MAP kinase module: The Ksr connection

Current Biology

Volumn 12, Issue 9, 2002, Pages R325-R327

  Roy, François ^a   Therrien, Marc ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

KSR 1 PROTEIN KINASE; KSR-1 PROTEIN KINASE; MAP3K1 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RAF PROTEIN;

ANIMAL; METABOLISM; MOUSE; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALS; MAP KINASE KINASE KINASE 1; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0037197949     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00831-X     Document Type: Review

References (20)

1. Small GTP-binding proteins
2. Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
3. C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation
4. Ksr is a scaffold required for activation of the ERK/MAP kinase module
5. C-TAK1 regulates Ras signaling by phosphorylating the MAP kinase scafford, Ksr1
6. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
7. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
8. Ksr, a novel protein kinase required for Ras signal transduction
9. Critical contribution of linker proteins to Raf kinase activation
10. Kinase suppressor of Ras is ceramide-activated protein kinase
11. Ksr stimulates Raf-1 activity in a kinase-independent manner
12. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization
13. Identification of B-Ksr1, a novel brain-specific isoform of Ksr1 that functions in neuronal signaling
14. Ksr: A MAP kinase scaffold of the Ras pathway?
15. Murine Ksr interacts with MEK and inhibits Ras-induced transformation
16. Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK
17. Identification of constitutive and ras-inducible phosphorylation sites of Ksr: Implications for 14-3-3 binding, mitogen-activated protein kinase binding and Ksr overexpression
18. The protein kinase Ksr interacts with 14-3-3 protein and Raf
19. Ksr modulates signal propagation within the MAP kinase cascade
20. Regulation of Raf-1 activation and signalling by dephosphorylation