) J. Neurosurg. , vol.77 , pp. 337-354
    • Siesjö, B.K.1
  • 18
    • 0001731522 scopus 로고
    • NN-dimethylthiourea dioxide formation from NN-dimethylthiourea reflects hydrogen peroxide concentrations in simple biological systems
    • W.E. Curtis, M.E. Muldrow, N.B. Parker, R. Barkley, S.L. Linas, and J.E. Repine NN-dimethylthiourea dioxide formation from NN-dimethylthiourea reflects hydrogen peroxide concentrations in simple biological systems Proc. Natl. Acad. Sci. U. S. A. 85 1988 3422 3425
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 3422-3425
    • Curtis, W.E.1    Muldrow, M.E.2    Parker, N.B.3    Barkley, R.4    Linas, S.L.5    Repine, J.E.6
  • 19
    • 0023223364 scopus 로고
    • 1- antiproteinase against inactivation by hypochlorous acid
    • M. Wasil, B. Halliwell, M. Grootveld, C.P. Moorhouse, D.C. Hutchison, and H. Baum The specificity of thioureadimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals: their protection of alpha 1-antiproteinase against inactivation by hypochlorous acid Biochem. J. 243 1987 867 870 (Pubitemid 17073729)
    • (1987) Biochemical Journal , vol.243 , Issue.3 , pp. 867-870
    • Wasil, M.1    Halliwell, B.2    Grootveld, M.3
  • 20
    • 0025259173 scopus 로고
    • Dimethylthiourea reduces ischemic brain edema without affecting cerebral blood flow
    • D. Martz, M. Beer, and A.L. Betz Dimethylthiourea reduces ischemic brain edema without affecting cerebral blood flow J. Cereb. Blood Flow Metab. 10 1990 352 357 (Pubitemid 20144614)
    • (1990) Journal of Cerebral Blood Flow and Metabolism , vol.10 , Issue.3 , pp. 352-357
    • Martz, D.1    Beer, M.2    Betz, A.L.3
  • 23
    • 0027446546 scopus 로고
    • Three openings of the blood-brain barrier produced by forebrain ischemia in the rat
    • DOI 10.1016/0304-3940(93)90351-K
    • E. Preston, G. Sutherland, and A. Finsten Three openings of the blood-brain barrier produced by forebrain ischemia in the rat Neurosci. Lett. 149 1993 75 78 (Pubitemid 23022134)
    • (1993) Neuroscience Letters , vol.149 , Issue.1 , pp. 75-78
    • Preston, E.1    Sutherland, G.2    Finsten, A.3
  • 24
    • 53749096762 scopus 로고    scopus 로고
    • Blood-brain barrier tight junction permeability and ischemic stroke
    • K.E. Sandoval, and K.A. Witt Blood-brain barrier tight junction permeability and ischemic stroke Neurobiol. Dis. 32 2008 200 219
    • (2008) Neurobiol. Dis. , vol.32 , pp. 200-219
    • Sandoval, K.E.1    Witt, K.A.2
  • 27
    • 0028128974 scopus 로고
    • Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats
    • G.Y. Yang, and A.L. Betz Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats Stroke 25 1994 1658 1664
    • (1994) Stroke , vol.25 , pp. 1658-1664
    • Yang, G.Y.1    Betz, A.L.2
  • 28
    • 0030049467 scopus 로고    scopus 로고
    • Amelioration of impaired cerebral metabolism after severe acidotic ischemia by tirilazad posttreatment in dogs
    • H. Kim, R.C. Koehler, P.D. Hurn, E.D. Hall, and R.J. Traystman Amelioration of impaired cerebral metabolism after severe acidotic ischemia by tirilazad post treatment in dogs Stroke 27 1996 114 121 (Pubitemid 26008305)
    • (1996) Stroke , vol.27 , Issue.1 , pp. 114-121
    • Kim, H.1    Koehler, R.C.2    Hurn, P.D.3    Hall, E.D.4    Traystman, R.J.5
  • 29
    • 0028117133 scopus 로고
    • Tirilazad treatment does not decrease early brain injury after transient focal ischemia in cats
    • R. Takeshima, J.R. Kirsch, R.C. Koehler, and R.J. Traystman Tirilazad treatment does not decrease early brain injury after transient focal ischemia in cats Stroke 25 1994 670 676 (Pubitemid 24067084)
    • (1994) Stroke , vol.25 , Issue.3 , pp. 670-676
    • Takeshima, R.1    Kirsch, J.R.2    Koehler, R.C.3    Traystman, R.J.4
  • 31
    • 0024515257 scopus 로고
    • Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats
    • D. Martz, G. Rayos, G.P. Schielke, and A.L. Betz Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats Stroke 20 1989 488 494 (Pubitemid 19117376)
    • (1989) Stroke , vol.20 , Issue.4 , pp. 488-494
    • Martz, D.1    Rayos, G.2    Schielke, G.P.3    Betz, A.L.4
  • 33
    • 4844223991 scopus 로고    scopus 로고
    • Early blood-brain barrier disruption in human focal brain ischemia
    • DOI 10.1002/ana.20199
    • L.L. Latour, D.W. Kang, M.A. Ezzeddine, J.A. Chalela, and S. Warach Early blood-brain barrier disruption in human focal brain ischemia Ann. Neurol. 56 2004 468 477 (Pubitemid 39319336)
    • (2004) Annals of Neurology , vol.56 , Issue.4 , pp. 468-477
    • Latour, L.L.1    Kang, D.-W.2    Ezzeddine, M.A.3    Chalela, J.A.4    Warach, S.5
  • 34
    • 7644223379 scopus 로고    scopus 로고
    • Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption
    • DOI 10.1161/01.STR.0000144051.32131.09
    • S. Warach, and L.L. Latour Evidence of reperfusion injury exacerbated by thrombolytic therapy in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption Stroke 35 11 Suppl. 1 2004 2659 2661 (Pubitemid 39458362)
    • (2004) Stroke , vol.35 , Issue.11 SUPPL. 1 , pp. 2659-2661
    • Warach, S.1    Latour, L.L.2
  • 35
    • 36248937189 scopus 로고    scopus 로고
    • Novel technique for estimating cerebrovascular permeability demonstrates capsazepine protection following ischemia-reperfusion
    • DOI 10.1080/10739680701410421, PII 782597523
    • V. Gauden, D.-E. Hu, T. Kurokawa, M.H. Sarker, and P.A. Fraser Novel technique for estimating cerebrovascular permeability demonstrates capsazepine protection following ischemia-reperfusion Microcirculation 14 2007 767 778 (Pubitemid 350131386)
    • (2007) Microcirculation , vol.14 , Issue.8 , pp. 767-778
    • Gauden, V.1    Hu, D.-E.2    Kurokawa, T.3    Sarker, M.H.4    Fraser, P.A.5
  • 37
    • 79251610937 scopus 로고    scopus 로고
    • Acute NADPH oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia-reperfusion
    • A. Woodfin, D.-E. Hu, M.H. Sarker, T. Kurokawa, and P.A. Fraser Acute NADPH oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia-reperfusion Free Radic. Biol. Med. 50 2011 518 524
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 518-524
    • Woodfin, A.1    Hu, D.-E.2    Sarker, M.H.3    Kurokawa, T.4    Fraser, P.A.5
  • 38
    • 0020567603 scopus 로고
    • Blood flow and vascular reactivity in collaterally perfused brain tissue. Evidence of an ischemic penumbra in patients with acute stroke
    • T.S. Olsen, B. Larsen, M. Herning, E.B. Skriver, and N.A. Lassen Blood flow and vascular reactivity in collaterally perfused brain tissue: evidence of an ischemic penumbra in patients with acute stroke Stroke 14 1983 332 341 (Pubitemid 13100309)
    • (1983) Stroke , vol.14 , Issue.3 , pp. 332-341
    • Olsen, T.S.1    Larsen, B.2    Herning, M.3
  • 39
    • 77952547253 scopus 로고    scopus 로고
    • Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator
    • R. Jin, G. Yang, and G. Li Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator Neurobiol. Dis. 38 2010 376 385
    • (2010) Neurobiol. Dis. , vol.38 , pp. 376-385
    • Jin, R.1    Yang, G.2    Li, G.3
  • 41
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • DOI 10.1016/S0166-2236(99)01401-0, PII S0166223699014010
    • U. Dirnagl, C. Iadecola, and M.A. Moskowitz Pathobiology of ischaemic stroke: an integrated view Trends Neurosci. 22 1999 391 397 (Pubitemid 29453643)
    • (1999) Trends in Neurosciences , vol.22 , Issue.9 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 42
    • 68549112966 scopus 로고    scopus 로고
    • Optimal duration of acquisition for dynamic perfusion CT assessment of blood-brain barrier permeability using the Patlak model
    • J. Hom, J.W. Dankbaar, T. Schneider, S.C. Cheng, J. Bredno, and M. Wintermark Optimal duration of acquisition for dynamic perfusion CT assessment of blood-brain barrier permeability using the Patlak model Am. J. Neuroradiol. 30 2009 1366 1370
    • (2009) Am. J. Neuroradiol. , vol.30 , pp. 1366-1370
    • Hom, J.1    Dankbaar, J.W.2    Schneider, T.3    Cheng, S.C.4    Bredno, J.5    Wintermark, M.6
  • 43
    • 78149362554 scopus 로고    scopus 로고
    • Increased blood-brain barrier permeability on perfusion CT might predict malignant middle cerebral artery infarction
    • H. Bektas, T.C. Wu, M. Kasam, N. Harun, C.W. Sitton, J.C. Grotta, and S.I. Savitz Increased blood-brain barrier permeability on perfusion CT might predict malignant middle cerebral artery infarction Stroke 41 2010 2539 2544
    • (2010) Stroke , vol.41 , pp. 2539-2544
    • Bektas, H.1    Wu, T.C.2    Kasam, M.3    Harun, N.4    Sitton, C.W.5    Grotta, J.C.6    Savitz, S.I.7
  • 45
    • 0029101066 scopus 로고
    • Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: Possible implication in tissue damage
    • E. Lancelot, J. Callebert, M.L. Revaud, R.G. Boulu, and M. Plotkine Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: possible implication in tissue damage Neurosci. Lett. 197 1995 85 88
    • (1995) Neurosci. Lett. , vol.197 , pp. 85-88
    • Lancelot, E.1    Callebert, J.2    Revaud, M.L.3    Boulu, R.G.4    Plotkine, M.5
  • 46
    • 0029112937 scopus 로고
    • Detection of free radical activity during transient global ischemia and recirculation: Effects of intra ischemic brain temperature modulation
    • M.Y. Globus, R. Busto, B. Lin, H. Schnippering, and M.D. Ginsberg Detection of free radical activity during transient global ischemia and recirculation: effects of intra ischemic brain temperature modulation J. Neurochem. 65 1995 1250 1256
    • (1995) J. Neurochem. , vol.65 , pp. 1250-1256
    • Globus, M.Y.1    Busto, R.2    Lin, B.3    Schnippering, H.4    Ginsberg, M.D.5
  • 47
    • 0345735607 scopus 로고    scopus 로고
    • Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke
    • DOI 10.1016/j.freeradbiomed.2003.09.013
    • M. Yamato, T. Egashira, and H. Utsumi Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke Free Radic. Biol. Med. 35 2003 1619 1631 (Pubitemid 37532913)
    • (2003) Free Radical Biology and Medicine , vol.35 , Issue.12 , pp. 1619-1631
    • Yamato, M.1    Egashira, T.2    Utsumi, H.3
  • 49
    • 42249088093 scopus 로고    scopus 로고
    • Reconciling the chemistry and biology of reactive oxygen species
    • DOI 10.1038/nchembio.85, PII NCHEMBIO85
    • C.C. Winterbourn Reconciling the chemistry and biology of reactive oxygen species Nat. Chem. Biol. 4 2008 278 286 (Pubitemid 351550893)
    • (2008) Nature Chemical Biology , vol.4 , Issue.5 , pp. 278-286
    • Winterbourn, C.C.1
  • 50
    • 67650153191 scopus 로고    scopus 로고
    • Involvement of ROS in BBB dysfunction
    • P.B. Pun, J. Lu, and S. Moochhala Involvement of ROS in BBB dysfunction Free. Radic. Res. 43 2009 348 364
    • (2009) Free. Radic. Res. , vol.43 , pp. 348-364
    • Pun, P.B.1    Lu, J.2    Moochhala, S.3
  • 52
    • 50949088772 scopus 로고    scopus 로고
    • Sites of generation of reactive oxygen species in homogenates of brain tissue determined with the use of respiratory substrates and inhibitors
    • A.P. Kudin, D. Malinska, and W.S. Kunz Sites of generation of reactive oxygen species in homogenates of brain tissue determined with the use of respiratory substrates and inhibitors Biochim. Biophys. Acta 1777 2008 689 695
    • (2008) Biochim. Biophys. Acta , vol.1777 , pp. 689-695
    • Kudin, A.P.1    Malinska, D.2    Kunz, W.S.3
  • 53
  • 54
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • DOI 10.1152/physrev.00044.2005
    • K. Bedard, and K.H. Krause The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology Physiol. Rev. 87 2007 245 313 (Pubitemid 46209993)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 245-313
    • Bedard, K.1    Krause, K.-H.2
  • 56
    • 0032498922 scopus 로고    scopus 로고
    • Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells
    • DOI 10.1016/S0006-8993(97)01407-8, PII S0006899397014078
    • J.W. Beetsch, T.S. Park, L.L. Dugan, A.R. Shah, and J.M. Gidday Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells Brain Res. 786 1998 89 95 (Pubitemid 28191717)
    • (1998) Brain Research , vol.786 , Issue.1-2 , pp. 89-95
    • Beetsch, J.W.1    Park, T.S.2    Dugan, L.L.3    Shah, A.R.4    Gidday, J.M.5
  • 58
    • 0021952697 scopus 로고
    • Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries
    • DOI 10.1111/j.1471-4159.1985.tb05451.x
    • A.L. Betz Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries J. Neurochem. 44 1985 574 579 (Pubitemid 15196094)
    • (1985) Journal of Neurochemistry , vol.44 , Issue.2 , pp. 574-579
    • Betz, A.L.1
  • 59
    • 70449334334 scopus 로고    scopus 로고
    • The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke: A randomized trial
    • J. Dawson, T.J. Quinn, C. Harrow, K.R. Lees, and M.R. Walters The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke: a randomized trial Br. J. Clin. Pharmacol. 68 2009 662 668
    • (2009) Br. J. Clin. Pharmacol. , vol.68 , pp. 662-668
    • Dawson, J.1    Quinn, T.J.2    Harrow, C.3    Lees, K.R.4    Walters, M.R.5
  • 61
    • 0026753661 scopus 로고
    • Vasogenic brain edema induced by arachidonic acid: Role of extracellular arachidonic acid in blood-brain barrier dysfunction
    • T. Ohnishi, J.B. Posner, and W.R. Shapiro Vasogenic brain edema induced by arachidonic acid: role of extracellular arachidonic acid in blood-brain barrier dysfunction Neurosurgery 30 1992 545 551
    • (1992) Neurosurgery , vol.30 , pp. 545-551
    • Ohnishi, T.1    Posner, J.B.2    Shapiro, W.R.3
  • 62
    • 0021951751 scopus 로고
    • Intravital fluorescence microscopy for the study of blood-brain-barrier function
    • M. Wahl, A. Unterberg, and A. Baethmann Intravital fluorescence microscopy for the study of blood-brain-barrier function Int. J. Microcirc. Clin. Exp. 4 1985 3 18
    • (1985) Int. J. Microcirc. Clin. Exp. , vol.4 , pp. 3-18
    • Wahl, M.1    Unterberg, A.2    Baethmann, A.3
  • 64
    • 0023553284 scopus 로고
    • In vivo studies of pial vascular permeability to sodium fluorescein: Absence of alterations by bradykinin, histamine, serotonin, or arachidonic acid
    • M. Watanabe, and W.I. Rosenblum In vivo studies of pial vascular permeability to sodium fluorescein: absence of alterations by bradykinin histamine serotonin or arachidonic acid Stroke 18 1987 1157 1159 (Pubitemid 18014488)
    • (1987) Stroke , vol.18 , Issue.6 , pp. 1157-1159
    • Watanabe, M.1    Rosenblum, W.I.2
  • 65
    • 0024330086 scopus 로고
    • Cerebral edema induced by arachidonic acid: Role of leukocytes and 5-lipoxygenase products
    • S.M. Papadopoulos, K.L. Black, and J.T. Hoff Cerebral edema induced by arachidonic acid: role of leukocytes and 5-lipoxygenase products Neurosurgery 25 1989 369 372 (Pubitemid 19224354)
    • (1989) Neurosurgery , vol.25 , Issue.3 , pp. 369-372
    • Papadopoulos, S.M.1    Black, K.L.2    Hoff, J.T.3
  • 66
    • 0027261055 scopus 로고
    • Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat
    • N.K. Boughton-Smith, A.M. Deakin, R.L. Follenfant, B.J. Whittle, and L.G. Garland Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat Br. J. Pharmacol. 110 1993 896 902 (Pubitemid 23279310)
    • (1993) British Journal of Pharmacology , vol.110 , Issue.2 , pp. 896-902
    • Boughton-Smith, N.K.1    Deakin, A.M.2    Follenfant, R.L.3    Whittle, B.J.R.4    Garland, L.G.5
  • 67
    • 0023553072 scopus 로고
    • Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats
    • M.H. Yen, and S.H. Lee Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats Eur. J. Pharmacol. 144 1987 369 373
    • (1987) Eur. J. Pharmacol. , vol.144 , pp. 369-373
    • Yen, M.H.1    Lee, S.H.2
  • 68
    • 0030662964 scopus 로고    scopus 로고
    • Two components of blood-brain barrier disruption in the rat
    • DOI 10.1111/j.1469-7793.1997.613bg.x
    • A.S. Easton, M.H. Sarker, and P.A. Fraser Two components of blood-brain barrier disruption in the rat J. Physiol. 503 1997 613 623 (Pubitemid 27496672)
    • (1997) Journal of Physiology , vol.503 , Issue.3 , pp. 613-623
    • Easton, A.S.1    Sarker, M.H.2    Fraser, P.A.3
  • 69
    • 0032030807 scopus 로고    scopus 로고
    • Arachidonic acid increases cerebral microvascular permeability by free radicals in single pial microvessels of the anaesthetized rat
    • DOI 10.1111/j.1469-7793.1998.541bt.x
    • A.S. Easton, and P.A. Fraser Arachidonic acid increases cerebral microvascular permeability by free radicals in single pial microvessels of the anaesthetized rat J. Physiol. 507 1998 541 547 (Pubitemid 28135202)
    • (1998) Journal of Physiology , vol.507 , Issue.2 , pp. 541-547
    • Easton, A.S.1    Fraser, P.A.2
  • 70
    • 0028001754 scopus 로고
    • Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells
    • L.S. Alexander-North, J.A. North, K.P. Kiminyo, G.R. Buettner, and A.A. Spector Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells J. Lipid Res. 35 1994 1773 1785 (Pubitemid 24331279)
    • (1994) Journal of Lipid Research , vol.35 , Issue.10 , pp. 1773-1785
    • Alexander-North, L.S.1    North, J.A.2    Kiminyo, K.P.3    Buettner, G.R.4    Spector, A.A.5
  • 71
    • 0026988984 scopus 로고
    • Biochemical and nutritional aspects of eicosanoids
    • DOI 10.1016/0955-2863(92)90050-S
    • V.M. Sardesai Biochemical and nutritional aspects of eicosanoids J. Nutr. Biochem. 3 1992 562 579 (Pubitemid 23177183)
    • (1992) Journal of Nutritional Biochemistry , vol.3 , Issue.11 , pp. 562-579
    • Sardesai, V.M.1
  • 74
    • 52549132911 scopus 로고    scopus 로고
    • Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion
    • C. Nito, H. Kamada, H. Endo, K. Niizuma, D.J. Myer, and P.H. Chan Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion J. Cereb. Blood Flow Metab. 10 2008 1686 1696
    • (2008) J. Cereb. Blood Flow Metab. , vol.10 , pp. 1686-1696
    • Nito, C.1    Kamada, H.2    Endo, H.3    Niizuma, K.4    Myer, D.J.5    Chan, P.H.6
  • 75
    • 79960749769 scopus 로고    scopus 로고
    • Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases
    • doi:10.1089/ars.2011.3923: (in press)
    • Lehner, C.; Gewolf, H.; Tempfler, H.; Krizbai, I.; Henning, B.; Bauer, H. C.; Bauer, H. Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases, Antioxid. Redox Signal. doi:10.1089/ars.2011.3923: (in press).
    • Antioxid. Redox Signal.
    • Lehner, C.1    Gewolf, H.2    Tempfler, H.3    Krizbai, I.4    Henning, B.5    Bauer, H.C.6    Bauer, H.7
  • 77
    • 14244257768 scopus 로고    scopus 로고
    • Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells
    • DOI 10.1016/j.mvr.2004.07.005
    • H.S. Lee, K. Namkoong, D.H. Kim, K.J. Kim, Y.H. Cheong, S.S. Kim, W.B. Lee, and K.Y. Kim Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells Microvasc. Res. 68 2004 231 238 (Pubitemid 40288119)
    • (2004) Microvascular Research , vol.68 , Issue.3 , pp. 231-238
    • Lee, H.-S.1    Namkoong, K.2    Kim, D.-H.3    Kim, K.-J.4    Cheong, Y.-H.5    Kim, S.-S.6    Lee, W.-B.7    Kim, K.-Y.8
  • 78
    • 21444450963 scopus 로고    scopus 로고
    • 2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway
    • DOI 10.1016/j.ejcb.2005.03.002, PII S0171933505000634
    • 2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway Eur. J. Cell Biol. 84 2005 687 697 (Pubitemid 40916303)
    • (2005) European Journal of Cell Biology , vol.84 , Issue.7 , pp. 687-697
    • Fischer, S.1    Wiesnet, M.2    Renz, D.3    Schaper, W.4
  • 79
    • 34047114464 scopus 로고    scopus 로고
    • Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction
    • DOI 10.1111/j.1471-4159.2006.04393.x
    • J. Haorah, S.H. Ramirez, K. Schall, D. Smith, R. Pandya, and Y. Persidsky Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction J. Neurochem. 101 2007 566 576 (Pubitemid 46525283)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.2 , pp. 566-576
    • Haorah, J.1    Ramirez, S.H.2    Schall, K.3    Smith, D.4    Pandya, R.5    Persidsky, Y.6
  • 82
    • 46149104117 scopus 로고    scopus 로고
    • Regulation of blood-brain barrier permeability by transient receptor potential type C and type V calcium-permeable channels
    • DOI 10.1080/10739680701762656, PII 790731063
    • R.C. Brown, L. Wu, K. Hicks, and R.G. O'Neil Regulation of blood-brain barrier permeability by transient receptor potential type C and type V calcium-permeable channels Microcirculation 15 2008 359 371 (Pubitemid 351903350)
    • (2008) Microcirculation , vol.15 , Issue.4 , pp. 359-371
    • Brown, R.C.1    Wu, L.2    Hicks, K.3    O'Neil, R.G.4
  • 83
    • 39449126892 scopus 로고    scopus 로고
    • Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability
    • DOI 10.1161/CIRCRESAHA.107.160176
    • 2+ entry and endothelial hyperpermeability Circ. Res. 102 2008 347 355 (Pubitemid 351271655)
    • (2008) Circulation Research , vol.102 , Issue.3 , pp. 347-355
    • Hecquet, C.M.1    Ahmmed, G.U.2    Vogel, S.M.3    Malik, A.B.4
  • 84
    • 0028229509 scopus 로고
    • Microsphere and dilution measurements of flow and interstitial space in dog heart
    • D.F. Cousineau, C.A. Goresky, J.R. Rouleau, and C.P. Rose Microsphere and dilution measurements of flow and interstitial space in dog heart J. Appl. Physiol. 77 1994 113 120 (Pubitemid 24226122)
    • (1994) Journal of Applied Physiology , vol.77 , Issue.1 , pp. 113-120
    • Cousineau, D.F.1    Goresky, C.A.2    Rouleau, J.R.3    Rose, C.P.4
  • 85
    • 0028210982 scopus 로고
    • Variable restriction of albumin diffusion across inflamed cerebral microvessels of the anaesthetized rat
    • A.S. Easton, and P.A. Fraser Variable restriction of albumin diffusion across inflamed cerebral microvessels of the anaesthetized rat J. Physiol. 475 1994 147 157 (Pubitemid 24081944)
    • (1994) Journal of Physiology , vol.475 , Issue.1 , pp. 147-157
    • Easton, A.S.1    Fraser, P.A.2
  • 86
    • 0030958851 scopus 로고    scopus 로고
    • Endothelial permeability for macromolecules: Mechanistic aspects of pathophysiological modulation
    • V.W. van Hinsbergh Endothelial permeability for macromolecules: mechanistic aspects of pathophysiological modulation Arterioscler. Thromb. Vasc. Biol. 17 1997 1018 1023 (Pubitemid 27260318)
    • (1997) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.17 , Issue.6 , pp. 1018-1023
    • Van Hinsbergh, V.W.M.1
  • 87
    • 0029020521 scopus 로고
    • Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    • H. Cambridge, and S.D. Brain Mechanism of bradykinin-induced plasma extravasation in the rat knee joint Br. J. Pharmacol. 115 1995 641 647
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 641-647
    • Cambridge, H.1    Brain, S.D.2
  • 88
    • 0029884577 scopus 로고    scopus 로고
    • Bradykinin and changes in microvascular permeability in the hamster cheek pouch: Role of nitric oxide
    • M. Félétou, E. Bonnardel, and E. Canet Bradykinin and changes in microvascular permeability in the hamster cheek pouch: role of nitric oxide Br. J. Pharmacol. 118 1996 1371 1376 (Pubitemid 26248786)
    • (1996) British Journal of Pharmacology , vol.118 , Issue.6 , pp. 1371-1376
    • Feletou, M.1    Bonnardel, E.2    Canet, E.3
  • 89
    • 48449107159 scopus 로고    scopus 로고
    • Thiol chemistry and specificity in redox signaling
    • C.C. Winterbourn, and M.B. Hampton Thiol chemistry and specificity in redox signaling Free Radic. Biol. Med. 45 2008 549 561
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 549-561
    • Winterbourn, C.C.1    Hampton, M.B.2
  • 90
    • 0032977061 scopus 로고    scopus 로고
    • Nitric oxide decreases microvascular permeability in bradykinin stimulated and nonstimulated conditions
    • DOI 10.1097/00005344-199906000-00015
    • S. Arnhold, D. Antoine, H. Bläser, W. Bloch, C. Andressen, and K. Addicks Nitric oxide decreases microvascular permeability in bradykinin stimulated and nonstimulated conditions J. Cardiovasc. Pharmacol. 33 1999 938 947 (Pubitemid 29242777)
    • (1999) Journal of Cardiovascular Pharmacology , vol.33 , Issue.6 , pp. 938-947
    • Arnhold, S.1    Antoine, D.2    Blaser, H.3    Bloch, W.4    Andressen, C.5    Addicks, K.6
  • 91
    • 37049057662 scopus 로고
    • Permeability response of cerebral and cutaneous blood vessels to vasoactive agents
    • E.M. Berkinshaw-Smith, R.S. Morgan, and G.P. Wright Permeability response of cerebral and cutaneous blood vessels to vasoactive agents Nature 196 1962 173
    • (1962) Nature , vol.196 , pp. 173
    • Berkinshaw-Smith, E.M.1    Morgan, R.S.2    Wright, G.P.3
  • 93
    • 0021158707 scopus 로고
    • Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats
    • H.A. Kontos, E.P. Wei, J.T. Povlishock, and C.W. Christman Oxygen radicals mediate the cerebral arteriolar dilatation from arachidonate and bradykinin in cats Circ. Res. 55 1984 295 303 (Pubitemid 14047491)
    • (1984) Circulation Research , vol.55 , Issue.3 , pp. 295-303
    • Kontos, H.A.1    Wei, E.P.2    Povlishock, J.T.3    Christman, C.W.4
  • 94
    • 0023202897 scopus 로고
    • Hydroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles
    • W.I. Rosenblum Hydroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles Circ. Res. 61 1987 601 603 (Pubitemid 17134969)
    • (1987) Circulation Research , vol.61 , Issue.4 , pp. 601-603
    • Rosenblum, W.I.1
  • 96
    • 0029838316 scopus 로고    scopus 로고
    • Influence of anti-inflammatory and antioxidant agents on endothelial permeability alterations induced by bradykinin
    • X. Deng, X. Wang, and R. Andersson Influence of anti-inflammatory and antioxidant agents on endothelial permeability alterations induced by bradykinin J. Invest. Surg. 9 1996 337 349 (Pubitemid 26411547)
    • (1996) Journal of Investigative Surgery , vol.9 , Issue.5 , pp. 337-349
    • Deng, X.1    Wang, X.2    Andersson, R.3
  • 97
    • 0022590412 scopus 로고
    • Substances that rapidly augment ionic conductance of endothelium in cerebral venules
    • S.P. Olesen, and C. Crone Substances that rapidly augment ionic conductance of endothelium in cerebral venules Acta Physiol. Scand. 127 1986 233 241 (Pubitemid 16122738)
    • (1986) Acta Physiologica Scandinavica , vol.127 , Issue.2 , pp. 233-241
    • Oleson, S.-P.1    Crone, C.2
  • 98
    • 0028879235 scopus 로고
    • Effect of inflammatory agents on electrical resistance across the blood-brain barrier in pial microvessels of anaesthetized rats
    • A.M. Butt Effect of inflammatory agents on electrical resistance across the blood-brain barrier in pial microvessels of anaesthetized rats Brain Res. 696 1995 145 150
    • (1995) Brain Res. , vol.696 , pp. 145-150
    • Butt, A.M.1
  • 99
    • 0034306002 scopus 로고    scopus 로고
    • Acute effects of bradykinin on cerebral microvascular permeability in the anaesthetized rat
    • M.H. Sarker, D.-E. Hu, and P.A. Fraser Acute effects of bradykinin on cerebral microvascular permeability in the anaesthetized rat J. Physiol. 528 2000 177 187
    • (2000) J. Physiol. , vol.528 , pp. 177-187
    • Sarker, M.H.1    Hu, D.-E.2    Fraser, P.A.3
  • 100
    • 3242671309 scopus 로고    scopus 로고
    • Cell surface receptors in lysophospholipid signaling
    • DOI 10.1016/j.semcdb.2004.05.005, PII S1084952104000618
    • B. Anliker, and J. Chun Cell surface receptors in lysophospholipid signaling Semin. Cell Dev. Biol. 15 2004 457 465 (Pubitemid 38953942)
    • (2004) Seminars in Cell and Developmental Biology , vol.15 , Issue.5 , pp. 457-465
    • Anliker, B.1    Chun, J.2
  • 101
    • 0033604620 scopus 로고    scopus 로고
    • Bioactive lysophospholipids and their G-protein-coupled receptors
    • W.H. Moolenaar Bioactive lysophospholipids and their G-protein-coupled receptors Exp. Cell Res. 253 1999 230 238
    • (1999) Exp. Cell Res. , vol.253 , pp. 230-238
    • Moolenaar, W.H.1
  • 103
    • 43649102478 scopus 로고    scopus 로고
    • Effect of lysophosphatidic acid increase the permeability of blood-brain barrier model
    • N. Gan, F. Yin, J. Peng, and W.D. Wang Effect of lysophosphatidic acid increase the permeability of blood-brain barrier model Zhonghua Yi Xue Za Zhi 88 2008 416 418 (Pubitemid 351682053)
    • (2008) National Medical Journal of China , vol.88 , Issue.6 , pp. 416-418
    • Gan, N.1    Yin, F.2    Peng, J.3    Wang, W.-D.4
  • 104
    • 0031033652 scopus 로고    scopus 로고
    • Lysophosphatidic acid increases tight junction permeability in cultured brain endothelial cells
    • C. Schulze, C. Smales, L.L. Rubin, and J.M. Staddon Lysophosphatidic acid increases tight junction permeability in cultured brain endothelial cells J. Neurochem. 68 1997 991 1000 (Pubitemid 27086203)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.3 , pp. 991-1000
    • Schulze, C.1    Smales, C.2    Rubin, L.L.3    Staddon, J.M.4
  • 106
    • 45849092920 scopus 로고    scopus 로고
    • Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases
    • DOI 10.1179/174313208X300369, Stroke Research in China
    • Z.G. Li, Z.C. Yu, D.Z. Wang, W.P. Ju, X. Zhan, Q.Z. Wu, X.J. Wu, H.M. Cong, and H.H. Man Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases Neurol. Res. 30 2008 366 369 (Pubitemid 351881288)
    • (2008) Neurological Research , vol.30 , Issue.4 , pp. 366-369
    • Li, Z.-G.1    Yu, Z.-C.2    Wang, D.-Z.3    Ju, W.-P.4    Zhan, X.5    Wu, Q.-Z.6    Wu, X.-J.7    Cong, H.-M.8    Man, H.-H.9
  • 107
    • 77953626927 scopus 로고    scopus 로고
    • Regulation of cerebromicrovascular permeability by lysophosphatidic acid
    • M.H. Sarker, D.-E. Hu, and P.A. Fraser Regulation of cerebromicrovascular permeability by lysophosphatidic acid Microcirculation 17 2010 39 46
    • (2010) Microcirculation , vol.17 , pp. 39-46
    • Sarker, M.H.1    Hu, D.-E.2    Fraser, P.A.3
  • 108
    • 0023023315 scopus 로고
    • Increased superoxide anion release from human endothelial cells in response to cytokines
    • T. Matsubara, and M. Ziff Increased superoxide anion release from human endothelial cells in response to cytokines J. Immunol. 137 1986 3295 3298 (Pubitemid 17181704)
    • (1986) Journal of Immunology , vol.137 , Issue.10 , pp. 3295-3298
    • Matsubara, T.1    Ziff, M.2
  • 110
    • 0028942661 scopus 로고
    • Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1 tumor necrosis factor-alpha and lipopolysaccharide
    • L. Feng, Y. Xia, G.E. Garcia, D. Hwang, and C.B. Wilson Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1 tumor necrosis factor-alpha and lipopolysaccharide J. Clin. Invest. 95 1995 1669 1675
    • (1995) J. Clin. Invest. , vol.95 , pp. 1669-1675
    • Feng, L.1    Xia, Y.2    Garcia, G.E.3    Hwang, D.4    Wilson, C.B.5
  • 111
    • 0033053617 scopus 로고    scopus 로고
    • Reactive oxygen intermediate-dependent NF-κB activation by interleukin- 1β requires 5-lipoxygenase or NADPH oxidase activity
    • G. Bonizzi, J. Piette, S. Schoonbroodt, R. Greimers, L. Havard, M.P. Merville, and V. Bours Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity Mol. Cell. Biol. 19 1999 1950 1960 (Pubitemid 29098253)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.3 , pp. 1950-1960
    • Bonizzi, G.1    Piette, J.2    Schoonbroodt, S.3    Greimers, R.4    Havard, L.5    Merville, M.-P.6    Bours, V.7
  • 113
  • 114
    • 65349157681 scopus 로고    scopus 로고
    • Compartmentalization of redox signaling through NADPH oxidase-derived ROS
    • M. Ushio-Fukai Compartmentalization of redox signaling through NADPH oxidase-derived ROS Antioxid. Redox Signal. 11 2009 1289 1299
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 1289-1299
    • Ushio-Fukai, M.1
  • 116
    • 77956367479 scopus 로고    scopus 로고
    • Membrane raft redox signalosomes in endothelial cells
    • C. Zhang, and P.-L. Li Membrane raft redox signalosomes in endothelial cells Free. Radic. Res. 44 2010 831 842
    • (2010) Free. Radic. Res. , vol.44 , pp. 831-842
    • Zhang, C.1    Li, P.-L.2
  • 117
    • 77954919974 scopus 로고    scopus 로고
    • Vascular dysfunction in cerebrovascular disease: Mechanisms and therapeutic intervention
    • A.A. Miller, K. Budzyn, and C.G. Sobey Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention Clin. Sci. (Lond.) 119 2010 1 17
    • (2010) Clin. Sci. (Lond.) , vol.119 , pp. 1-17
    • Miller, A.A.1    Budzyn, K.2    Sobey, C.G.3
  • 118
    • 35649015344 scopus 로고    scopus 로고
    • NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    • DOI 10.1161/STROKEAHA.107.489765, PII 0000767020071100000022
    • T. Kahles, P. Luedike, M. Endres, H.-J. Galla, H. Steinmetz, R. Busse, T. Neumann-Haefelin, and R.P. Brandes NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke Stroke 38 2007 3000 3006 (Pubitemid 350035696)
    • (2007) Stroke , vol.38 , Issue.11 , pp. 3000-3006
    • Kahles, T.1    Luedike, P.2    Endres, M.3    Galla, H.-J.4    Steinmetz, H.5    Busse, R.6    Neumann-Haefelin, T.7    Brandes, R.P.8
  • 120
    • 63849340999 scopus 로고    scopus 로고
    • RAGE signaling in inflammation and arterial aging
    • L. Lin, S. Park, and E.G. Lakatta RAGE signaling in inflammation and arterial aging Front. Biosci. 14 2009 1403 1413
    • (2009) Front. Biosci. , vol.14 , pp. 1403-1413
    • Lin, L.1    Park, S.2    Lakatta, E.G.3
  • 121
    • 71549141594 scopus 로고    scopus 로고
    • Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway
    • A. Hirose, T. Tanikawa, H. Mori, Y. Okada, and Y. Tanaka Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway FEBS Lett. 584 2010 61 66
    • (2010) FEBS Lett. , vol.584 , pp. 61-66
    • Hirose, A.1    Tanikawa, T.2    Mori, H.3    Okada, Y.4    Tanaka, Y.5
  • 122
    • 79651474104 scopus 로고    scopus 로고
    • HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption
    • R.K. Wolfson, E.T. Chiang, and J.G.N. Garcia HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption Microvasc. Res. 81 2011 189 197
    • (2011) Microvasc. Res. , vol.81 , pp. 189-197
    • Wolfson, R.K.1    Chiang, E.T.2    Garcia, J.G.N.3
  • 124
    • 62649094525 scopus 로고    scopus 로고
    • Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation
    • C.M. Warboys, H.B. Toh, and P.A. Fraser Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation Invest. Ophthalmol. Vis. Sci. 50 2009 1319 1328
    • (2009) Invest. Ophthalmol. Vis. Sci. , vol.50 , pp. 1319-1328
    • Warboys, C.M.1    Toh, H.B.2    Fraser, P.A.3
  • 127
    • 0037144171 scopus 로고    scopus 로고
    • Effects of LF 16-0687 Ms a bradykinin B2 receptor antagonist on brain edema formation and tissue damage in a rat model of temporary focal cerebral ischemia
    • S. Zausinger, D.B. Lumenta, D. Pruneau, R. Schmid-Elsaesser, N. Plesnila, and A. Baethmann Effects of LF 16-0687 Ms a bradykinin B2 receptor antagonist on brain edema formation and tissue damage in a rat model of temporary focal cerebral ischemia Brain Res. 950 2002 68 278
    • (2002) Brain Res. , vol.950 , pp. 68-278
    • Zausinger, S.1    Lumenta, D.B.2    Pruneau, D.3    Schmid-Elsaesser, R.4    Plesnila, N.5    Baethmann, A.6
  • 128
    • 0030878204 scopus 로고    scopus 로고
    • 2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion
    • J.K. Relton, V.E. Beckey, W.L. Hanson, and E.T. Whalley CP-0597 a selective bradykinin B2 receptor antagonist inhibits brain injury in a rat model of reversible middle cerebral artery occlusion Stroke 28 1997 1430 1436 (Pubitemid 27300683)
    • (1997) Stroke , vol.28 , Issue.7 , pp. 1430-1436
    • Relton, J.K.1    Beckey, V.E.2    Hanson, W.L.3    Whalley, E.T.4
  • 129
    • 0027458015 scopus 로고
    • The role of bradykinin in mediating ischemic brain edema in rats
    • T. Kamiya, Y. Katayama, F. Kashiwagi, and A. Terashi The role of bradykinin in mediating ischemic brain edema in rats Stroke 24 1993 571 575
    • (1993) Stroke , vol.24 , pp. 571-575
    • Kamiya, T.1    Katayama, Y.2    Kashiwagi, F.3    Terashi, A.4
  • 130
    • 69249212164 scopus 로고    scopus 로고
    • Blockade of bradykinin B2 receptor more effectively reduces postischemic blood-brain barrier disruption and cytokines release than B1 receptor inhibition
    • J. Su, M. Cui, Y. Tang, H. Zhou, L. Liu, and Q. Dong Blockade of bradykinin B2 receptor more effectively reduces postischemic blood-brain barrier disruption and cytokines release than B1 receptor inhibition Biochem. Biophys. Res. Commun. 388 2009 205 211
    • (2009) Biochem. Biophys. Res. Commun. , vol.388 , pp. 205-211
    • Su, J.1    Cui, M.2    Tang, Y.3    Zhou, H.4    Liu, L.5    Dong, Q.6
  • 131
    • 33746870398 scopus 로고    scopus 로고
    • 2 receptor inhibition after focal cerebral ischemia in rats
    • DOI 10.1016/j.neuint.2006.02.010, PII S0197018606001252
    • B. Kläsner, D.B. Lumenta, D. Pruneau, S. Zausinger, and N. Plesnila Therapeutic window of bradykinin B2 receptor inhibition after focal cerebral ischemia in rats Neurochem. Int. 49 2006 442 447 (Pubitemid 44189639)
    • (2006) Neurochemistry International , vol.49 , Issue.5 , pp. 442-447
    • Klasner, B.1    Lumenta, D.B.2    Pruneau, D.3    Zausinger, S.4    Plesnila, N.5
  • 132
    • 23044478435 scopus 로고    scopus 로고
    • 2 receptors in the brain: Role for cell death and brain edema formation after focal cerebral ischemia in mice
    • DOI 10.1038/sj.jcbfm.9600096
    • M. Gröger, D. Lebesgue, D. Pruneau, J. Relton, S.W. Kim, J. Nussberger, and N. Plesnila Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice J. Cereb. Blood Flow Metab. 25 2005 978 989 (Pubitemid 41061713)
    • (2005) Journal of Cerebral Blood Flow and Metabolism , vol.25 , Issue.8 , pp. 978-989
    • Groger, M.1    Lebesgue, D.2    Pruneau, D.3    Relton, J.4    Kim, S.-W.5    Nussberger, J.6    Plesnila, N.7
  • 133
    • 0141844666 scopus 로고    scopus 로고
    • 2 receptor antagonist, reduces ischemic brain injury in a murine model of transient focal cerebral ischemia
    • DOI 10.1038/sj.bjp.0705385
    • L. Ding-Zhou, I. Margaill, B. Palmier, D. Pruneau, M. Plotkine, and C. Marchand-Verrecchia LF 16-0687 Ms a bradykinin B2 receptor antagonist reduces ischemic brain injury in a murine model of transient focal cerebral ischemia Br. J. Pharmacol. 139 2003 1539 1547 (Pubitemid 37174669)
    • (2003) British Journal of Pharmacology , vol.139 , Issue.8 , pp. 1539-1547
    • Ding-Zhou, L.1    Margaill, I.2    Palmier, B.3    Pruneau, D.4    Plotkine, M.5    Marchand-Verrecchia, C.6
  • 134
    • 79952901303 scopus 로고    scopus 로고
    • Contribution of bradykinin receptors to the development of secondary brain damage after experimental subarachnoid hemorrhage
    • K. Schöller, S. Feiler, S. Anetsberger, S.W. Kim, and N. Plesnila Contribution of bradykinin receptors to the development of secondary brain damage after experimental subarachnoid hemorrhage Neurosurgery 68 2011 1118 1123
    • (2011) Neurosurgery , vol.68 , pp. 1118-1123
    • Schöller, K.1    Feiler, S.2    Anetsberger, S.3    Kim, S.W.4    Plesnila, N.5
  • 135
    • 0028986034 scopus 로고
    • The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
    • R. Kozma, S. Ahmed, A. Best, and L. Lim The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts Mol. Cell. Biol. 15 1995 1942 1952
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1942-1952
    • Kozma, R.1    Ahmed, S.2    Best, A.3    Lim, L.4
  • 136
    • 0345352657 scopus 로고    scopus 로고
    • Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-α in endothelial cells
    • DOI 10.1124/jpet.102.047894
    • X.L. Chen, Q. Zhang, R. Zhao, X. Ding, P.E. Tummala, and R.M. Medford Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells J. Pharmacol. Exp. Ther. 305 2003 573 580 (Pubitemid 36459172)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.305 , Issue.2 , pp. 573-580
    • Chen, X.-L.1    Zhang, Q.2    Zhao, R.3    Ding, X.4    Tummala, P.E.5    Medford, R.M.6
  • 137
    • 0032520791 scopus 로고    scopus 로고
    • Role of the Rho GTPase in bradykinin-stimulated nuclear factor-κb activation and IL-1β gene expression in cultured human epithelial cells
    • Z.K. Pan, R.D. Ye, S.C. Christiansen, M.A. Jagels, G.M. Bokoch, and B.L. Zuraw Role of the Rho GTPase in bradykinin-stimulated nuclear-κB activation and IL-1β gene expression in cultured epithelial cells J. Immunol. 160 1998 3038 3045 (Pubitemid 28136761)
    • (1998) Journal of Immunology , vol.160 , Issue.6 , pp. 3038-3045
    • Pan, Z.K.1    Ye, R.D.2    Christiansen, S.C.3    Jagels, M.A.4    Bokoch, G.M.5    Zuraw, B.L.6
  • 138
    • 21444442708 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: A systematic review
    • DOI 10.1016/j.freeradbiomed.2005.03.028, PII S089158490500170X
    • M. Willmot, C. Gibson, L. Gray, S. Murphy, and P. Bath Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review Free Radic. Biol. Med. 39 2005 412 425 (Pubitemid 40916222)
    • (2005) Free Radical Biology and Medicine , vol.39 , Issue.3 , pp. 412-425
    • Willmot, M.1    Gibson, C.2    Gray, L.3    Murphy, S.4    Bath, P.5
  • 139
    • 68249091754 scopus 로고    scopus 로고
    • The Penumbra Pivotal Stroke Trial: Safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease
    • S. Po Sit The Penumbra Pivotal Stroke Trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease Stroke 40 2009 2761 2768
    • (2009) Stroke , vol.40 , pp. 2761-2768
    • Po Sit, S.1
  • 140
    • 46849106962 scopus 로고    scopus 로고
    • The novel antioxidant edaravone: From bench to bedside
    • DOI 10.1111/j.1527-3466.2008.00041.x
    • T. Watanabe, M. Tahara, and S. Todo The novel antioxidant edaravone: from bench to bedside Cardiovasc. Ther. 26 2008 101 114 (Pubitemid 351952827)
    • (2008) Cardiovascular Therapeutics , vol.26 , Issue.2 , pp. 101-114
    • Watanabe, T.1    Tahara, M.2    Todo, S.3
  • 141
    • 0033034999 scopus 로고    scopus 로고
    • Effects of the bradykinin antagonist Bradycor(TM) (Deltibant, CP-1027) in severe traumatic brain injury: Results of a multi-center, randomized, placebo-controlled trial
    • A. Marmarou, J. Nichols, J. Burgess, D. Newell, J. Troha, D. Burnham, and L. Pitts Effects of the bradykinin antagonist Bradycordeltibant CP-1027 in severe traumatic brain injury: results of a multi-center randomized placebo-controlled trial. American Brain Injury Consortium Study Group J. Neurotrauma 16 1999 431 444 (Pubitemid 29297899)
    • (1999) Journal of Neurotrauma , vol.16 , Issue.6 , pp. 431-444
    • Marmarou, A.1    Nichols, J.2    Burgess, J.3    Newell, D.4    Troha, J.5    Burnham, D.6    Pitts, L.7
  • 143
    • 53749096762 scopus 로고    scopus 로고
    • Blood-brain barrier tight junction permeability and ischemic stroke
    • K.E. Sandoval, and K.A. Witt Blood-brain barrier tight junction permeability and ischemic stroke Neurobiol. Dis. 32 2008 200 219
    • (2008) Neurobiol. Dis. , vol.32 , pp. 200-219
    • Sandoval, K.E.1    Witt, K.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.