14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo

Molecular and Cellular Biology

Volumn 18, Issue 7, 1998, Pages 3947-3955

  Roy, Sandrine ^a   McPherson, Robert A ^a   Apolloni, Ann ^a   Yan, Jun ^a   Lane, Annette ^a   Clyde Smith, Jodi ^a   Hancock, John F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0031862578     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.7.3947     Document Type: Article

References (58)

1. Baek, K. H., J. R. Fabian, F. Sprenger, D. K. Morrison, and L. Ambrosio. 1996. The activity of D-raf in torso signal transduction is altered by serine substitution, N-terminal deletion, and membrane targeting. Dev. Biol. 175: 191-204
2. Brtva, T. R., J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell Burk, R. M. Bell, and C. J. Der. 1995. Two distinct Raf domains mediate interaction with Ras. J. Biol. Chem. 270:9809-9812.
3. Canagarajah, B. J., A. Khokhlatchev, M. H. Cobb, and E. J. Goldsmith. 1997. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell 90:859-869.
4. Carroll, M. P., and W. S. May. 1994. Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. J. Biol. Chem. 269:1249-1256.
5. Chang, H. C., and G. M. Rubin. 1997. 14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila. Genes Dev. 11:1132-1139.
6. Clark, G. J., J. K. Drugan, K. L. Rossman, J. W. Carpenter, K. Rogers-Graham, H. Fu, C. J. Der, and S. L. Campbell. 1997. 14-3-3ζ negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain. J. Biol. Chem. 272:20990-20993.
7. Drugan, J. K., R. Khosravi Far, M. A. White, C. J. Der, Y. J. Sung, Y. W. Hwang and S. L. Campbell. 1996. Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. J. Biol. Chem. 271:233-237.
8. Fabian, J. R., I. O. Daar, and D. K. Morrison. 1993. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol. Cell. Biol. 13:7170-7179.
9. Fabian, J. R., D. K. Morrison, and I. O. Daar. 1993. Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes. J. Cell Biol. 122:645-652.
10. Fabian, J. R., A. B. Vojtek, J. A. Cooper, and D. K. Morrison. 1994. A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function. Proc. Natl. Acad. Sci. USA 91:5982-5986.
11. Fantl, W. J., A. J. Muslin, A. Kikuchi, J. A. Martin, A. M. MacNicol, R. W. Gross, and L. T. Williams. 1994. Activation of Raf-1 by 14-3-3 proteins. Nature 371:612-614.
12. Farrar, M. A., I. Alberol, and R. M. Perlmutter. 1996. Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. Nature 383:178-181.
13. Ferrier A. F., M. Lee, W. B. Anderson, G. Benvenuto, D. K. Morrison, D. R. Lowy, and J. E. DeClue. 1997. Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility. J. Biol. Chem. 272:2136-2142.
14. Freed, E., M. Symons, S. G. Macdonald, F. McCormick, and R. Ruggieri. 1994. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science 265:1713-1716.
15. Fu, H., Xia, D.C. Pallas, C. Cui, K. Conroy, R. P. Narsimhan, H. Mamon, R. J. Collier, and T. M. Roberts. 1994. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science 266:126-129.
16. Ghosh S., and R. M. Bell. 1994. Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras. J. Biol. Chem. 269:30785-30788.
17. Ghosh, S., J. C. Strum, V. A. Sciorra, L. Daniel, and R. M. Bell. 1996. Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells. J. Biol. Chem. 271:8472-8480.
18. Ghosh, S., W. Q. Xie, A. F. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell. 1994. The cysteine-rich region of Raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras. J. Biol. Chem. 269:10000-10007.
19. Hancock, J. F., and A. Hall. 1993. A novel role for RhoGDI as inhibitor of GAP proteins. EMBO J. 12:1915-1921.
20. Hu, C. D., K. Kariya, M. Tamada, K. Akasaka, M. Shirouzu, S. Yokoyama, and T. Kataoka. 1995. Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras. J. Biol. Chem. 270:30274-30277.
21. ras function. Mol. Cell. Biol. 13:2420-2431.
22. Irie, K., Y. Gotoh, B. M. Yashar, B. Errede, E. Nishida, and K. Matsumoto. 1994. Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science 265:1716-1719.
23. Jelinek, T., P. Dent, T. W. Sturgill, and M. J. Weber. 1996. Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation. Mol. Cell. Biol. 16:1027-1034.
24. Kockel, L., G. Vorbruggen, H. Jackle, M. Mlodzik, and D. Bohmann. 1997. Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development. Genes Dev. 11:1140-1147.
25. Leevers, S. J., H. F. Paterson, and C. J. Marshall. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369:411-414.
26. Li, S., P. Janosch, M. Tanji, G. C. Rosenfeld, J. C. Waymire, H. Mischak, W. Kolch, and J. M. Sedivy. 1995. Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins. EMBO J. 14:685-696.
27. Luo, Z., B. Diaz, M. Marshall, and J. Avruch. 1997. An intact zinc finger is required for optimal binding to processed Ras and for Ras-dependent Raf activation in situ. Mol. Cell. Biol. 17:46-53.
28. Luo, Z., G. Tzivion, P. J. Belshaw, D. Vavvas, M. Marshall, and J. Avruch. 1996. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature 383:181-185.
29. Luo, Z. J., X. F. Zhang, U. Rapp, and J. Avruch. 1995. Identification of the 14.3.3 zeta domains important for self-association and Raf binding. J. Biol. Chem. 270:23681-23687.
30. Marais, R., Y. Light, H. F. Paterson, and C. J. Marshall. 1995. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 14:3136-3145.
31. Marais, R., Y. Light, H. F. Paterson, C. S. Mason, and C. J. Marshall. 1997. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J. Biol. Chem. 272:4378-4383.
32. Marais, R., and C. J. Marshall. 1996. Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv. 27:101-125.
33. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
34. McPherson, R. A. Unpublished data.
35. McPherson, R. A., and J. F. Hancock. Unpublished data.
36. Michaud, N. R., J. R. Fabian, K. D. Mathes, and D. K. Morrison. 1995. 14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner. Mol. Cell. Biol. 15:3390-3397.
37. Mineo, C., R. G. Anderson, and M. A. White. 1997. Physical association with ras enhances activation of membrane-bound raf (RafCAAX). J. Biol. Chem. 272:10345-10348.
38. Mischak, H., T. Seitz, P. Janosch, M. Eulitz, H. Steen, M. Schellerer, A. Philipp, and W. Kolch. 1996. Negative regulation of Raf-1 by phosphorylation of serine 621. Mol. Cell. Biol. 16:5409-5418.
39. Morrison, D. K., and R. E. Cutler. 1997. The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9:174-179.
40. Morrison, D. K., G. Heidecker, U. R. Rapp, and T. D. Copeland. 1993. Identification of the major phosphorylation sites of the Raf-1 kinase. J. Biol. Chem. 268:17309-17316.
41. Muslin, A. J., J. W. Tanner, P. M. Allen, and A. S. Shaw. 1996. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 84:889-897.
42. Radziwill, G., U. Steinhusen, A. Aitken, and K. Moelling. 1996. Inhibition of Raf/MAPK signaling in Xenopus oocyte extracts by Raf-1-specific peptides. Biochem. Biophys. Res. Commun. 227:20-26.
43. Rommel, C., G. Radziwill, J. Lovric, J. Noeldeke, T. Heinicke, D. Jones, A. Aitken, and K. Moelling. 1996. Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1. Oncogene 12:609-619.
44. Rommel, C., G. Radziwill, K. Moelling, and E. Hafen. 1997. Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo. Mech. Dev. 64:95-104.
45. Roy, S., A. Lane, J. Yan, R. McPherson, and J. F. Hancock. 1997. Activity of plasma membrane recruited Raf-1 is regulated by Ras via the Raf zinc finger. J. Biol. Chem. 272:20139-20145.
46. Stokoe, D., S. G. Macdonald, K. Cadwallader, M. Symons, and J. F. Hancock. 1994. Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463-1467.
47. Stokoe, D., and F. McCormick. 1997. Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro. EMBO J. 16:2384-2396.
48. Suen, K. L., X. R. Bustelo, and M. Barbacid. 1995. Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells. Oncogene 11:825-831.
49. Therrien, M., N. R. Michaud, G. M. Rubin, and D. K. Morrison. 1996. KSR modulates signal propagation within the MAPK cascade. Genes Dev. 10: 2684-2695.
50. Traverse, S., P. Cohen, H. Paterson, C. Marshall, U. Rapp, and R. J. Grand. 1993. Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells. Oncogene 8:3175-3181.
51. Ueda, Y., S. Hirai, S. Osada, A. Suzuki, K. Mizuno, and S. Ohno. 1996. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271:23512-23519.
52. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
53. Warne, P. H., P. R. Viciana, and J. Downward. 1993. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature 364:352-355.
54. Wartmann, M., and R. J. Davis. 1994. The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex. J. Biol. Chem. 269:6695-6701.
55. Wartmann, M., P. Hofer, P. Turowski, A. R. Saltiel, and N. E. Hynes. 1997. Negative modulation of membrane localization of the Raf-1 protein kinase by hyperphosphorylation. J. Biol. Chem. 272:3915-3923.
56. Yao, B., Y. Zhang, S. Delikat, S. Mathias, S. Basu, and R. Kolesnick. 1995. Phosphorylation of Raf by ceramide-activated protein kinase. Nature 378: 307-310.
57. Zha, J., H. Harada, E. Yang, J. Jockel, and S. J. Korsmeyer. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-628.
58. Zhang, X., J. Settleman, J. M. Kyriakis, E. Takeuchi-Suzuki, S. J. Elledge, M. S. Marshall, J. T. Bruder, U. R. Rapp, and J. Avruch. 1993. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364:308-365.