-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning, G.; Whyte, D.B.; Martinez, R.; Hunter, T.; Sudarsanam, S. The protein kinase complement of the human genome. Science 2002, 298, 1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
2942581416
-
Protein tyrosine phosphatases in the human genome
-
Alonso, A.; Sasin, J.; Bottini, N.; Friedberg, I.; Friedberg, I.; Osterman, A.; Godzik, A.; Hunter, T.; Dixon, J.; Mustelin, T. Protein tyrosine phosphatases in the human genome. Cell 2004, 117, 699-711.
-
(2004)
Cell
, vol.117
, pp. 699-711
-
-
Alonso, A.1
Sasin, J.2
Bottini, N.3
Friedberg, I.4
Friedberg, I.5
Osterman, A.6
Godzik, A.7
Hunter, T.8
Dixon, J.9
Mustelin, T.10
-
3
-
-
0027320431
-
Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation
-
Zhou, M.; Felder, S.; Rubinstein, M.; Hurwitz, D.R.; Ullrich, A.; Lax, I.; Schlessinger, J. Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation. Biochemistry 1993, 32, 8193-8198.
-
(1993)
Biochemistry
, vol.32
, pp. 8193-8198
-
-
Zhou, M.1
Felder, S.2
Rubinstein, M.3
Hurwitz, D.R.4
Ullrich, A.5
Lax, I.6
Schlessinger, J.7
-
4
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon, M.A.; Schlessinger, J. Cell signaling by receptor tyrosine kinases. Cell 2010, 141, 1117-1134.
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
5
-
-
0023156382
-
Self-phosphorylation of epidermal growth factor receptor: Evidence for a model of intermolecular allosteric activation
-
Yarden, Y.; Schlessinger, J. Self-phosphorylation of epidermal growth factor receptor: Evidence for a model of intermolecular allosteric activation. Biochemistry 1987, 26, 1434-1442.
-
(1987)
Biochemistry
, vol.26
, pp. 1434-1442
-
-
Yarden, Y.1
Schlessinger, J.2
-
6
-
-
0027153103
-
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
-
Buday, L.; Downward, J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 1993, 73, 611-620.
-
(1993)
Cell
, vol.73
, pp. 611-620
-
-
Buday, L.1
Downward, J.2
-
7
-
-
0027910431
-
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
-
Egan, S.E.; Giddings, B.W.; Brooks, M.W.; Buday, L.; Sizeland, A.M.; Weinberg, R.A. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 1993, 363, 45-51.
-
(1993)
Nature
, vol.363
, pp. 45-51
-
-
Egan, S.E.1
Giddings, B.W.2
Brooks, M.W.3
Buday, L.4
Sizeland, A.M.5
Weinberg, R.A.6
-
8
-
-
0027312272
-
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
-
Li, N.; Batzer, A.; Daly, R.; Yajnik, V.; Skolnik, E.; Chardin, P.; Bar-Sagi, D.; Margolis, B.; Schlessinger, J. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 1993, 363, 85-88.
-
(1993)
Nature
, vol.363
, pp. 85-88
-
-
Li, N.1
Batzer, A.2
Daly, R.3
Yajnik, V.4
Skolnik, E.5
Chardin, P.6
Bar-Sagi, D.7
Margolis, B.8
Schlessinger, J.9
-
9
-
-
0026729382
-
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
-
Lowenstein, E.J.; Daly, R.J.; Batzer, A.G.; Li, W.; Margolis, B.; Lammers, R.; Ullrich, A.; Skolnik, E.Y.; Bar-Sagi, D.; Schlessinger, J. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 1992, 70, 431-442.
-
(1992)
Cell
, vol.70
, pp. 431-442
-
-
Lowenstein, E.J.1
Daly, R.J.2
Batzer, A.G.3
Li, W.4
Margolis, B.5
Lammers, R.6
Ullrich, A.7
Skolnik, E.Y.8
Bar-Sagi, D.9
Schlessinger, J.10
-
10
-
-
0028040812
-
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
-
Batzer, A.G.; Rotin, D.; Urena, J.M.; Skolnik, E.Y.; Schlessinger, J. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol. Cell. Biol. 1994, 14, 5192-5201.
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 5192-5201
-
-
Batzer, A.G.1
Rotin, D.2
Urena, J.M.3
Skolnik, E.Y.4
Schlessinger, J.5
-
11
-
-
0027294981
-
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
-
Rozakis-Adcock, M.; Fernley, R.; Wade, J.; Pawson, T.; Bowtell, D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 1993, 363, 83-85.
-
(1993)
Nature
, vol.363
, pp. 83-85
-
-
Rozakis-Adcock, M.1
Fernley, R.2
Wade, J.3
Pawson, T.4
Bowtell, D.5
-
12
-
-
0027304731
-
Human Sos1: A guanine nucleotide exchange factor for Ras that binds to GRB2
-
Chardin, P.; Camonis, J.H.; Gale, N.W.; van Aelst, L.; Schlessinger, J.; Wigler, M.H.; Bar-Sagi, D. Human Sos1: A guanine nucleotide exchange factor for Ras that binds to GRB2. Science 1993, 260, 1338-1343.
-
(1993)
Science
, vol.260
, pp. 1338-1343
-
-
Chardin, P.1
Camonis, J.H.2
Gale, N.W.3
van Aelst, L.4
Schlessinger, J.5
Wigler, M.H.6
Bar-Sagi, D.7
-
13
-
-
0027529827
-
Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras
-
Medema, R.H.; de Vries-Smits, A.M.; van der Zon, G.C.; Maassen, J.A.; Bos, J.L. Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Mol. Cell. Biol. 1993, 13, 155-162.
-
(1993)
Mol. Cell. Biol
, vol.13
, pp. 155-162
-
-
Medema, R.H.1
de Vries-Smits, A.M.2
van der Zon, G.C.3
Maassen, J.A.4
Bos, J.L.5
-
14
-
-
0025195107
-
Accumulation of p21ras. GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity
-
Satoh, T.; Endo, M.; Nakafuku, M.; Akiyama, T.; Yamamoto, T.; Kaziro, Y. Accumulation of p21ras. GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 1990, 87, 7926-7929.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 7926-7929
-
-
Satoh, T.1
Endo, M.2
Nakafuku, M.3
Akiyama, T.4
Yamamoto, T.5
Kaziro, Y.6
-
15
-
-
0026523559
-
Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP Kinase, Raf-1, and RSK
-
Wood, K.W.; Sarnecki, C.; Roberts, T.M.; Blenis, J. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 1992, 68, 1041-1050.
-
(1992)
Cell
, vol.68
, pp. 1041-1050
-
-
Wood, K.W.1
Sarnecki, C.2
Roberts, T.M.3
Blenis, J.4
-
16
-
-
0027161398
-
Complex formation between Ras and Raf and other protein kinases
-
Van Aelst, L.; Barr, M.; Marcus, S.; Polverino, A.; Wigler, M. Complex formation between Ras and Raf and other protein kinases. Proc. Natl. Acad. Sci. USA 1993, 90, 6213-6217.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6213-6217
-
-
van Aelst, L.1
Barr, M.2
Marcus, S.3
Polverino, A.4
Wigler, M.5
-
17
-
-
0027250250
-
Mammalian Ras interacts directly with the serine/threonine kinase Raf
-
Vojtek, A.B.; Hollenberg, S.M.; Cooper, J.A. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 1993, 74, 205-214.
-
(1993)
Cell
, vol.74
, pp. 205-214
-
-
Vojtek, A.B.1
Hollenberg, S.M.2
Cooper, J.A.3
-
18
-
-
0027200883
-
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
-
Warne, P.H.; Viciana, P.R.; Downward, J. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature 1993, 364, 352-355.
-
(1993)
Nature
, vol.364
, pp. 352-355
-
-
Warne, P.H.1
Viciana, P.R.2
Downward, J.3
-
19
-
-
0027337248
-
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
-
Zhang, X.F.; Settleman, J.; Kyriakis, J.M.; Takeuchi-Suzuki, E.; Elledge, S.J.; Marshall, M.S.; Bruder, J.T.; Rapp, U.R.; Avruch, J. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 1993, 364, 308-313.
-
(1993)
Nature
, vol.364
, pp. 308-313
-
-
Zhang, X.F.1
Settleman, J.2
Kyriakis, J.M.3
Takeuchi-Suzuki, E.4
Elledge, S.J.5
Marshall, M.S.6
Bruder, J.T.7
Rapp, U.R.8
Avruch, J.9
-
20
-
-
0027337519
-
Complexes of Ras. GTP with Raf-1 and mitogen-activated protein kinase kinase
-
Moodie, S.A.; Willumsen, B.M.; Weber, M.J.; Wolfman, A. Complexes of Ras. GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 1993, 260, 1658-1661.
-
(1993)
Science
, vol.260
, pp. 1658-1661
-
-
Moodie, S.A.1
Willumsen, B.M.2
Weber, M.J.3
Wolfman, A.4
-
21
-
-
0028272507
-
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
-
Leevers, S.J.; Paterson, H.F.; Marshall, C.J. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 1994, 369, 411-414.
-
(1994)
Nature
, vol.369
, pp. 411-414
-
-
Leevers, S.J.1
Paterson, H.F.2
Marshall, C.J.3
-
22
-
-
0029006126
-
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
-
Marais, R.; Light, Y.; Paterson, H.F.; Marshall, C.J. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 1995, 14, 3136-3145.
-
(1995)
EMBO J
, vol.14
, pp. 3136-3145
-
-
Marais, R.1
Light, Y.2
Paterson, H.F.3
Marshall, C.J.4
-
23
-
-
0028241533
-
Activation of Raf as a result of recruitment to the plasma membrane
-
Stokoe, D.; Macdonald, S.G.; Cadwallader, K.; Symons, M.; Hancock, J.F. Activation of Raf as a result of recruitment to the plasma membrane. Science 1994, 264, 1463-1467.
-
(1994)
Science
, vol.264
, pp. 1463-1467
-
-
Stokoe, D.1
Macdonald, S.G.2
Cadwallader, K.3
Symons, M.4
Hancock, J.F.5
-
24
-
-
0030831968
-
14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain
-
Clark, G.J.; Drugan, J.K.; Rossman, K.L.; Carpenter, J.W.; Rogers-Graham, K.; Fu, H.; Der, C.J.; Campbell, S.L. 14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain. J. Biol. Chem. 1997, 272, 20990-20993.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 20990-20993
-
-
Clark, G.J.1
Drugan, J.K.2
Rossman, K.L.3
Carpenter, J.W.4
Rogers-Graham, K.5
Fu, H.6
Der, C.J.7
Campbell, S.L.8
-
25
-
-
0031862578
-
14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo
-
Roy, S.; McPherson, R.A.; Apolloni, A.; Yan, J.; Lane, A.; Clyde-Smith, J.; Hancock, J.F. 14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo. Mol. Cell. Biol. 1998, 18, 3947-3955.
-
(1998)
Mol. Cell. Biol
, vol.18
, pp. 3947-3955
-
-
Roy, S.1
McPherson, R.A.2
Apolloni, A.3
Yan, J.4
Lane, A.5
Clyde-Smith, J.6
Hancock, J.F.7
-
26
-
-
0029789967
-
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
-
Ueda, Y.; Hirai, S.; Osada, S.; Suzuki, A.; Mizuno, K.; Ohno, S. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 1996, 271, 23512-23519.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 23512-23519
-
-
Ueda, Y.1
Hirai, S.2
Osada, S.3
Suzuki, A.4
Mizuno, K.5
Ohno, S.6
-
27
-
-
0030449250
-
Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes
-
Zou, Y.; Komuro, I.; Yamazaki, T.; Aikawa, R.; Kudoh, S.; Shiojima, I.; Hiroi, Y.; Mizuno, T.; Yazaki, Y. Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes. J. Biol. Chem. 1996, 271, 33592-33597.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 33592-33597
-
-
Zou, Y.1
Komuro, I.2
Yamazaki, T.3
Aikawa, R.4
Kudoh, S.5
Shiojima, I.6
Hiroi, Y.7
Mizuno, T.8
Yazaki, Y.9
-
28
-
-
0027237273
-
A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras
-
Schaap, D.; van der Wal, J.; Howe, L.R.; Marshall, C.J.; van Blitterswijk, W.J. A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras. J. Biol. Chem. 1993, 268, 20232-20236.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 20232-20236
-
-
Schaap, D.1
van der Wal, J.2
Howe, L.R.3
Marshall, C.J.4
van Blitterswijk, W.J.5
-
29
-
-
0025290028
-
Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro
-
Ahn, N.G.; Krebs, E.G. Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro. J. Biol. Chem. 1990, 265, 11495-11501.
-
(1990)
J. Biol. Chem
, vol.265
, pp. 11495-11501
-
-
Ahn, N.G.1
Krebs, E.G.2
-
30
-
-
0028293931
-
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1
-
Alessi, D.R.; Saito, Y.; Campbell, D.G.; Cohen, P.; Sithanandam, G.; Rapp, U.; Ashworth, A.; Marshall, C.J.; Cowley, S. Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J. 1994, 13, 1610-1619.
-
(1994)
EMBO J
, vol.13
, pp. 1610-1619
-
-
Alessi, D.R.1
Saito, Y.2
Campbell, D.G.3
Cohen, P.4
Sithanandam, G.5
Rapp, U.6
Ashworth, A.7
Marshall, C.J.8
Cowley, S.9
-
31
-
-
0025875819
-
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
-
Gomez, N.; Cohen, P. Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases. Nature 1991, 353, 170-173.
-
(1991)
Nature
, vol.353
, pp. 170-173
-
-
Gomez, N.1
Cohen, P.2
-
32
-
-
0026647749
-
Raf-1 activates MAP kinase-kinase
-
Kyriakis, J.M.; App, H.; Zhang, X.F.; Banerjee, P.; Brautigan, D.L.; Rapp, U.R.; Avruch, J. Raf-1 activates MAP kinase-kinase. Nature 1992, 358, 417-421.
-
(1992)
Nature
, vol.358
, pp. 417-421
-
-
Kyriakis, J.M.1
App, H.2
Zhang, X.F.3
Banerjee, P.4
Brautigan, D.L.5
Rapp, U.R.6
Avruch, J.7
-
33
-
-
17344362761
-
Signaling by dual specificity kinases
-
Dhanasekaran, N.; Premkumar Reddy, E. Signaling by dual specificity kinases. Oncogene 1998, 17, 1447-1455.
-
(1998)
Oncogene
, vol.17
, pp. 1447-1455
-
-
Dhanasekaran, N.1
Premkumar, R.E.2
-
34
-
-
0025832605
-
Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase
-
Ahn, N.G.; Seger, R.; Bratlien, R.L.; Diltz, C.D.; Tonks, N.K.; Krebs, E.G. Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J. Biol. Chem. 1991, 266, 4220-4227.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 4220-4227
-
-
Ahn, N.G.1
Seger, R.2
Bratlien, R.L.3
Diltz, C.D.4
Tonks, N.K.5
Krebs, E.G.6
-
35
-
-
0026539931
-
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
-
Crews, C.M.; Alessandrini, A.; Erikson, R.L. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 1992, 258, 478-480.
-
(1992)
Science
, vol.258
, pp. 478-480
-
-
Crews, C.M.1
Alessandrini, A.2
Erikson, R.L.3
-
36
-
-
0025969093
-
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
-
Payne, D.M.; Rossomando, A.J.; Martino, P.; Erickson, A.K.; Her, J.H.; Shabanowitz, J.; Hunt, D.F.; Weber, M.J.; Sturgill, T.W. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J. 1991, 10, 885-892.
-
(1991)
EMBO J
, vol.10
, pp. 885-892
-
-
Payne, D.M.1
Rossomando, A.J.2
Martino, P.3
Erickson, A.K.4
Her, J.H.5
Shabanowitz, J.6
Hunt, D.F.7
Weber, M.J.8
Sturgill, T.W.9
-
37
-
-
0030866897
-
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
-
Canagarajah, B.J.; Khokhlatchev, A.; Cobb, M.H.; Goldsmith, E.J. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell 1997, 90, 859-869.
-
(1997)
Cell
, vol.90
, pp. 859-869
-
-
Canagarajah, B.J.1
Khokhlatchev, A.2
Cobb, M.H.3
Goldsmith, E.J.4
-
38
-
-
0026608787
-
Nuclear localization and regulation of erk-and rsk-encoded protein kinases
-
Chen, R.H.; Sarnecki, C.; Blenis, J. Nuclear localization and regulation of erk-and rsk-encoded protein kinases. Mol. Cell. Biol. 1992, 12, 915-927.
-
(1992)
Mol. Cell. Biol
, vol.12
, pp. 915-927
-
-
Chen, R.H.1
Sarnecki, C.2
Blenis, J.3
-
39
-
-
0032524356
-
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
-
Khokhlatchev, A.V.; Canagarajah, B.; Wilsbacher, J.; Robinson, M.; Atkinson, M.; Goldsmith, E.; Cobb, M.H. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell 1998, 93, 605-615.
-
(1998)
Cell
, vol.93
, pp. 605-615
-
-
Khokhlatchev, A.V.1
Canagarajah, B.2
Wilsbacher, J.3
Robinson, M.4
Atkinson, M.5
Goldsmith, E.6
Cobb, M.H.7
-
40
-
-
60349101656
-
Mapping of signaling pathways by functional interaction proteomics
-
Kriegsheim, A.; Preisinger, C.; Kolch, W. Mapping of signaling pathways by functional interaction proteomics. Methods Mol. Biol. 2008, 484, 177-192.
-
(2008)
Methods Mol. Biol
, vol.484
, pp. 177-192
-
-
Kriegsheim, A.1
Preisinger, C.2
Kolch, W.3
-
41
-
-
30944447568
-
The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
-
Yoon, S.; Seger, R. The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions. Growth Factors 2006, 24, 21-44.
-
(2006)
Growth Factors
, vol.24
, pp. 21-44
-
-
Yoon, S.1
Seger, R.2
-
42
-
-
0141611211
-
Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase
-
Rossomando, A.J.; Payne, D.M.; Weber, M.J.; Sturgill, T.W. Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. Proc. Natl. Acad. Sci. USA 1989, 86, 6940-6943.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 6940-6943
-
-
Rossomando, A.J.1
Payne, D.M.2
Weber, M.J.3
Sturgill, T.W.4
-
43
-
-
0025871767
-
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase
-
Alvarez, E.; Northwood, I.C.; Gonzalez, F.A.; Latour, D.A.; Seth, A.; Abate, C.; Curran, T.; Davis, R.J. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem. 1991, 266, 15277-15285.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 15277-15285
-
-
Alvarez, E.1
Northwood, I.C.2
Gonzalez, F.A.3
Latour, D.A.4
Seth, A.5
Abate, C.6
Curran, T.7
Davis, R.J.8
-
44
-
-
0025888298
-
Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases
-
Gonzalez, F.A.; Raden, D.L.; Davis, R.J. Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem. 1991, 266, 22159-22163.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 22159-22163
-
-
Gonzalez, F.A.1
Raden, D.L.2
Davis, R.J.3
-
45
-
-
7644222270
-
Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function
-
Aebersold, D.M.; Shaul, Y.D.; Yung, Y.; Yarom, N.; Yao, Z.; Hanoch, T.; Seger, R. Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function. Mol. Cell. Biol. 2004, 24, 10000-10015.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 10000-10015
-
-
Aebersold, D.M.1
Shaul, Y.D.2
Yung, Y.3
Yarom, N.4
Yao, Z.5
Hanoch, T.6
Seger, R.7
-
46
-
-
0034717036
-
ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK
-
Yung, Y.; Yao, Z.; Hanoch, T.; Seger, R. ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK. J. Biol. Chem. 2000, 275, 15799-15808.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 15799-15808
-
-
Yung, Y.1
Yao, Z.2
Hanoch, T.3
Seger, R.4
-
47
-
-
26644459229
-
The role of erk1 and erk2 in multiple stages of T cell development
-
Fischer, A.M.; Katayama, C.D.; Pages, G.; Pouyssegur, J.; Hedrick, S.M. The role of erk1 and erk2 in multiple stages of T cell development. Immunity 2005, 23, 431-443.
-
(2005)
Immunity
, vol.23
, pp. 431-443
-
-
Fischer, A.M.1
Katayama, C.D.2
Pages, G.3
Pouyssegur, J.4
Hedrick, S.M.5
-
48
-
-
37549016809
-
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels
-
Lefloch, R.; Pouyssegur, J.; Lenormand, P. Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol. Cell. Biol. 2008, 28, 511-527.
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 511-527
-
-
Lefloch, R.1
Pouyssegur, J.2
Lenormand, P.3
-
49
-
-
23444444748
-
ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis
-
Nekrasova, T.; Shive, C.; Gao, Y.; Kawamura, K.; Guardia, R.; Landreth, G.; Forsthuber, T.G. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J. Immunol. 2005, 175, 2374-2380.
-
(2005)
J. Immunol
, vol.175
, pp. 2374-2380
-
-
Nekrasova, T.1
Shive, C.2
Gao, Y.3
Kawamura, K.4
Guardia, R.5
Landreth, G.6
Forsthuber, T.G.7
-
50
-
-
0242607637
-
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
-
Saba-El-Leil, M.K.; Vella, F.D.; Vernay, B.; Voisin, L.; Chen, L.; Labrecque, N.; Ang, S.L.; Meloche, S. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 2003, 4, 964-968.
-
(2003)
EMBO Rep
, vol.4
, pp. 964-968
-
-
Saba-El-Leil, M.K.1
Vella, F.D.2
Vernay, B.3
Voisin, L.4
Chen, L.5
Labrecque, N.6
Ang, S.L.7
Meloche, S.8
-
51
-
-
33845904217
-
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially
-
Vantaggiato, C.; Formentini, I.; Bondanza, A.; Bonini, C.; Naldini, L.; Brambilla, R. ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. J. Biol. 2006, 5, 14.
-
(2006)
J. Biol
, vol.5
, pp. 14
-
-
Vantaggiato, C.1
Formentini, I.2
Bondanza, A.3
Bonini, C.4
Naldini, L.5
Brambilla, R.6
-
52
-
-
77953387301
-
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation
-
Voisin, L.; Saba-El-Leil, M.K.; Julien, C.; Fremin, C.; Meloche, S. Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol. Cell. Biol. 2010, 30, 2918-2932.
-
(2010)
Mol. Cell. Biol
, vol.30
, pp. 2918-2932
-
-
Voisin, L.1
Saba-El-Leil, M.K.2
Julien, C.3
Fremin, C.4
Meloche, S.5
-
53
-
-
84861206864
-
ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-beta2
-
Von Thun, A.; Birtwistle, M.; Kalna, G.; Grindlay, J.; Strachan, D.; Kolch, W.; von Kriegsheim, A.; Norman, J.C. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-beta2. J. Cell Sci. 2012, 125, 1465-1477.
-
(2012)
J. Cell Sci
, vol.125
, pp. 1465-1477
-
-
von Thun, A.1
Birtwistle, M.2
Kalna, G.3
Grindlay, J.4
Strachan, D.5
Kolch, W.6
von Kriegsheim, A.7
Norman, J.C.8
-
54
-
-
17144458301
-
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
-
Pages, G.; Guerin, S.; Grall, D.; Bonino, F.; Smith, A.; Anjuere, F.; Auberger, P.; Pouyssegur, J. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 1999, 286, 1374-1377.
-
(1999)
Science
, vol.286
, pp. 1374-1377
-
-
Pages, G.1
Guerin, S.2
Grall, D.3
Bonino, F.4
Smith, A.5
Anjuere, F.6
Auberger, P.7
Pouyssegur, J.8
-
55
-
-
0242300107
-
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
-
Yao, Y.; Li, W.; Wu, J.; Germann, U.A.; Su, M.S.; Kuida, K.; Boucher, D.M. Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc. Natl. Acad. Sci. USA 2003, 100, 12759-12764.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12759-12764
-
-
Yao, Y.1
Li, W.2
Wu, J.3
Germann, U.A.4
Su, M.S.5
Kuida, K.6
Boucher, D.M.7
-
56
-
-
0033081066
-
Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
-
Brunet, A.; Roux, D.; Lenormand, P.; Dowd, S.; Keyse, S.; Pouyssegur, J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J. 1999, 18, 664-674.
-
(1999)
EMBO J
, vol.18
, pp. 664-674
-
-
Brunet, A.1
Roux, D.2
Lenormand, P.3
Dowd, S.4
Keyse, S.5
Pouyssegur, J.6
-
57
-
-
50549083633
-
Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes
-
Casar, B.; Pinto, A.; Crespo, P. Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes. Mol. Cell 2008, 31, 708-721.
-
(2008)
Mol. Cell
, vol.31
, pp. 708-721
-
-
Casar, B.1
Pinto, A.2
Crespo, P.3
-
58
-
-
0035816678
-
Involvement of the activation loop of ERK in the detachment from cytosolic anchoring
-
Wolf, I.; Rubinfeld, H.; Yoon, S.; Marmor, G.; Hanoch, T.; Seger, R. Involvement of the activation loop of ERK in the detachment from cytosolic anchoring. J. Biol. Chem. 2001, 276, 24490-24497.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 24490-24497
-
-
Wolf, I.1
Rubinfeld, H.2
Yoon, S.3
Marmor, G.4
Hanoch, T.5
Seger, R.6
-
59
-
-
0033215340
-
Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer
-
Adachi, M.; Fukuda, M.; Nishida, E. Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer. EMBO J. 1999, 18, 5347-5358.
-
(1999)
EMBO J
, vol.18
, pp. 5347-5358
-
-
Adachi, M.1
Fukuda, M.2
Nishida, E.3
-
60
-
-
52049108218
-
Identification and characterization of a general nuclear translocation signal in signaling proteins
-
Chuderland, D.; Konson, A.; Seger, R. Identification and characterization of a general nuclear translocation signal in signaling proteins. Mol. Cell 2008, 31, 850-861.
-
(2008)
Mol. Cell
, vol.31
, pp. 850-861
-
-
Chuderland, D.1
Konson, A.2
Seger, R.3
-
61
-
-
70349795274
-
Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
-
Kosako, H.; Yamaguchi, N.; Aranami, C.; Ushiyama, M.; Kose, S.; Imamoto, N.; Taniguchi, H.; Nishida, E.; Hattori, S. Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport. Nat. Structr. Mol. Biol. 2009, 16, 1026-1035.
-
(2009)
Nat. Structr. Mol. Biol
, vol.16
, pp. 1026-1035
-
-
Kosako, H.1
Yamaguchi, N.2
Aranami, C.3
Ushiyama, M.4
Kose, S.5
Imamoto, N.6
Taniguchi, H.7
Nishida, E.8
Hattori, S.9
-
62
-
-
0035036212
-
Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin
-
Lorenzen, J.A.; Baker, S.E.; Denhez, F.; Melnick, M.B.; Brower, D.L.; Perkins, L.A. Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin. Development 2001, 128, 1403-1414.
-
(2001)
Development
, vol.128
, pp. 1403-1414
-
-
Lorenzen, J.A.1
Baker, S.E.2
Denhez, F.3
Melnick, M.B.4
Brower, D.L.5
Perkins, L.A.6
-
63
-
-
80052332583
-
Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation
-
Plotnikov, A.; Chuderland, D.; Karamansha, Y.; Livnah, O.; Seger, R. Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation. Mol. Cell. Biol. 2011, 31, 3515-3530.
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 3515-3530
-
-
Plotnikov, A.1
Chuderland, D.2
Karamansha, Y.3
Livnah, O.4
Seger, R.5
-
64
-
-
0038351827
-
Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs
-
Eblen, S.T.; Kumar, N.V.; Shah, K.; Henderson, M.J.; Watts, C.K.; Shokat, K.M.; Weber, M.J. Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J. Biol. Chem. 2003, 278, 14926-14935.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14926-14935
-
-
Eblen, S.T.1
Kumar, N.V.2
Shah, K.3
Henderson, M.J.4
Watts, C.K.5
Shokat, K.M.6
Weber, M.J.7
-
65
-
-
55849136848
-
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
-
Vomastek, T.; Iwanicki, M.P.; Burack, W.R.; Tiwari, D.; Kumar, D.; Parsons, J.T.; Weber, M.J.; Nandicoori, V.K. Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol. Cell. Biol. 2008, 28, 6954-6966.
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 6954-6966
-
-
Vomastek, T.1
Iwanicki, M.P.2
Burack, W.R.3
Tiwari, D.4
Kumar, D.5
Parsons, J.T.6
Weber, M.J.7
Nandicoori, V.K.8
-
66
-
-
0033599014
-
ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry
-
Cruzalegui, F.H.; Cano, E.; Treisman, R. ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. Oncogene 1999, 18, 7948-7957.
-
(1999)
Oncogene
, vol.18
, pp. 7948-7957
-
-
Cruzalegui, F.H.1
Cano, E.2
Treisman, R.3
-
67
-
-
0026695645
-
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
-
Gille, H.; Sharrocks, A.D.; Shaw, P.E. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 1992, 358, 414-417.
-
(1992)
Nature
, vol.358
, pp. 414-417
-
-
Gille, H.1
Sharrocks, A.D.2
Shaw, P.E.3
-
68
-
-
0027297647
-
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
-
Marais, R.; Wynne, J.; Treisman, R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 1993, 73, 381-393.
-
(1993)
Cell
, vol.73
, pp. 381-393
-
-
Marais, R.1
Wynne, J.2
Treisman, R.3
-
69
-
-
0028356516
-
Elk-1 proteins interact with MAP kinases
-
Rao, V.N.; Reddy, E.S. Elk-1 proteins interact with MAP kinases. Oncogene 1994, 9, 1855-1860.
-
(1994)
Oncogene
, vol.9
, pp. 1855-1860
-
-
Rao, V.N.1
Reddy, E.S.2
-
70
-
-
0027361017
-
Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase
-
Chen, R.H.; Abate, C.; Blenis, J. Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc. Natl. Acad. Sci. USA 1993, 90, 10952-10956.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10952-10956
-
-
Chen, R.H.1
Abate, C.2
Blenis, J.3
-
71
-
-
0029937701
-
Phosphorylation of c-Fos at the C-terminus enhances its transforming activity
-
Chen, R.H.; Juo, P.C.; Curran, T.; Blenis, J. Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. Oncogene 1996, 12, 1493-1502.
-
(1996)
Oncogene
, vol.12
, pp. 1493-1502
-
-
Chen, R.H.1
Juo, P.C.2
Curran, T.3
Blenis, J.4
-
72
-
-
44449113769
-
Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
-
Ekerot, M.; Stavridis, M.P.; Delavaine, L.; Mitchell, M.P.; Staples, C.; Owens, D.M.; Keenan, I.D.; Dickinson, R.J.; Storey, K.G.; Keyse, S.M. Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter. Biochem. J. 2008, 412, 287-298.
-
(2008)
Biochem. J
, vol.412
, pp. 287-298
-
-
Ekerot, M.1
Stavridis, M.P.2
Delavaine, L.3
Mitchell, M.P.4
Staples, C.5
Owens, D.M.6
Keenan, I.D.7
Dickinson, R.J.8
Storey, K.G.9
Keyse, S.M.10
-
73
-
-
0030028222
-
MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
-
Muda, M.; Boschert, U.; Dickinson, R.; Martinou, J.C.; Martinou, I.; Camps, M.; Schlegel, W.; Arkinstall, S. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. J. Biol. Chem. 1996, 271, 4319-4326.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 4319-4326
-
-
Muda, M.1
Boschert, U.2
Dickinson, R.3
Martinou, J.C.4
Martinou, I.5
Camps, M.6
Schlegel, W.7
Arkinstall, S.8
-
74
-
-
77950877457
-
Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells
-
Zhang, Z.; Kobayashi, S.; Borczuk, A.C.; Leidner, R.S.; Laframboise, T.; Levine, A.D.; Halmos, B. Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. Carcinogenesis 2010, 31, 577-586.
-
(2010)
Carcinogenesis
, vol.31
, pp. 577-586
-
-
Zhang, Z.1
Kobayashi, S.2
Borczuk, A.C.3
Leidner, R.S.4
Laframboise, T.5
Levine, A.D.6
Halmos, B.7
-
75
-
-
0029095176
-
ERF: An ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation
-
Sgouras, D.N.; Athanasiou, M.A.; Beal, G.J., Jr.; Fisher, R.J.; Blair, D.G.; Mavrothalassitis, G.J. ERF: An ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. EMBO J. 1995, 14, 4781-4793.
-
(1995)
EMBO J
, vol.14
, pp. 4781-4793
-
-
Sgouras, D.N.1
Athanasiou, M.A.2
Beal Jr., G.J.3
Fisher, R.J.4
Blair, D.G.5
Mavrothalassitis, G.J.6
-
76
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
Kato, S.; Endoh, H.; Masuhiro, Y.; Kitamoto, T.; Uchiyama, S.; Sasaki, H.; Masushige, S.; Gotoh, Y.; Nishida, E.; Kawashima, H., et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995, 270, 1491-1494.
-
(1995)
Science
, vol.270
, pp. 1491-1494
-
-
Kato, S.1
Endoh, H.2
Masuhiro, Y.3
Kitamoto, T.4
Uchiyama, S.5
Sasaki, H.6
Masushige, S.7
Gotoh, Y.8
Nishida, E.9
Kawashima, H.10
-
77
-
-
78751683777
-
Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs
-
Madak-Erdogan, Z.; Lupien, M.; Stossi, F.; Brown, M.; Katzenellenbogen, B.S. Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol. Cell. Biol. 2011, 31, 226-236.
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 226-236
-
-
Madak-Erdogan, Z.1
Lupien, M.2
Stossi, F.3
Brown, M.4
Katzenellenbogen, B.S.5
-
78
-
-
0038776380
-
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
-
Hu, E.; Kim, J.B.; Sarraf, P.; Spiegelman, B.M. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science 1996, 274, 2100-2103.
-
(1996)
Science
, vol.274
, pp. 2100-2103
-
-
Hu, E.1
Kim, J.B.2
Sarraf, P.3
Spiegelman, B.M.4
-
79
-
-
33846362869
-
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: A link to histone acetylation
-
Cohen-Armon, M.; Visochek, L.; Rozensal, D.; Kalal, A.; Geistrikh, I.; Klein, R.; Bendetz-Nezer, S.; Yao, Z.; Seger, R. DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: A link to histone acetylation. Mol. Cell 2007, 25, 297-308.
-
(2007)
Mol. Cell
, vol.25
, pp. 297-308
-
-
Cohen-Armon, M.1
Visochek, L.2
Rozensal, D.3
Kalal, A.4
Geistrikh, I.5
Klein, R.6
Bendetz-Nezer, S.7
Yao, Z.8
Seger, R.9
-
80
-
-
77953710050
-
Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex
-
Drobic, B.; Perez-Cadahia, B.; Yu, J.; Kung, S.K.; Davie, J.R. Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex. Nucleic Acids Res. 2010, 38, 3196-3208.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 3196-3208
-
-
Drobic, B.1
Perez-Cadahia, B.2
Yu, J.3
Kung, S.K.4
Davie, J.R.5
-
81
-
-
0038182524
-
MSK2 and MSK1 mediate the mitogen-and stress-induced phosphorylation of histone H3 and HMG-14
-
Soloaga, A.; Thomson, S.; Wiggin, G.R.; Rampersaud, N.; Dyson, M.H.; Hazzalin, C.A.; Mahadevan, L.C.; Arthur, J.S. MSK2 and MSK1 mediate the mitogen-and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 2003, 22, 2788-2797.
-
(2003)
EMBO J
, vol.22
, pp. 2788-2797
-
-
Soloaga, A.1
Thomson, S.2
Wiggin, G.R.3
Rampersaud, N.4
Dyson, M.H.5
Hazzalin, C.A.6
Mahadevan, L.C.7
Arthur, J.S.8
-
82
-
-
33750448996
-
Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3
-
Vicent, G.P.; Ballare, C.; Nacht, A.S.; Clausell, J.; Subtil-Rodriguez, A.; Quiles, I.; Jordan, A.; Beato, M. Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol. Cell 2006, 24, 367-381.
-
(2006)
Mol. Cell
, vol.24
, pp. 367-381
-
-
Vicent, G.P.1
Ballare, C.2
Nacht, A.S.3
Clausell, J.4
Subtil-Rodriguez, A.5
Quiles, I.6
Jordan, A.7
Beato, M.8
-
83
-
-
35649007784
-
PARP-1 activation in the ERK signaling pathway
-
Cohen-Armon, M. PARP-1 activation in the ERK signaling pathway. Trends Pharm. Sci. 2007, 28, 556-560.
-
(2007)
Trends Pharm. Sci
, vol.28
, pp. 556-560
-
-
Cohen-Armon, M.1
-
84
-
-
62049084764
-
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes
-
Nada, S.; Hondo, A.; Kasai, A.; Koike, M.; Saito, K.; Uchiyama, Y.; Okada, M. The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J. 2009, 28, 477-489.
-
(2009)
EMBO J
, vol.28
, pp. 477-489
-
-
Nada, S.1
Hondo, A.2
Kasai, A.3
Koike, M.4
Saito, K.5
Uchiyama, Y.6
Okada, M.7
-
85
-
-
0032508538
-
MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
-
Schaeffer, H.J.; Catling, A.D.; Eblen, S.T.; Collier, L.S.; Krauss, A.; Weber, M.J. MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 1998, 281, 1668-1671.
-
(1998)
Science
, vol.281
, pp. 1668-1671
-
-
Schaeffer, H.J.1
Catling, A.D.2
Eblen, S.T.3
Collier, L.S.4
Krauss, A.5
Weber, M.J.6
-
86
-
-
0035911147
-
A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment
-
Wunderlich, W.; Fialka, I.; Teis, D.; Alpi, A.; Pfeifer, A.; Parton, R.G.; Lottspeich, F.; Huber, L.A. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J. Cell Biol. 2001, 152, 765-776.
-
(2001)
J. Cell Biol
, vol.152
, pp. 765-776
-
-
Wunderlich, W.1
Fialka, I.2
Teis, D.3
Alpi, A.4
Pfeifer, A.5
Parton, R.G.6
Lottspeich, F.7
Huber, L.A.8
-
87
-
-
1842562333
-
Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development
-
Alonso, M.; Melani, M.; Converso, D.; Jaitovich, A.; Paz, C.; Carreras, M.C.; Medina, J.H.; Poderoso, J.J. Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development. J. Neurochem. 2004, 89, 248-256.
-
(2004)
J. Neurochem
, vol.89
, pp. 248-256
-
-
Alonso, M.1
Melani, M.2
Converso, D.3
Jaitovich, A.4
Paz, C.5
Carreras, M.C.6
Medina, J.H.7
Poderoso, J.J.8
-
88
-
-
70449591270
-
A new paradigm for MAPK: Structural interactions of hERK1 with mitochondria in HeLa cells
-
Galli, S.; Jahn, O.; Hitt, R.; Hesse, D.; Opitz, L.; Plessmann, U.; Urlaub, H.; Poderoso, J.J.; Jares-Erijman, E.A.; Jovin, T.M. A new paradigm for MAPK: Structural interactions of hERK1 with mitochondria in HeLa cells. PLoS One 2009, 4, e7541.
-
(2009)
PLoS One
, vol.4
-
-
Galli, S.1
Jahn, O.2
Hitt, R.3
Hesse, D.4
Opitz, L.5
Plessmann, U.6
Urlaub, H.7
Poderoso, J.J.8
Jares-Erijman, E.A.9
Jovin, T.M.10
-
89
-
-
65949119310
-
How ERK1/2 activation controls cell proliferation and cell death Is Subcellular Localization the Answer?
-
Mebratu, Y.; Tesfaigzi, Y. How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle 2009, 8, 1168-1175.
-
(2009)
Cell Cycle
, vol.8
, pp. 1168-1175
-
-
Mebratu, Y.1
Tesfaigzi, Y.2
-
90
-
-
84555218961
-
Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration
-
Asano, E.; Maeda, M.; Hasegawa, H.; Ito, S.; Hyodo, T.; Yuan, H.; Takahashi, M.; Hamaguchi, M.; Senga, T. Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration. PLoS One 2011, 6, e29338.
-
(2011)
PLoS One
, vol.6
-
-
Asano, E.1
Maeda, M.2
Hasegawa, H.3
Ito, S.4
Hyodo, T.5
Yuan, H.6
Takahashi, M.7
Hamaguchi, M.8
Senga, T.9
-
91
-
-
0037155919
-
Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association
-
Liu, Z.X.; Yu, C.F.; Nickel, C.; Thomas, S.; Cantley, L.G. Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association. J. Biol. Chem. 2002, 277, 10452-10458.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 10452-10458
-
-
Liu, Z.X.1
Yu, C.F.2
Nickel, C.3
Thomas, S.4
Cantley, L.G.5
-
92
-
-
84555189440
-
Regulation and function of the RSK family of protein kinases
-
Romeo, Y.; Zhang, X.; Roux, P.P. Regulation and function of the RSK family of protein kinases. Biochem. J. 2012, 441, 553-569.
-
(2012)
Biochem. J
, vol.441
, pp. 553-569
-
-
Romeo, Y.1
Zhang, X.2
Roux, P.P.3
-
93
-
-
0023766145
-
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
-
Sturgill, T.W.; Ray, L.B.; Erikson, E.; Maller, J.L. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature 1988, 334, 715-718.
-
(1988)
Nature
, vol.334
, pp. 715-718
-
-
Sturgill, T.W.1
Ray, L.B.2
Erikson, E.3
Maller, J.L.4
-
94
-
-
0028276218
-
Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)
-
Brunet, A.; Pages, G.; Pouyssegur, J. Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1). FEBS Lett. 1994, 346, 299-303.
-
(1994)
FEBS Lett
, vol.346
, pp. 299-303
-
-
Brunet, A.1
Pages, G.2
Pouyssegur, J.3
-
95
-
-
0027932676
-
Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: Determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis
-
Mansour, S.J.; Resing, K.A.; Candi, J.M.; Hermann, A.S.; Gloor, J.W.; Herskind, K.R.; Wartmann, M.; Davis, R.J.; Ahn, N.G. Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: Determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis. J. Biochem. 1994, 116, 304-314.
-
(1994)
J. Biochem
, vol.116
, pp. 304-314
-
-
Mansour, S.J.1
Resing, K.A.2
Candi, J.M.3
Hermann, A.S.4
Gloor, J.W.5
Herskind, K.R.6
Wartmann, M.7
Davis, R.J.8
Ahn, N.G.9
-
96
-
-
1542284071
-
Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion
-
Eblen, S.T.; Slack-Davis, J.K.; Tarcsafalvi, A.; Parsons, J.T.; Weber, M.J.; Catling, A.D. Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion. Mol. Cell. Biol. 2004, 24, 2308-2317.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 2308-2317
-
-
Eblen, S.T.1
Slack-Davis, J.K.2
Tarcsafalvi, A.3
Parsons, J.T.4
Weber, M.J.5
Catling, A.D.6
-
97
-
-
62049085543
-
Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal
-
Catalanotti, F.; Reyes, G.; Jesenberger, V.; Galabova-Kovacs, G.; de Matos Simoes, R.; Carugo, O.; Baccarini, M. A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat. Structr. Mol. Biol. 2009, 16, 294-303.
-
(2009)
Nat. Structr. Mol. Biol
, vol.16
, pp. 294-303
-
-
Catalanotti, F.1
Reyes, G.2
Jesenberger, V.3
Galabova-Kovacs, G.4
de Matos, S.R.5
Carugo, O.6
Baccarini, M.A.7
-
98
-
-
0029791452
-
Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2
-
Corbalan-Garcia, S.; Yang, S.S.; Degenhardt, K.R.; Bar-Sagi, D. Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. Mol. Cell. Biol. 1996, 16, 5674-5682.
-
(1996)
Mol. Cell. Biol
, vol.16
, pp. 5674-5682
-
-
Corbalan-Garcia, S.1
Yang, S.S.2
Degenhardt, K.R.3
Bar-Sagi, D.4
-
99
-
-
34248595035
-
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
-
Owens, D.M.; Keyse, S.M. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 2007, 26, 3203-3213.
-
(2007)
Oncogene
, vol.26
, pp. 3203-3213
-
-
Owens, D.M.1
Keyse, S.M.2
-
100
-
-
0031033716
-
The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade
-
Brondello, J.M.; Brunet, A.; Pouyssegur, J.; McKenzie, F.R. The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade. J. Biol. Chem. 1997, 272, 1368-1376.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 1368-1376
-
-
Brondello, J.M.1
Brunet, A.2
Pouyssegur, J.3
McKenzie, F.R.4
-
101
-
-
0038832564
-
Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
-
Brondello, J.M.; Pouyssegur, J.; McKenzie, F.R. Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 1999, 286, 2514-2517.
-
(1999)
Science
, vol.286
, pp. 2514-2517
-
-
Brondello, J.M.1
Pouyssegur, J.2
McKenzie, F.R.3
-
102
-
-
11844294679
-
Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation
-
Marchetti, S.; Gimond, C.; Chambard, J.C.; Touboul, T.; Roux, D.; Pouyssegur, J.; Pages, G. Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol. Cell. Biol. 2005, 25, 854-864.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 854-864
-
-
Marchetti, S.1
Gimond, C.2
Chambard, J.C.3
Touboul, T.4
Roux, D.5
Pouyssegur, J.6
Pages, G.7
-
103
-
-
0036173032
-
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling
-
Furthauer, M.; Lin, W.; Ang, S.L.; Thisse, B.; Thisse, C. Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat. Cell. Biol. 2002, 4, 170-174.
-
(2002)
Nat. Cell. Biol
, vol.4
, pp. 170-174
-
-
Furthauer, M.1
Lin, W.2
Ang, S.L.3
Thisse, B.4
Thisse, C.5
-
104
-
-
4344682999
-
Sef is a spatial regulator for Ras/MAP kinase signaling
-
Torii, S.; Kusakabe, M.; Yamamoto, T.; Maekawa, M.; Nishida, E. Sef is a spatial regulator for Ras/MAP kinase signaling. Dev. Cell 2004, 7, 33-44.
-
(2004)
Dev. Cell
, vol.7
, pp. 33-44
-
-
Torii, S.1
Kusakabe, M.2
Yamamoto, T.3
Maekawa, M.4
Nishida, E.5
-
105
-
-
0036170142
-
Identification of Sef, a novel modulator of FGF signalling
-
Tsang, M.; Friesel, R.; Kudoh, T.; Dawid, I.B. Identification of Sef, a novel modulator of FGF signalling. Nat. Cell. Biol. 2002, 4, 165-169.
-
(2002)
Nat. Cell. Biol
, vol.4
, pp. 165-169
-
-
Tsang, M.1
Friesel, R.2
Kudoh, T.3
Dawid, I.B.4
-
106
-
-
0036285634
-
Mathematical models of protein kinase signal transduction
-
Heinrich, R.; Neel, B.G.; Rapoport, T.A. Mathematical models of protein kinase signal transduction. Mol. Cell 2002, 9, 957-970.
-
(2002)
Mol. Cell
, vol.9
, pp. 957-970
-
-
Heinrich, R.1
Neel, B.G.2
Rapoport, T.A.3
-
107
-
-
34548059483
-
Scaffold proteins confer diverse regulatory properties to protein kinase cascades
-
Locasale, J.W.; Shaw, A.S.; Chakraborty, A.K. Scaffold proteins confer diverse regulatory properties to protein kinase cascades. Proc. Natl. Acad. Sci. USA 2007, 104, 13307-13312.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 13307-13312
-
-
Locasale, J.W.1
Shaw, A.S.2
Chakraborty, A.K.3
-
108
-
-
0031974812
-
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK
-
Yu, W.; Fantl, W.J.; Harrowe, G.; Williams, L.T. Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr. Biol. 1998, 8, 56-64.
-
(1998)
Curr. Biol
, vol.8
, pp. 56-64
-
-
Yu, W.1
Fantl, W.J.2
Harrowe, G.3
Williams, L.T.4
-
109
-
-
0034601685
-
What do scaffold proteins really do?
-
pe1
-
Ferrell, J.E., Jr. What do scaffold proteins really do? Sci. STKE 2000, 2000, pe1.
-
(2000)
Sci. STKE 2000
-
-
Ferrell, J.E.1
-
110
-
-
0034705227
-
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
-
Levchenko, A.; Bruck, J.; Sternberg, P.W. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl. Acad. Sci. USA 2000, 97, 5818-5823.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5818-5823
-
-
Levchenko, A.1
Bruck, J.2
Sternberg, P.W.3
-
111
-
-
33644506760
-
Scaffold proteins in MAP kinase signaling: More Than Simple Passive Activating Platforms
-
Dard, N.; Peter, M. Scaffold proteins in MAP kinase signaling: More than simple passive activating platforms. Bioessays 2006, 28, 146-156.
-
(2006)
Bioessays
, vol.28
, pp. 146-156
-
-
Dard, N.1
Peter, M.2
-
112
-
-
0035195491
-
The Ste5p scaffold
-
Elion, E.A. The Ste5p scaffold. J. Cell Sci. 2001, 114, 3967-3978.
-
(2001)
J. Cell Sci
, vol.114
, pp. 3967-3978
-
-
Elion, E.A.1
-
113
-
-
73349108440
-
The role of scaffold proteins in JNK signalling
-
Engstrom, W.; Ward, A.; Moorwood, K. The role of scaffold proteins in JNK signalling. Cell Prolif. 2010, 43, 56-66.
-
(2010)
Cell Prolif
, vol.43
, pp. 56-66
-
-
Engstrom, W.1
Ward, A.2
Moorwood, K.3
-
114
-
-
78649656028
-
Regulation of cross-talk in yeast MAPK signaling pathways
-
Saito, H. Regulation of cross-talk in yeast MAPK signaling pathways. Curr. Opin. Microbiol. 2010, 13, 677-683.
-
(2010)
Curr. Opin. Microbiol
, vol.13
, pp. 677-683
-
-
Saito, H.1
-
115
-
-
34248525404
-
Scaffold proteins of MAP-kinase modules
-
Dhanasekaran, D.N.; Kashef, K.; Lee, C.M.; Xu, H.; Reddy, E.P. Scaffold proteins of MAP-kinase modules. Oncogene 2007, 26, 3185-3202.
-
(2007)
Oncogene
, vol.26
, pp. 3185-3202
-
-
Dhanasekaran, D.N.1
Kashef, K.2
Lee, C.M.3
Xu, H.4
Reddy, E.P.5
-
116
-
-
79960791372
-
IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload
-
Sbroggio, M.; Carnevale, D.; Bertero, A.; Cifelli, G.; De Blasio, E.; Mascio, G.; Hirsch, E.; Bahou, W.F.; Turco, E.; Silengo, L., et al. IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovasc. Res. 2011, 91, 456-464.
-
(2011)
Cardiovasc. Res
, vol.91
, pp. 456-464
-
-
Sbroggio, M.1
Carnevale, D.2
Bertero, A.3
Cifelli, G.4
de Blasio, E.5
Mascio, G.6
Hirsch, E.7
Bahou, W.F.8
Turco, E.9
Silengo, L.10
-
117
-
-
34547548629
-
IQGAP1 modulates activation of B-Raf
-
Ren, J.G.; Li, Z.; Sacks, D.B. IQGAP1 modulates activation of B-Raf. Proc. Natl. Acad. Sci. USA 2007, 104, 10465-10469.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10465-10469
-
-
Ren, J.G.1
Li, Z.2
Sacks, D.B.3
-
118
-
-
2342424547
-
IQGAP1 binds ERK2 and modulates its activity
-
Roy, M.; Li, Z.; Sacks, D.B. IQGAP1 binds ERK2 and modulates its activity. J. Biol. Chem. 2004, 279, 17329-17337.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 17329-17337
-
-
Roy, M.1
Li, Z.2
Sacks, D.B.3
-
119
-
-
24344491858
-
IQGAP1 is a scaffold for mitogen-activated protein kinase signaling
-
Roy, M.; Li, Z.; Sacks, D.B. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol. Cell. Biol. 2005, 25, 7940-7952.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 7940-7952
-
-
Roy, M.1
Li, Z.2
Sacks, D.B.3
-
120
-
-
0029588204
-
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
-
Kornfeld, K.; Hom, D.B.; Horvitz, H.R. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 1995, 83, 903-913.
-
(1995)
Cell
, vol.83
, pp. 903-913
-
-
Kornfeld, K.1
Hom, D.B.2
Horvitz, H.R.3
-
121
-
-
0029559183
-
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
-
Sundaram, M.; Han, M. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 1995, 83, 889-901.
-
(1995)
Cell
, vol.83
, pp. 889-901
-
-
Sundaram, M.1
Han, M.2
-
122
-
-
0029584327
-
KSR, a novel protein kinase required for RAS signal transduction
-
Therrien, M.; Chang, H.C.; Solomon, N.M.; Karim, F.D.; Wassarman, D.A.; Rubin, G.M. KSR, a novel protein kinase required for RAS signal transduction. Cell 1995, 83, 879-888.
-
(1995)
Cell
, vol.83
, pp. 879-888
-
-
Therrien, M.1
Chang, H.C.2
Solomon, N.M.3
Karim, F.D.4
Wassarman, D.A.5
Rubin, G.M.6
-
123
-
-
0029850713
-
KSR modulates signal propagation within the MAPK cascade
-
Therrien, M.; Michaud, N.R.; Rubin, G.M.; Morrison, D.K. KSR modulates signal propagation within the MAPK cascade. Genes Dev. 1996, 10, 2684-2695.
-
(1996)
Genes Dev
, vol.10
, pp. 2684-2695
-
-
Therrien, M.1
Michaud, N.R.2
Rubin, G.M.3
Morrison, D.K.4
-
124
-
-
0344875502
-
Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling
-
Channavajhala, P.L.; Wu, L.; Cuozzo, J.W.; Hall, J.P.; Liu, W.; Lin, L.L.; Zhang, Y. Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. J. Biol. Chem. 2003, 278, 47089-47097.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 47089-47097
-
-
Channavajhala, P.L.1
Wu, L.2
Cuozzo, J.W.3
Hall, J.P.4
Liu, W.5
Lin, L.L.6
Zhang, Y.7
-
125
-
-
0037022533
-
C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation
-
Ohmachi, M.; Rocheleau, C.E.; Church, D.; Lambie, E.; Schedl, T.; Sundaram, M.V. C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation. Curr. Biol. 2002, 12, 427-433.
-
(2002)
Curr. Biol
, vol.12
, pp. 427-433
-
-
Ohmachi, M.1
Rocheleau, C.E.2
Church, D.3
Lambie, E.4
Schedl, T.5
Sundaram, M.V.6
-
127
-
-
0042172963
-
Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice
-
Lozano, J.; Xing, R.; Cai, Z.; Jensen, H.L.; Trempus, C.; Mark, W.; Cannon, R.; Kolesnick, R. Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res. 2003, 63, 4232-4238.
-
(2003)
Cancer Res
, vol.63
, pp. 4232-4238
-
-
Lozano, J.1
Xing, R.2
Cai, Z.3
Jensen, H.L.4
Trempus, C.5
Mark, W.6
Cannon, R.7
Kolesnick, R.8
-
128
-
-
0036239642
-
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
-
Nguyen, A.; Burack, W.R.; Stock, J.L.; Kortum, R.; Chaika, O.V.; Afkarian, M.; Muller, W.J.; Murphy, K.M.; Morrison, D.K.; Lewis, R.E., et al. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol. Cell. Biol. 2002, 22, 3035-3045.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 3035-3045
-
-
Nguyen, A.1
Burack, W.R.2
Stock, J.L.3
Kortum, R.4
Chaika, O.V.5
Afkarian, M.6
Muller, W.J.7
Murphy, K.M.8
Morrison, D.K.9
Lewis, R.E.10
-
129
-
-
33646848241
-
Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation
-
Shalin, S.C.; Hernandez, C.M.; Dougherty, M.K.; Morrison, D.K.; Sweatt, J.D. Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation. Neuron 2006, 50, 765-779.
-
(2006)
Neuron
, vol.50
, pp. 765-779
-
-
Shalin, S.C.1
Hernandez, C.M.2
Dougherty, M.K.3
Morrison, D.K.4
Sweatt, J.D.5
-
130
-
-
33750322263
-
The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis
-
Fusello, A.M.; Mandik-Nayak, L.; Shih, F.; Lewis, R.E.; Allen, P.M.; Shaw, A.S. The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis. J. Immunol. 2006, 177, 6152-6158.
-
(2006)
J. Immunol
, vol.177
, pp. 6152-6158
-
-
Fusello, A.M.1
Mandik-Nayak, L.2
Shih, F.3
Lewis, R.E.4
Allen, P.M.5
Shaw, A.S.6
-
131
-
-
33644758575
-
The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence
-
Kortum, R.L.; Johnson, H.J.; Costanzo, D.L.; Volle, D.J.; Razidlo, G.L.; Fusello, A.M.; Shaw, A.S.; Lewis, R.E. The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Mol. Cell. Biol. 2006, 26, 2202-2214.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 2202-2214
-
-
Kortum, R.L.1
Johnson, H.J.2
Costanzo, D.L.3
Volle, D.J.4
Razidlo, G.L.5
Fusello, A.M.6
Shaw, A.S.7
Lewis, R.E.8
-
132
-
-
0035018017
-
KSR: A MAPK scaffold of the Ras pathway
-
Morrison, D.K. KSR: A MAPK scaffold of the Ras pathway? J. Cell Sci. 2001, 114, 1609-1612.
-
(2001)
J. Cell Sci
, vol.114
, pp. 1609-1612
-
-
Morrison, D.K.1
-
133
-
-
0035930343
-
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
-
Muller, J.; Ory, S.; Copeland, T.; Piwnica-Worms, H.; Morrison, D.K. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol. Cell 2001, 8, 983-993.
-
(2001)
Mol. Cell
, vol.8
, pp. 983-993
-
-
Muller, J.1
Ory, S.2
Copeland, T.3
Piwnica-Worms, H.4
Morrison, D.K.5
-
134
-
-
0037197949
-
MAP kinase module: The Ksr connection
-
Roy, F.; Therrien, M. MAP kinase module: The Ksr connection. Curr. Biol. 2002, 12, R325-R327.
-
(2002)
Curr. Biol
, vol.12
-
-
Roy, F.1
Therrien, M.2
-
135
-
-
0030724987
-
KSR stimulates Raf-1 activity in a kinase-independent manner
-
Michaud, N.R.; Therrien, M.; Cacace, A.; Edsall, L.C.; Spiegel, S.; Rubin, G.M.; Morrison, D.K. KSR stimulates Raf-1 activity in a kinase-independent manner. Proc. Natl. Acad. Sci. USA 1997, 94, 12792-12796.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12792-12796
-
-
Michaud, N.R.1
Therrien, M.2
Cacace, A.3
Edsall, L.C.4
Spiegel, S.5
Rubin, G.M.6
Morrison, D.K.7
-
136
-
-
23044510085
-
HKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation
-
Channavajhala, P.L.; Rao, V.R.; Spaulding, V.; Lin, L.L.; Zhang, Y.G. hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation. Biochem. Biophys. Res. Commun. 2005, 334, 1214-1218.
-
(2005)
Biochem. Biophys. Res. Commun
, vol.334
, pp. 1214-1218
-
-
Channavajhala, P.L.1
Rao, V.R.2
Spaulding, V.3
Lin, L.L.4
Zhang, Y.G.5
-
137
-
-
0031974151
-
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
-
Denouel-Galy, A.; Douville, E.M.; Warne, P.H.; Papin, C.; Laugier, D.; Calothy, G.; Downward, J.; Eychene, A. Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Curr. Biol. 1998, 8, 46-55.
-
(1998)
Curr. Biol
, vol.8
, pp. 46-55
-
-
Denouel-Galy, A.1
Douville, E.M.2
Warne, P.H.3
Papin, C.4
Laugier, D.5
Calothy, G.6
Downward, J.7
Eychene, A.8
-
138
-
-
0036293754
-
H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis
-
Roy, S.; Wyse, B.; Hancock, J.F. H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Mol. Cell. Biol. 2002, 22, 5128-5140.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 5128-5140
-
-
Roy, S.1
Wyse, B.2
Hancock, J.F.3
-
139
-
-
33747886526
-
Emerging roles of pseudokinases
-
Boudeau, J.; Miranda-Saavedra, D.; Barton, G.J.; Alessi, D.R. Emerging roles of pseudokinases. Trends Cell Biol. 2006, 16, 443-452.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 443-452
-
-
Boudeau, J.1
Miranda-Saavedra, D.2
Barton, G.J.3
Alessi, D.R.4
-
140
-
-
78651441816
-
KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1
-
Goettel, J.A.; Liang, D.; Hilliard, V.C.; Edelblum, K.L.; Broadus, M.R.; Gould, K.L.; Hanks, S.K.; Polk, D.B. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp. Cell. Res. 2011, 317, 452-463.
-
(2011)
Exp. Cell. Res
, vol.317
, pp. 452-463
-
-
Goettel, J.A.1
Liang, D.2
Hilliard, V.C.3
Edelblum, K.L.4
Broadus, M.R.5
Gould, K.L.6
Hanks, S.K.7
Polk, D.B.8
-
141
-
-
0032536853
-
The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation
-
Sugimoto, T.; Stewart, S.; Han, M.; Guan, K.L. The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation. EMBO J. 1998, 17, 1717-1727.
-
(1998)
EMBO J
, vol.17
, pp. 1717-1727
-
-
Sugimoto, T.1
Stewart, S.2
Han, M.3
Guan, K.L.4
-
142
-
-
0035116903
-
Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells
-
Yan, F.; Polk, D.B. Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells. Cancer Res. 2001, 61, 963-969.
-
(2001)
Cancer Res
, vol.61
, pp. 963-969
-
-
Yan, F.1
Polk, D.B.2
-
143
-
-
0029928988
-
Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate
-
Robinson, M.J.; Harkins, P.C.; Zhang, J.; Baer, R.; Haycock, J.W.; Cobb, M.H.; Goldsmith, E.J. Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate. Biochemistry 1996, 35, 5641-5646.
-
(1996)
Biochemistry
, vol.35
, pp. 5641-5646
-
-
Robinson, M.J.1
Harkins, P.C.2
Zhang, J.3
Baer, R.4
Haycock, J.W.5
Cobb, M.H.6
Goldsmith, E.J.7
-
144
-
-
0023885305
-
The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
-
Hanks, S.K.; Quinn, A.M.; Hunter, T. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science 1988, 241, 42-52.
-
(1988)
Science
, vol.241
, pp. 42-52
-
-
Hanks, S.K.1
Quinn, A.M.2
Hunter, T.3
-
145
-
-
79955472800
-
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK
-
Brennan, D.F.; Dar, A.C.; Hertz, N.T.; Chao, W.C.; Burlingame, A.L.; Shokat, K.M.; Barford, D. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature 2011, 472, 366-369.
-
(2011)
Nature
, vol.472
, pp. 366-369
-
-
Brennan, D.F.1
Dar, A.C.2
Hertz, N.T.3
Chao, W.C.4
Burlingame, A.L.5
Shokat, K.M.6
Barford, D.7
-
146
-
-
79955044151
-
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF
-
Hu, J.; Yu, H.; Kornev, A.P.; Zhao, J.; Filbert, E.L.; Taylor, S.S.; Shaw, A.S. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc. Natl. Acad. Sci. USA 2011, 108, 6067-6072.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 6067-6072
-
-
Hu, J.1
Yu, H.2
Kornev, A.P.3
Zhao, J.4
Filbert, E.L.5
Taylor, S.S.6
Shaw, A.S.7
-
147
-
-
0042178312
-
Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
-
Ory, S.; Zhou, M.; Conrads, T.P.; Veenstra, T.D.; Morrison, D.K. Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites. Curr. Biol. 2003, 13, 1356-1364.
-
(2003)
Curr. Biol
, vol.13
, pp. 1356-1364
-
-
Ory, S.1
Zhou, M.2
Conrads, T.P.3
Veenstra, T.D.4
Morrison, D.K.5
-
148
-
-
66449131737
-
Signaling threshold regulation by the Ras effector IMP
-
Matheny, S.A.; White, M.A. Signaling threshold regulation by the Ras effector IMP. J. Biol. Chem. 2009, 284, 11007-11011.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 11007-11011
-
-
Matheny, S.A.1
White, M.A.2
-
149
-
-
45149103530
-
IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds
-
Chen, C.; Lewis, R.E.; White, M.A. IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. J. Biol. Chem. 2008, 283, 12789-12796.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 12789-12796
-
-
Chen, C.1
Lewis, R.E.2
White, M.A.3
-
150
-
-
0035819073
-
NGF signaling from clathrin-coated vesicles: Evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway
-
Howe, C.L.; Valletta, J.S.; Rusnak, A.S.; Mobley, W.C. NGF signaling from clathrin-coated vesicles: Evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron 2001, 32, 801-814.
-
(2001)
Neuron
, vol.32
, pp. 801-814
-
-
Howe, C.L.1
Valletta, J.S.2
Rusnak, A.S.3
Mobley, W.C.4
-
151
-
-
0035999983
-
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cell
-
Jiang, X.; Sorkin, A. Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol. Biol. Cell. 2002, 13, 1522-1535.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 1522-1535
-
-
Jiang, X.1
Sorkin, A.2
-
152
-
-
0035956983
-
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds
-
Luttrell, L.M.; Roudabush, F.L.; Choy, E.W.; Miller, W.E.; Field, M.E.; Pierce, K.L.; Lefkowitz, R.J. Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc. Natl. Acad. Sci. USA 2001, 98, 2449-2454.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 2449-2454
-
-
Luttrell, L.M.1
Roudabush, F.L.2
Choy, E.W.3
Miller, W.E.4
Field, M.E.5
Pierce, K.L.6
Lefkowitz, R.J.7
-
153
-
-
0035426219
-
Nerve growth factor activates persistent Rap1 signaling in endosomes
-
Wu, C.; Lai, C.F.; Mobley, W.C. Nerve growth factor activates persistent Rap1 signaling in endosomes. J. Neurosci. 2001, 21, 5406-5416.
-
(2001)
J. Neurosci
, vol.21
, pp. 5406-5416
-
-
Wu, C.1
Lai, C.F.2
Mobley, W.C.3
-
154
-
-
0036899420
-
Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
-
Teis, D.; Wunderlich, W.; Huber, L.A. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 2002, 3, 803-814.
-
(2002)
Dev. Cell
, vol.3
, pp. 803-814
-
-
Teis, D.1
Wunderlich, W.2
Huber, L.A.3
-
155
-
-
2542432265
-
The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling
-
Lunin, V.V.; Munger, C.; Wagner, J.; Ye, Z.; Cygler, M.; Sacher, M. The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling. J. Biol. Chem. 2004, 279, 23422-23430.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 23422-23430
-
-
Lunin, V.V.1
Munger, C.2
Wagner, J.3
Ye, Z.4
Cygler, M.5
Sacher, M.6
-
156
-
-
33846109356
-
A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14
-
Bohn, G.; Allroth, A.; Brandes, G.; Thiel, J.; Glocker, E.; Schaffer, A.A.; Rathinam, C.; Taub, N.; Teis, D.; Zeidler, C., et al. A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. Nat. Med. 2007, 13, 38-45.
-
(2007)
Nat. Med
, vol.13
, pp. 38-45
-
-
Bohn, G.1
Allroth, A.2
Brandes, G.3
Thiel, J.4
Glocker, E.5
Schaffer, A.A.6
Rathinam, C.7
Taub, N.8
Teis, D.9
Zeidler, C.10
-
157
-
-
33845709128
-
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis
-
Teis, D.; Taub, N.; Kurzbauer, R.; Hilber, D.; de Araujo, M.E.; Erlacher, M.; Offterdinger, M.; Villunger, A.; Geley, S.; Bohn, G., et al. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J. Cell Biol. 2006, 175, 861-868.
-
(2006)
J. Cell Biol
, vol.175
, pp. 861-868
-
-
Teis, D.1
Taub, N.2
Kurzbauer, R.3
Hilber, D.4
de Araujo, M.E.5
Erlacher, M.6
Offterdinger, M.7
Villunger, A.8
Geley, S.9
Bohn, G.10
-
158
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak, Y.; Bar-Peled, L.; Zoncu, R.; Markhard, A.L.; Nada, S.; Sabatini, D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141, 290-303.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
159
-
-
0030593035
-
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
-
Ferguson, S.S.; Downey, W.E., 3rd; Colapietro, A.M.; Barak, L.S.; Menard, L.; Caron, M.G. Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 1996, 271, 363-366.
-
(1996)
Science
, vol.271
, pp. 363-366
-
-
Ferguson, S.S.1
Downey III, W.E.2
Colapietro, A.M.3
Barak, L.S.4
Menard, L.5
Caron, M.G.6
-
160
-
-
0031692337
-
G protein-coupled receptor kinases
-
Pitcher, J.A.; Freedman, N.J.; Lefkowitz, R.J. G protein-coupled receptor kinases. Annu. Rev. Biochem. 1998, 67, 653-692.
-
(1998)
Annu. Rev. Biochem
, vol.67
, pp. 653-692
-
-
Pitcher, J.A.1
Freedman, N.J.2
Lefkowitz, R.J.3
-
161
-
-
70349986967
-
Arrestin development: Emerging roles for beta-arrestins in developmental signaling pathways
-
Kovacs, J.J.; Hara, M.R.; Davenport, C.L.; Kim, J.; Lefkowitz, R.J. Arrestin development: Emerging roles for beta-arrestins in developmental signaling pathways. Dev. Cell 2009, 17, 443-458.
-
(2009)
Dev. Cell
, vol.17
, pp. 443-458
-
-
Kovacs, J.J.1
Hara, M.R.2
Davenport, C.L.3
Kim, J.4
Lefkowitz, R.J.5
-
162
-
-
33845870964
-
Arrestins: Ubiquitous regulators of cellular signaling pathways
-
Gurevich, E.V.; Gurevich, V.V. Arrestins: Ubiquitous regulators of cellular signaling pathways. Genome Biol. 2006, 7, 236.
-
(2006)
Genome Biol
, vol.7
, pp. 236
-
-
Gurevich, E.V.1
Gurevich, V.V.2
-
163
-
-
0242412524
-
Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination
-
Martin, N.P.; Lefkowitz, R.J.; Shenoy, S.K. Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. J. Biol. Chem. 2003, 278, 45954-45959.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 45954-45959
-
-
Martin, N.P.1
Lefkowitz, R.J.2
Shenoy, S.K.3
-
164
-
-
0037737763
-
Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination
-
Shenoy, S.K.; Lefkowitz, R.J. Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. J. Biol. Chem. 2003, 278, 14498-14506.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14498-14506
-
-
Shenoy, S.K.1
Lefkowitz, R.J.2
-
165
-
-
0035834428
-
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin
-
Shenoy, S.K.; McDonald, P.H.; Kohout, T.A.; Lefkowitz, R.J. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 2001, 294, 1307-1313.
-
(2001)
Science
, vol.294
, pp. 1307-1313
-
-
Shenoy, S.K.1
McDonald, P.H.2
Kohout, T.A.3
Lefkowitz, R.J.4
-
166
-
-
52049117442
-
Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
-
Shenoy, S.K.; Xiao, K.; Venkataramanan, V.; Snyder, P.M.; Freedman, N.J.; Weissman, A.M. Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J. Biol. Chem. 2008, 283, 22166-22176.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 22166-22176
-
-
Shenoy, S.K.1
Xiao, K.2
Venkataramanan, V.3
Snyder, P.M.4
Freedman, N.J.5
Weissman, A.M.6
-
167
-
-
35748944113
-
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
-
Shenoy, S.K.; Barak, L.S.; Xiao, K.; Ahn, S.; Berthouze, M.; Shukla, A.K.; Luttrell, L.M.; Lefkowitz, R.J. Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. J. Biol. Chem. 2007, 282, 29549-29562.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 29549-29562
-
-
Shenoy, S.K.1
Barak, L.S.2
Xiao, K.3
Ahn, S.4
Berthouze, M.5
Shukla, A.K.6
Luttrell, L.M.7
Lefkowitz, R.J.8
-
168
-
-
33846998992
-
Beta-arrestin signaling and regulation of transcription
-
Ma, L.; Pei, G. Beta-arrestin signaling and regulation of transcription. J. Cell Sci. 2007, 120, 213-218.
-
(2007)
J. Cell Sci
, vol.120
, pp. 213-218
-
-
Ma, L.1
Pei, G.2
-
169
-
-
33644857279
-
Beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor
-
Shenoy, S.K.; Drake, M.T.; Nelson, C.D.; Houtz, D.A.; Xiao, K.; Madabushi, S.; Reiter, E.; Premont, R.T.; Lichtarge, O.; Lefkowitz, R.J. Beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J. Biol. Chem. 2006, 281, 1261-1273.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 1261-1273
-
-
Shenoy, S.K.1
Drake, M.T.2
Nelson, C.D.3
Houtz, D.A.4
Xiao, K.5
Madabushi, S.6
Reiter, E.7
Premont, R.T.8
Lichtarge, O.9
Lefkowitz, R.J.10
-
170
-
-
33947401068
-
Beta-arrestins and cell signaling
-
DeWire, S.M.; Ahn, S.; Lefkowitz, R.J.; Shenoy, S.K. Beta-arrestins and cell signaling. Annu. Rev. Physiol. 2007, 69, 483-510.
-
(2007)
Annu. Rev. Physiol
, vol.69
, pp. 483-510
-
-
Dewire, S.M.1
Ahn, S.2
Lefkowitz, R.J.3
Shenoy, S.K.4
-
171
-
-
0034689003
-
beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
-
DeFea, K.A.; Zalevsky, J.; Thoma, M.S.; Dery, O.; Mullins, R.D.; Bunnett, N.W. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 2000, 148, 1267-1281.
-
(2000)
J. Cell Biol
, vol.148
, pp. 1267-1281
-
-
Defea, K.A.1
Zalevsky, J.2
Thoma, M.S.3
Dery, O.4
Mullins, R.D.5
Bunnett, N.W.6
-
172
-
-
0033522896
-
Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases
-
Lin, F.T.; Miller, W.E.; Luttrell, L.M.; Lefkowitz, R.J. Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. J. Biol. Chem. 1999, 274, 15971-15974.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 15971-15974
-
-
Lin, F.T.1
Miller, W.E.2
Luttrell, L.M.3
Lefkowitz, R.J.4
-
173
-
-
0030680131
-
Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1
-
Lin, F.T.; Krueger, K.M.; Kendall, H.E.; Daaka, Y.; Fredericks, Z.L.; Pitcher, J.A.; Lefkowitz, R.J. Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J. Biol. Chem. 1997, 272, 31051-31057.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 31051-31057
-
-
Lin, F.T.1
Krueger, K.M.2
Kendall, H.E.3
Daaka, Y.4
Fredericks, Z.L.5
Pitcher, J.A.6
Lefkowitz, R.J.7
-
174
-
-
0034711397
-
Beta-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3
-
McDonald, P.H.; Chow, C.W.; Miller, W.E.; Laporte, S.A.; Field, M.E.; Lin, F.T.; Davis, R.J.; Lefkowitz, R.J. Beta-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3. Science 2000, 290, 1574-1577.
-
(2000)
Science
, vol.290
, pp. 1574-1577
-
-
McDonald, P.H.1
Chow, C.W.2
Miller, W.E.3
Laporte, S.A.4
Field, M.E.5
Lin, F.T.6
Davis, R.J.7
Lefkowitz, R.J.8
-
175
-
-
0030732503
-
Beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation
-
Conner, D.A.; Mathier, M.A.; Mortensen, R.M.; Christe, M.; Vatner, S.F.; Seidman, C.E.; Seidman, J.G. Beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation. Circ Res 1997, 81, 1021-1026.
-
(1997)
Circ Res
, vol.81
, pp. 1021-1026
-
-
Conner, D.A.1
Mathier, M.A.2
Mortensen, R.M.3
Christe, M.4
Vatner, S.F.5
Seidman, C.E.6
Seidman, J.G.7
-
176
-
-
0033601341
-
Enhanced morphine analgesia in mice lacking beta-arrestin 2
-
Bohn, L.M.; Lefkowitz, R.J.; Gainetdinov, R.R.; Peppel, K.; Caron, M.G.; Lin, F.T. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 1999, 286, 2495-2498.
-
(1999)
Science
, vol.286
, pp. 2495-2498
-
-
Bohn, L.M.1
Lefkowitz, R.J.2
Gainetdinov, R.R.3
Peppel, K.4
Caron, M.G.5
Lin, F.T.6
-
177
-
-
0035852697
-
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
-
Kohout, T.A.; Lin, F.S.; Perry, S.J.; Conner, D.A.; Lefkowitz, R.J. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc. Natl. Acad. Sci. USA 2001, 98, 1601-1606.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1601-1606
-
-
Kohout, T.A.1
Lin, F.S.2
Perry, S.J.3
Conner, D.A.4
Lefkowitz, R.J.5
-
178
-
-
0030706168
-
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
-
Kouhara, H.; Hadari, Y.R.; Spivak-Kroizman, T.; Schilling, J.; Bar-Sagi, D.; Lax, I.; Schlessinger, J. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 1997, 89, 693-702.
-
(1997)
Cell
, vol.89
, pp. 693-702
-
-
Kouhara, H.1
Hadari, Y.R.2
Spivak-Kroizman, T.3
Schilling, J.4
Bar-Sagi, D.5
Lax, I.6
Schlessinger, J.7
-
179
-
-
0034464962
-
Potential involvement of FRS2 in insulin signaling
-
Delahaye, L.; Rocchi, S.; Van Obberghen, E. Potential involvement of FRS2 in insulin signaling. Endocrinology 2000, 141, 621-628.
-
(2000)
Endocrinology
, vol.141
, pp. 621-628
-
-
Delahaye, L.1
Rocchi, S.2
van Obberghen, E.3
-
180
-
-
0035902581
-
Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways
-
Hadari, Y.R.; Gotoh, N.; Kouhara, H.; Lax, I.; Schlessinger, J. Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. Proc. Natl. Acad. Sci. USA 2001, 98, 8578-8583.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8578-8583
-
-
Hadari, Y.R.1
Gotoh, N.2
Kouhara, H.3
Lax, I.4
Schlessinger, J.5
-
181
-
-
0035848684
-
Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction
-
Kurokawa, K.; Iwashita, T.; Murakami, H.; Hayashi, H.; Kawai, K.; Takahashi, M. Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction. Oncogene 2001, 20, 1929-1938.
-
(2001)
Oncogene
, vol.20
, pp. 1929-1938
-
-
Kurokawa, K.1
Iwashita, T.2
Murakami, H.3
Hayashi, H.4
Kawai, K.5
Takahashi, M.6
-
182
-
-
0033515534
-
The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
-
Meakin, S.O.; MacDonald, J.I.; Gryz, E.A.; Kubu, C.J.; Verdi, J.M. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J. Biol. Chem. 1999, 274, 9861-9870.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 9861-9870
-
-
Meakin, S.O.1
Macdonald, J.I.2
Gryz, E.A.3
Kubu, C.J.4
Verdi, J.M.5
-
183
-
-
0034967978
-
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade
-
Melillo, R.M.; Santoro, M.; Ong, S.H.; Billaud, M.; Fusco, A.; Hadari, Y.R.; Schlessinger, J.; Lax, I. Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol. Cell. Biol. 2001, 21, 4177-4187.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 4177-4187
-
-
Melillo, R.M.1
Santoro, M.2
Ong, S.H.3
Billaud, M.4
Fusco, A.5
Hadari, Y.R.6
Schlessinger, J.7
Lax, I.8
-
184
-
-
0942300661
-
Model analysis of difference between EGF pathway and FGF pathway
-
Yamada, S.; Taketomi, T.; Yoshimura, A. Model analysis of difference between EGF pathway and FGF pathway. Biochem. Biophys. Res. Commun. 2004, 314, 1113-1120.
-
(2004)
Biochem. Biophys. Res. Commun
, vol.314
, pp. 1113-1120
-
-
Yamada, S.1
Taketomi, T.2
Yoshimura, A.3
-
185
-
-
0033974109
-
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
-
Ong, S.H.; Guy, G.R.; Hadari, Y.R.; Laks, S.; Gotoh, N.; Schlessinger, J.; Lax, I. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol. Cell. Biol. 2000, 20, 979-989.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 979-989
-
-
Ong, S.H.1
Guy, G.R.2
Hadari, Y.R.3
Laks, S.4
Gotoh, N.5
Schlessinger, J.6
Lax, I.7
-
186
-
-
0033635195
-
Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors
-
Dhalluin, C.; Yan, K.S.; Plotnikova, O.; Lee, K.W.; Zeng, L.; Kuti, M.; Mujtaba, S.; Goldfarb, M.P.; Zhou, M.M. Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors. Mol. Cell 2000, 6, 921-929.
-
(2000)
Mol. Cell
, vol.6
, pp. 921-929
-
-
Dhalluin, C.1
Yan, K.S.2
Plotnikova, O.3
Lee, K.W.4
Zeng, L.5
Kuti, M.6
Mujtaba, S.7
Goldfarb, M.P.8
Zhou, M.M.9
-
187
-
-
33645883804
-
The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor
-
Easton, J.B.; Royer, A.R.; Middlemas, D.S. The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor. J. Neurochem. 2006, 97, 834-845.
-
(2006)
J. Neurochem
, vol.97
, pp. 834-845
-
-
Easton, J.B.1
Royer, A.R.2
Middlemas, D.S.3
-
188
-
-
0032540941
-
Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins
-
Xu, H.; Lee, K.W.; Goldfarb, M. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. J. Biol. Chem. 1998, 273, 17987-17990.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 17987-17990
-
-
Xu, H.1
Lee, K.W.2
Goldfarb, M.3
-
189
-
-
0031835659
-
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
-
Hadari, Y.R.; Kouhara, H.; Lax, I.; Schlessinger, J. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol. Cell. Biol. 1998, 18, 3966-3973.
-
(1998)
Mol. Cell. Biol
, vol.18
, pp. 3966-3973
-
-
Hadari, Y.R.1
Kouhara, H.2
Lax, I.3
Schlessinger, J.4
-
190
-
-
0035933094
-
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
-
Ong, S.H.; Hadari, Y.R.; Gotoh, N.; Guy, G.R.; Schlessinger, J.; Lax, I. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc. Natl. Acad. Sci. USA 2001, 98, 6074-6079.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6074-6079
-
-
Ong, S.H.1
Hadari, Y.R.2
Gotoh, N.3
Guy, G.R.4
Schlessinger, J.5
Lax, I.6
-
191
-
-
0037076329
-
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
-
Wong, A.; Lamothe, B.; Lee, A.; Schlessinger, J.; Lax, I. FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc. Natl. Acad. Sci. USA 2002, 99, 6684-6689.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6684-6689
-
-
Wong, A.1
Lamothe, B.2
Lee, A.3
Schlessinger, J.4
Lax, I.5
-
192
-
-
0035019115
-
Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis
-
McDougall, K.; Kubu, C.; Verdi, J.M.; Meakin, S.O. Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis. Mech. Dev. 2001, 103, 145-148.
-
(2001)
Mech. Dev
, vol.103
, pp. 145-148
-
-
McDougall, K.1
Kubu, C.2
Verdi, J.M.3
Meakin, S.O.4
-
193
-
-
1842850649
-
FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts
-
Gotoh, N.; Laks, S.; Nakashima, M.; Lax, I.; Schlessinger, J. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS Lett. 2004, 564, 14-18.
-
(2004)
FEBS Lett
, vol.564
, pp. 14-18
-
-
Gotoh, N.1
Laks, S.2
Nakashima, M.3
Lax, I.4
Schlessinger, J.5
-
194
-
-
2342474379
-
Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists
-
Vomastek, T.; Schaeffer, H.J.; Tarcsafalvi, A.; Smolkin, M.E.; Bissonette, E.A.; Weber, M.J. Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Proc. Natl. Acad. Sci. USA 2004, 101, 6981-6986.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6981-6986
-
-
Vomastek, T.1
Schaeffer, H.J.2
Tarcsafalvi, A.3
Smolkin, M.E.4
Bissonette, E.A.5
Weber, M.J.6
-
195
-
-
33646852807
-
The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)
-
Hopfer, U.; Hopfer, H.; Jablonski, K.; Stahl, R.A.; Wolf, G. The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3). J. Biol. Chem. 2006, 281, 8645-8655.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 8645-8655
-
-
Hopfer, U.1
Hopfer, H.2
Jablonski, K.3
Stahl, R.A.4
Wolf, G.5
-
196
-
-
63449105562
-
Reduced Morg1 expression in ischemic human brain
-
Haase, D.; Keiner, S.; Mawrin, C.; Wolf, G. Reduced Morg1 expression in ischemic human brain. Neurosci. Lett. 2009, 455, 46-50.
-
(2009)
Neurosci. Lett
, vol.455
, pp. 46-50
-
-
Haase, D.1
Keiner, S.2
Mawrin, C.3
Wolf, G.4
-
197
-
-
70350705956
-
Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury
-
Hammerschmidt, E.; Loeffler, I.; Wolf, G. Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury. Am. J. Physiol. Renal. Physiol. 2009, 297, F1273-F1287.
-
(2009)
Am. J. Physiol. Renal. Physiol
, vol.297
-
-
Hammerschmidt, E.1
Loeffler, I.2
Wolf, G.3
-
198
-
-
84867334170
-
Morg1(+/-) heterozygous mice are protected from experimentally induced focal cerebral ischemia
-
Stahr, A.; Frahm, C.; Kretz, A.; Bondeva, T.; Witte, O.W.; Wolf, G. Morg1(+/-) heterozygous mice are protected from experimentally induced focal cerebral ischemia. Brain Res. 2012, 1482, 22-31.
-
(2012)
Brain Res
, vol.1482
, pp. 22-31
-
-
Stahr, A.1
Frahm, C.2
Kretz, A.3
Bondeva, T.4
Witte, O.W.5
Wolf, G.6
-
199
-
-
77957167810
-
Revitalizing membrane rafts: New tools and insights
-
Simons, K.; Gerl, M.J. Revitalizing membrane rafts: New tools and insights. Nat. Rev. 2010, 11, 688-699.
-
(2010)
Nat. Rev
, vol.11
, pp. 688-699
-
-
Simons, K.1
Gerl, M.J.2
-
201
-
-
0031010267
-
Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins
-
Bickel, P.E.; Scherer, P.E.; Schnitzer, J.E.; Oh, P.; Lisanti, M.P.; Lodish, H.F. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J. Biol. Chem. 1997, 272, 13793-13802.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 13793-13802
-
-
Bickel, P.E.1
Scherer, P.E.2
Schnitzer, J.E.3
Oh, P.4
Lisanti, M.P.5
Lodish, H.F.6
-
202
-
-
0031054457
-
Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration
-
Schulte, T.; Paschke, K.A.; Laessing, U.; Lottspeich, F.; Stuermer, C.A. Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration. Development 1997, 124, 577-587.
-
(1997)
Development
, vol.124
, pp. 577-587
-
-
Schulte, T.1
Paschke, K.A.2
Laessing, U.3
Lottspeich, F.4
Stuermer, C.A.5
-
203
-
-
84857128669
-
Functional aspects of membrane association of reggie/flotillin proteins
-
Banning, A.; Tomasovic, A.; Tikkanen, R. Functional aspects of membrane association of reggie/flotillin proteins. Curr. Protein Peptide Sci. 2011, 12, 725-735.
-
(2011)
Curr. Protein Peptide Sci
, vol.12
, pp. 725-735
-
-
Banning, A.1
Tomasovic, A.2
Tikkanen, R.3
-
204
-
-
67349189783
-
Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis
-
Babuke, T.; Ruonala, M.; Meister, M.; Amaddii, M.; Genzler, C.; Esposito, A.; Tikkanen, R. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. Cell. Signal. 2009, 21, 1287-1297.
-
(2009)
Cell. Signal
, vol.21
, pp. 1287-1297
-
-
Babuke, T.1
Ruonala, M.2
Meister, M.3
Amaddii, M.4
Genzler, C.5
Esposito, A.6
Tikkanen, R.7
-
205
-
-
34547726345
-
Dissecting the molecular function of reggie/flotillin proteins
-
Babuke, T.; Tikkanen, R. Dissecting the molecular function of reggie/flotillin proteins. Eur. J. Cell Biol. 2007, 86, 525-532.
-
(2007)
Eur. J. Cell Biol
, vol.86
, pp. 525-532
-
-
Babuke, T.1
Tikkanen, R.2
-
206
-
-
34250851923
-
Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding
-
Frick, M.; Bright, N.A.; Riento, K.; Bray, A.; Merrified, C.; Nichols, B.J. Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding. Curr. Biol. 2007, 17, 1151-1156.
-
(2007)
Curr. Biol
, vol.17
, pp. 1151-1156
-
-
Frick, M.1
Bright, N.A.2
Riento, K.3
Bray, A.4
Merrified, C.5
Nichols, B.J.6
-
207
-
-
0037073697
-
Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation
-
Morrow, I.C.; Rea, S.; Martin, S.; Prior, I.A.; Prohaska, R.; Hancock, J.F.; James, D.E.; Parton, R.G. Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation. J. Biol. Chem. 2002, 277, 48834-48841.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 48834-48841
-
-
Morrow, I.C.1
Rea, S.2
Martin, S.3
Prior, I.A.4
Prohaska, R.5
Hancock, J.F.6
James, D.E.7
Parton, R.G.8
-
208
-
-
1642271441
-
Membrane and raft association of reggie-1/flotillin-2: Role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression
-
Neumann-Giesen, C.; Falkenbach, B.; Beicht, P.; Claasen, S.; Luers, G.; Stuermer, C.A.; Herzog, V.; Tikkanen, R. Membrane and raft association of reggie-1/flotillin-2: Role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Biochem. J. 2004, 378, 509-518.
-
(2004)
Biochem. J
, vol.378
, pp. 509-518
-
-
Neumann-Giesen, C.1
Falkenbach, B.2
Beicht, P.3
Claasen, S.4
Luers, G.5
Stuermer, C.A.6
Herzog, V.7
Tikkanen, R.8
-
209
-
-
33847387596
-
Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton
-
Neumann-Giesen, C.; Fernow, I.; Amaddii, M.; Tikkanen, R. Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J. Cell Sci. 2007, 120, 395-406.
-
(2007)
J. Cell Sci
, vol.120
, pp. 395-406
-
-
Neumann-Giesen, C.1
Fernow, I.2
Amaddii, M.3
Tikkanen, R.4
-
210
-
-
34247159449
-
Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains
-
Solis, G.P.; Hoegg, M.; Munderloh, C.; Schrock, Y.; Malaga-Trillo, E.; Rivera-Milla, E.; Stuermer, C.A. Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains. Biochem. J. 2007, 403, 313-322.
-
(2007)
Biochem. J
, vol.403
, pp. 313-322
-
-
Solis, G.P.1
Hoegg, M.2
Munderloh, C.3
Schrock, Y.4
Malaga-Trillo, E.5
Rivera-Milla, E.6
Stuermer, C.A.7
-
211
-
-
0035947599
-
Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes
-
Dermine, J.F.; Duclos, S.; Garin, J.; St-Louis, F.; Rea, S.; Parton, R.G.; Desjardins, M. Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes. J. Biol. Chem. 2001, 276, 18507-18512.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 18507-18512
-
-
Dermine, J.F.1
Duclos, S.2
Garin, J.3
St-Louis, F.4
Rea, S.5
Parton, R.G.6
Desjardins, M.7
-
212
-
-
30344486984
-
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
-
Glebov, O.O.; Bright, N.A.; Nichols, B.J. Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Nat. Cell. Biol. 2006, 8, 46-54.
-
(2006)
Nat. Cell. Biol
, vol.8
, pp. 46-54
-
-
Glebov, O.O.1
Bright, N.A.2
Nichols, B.J.3
-
213
-
-
14044268814
-
PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts
-
Santamaria, A.; Castellanos, E.; Gomez, V.; Benedit, P.; Renau-Piqueras, J.; Morote, J.; Reventos, J.; Thomson, T.M.; Paciucci, R. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol. Cell. Biol. 2005, 25, 1900-1911.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 1900-1911
-
-
Santamaria, A.1
Castellanos, E.2
Gomez, V.3
Benedit, P.4
Renau-Piqueras, J.5
Morote, J.6
Reventos, J.7
Thomson, T.M.8
Paciucci, R.9
-
214
-
-
0035171631
-
Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2
-
Stuermer, C.A.; Lang, D.M.; Kirsch, F.; Wiechers, M.; Deininger, S.O.; Plattner, H. Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. Mol. Biol. Cell. 2001, 12, 3031-3045.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 3031-3045
-
-
Stuermer, C.A.1
Lang, D.M.2
Kirsch, F.3
Wiechers, M.4
Deininger, S.O.5
Plattner, H.6
-
215
-
-
84864886909
-
ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation
-
Raemaekers, T.; Peric, A.; Baatsen, P.; Sannerud, R.; Declerck, I.; Baert, V.; Michiels, C.; Annaert, W. ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation. EMBO J. 2012, 31, 3252-3269.
-
(2012)
EMBO J
, vol.31
, pp. 3252-3269
-
-
Raemaekers, T.1
Peric, A.2
Baatsen, P.3
Sannerud, R.4
Declerck, I.5
Baert, V.6
Michiels, C.7
Annaert, W.8
-
216
-
-
84866519402
-
Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes
-
Banning, A.; Ockenga, W.; Finger, F.; Siebrasse, P.; Tikkanen, R. Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes. PLoS One 2012, 7, e45514.
-
(2012)
PLoS One
, vol.7
-
-
Banning, A.1
Ockenga, W.2
Finger, F.3
Siebrasse, P.4
Tikkanen, R.5
-
217
-
-
84857746692
-
Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling
-
Amaddii, M.; Meister, M.; Banning, A.; Tomasovic, A.; Mooz, J.; Rajalingam, K.; Tikkanen, R. Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling. J. Biol. Chem. 2012, 287, 7265-7278.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 7265-7278
-
-
Amaddii, M.1
Meister, M.2
Banning, A.3
Tomasovic, A.4
Mooz, J.5
Rajalingam, K.6
Tikkanen, R.7
-
218
-
-
79956033520
-
Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a
-
Lin, C.; Wu, Z.; Lin, X.; Yu, C.; Shi, T.; Zeng, Y.; Wang, X.; Li, J.; Song, L. Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a. Clin. Cancer Res. 2011, 17, 3089-3099.
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 3089-3099
-
-
Lin, C.1
Wu, Z.2
Lin, X.3
Yu, C.4
Shi, T.5
Zeng, Y.6
Wang, X.7
Li, J.8
Song, L.9
-
219
-
-
79953193710
-
Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT
-
Cremona, M.L.; Matthies, H.J.; Pau, K.; Bowton, E.; Speed, N.; Lute, B.J.; Anderson, M.; Sen, N.; Robertson, S.D.; Vaughan, R.A., et al. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat. Neurosci. 2011, 14, 469-477.
-
(2011)
Nat. Neurosci
, vol.14
, pp. 469-477
-
-
Cremona, M.L.1
Matthies, H.J.2
Pau, K.3
Bowton, E.4
Speed, N.5
Lute, B.J.6
Anderson, M.7
Sen, N.8
Robertson, S.D.9
Vaughan, R.A.10
-
220
-
-
34548664143
-
Linking membrane microdomains to the cytoskeleton: Regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin
-
Langhorst, M.F.; Solis, G.P.; Hannbeck, S.; Plattner, H.; Stuermer, C.A. Linking membrane microdomains to the cytoskeleton: Regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. FEBS Lett. 2007, 581, 4697-4703.
-
(2007)
FEBS Lett
, vol.581
, pp. 4697-4703
-
-
Langhorst, M.F.1
Solis, G.P.2
Hannbeck, S.3
Plattner, H.4
Stuermer, C.A.5
-
221
-
-
5644300960
-
Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1
-
Hazarika, P.; McCarty, M.F.; Prieto, V.G.; George, S.; Babu, D.; Koul, D.; Bar-Eli, M.; Duvic, M. Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. Cancer Res. 2004, 64, 7361-7369.
-
(2004)
Cancer Res
, vol.64
, pp. 7361-7369
-
-
Hazarika, P.1
McCarty, M.F.2
Prieto, V.G.3
George, S.4
Babu, D.5
Koul, D.6
Bar-Eli, M.7
Duvic, M.8
-
222
-
-
33745308786
-
Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells
-
Kato, N.; Nakanishi, M.; Hirashima, N. Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells. J. Immunol. 2006, 177, 147-154.
-
(2006)
J. Immunol
, vol.177
, pp. 147-154
-
-
Kato, N.1
Nakanishi, M.2
Hirashima, N.3
-
223
-
-
34547858867
-
Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein
-
Limpert, A.S.; Karlo, J.C.; Landreth, G.E. Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein. Mol. Cell. Biol. 2007, 27, 5686-5698.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 5686-5698
-
-
Limpert, A.S.1
Karlo, J.C.2
Landreth, G.E.3
-
224
-
-
34147166070
-
The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase
-
Sugawara, Y.; Nishii, H.; Takahashi, T.; Yamauchi, J.; Mizuno, N.; Tago, K.; Itoh, H. The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. Cell. Signal. 2007, 19, 1301-1308.
-
(2007)
Cell. Signal
, vol.19
, pp. 1301-1308
-
-
Sugawara, Y.1
Nishii, H.2
Takahashi, T.3
Yamauchi, J.4
Mizuno, N.5
Tago, K.6
Itoh, H.7
-
225
-
-
66849106387
-
Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase
-
Riento, K.; Frick, M.; Schafer, I.; Nichols, B.J. Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase. J. Cell Sci. 2009, 122, 912-918.
-
(2009)
J. Cell Sci
, vol.122
, pp. 912-918
-
-
Riento, K.1
Frick, M.2
Schafer, I.3
Nichols, B.J.4
-
226
-
-
0034648794
-
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
-
Baumann, C.A.; Ribon, V.; Kanzaki, M.; Thurmond, D.C.; Mora, S.; Shigematsu, S.; Bickel, P.E.; Pessin, J.E.; Saltiel, A.R. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 2000, 407, 202-207.
-
(2000)
Nature
, vol.407
, pp. 202-207
-
-
Baumann, C.A.1
Ribon, V.2
Kanzaki, M.3
Thurmond, D.C.4
Mora, S.5
Shigematsu, S.6
Bickel, P.E.7
Pessin, J.E.8
Saltiel, A.R.9
-
227
-
-
84855335580
-
Molecular networks in FGF signaling: Flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2
-
Tomasovic, A.; Traub, S.; Tikkanen, R. Molecular networks in FGF signaling: Flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. PLoS One 2012, 7, e29739.
-
(2012)
PLoS One
, vol.7
-
-
Tomasovic, A.1
Traub, S.2
Tikkanen, R.3
-
228
-
-
0036771763
-
The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors
-
Lax, I.; Wong, A.; Lamothe, B.; Lee, A.; Frost, A.; Hawes, J.; Schlessinger, J. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. Mol. Cell 2002, 10, 709-719.
-
(2002)
Mol. Cell
, vol.10
, pp. 709-719
-
-
Lax, I.1
Wong, A.2
Lamothe, B.3
Lee, A.4
Frost, A.5
Hawes, J.6
Schlessinger, J.7
-
229
-
-
0141738653
-
EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2
-
Wu, Y.; Chen, Z.; Ullrich, A. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol. Chem. 2003, 384, 1215-1226.
-
(2003)
Biol. Chem
, vol.384
, pp. 1215-1226
-
-
Wu, Y.1
Chen, Z.2
Ullrich, A.3
-
230
-
-
20344379187
-
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals
-
Pullikuth, A.; McKinnon, E.; Schaeffer, H.J.; Catling, A.D. The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol. Cell. Biol. 2005, 25, 5119-5133.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 5119-5133
-
-
Pullikuth, A.1
McKinnon, E.2
Schaeffer, H.J.3
Catling, A.D.4
-
231
-
-
0042672912
-
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
-
Slack-Davis, J.K.; Eblen, S.T.; Zecevic, M.; Boerner, S.A.; Tarcsafalvi, A.; Diaz, H.B.; Marshall, M.S.; Weber, M.J.; Parsons, J.T.; Catling, A.D. PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. J. Cell Biol. 2003, 162, 281-291.
-
(2003)
J. Cell Biol
, vol.162
, pp. 281-291
-
-
Slack-Davis, J.K.1
Eblen, S.T.2
Zecevic, M.3
Boerner, S.A.4
Tarcsafalvi, A.5
Diaz, H.B.6
Marshall, M.S.7
Weber, M.J.8
Parsons, J.T.9
Catling, A.D.10
-
232
-
-
36849058617
-
RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility
-
Vomastek, T.; Iwanicki, M.P.; Schaeffer, H.J.; Tarcsafalvi, A.; Parsons, J.T.; Weber, M.J. RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol. Cell. Biol. 2007, 27, 8296-8305
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 8296-8305
-
-
Vomastek, T.1
Iwanicki, M.P.2
Schaeffer, H.J.3
Tarcsafalvi, A.4
Parsons, J.T.5
Weber, M.J.6
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