IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 12789-12796

  Chen, Chiyuan ^a   Lewis, Robert E ^b   White, Michael A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; OLIGOMERIZATION; OLIGOMERS; POLYMERS; PROTEINS;

COMPLEX FORMATIONS; FAMILY MEMBERS; FUNCTIONAL COUPLINGS; ISOPEPTIDE LIGASE; KINASE MODULES; RAF KINASES; SIGNAL AMPLITUDES; SIGNAL PROPAGATIONS; UBIQUITIN;

MODULATION;

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAF PROTEIN; RAS PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; BRAP PROTEIN, HUMAN; KSR 1 PROTEIN KINASE; KSR-1 PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE;

ARTICLE; CELL STRAIN HEK293; COMPLEX FORMATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; OLIGOMERIZATION; PLASMID; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL LINE; CLASSIFICATION; GENETICS; METABOLISM; MITOSIS; PROTEIN BINDING; SENSITIVITY AND SPECIFICITY;

CELL LINE; ENZYME ACTIVATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOSIS; PROTEIN BINDING; PROTEIN KINASES; RAF KINASES; SENSITIVITY AND SPECIFICITY; UBIQUITIN-PROTEIN LIGASES;

EID: 45149103530     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709305200     Document Type: Article

References (26)

1. Pearson, G., Robinson, F., Beers Gibson, T., Xu, B. E., Karandikar, M., Berman, K., and Cobb, M. H. (2001) Endocr. Rev. 22, 153-183
2. Wellbrock, C., Karasarides, M., and Marais, R. (2004) Nat. Rev. Mol. Cell Biol. 5, 875-885
3. Dhillon, A. S., Hagan, S., Rath, O., and Kolch, W. (2007) Oncogene 26, 3279-3290
4. Whitehurst, A., Cobb, M. H., and White, M. A. (2004) Mol. Cell. Biol. 24, 10145-10150
5. Mackeigan, J. P., Murphy, L. O., Dimitri, C. A., and Blenis, J. (2005) Mol. Cell. Biol. 25, 4676-4682
6. Raman, M., Chen, W., and Cobb, M. H. (2007) Oncogene 26, 3100-3112
7. McKay, M. M., and Morrison, D. K. (2007) Oncogene 26, 3113-3121
8. Bumeister, R., Rosse, C., Anselmo, A., Camonis, J., and White, M. A. (2004) Curr. Biol. 14, 439-445
9. Morrison, D. K., and Davis, R. J. (2003) Annu. Rev. Cell Dev. Biol. 19, 91-118
10. Kolch, W. (2005) Nat. Rev. Mol. Cell Biol. 6, 827-837
11. Claperon, A., and Therrien, M. (2007) Oncogene 26, 3143-3158
12. Matheny, S. A., Chen, C., Kortum, R. L., Razidlo, G. L., Lewis, R. E., and White, M. A. (2004) Nature 427, 256-260
13. Ory, S., and Morrison, D. K. (2004) Curr. Biol. 14, R277-R278
14. Joneson, T., Fulton, J. A., Volle, D. J., Chaika, O. V., Bar-Sagi, D., and Lewis, R. E. (1998) J. Biol. Chem. 273, 7743-7748
15. Therrien, M., Michaud, N. R., Rubin, G. M., and Morrison, D. K. (1996) Genes Dev. 10, 2684-2695
16. Wan, P. T., Garnett, M. J., Roe, S. M., Lee, S., Niculescu-Duvaz, D., Good, V. M., Jones, C. M., Marshall, C. J., Springer, C. J., Barford, D., and Marais, R. (2004) Cell 116, 855-867
17. Garnett, M. J., Rana, S., Paterson, H., Barford, D., and Marais, R. (2005) Mol. Cell 20, 963-969
18. Tran, N. H., Wu, X., and Frost, J. A. (2005) J. Biol. Chem. 280, 16244-16253
19. Whitehurst, A. W., Bodemann, B. O., Cardenas, J., Ferguson, D., Girard, L., Peyton, M., Minna, J. D., Michnoff, C., Hao, W., Roth, M. G., Xie, X. J., and White, M. A. (2007) Nature 446, 815-819
20. Weber, C. K., Slupsky, J. R., Kalmes, H. A., and Rapp, U. R. (2001) Cancer Res. 61, 3595-3598
21. Rushworth, L. K., Hindley, A. D., O'Neill, E., and Kolch, W. (2006) Mol. Cell. Biol. 26, 2262-2272
22. Morrison, D. K. (2001) J. Cell Sci. 114, 1609-1612
23. Muller, J., Ory, S., Copeland, T., Piwnica-Worms, H., and Morrison, D. K. (2001) Mol. Cell 8, 983-993
24. Roy, F., Laberge, G., Douziech, M., Ferland-McCollough, D., and Therrien, M. (2002) Genes Dev. 16, 427-438
25. Anselmo, A. N., Bumeister, R., Thomas, J. M., and White, M. A. (2002) J. Biol. Chem. 277, 5940-5943
26. Douziech, M., Sahmi, M., Laberge, G., and Therrien, M. (2006) Genes Dev. 20, 807-819